Published in Chem Biol on March 21, 2013
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci (2013) 0.96
Chemical modulation of glycerolipid signaling and metabolic pathways. Biochim Biophys Acta (2014) 0.89
Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition. ACS Chem Biol (2013) 0.87
Monoglyceride lipase: Structure and inhibitors. Chem Phys Lipids (2015) 0.82
Radiosynthesis and ex vivo evaluation of [(11)C-carbonyl]carbamate- and urea-based monoacylglycerol lipase inhibitors. Nucl Med Biol (2014) 0.81
Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). PLoS One (2014) 0.79
Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem (2014) 0.78
Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12). PLoS One (2014) 0.78
Discovery libraries targeting the major enzyme classes: the serine hydrolases. Bioorg Med Chem Lett (2014) 0.76
Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer (2017) 0.75
Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future Antidepressants. Curr Neuropharmacol (2015) 0.75
Synthesis of quinolinyl and isoquinolinyl phenyl ketones as novel agonists for the cannabinoid CB2 receptor. Bioorg Med Chem (2009) 2.12
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem Biol (2005) 1.74
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3. Exp Cell Res (2009) 1.59
Celastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun (2010) 1.45
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma. Melanoma Res (2015) 1.39
Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes. Biochem Pharmacol (2004) 1.34
Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12). J Lipid Res (2012) 1.28
Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury. J Invest Dermatol (2005) 1.20
Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem (2003) 1.16
Influence of tamsulosin on the iris and its implications for cataract surgery. Invest Ophthalmol Vis Sci (2006) 1.15
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain. Chem Biol (2006) 1.14
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. Br J Pharmacol (2003) 1.12
The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene. J Biol Chem (2005) 1.10
Birch PR-10c interacts with several biologically important ligands. Phytochemistry (2005) 1.08
S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol (2005) 1.07
Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem (2008) 1.06
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem (2006) 1.06
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal (2006) 1.05
The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D-lysophosphatidic acid receptor axis and 5-HT1A receptors in rat brain sections. Br J Pharmacol (2006) 1.04
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling. J Biol Chem (2009) 1.02
A structure-activity relationship study of catechol-O-methyltransferase inhibitors combining molecular docking and 3D QSAR methods. J Comput Aided Mol Des (2003) 1.02
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty. Aging Cell (2013) 1.01
An in silico approach to discovering novel inhibitors of human sirtuin type 2. J Med Chem (2004) 0.99
The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor. J Invest Dermatol (2004) 0.98
Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors. Basic Clin Pharmacol Toxicol (2007) 0.98
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. J Med Chem (2012) 0.96
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors. J Med Chem (2008) 0.95
Large neutral amino acid transporter enables brain drug delivery via prodrugs. J Med Chem (2008) 0.95
Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor. J Med Chem (2005) 0.94
Development of a 3D model for the human cannabinoid CB1 receptor. J Med Chem (2004) 0.93
Comparative and pharmacophore model for deacetylase SIRT1. J Comput Aided Mol Des (2006) 0.93
BRUTUS: optimization of a grid-based similarity function for rigid-body molecular superposition. 1. Alignment and virtual screening applications. J Med Chem (2005) 0.92
Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol. Chem Biodivers (2007) 0.92
Transcriptional analysis reveals gender-specific changes in the aging of the human immune system. PLoS One (2013) 0.92
Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors. Curr Top Med Chem (2010) 0.91
Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors. J Med Chem (2007) 0.91
Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique. Anal Biochem (2009) 0.90
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. Biochem Pharmacol (2002) 0.90
Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem (2005) 0.90
Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.90
Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors. J Med Chem (2013) 0.90
Amino acids important for ligand specificity of the human constitutive androstane receptor. J Biol Chem (2004) 0.89
Molecular dynamics studies on the thermostability of family 11 xylanases. Protein Eng Des Sel (2007) 0.89
The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol (2006) 0.88
Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children. Br J Clin Pharmacol (2010) 0.88
N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors. J Med Chem (2009) 0.88
Usability of electronic nursing record systems: definition and results from an evaluation study in Finland. Stud Health Technol Inform (2011) 0.88
2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12. Neuropharmacology (2003) 0.87
Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry. Rapid Commun Mass Spectrom (2007) 0.87
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression. J Invest Dermatol (2005) 0.87
Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2. J Med Chem (2011) 0.87
Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. J Med Chem (2005) 0.86
Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat. BMC Neurosci (2007) 0.86
Hyaluronan production enhances shedding of plasma membrane-derived microvesicles. Exp Cell Res (2013) 0.86
Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone. J Med Chem (2004) 0.86
Controlled release of saccharides from matrix tablets. Eur J Pharm Biopharm (2005) 0.86
Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone. Bioorg Med Chem (2008) 0.86
Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship. J Med Chem (2008) 0.85
Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization. J Chem Inf Model (2014) 0.85
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists. J Med Chem (2006) 0.85
Critical comparison of virtual screening methods against the MUV data set. J Chem Inf Model (2009) 0.85
Comprehensive data-driven analysis of the impact of chemoinformatic structure on the genome-wide biological response profiles of cancer cells to 1159 drugs. BMC Bioinformatics (2012) 0.84
N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors. J Med Chem (2006) 0.84
Localization and variable expression of G alpha(i2) in human endometrium and Fallopian tubes. Hum Reprod (2007) 0.84
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. J Pharmacol Exp Ther (2003) 0.83
Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. ChemMedChem (2009) 0.83
Quantification of endocannabinoids in postmortem brain of schizophrenic subjects. Schizophr Res (2013) 0.83
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis. J Neurosci Methods (2010) 0.83
New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol Pharm (2011) 0.83
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem (2009) 0.83
Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol Pharmacol (2013) 0.83
BRUTUS: optimization of a grid-based similarity function for rigid-body molecular superposition. II. Description and characterization. J Comput Aided Mol Des (2006) 0.83