Published in PLoS One on March 28, 2013
Emerging technologies for the clinical microbiology laboratory. Clin Microbiol Rev (2014) 0.98
Non-instrumented incubation of a recombinase polymerase amplification assay for the rapid and sensitive detection of proviral HIV-1 DNA. PLoS One (2014) 0.98
Electricity-free amplification and detection for molecular point-of-care diagnosis of HIV-1. PLoS One (2014) 0.96
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A (2015) 0.92
Paper-based molecular diagnostic for Chlamydia trachomatis. RSC Adv (2014) 0.85
A low complexity rapid molecular method for detection of Clostridium difficile in stool. PLoS One (2014) 0.84
A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples. Lab Chip (2016) 0.80
Low-Cost 3D Printers Enable High-Quality and Automated Sample Preparation and Molecular Detection. PLoS One (2016) 0.77
A novel cassette method for probe evaluation in the designed biochips. PLoS One (2014) 0.75
Future developments in biosensors for field-ready Zika virus diagnostics. J Biol Eng (2017) 0.75
Rapid and simple method for purification of nucleic acids. J Clin Microbiol (1990) 44.73
An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med (2005) 18.10
Top ten biotechnologies for improving health in developing countries. Nat Genet (2002) 8.12
Microfluidic diagnostic technologies for global public health. Nature (2006) 7.08
Diagnostics for the developing world. Nat Rev Microbiol (2004) 5.62
Diagnostics for the developing world: microfluidic paper-based analytical devices. Anal Chem (2010) 4.88
Lab-on-a-chip devices for global health: past studies and future opportunities. Lab Chip (2006) 4.81
Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis. Anal Chem (2008) 4.59
Blood-on-a-chip. Annu Rev Biomed Eng (2005) 4.46
Childhood pneumonia and diarrhoea: setting our priorities right. Lancet Infect Dis (2007) 4.42
Point-of-care diagnostics for global health. Annu Rev Biomed Eng (2008) 4.11
Point-of-care testing for infectious diseases: diversity, complexity, and barriers in low- and middle-income countries. PLoS Med (2012) 2.84
Detection of biological threat agents by real-time PCR: comparison of assay performance on the R.A.P.I.D., the LightCycler, and the Smart Cycler platforms. Clin Chem (2006) 1.85
Nucleic acid-based methods for the detection of cancer. Science (1997) 1.80
Inkjet-printed microfluidic multianalyte chemical sensing paper. Anal Chem (2008) 1.78
Nucleic acid detection technologies -- labels, strategies, and formats. Clin Chem (1999) 1.71
Towards non- and minimally instrumented, microfluidics-based diagnostic devices. Lab Chip (2008) 1.60
A simple, inexpensive device for nucleic acid amplification without electricity-toward instrument-free molecular diagnostics in low-resource settings. PLoS One (2011) 1.50
Isothermal amplification using a chemical heating device for point-of-care detection of HIV-1. PLoS One (2012) 1.43
Application of isothermal helicase-dependent amplification with a disposable detection device in a simple sensitive stool test for toxigenic Clostridium difficile. J Mol Diagn (2008) 1.41
Egg beater as centrifuge: isolating human blood plasma from whole blood in resource-poor settings. Lab Chip (2008) 1.31
Nucleic acid approaches for detection and identification of biological warfare and infectious disease agents. Biotechniques (2003) 1.24
Non-instrumented nucleic acid amplification (NINA): instrument-free molecular malaria diagnostics for low-resource settings. Conf Proc IEEE Eng Med Biol Soc (2010) 1.22
Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip. Lab Chip (2009) 1.20
Identification of Staphylococcus aureus and determination of methicillin resistance directly from positive blood cultures by isothermal amplification and a disposable detection device. J Clin Microbiol (2008) 1.16
Microfluidics and point-of-care testing. Lab Chip (2008) 1.15
Evaluation of conventional and real-time PCR assays using two targets for confirmation of results of the COBAS AMPLICOR Chlamydia trachomatis/Neisseria gonorrhoeae test for detection of Neisseria gonorrhoeae in clinical samples. J Clin Microbiol (2005) 1.12
