Published in J Cell Biol on March 08, 2004
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A disease- and phosphorylation-related nonmechanical function for keratin 8. J Cell Biol (2006) 1.68
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Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. Mol Biol Cell (2003) 1.29
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Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations. Gastroenterology (2010) 1.28
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. J Biol Chem (2002) 