Preliminary evaluation of an immunochromatographic strip test for specific Treponema pallidum antibodies. J Clin Microbiol (2002) 1.10
An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices (2010) 1.05
A low-cost microfluidic chip for rapid genotyping of malaria-transmitting mosquitoes. PLoS One (2012) 1.03
Protein biochip systems for the clinical laboratory. Clin Chem Lab Med (2005) 1.00
Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens. PLoS One (2012) 0.97
Immunochromatographic strip test for rapid detection of diphtheria toxin: description and multicenter evaluation in areas of low and high prevalence of diphtheria. J Clin Microbiol (2002) 0.90
Development of a rapid immunodiagnostic test for Haemophilus ducreyi. J Clin Microbiol (2002) 0.89
Overview of PCR-based systems in identity testing. Methods Mol Biol (1998) 0.89
Towards stationary phases for chromatography on a microchip: molded porous polymer monoliths prepared in capillaries by photoinitiated in situ polymerization as separation media for electrochromatography. Electrophoresis (2000) 0.88
Handheld mechanical cell lysis chip with ultra-sharp silicon nano-blade arrays for rapid intracellular protein extraction. Lab Chip (2010) 0.87
Microscale sample preparation for PCR of C. difficile infected stool. J Microbiol Methods (2009) 0.84
Improving isothermal DNA amplification speed for the rapid detection of Mycobacterium tuberculosis. J Microbiol Methods (2010) 0.82
A Portable Analyzer for Pouch-Actuated, Immunoassay Cassettes. Sens Actuators B Chem (2011) 0.82
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer. J Proteome Res (2007) 3.48
Comparative analysis of a large dataset indicates that internal transcribed spacer (ITS) should be incorporated into the core barcode for seed plants. Proc Natl Acad Sci U S A (2011) 3.41
A targeted proteomics-based pipeline for verification of biomarkers in plasma. Nat Biotechnol (2011) 2.91
Observed increase in local cooling effect of deforestation at higher latitudes. Nature (2011) 2.69
Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers. Anal Biochem (2006) 2.55
An automated and multiplexed method for high throughput peptide immunoaffinity enrichment and multiple reaction monitoring mass spectrometry-based quantification of protein biomarkers. Mol Cell Proteomics (2009) 2.40
Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy. J Virol (2003) 2.31
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am J Med Genet (2002) 2.21
Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study. Acta Diabetol (2010) 2.01
Gastric mucosal necrosis with vascular degeneration induced by doxycycline. Am J Surg Pathol (2013) 1.99
Comparison of oligonucleotide ligation assay and consensus sequencing for detection of drug-resistant mutants of human immunodeficiency virus type 1 in peripheral blood mononuclear cells and plasma. J Clin Microbiol (2004) 1.97
Stepwise metastatic human hepatocellular carcinoma cell model system with multiple metastatic potentials established through consecutive in vivo selection and studies on metastatic characteristics. J Cancer Res Clin Oncol (2004) 1.86
Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7. Mol Cell (2010) 1.83
Mechanical and chemical analysis of plasma and ultraviolet-ozone surface treatments for thermal bonding of polymeric microfluidic devices. Lab Chip (2007) 1.70
Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 1.70
Rapid and sensitive oligonucleotide ligation assay for detection of mutations in human immunodeficiency virus type 1 associated with high-level resistance to protease inhibitors. J Clin Microbiol (2002) 1.66
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J Clin Invest (2011) 1.63
Connections between genetics and clinical data: Role of MCP-1, CFTR, and SPINK-1 in the setting of acute, acute recurrent, and chronic pancreatitis. Am J Gastroenterol (2009) 1.63
Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem (2004) 1.59
Thermoplastic microfluidic device for on-chip purification of nucleic acids for disposable diagnostics. Anal Chem (2006) 1.58
Differential effects of pyrrolidine dithiocarbamate on TNF-alpha-mediated liver injury in two different models of fulminant hepatitis. J Hepatol (2008) 1.55
Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle. J Biomed Opt (2009) 1.55
Analysis of changes in reflectance measurements on biological tissues subjected to different probe pressures. J Biomed Opt (2008) 1.55
Interobserver agreement for confocal imaging of ampullary lesions: a multicenter single-blinded study. J Clin Gastroenterol (2013) 1.53
Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry. Mol Cell Proteomics (2011) 1.52
Laparoendoscopic single-site radical cystectomy and urinary diversion: initial experience in China using a homemade single-port device. J Endourol (2011) 1.48
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol (2004) 1.47
Interpretation of probe-based confocal laser endomicroscopy of indeterminate biliary strictures: is there any interobserver agreement? Dig Dis Sci (2012) 1.46
De novo sequencing and characterization of the floral transcriptome of Dendrocalamus latiflorus (Poaceae: Bambusoideae). PLoS One (2012) 1.45
Interlaboratory evaluation of automated, multiplexed peptide immunoaffinity enrichment coupled to multiple reaction monitoring mass spectrometry for quantifying proteins in plasma. Mol Cell Proteomics (2011) 1.44
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus. Hum Mol Genet (2008) 1.43
Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. J Hepatol (2010) 1.41
Ethanol Extract from Ampelopsis sinica Root Exerts Anti-Hepatitis B Virus Activity via Inhibition of p53 Pathway In Vitro. Evid Based Complement Alternat Med (2011) 1.39
Effect of low-dose aspirin on vascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation (2002) 1.34
Lipoxygenase genes and their targeted disruption. Prostaglandins Other Lipid Mediat (2002) 1.25
Evaluation of passively transferred, nonneutralizing antibody-dependent cellular cytotoxicity-mediating IgG in protection of neonatal rhesus macaques against oral SIVmac251 challenge. J Immunol (2006) 1.22
Strong polarization dependence of plasmon-enhanced fluorescence on single gold nanorods. Nano Lett (2009) 1.21
Cell lysis and DNA extraction of gram-positive and gram-negative bacteria from whole blood in a disposable microfluidic chip. Lab Chip (2009) 1.20
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs (2009) 1.20
Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Mol Cell Biol (2005) 1.19
Keratins modulate colonocyte electrolyte transport via protein mistargeting. J Cell Biol (2004) 1.18
Tissue-specific, development-dependent phenolic compounds accumulation profile and gene expression pattern in tea plant [Camellia sinensis]. PLoS One (2013) 1.15
The complete mitochondrial genome of the fall webworm, Hyphantria cunea (Lepidoptera: Arctiidae). Int J Biol Sci (2010) 1.14
Immunogenicity of protein aggregates--concerns and realities. Int J Pharm (2012) 1.14
The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol (2006) 1.14
Rapid point-of-care concentration of bacteria in a disposable microfluidic device using meniscus dragging effect. Lab Chip (2010) 1.13
Thrombin-activatable fibrinolysis inhibitor (TAFI) deficiency is compatible with murine life. J Clin Invest (2002) 1.13
Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain (2010) 1.12
Low cost and manufacturable complete microTAS for detecting bacteria. Lab Chip (2009) 1.11
Effectiveness of stereotactic body radiotherapy for hepatocellular carcinoma with portal vein and/or inferior vena cava tumor thrombosis. PLoS One (2013) 1.10
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.09
Identification of a novel functional domain of ricin responsible for its potent toxicity. J Biol Chem (2011) 1.08
A general and robust strategy for the synthesis of nearly monodisperse colloidal nanocrystals. Nat Nanotechnol (2013) 1.08
The essential role of the flexible termini in the temperature-responsiveness of the oligomeric state and chaperone-like activity for the polydisperse small heat shock protein IbpB from Escherichia coli. J Mol Biol (2005) 1.07
Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions. J Pharm Sci (2011) 1.07
Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Eur J Pharmacol (2008) 1.07
Bis{1-[(1H-benzimidazol-2-yl)meth-yl]-1H-imidazole-κN}-bis-(3,5-dicarb-oxy-benzoato-κO)zinc octa-hydrate. Acta Crystallogr Sect E Struct Rep Online (2012) 1.07
Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity. Cancer Res (2008) 1.07
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Am J Physiol Gastrointest Liver Physiol (2010) 1.06
Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. J Virol (2012) 1.06
Observation of a charged charmoniumlike structure in e+ e- → π+ π- J/ψ at sqrt[s] = 4.26 GeV. Phys Rev Lett (2013) 1.05
Attenuation of p38-mediated miR-1/133 expression facilitates myoblast proliferation during the early stage of muscle regeneration. PLoS One (2012) 1.05
An integrated disposable device for DNA extraction and helicase dependent amplification. Biomed Microdevices (2010) 1.05
Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation . Biochemistry (2009) 1.04
Coronary MR angiography: respiratory motion correction with BACSPIN. J Magn Reson Imaging (2003) 1.04
Influence of Etoposide on anti-apoptotic and multidrug resistance-associated protein genes in CD133 positive U251 glioblastoma stem-like cells. Brain Res (2010) 1.03
TiO2 nanoparticles promote beta-amyloid fibrillation in vitro. Biochem Biophys Res Commun (2008) 1.03
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain (2010) 1.03
HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells. Am J Physiol Cell Physiol (2003) 1.02
Thermodynamics of DNA target site recognition by homing endonucleases. Nucleic Acids Res (2007) 1.01
Automated screening of monoclonal antibodies for SISCAPA assays using a magnetic bead processor and liquid chromatography-selected reaction monitoring-mass spectrometry. J Immunol Methods (2009) 1.01
Sequential multiplexed analyte quantification using peptide immunoaffinity enrichment coupled to mass spectrometry. Mol Cell Proteomics (2011) 1.01
Surface detection errors cause overestimation of the modulus in nanoindentation on soft materials. J Mech Behav Biomed Mater (2008) 1.01
Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation. Biotechnol Prog (2010) 1.00
Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm Res (2011) 1.00
Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma. Blood (2009) 1.00
Loss or retention of chloroplast DNA in maize seedlings is affected by both light and genotype. Planta (2006) 0.99
Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice. Toxicol Lett (2005) 0.99
Anti-inflammatory effects of ethyl acetate fraction from Melilotus suaveolens Ledeb on LPS-stimulated RAW 264.7 cells. J Ethnopharmacol (2009) 0.98
Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis. BMC Gastroenterol (2013) 0.98
A simple tool detected diabetes and prediabetes in rural Chinese. J Clin Epidemiol (2010) 0.98
A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo. Cancer Immunol Immunother (2009) 0.98
Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats. Am J Respir Cell Mol Biol (2012) 0.98
Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry (2005) 0.97
Microfluidic chip for molecular amplification of influenza A RNA in human respiratory specimens. PLoS One (2012) 0.97
Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab. Biochem Biophys Res Commun (2008) 0.97
12,12'-[2,2'-Oxybis(ethane-2,1-di-yl)bis-(-oxy)]bis-[(R(p))-4-bromo-[2.2]paracyclo-phane]. Acta Crystallogr Sect E Struct Rep Online (2011) 0.97
Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: a case-control study and meta-analysis. Med Sci Monit (2010) 0.97
Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions. Pharm Res (2011) 0.97
Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis. Pharm Res (2010) 0.96
Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS One (2012) 0.95
Spinal extradural en plaque meningiomas: clinical features and long-term outcomes of 12 cases. J Neurosurg Spine (2014) 0.95
Deformation-induced localized solid-state amorphization in nanocrystalline nickel. Sci Rep (2012) 0.94
Clinically relevant microfluidic magnetophoretic isolation of rare-cell populations for diagnostic and therapeutic monitoring applications. Anal Chem (2012) 0.94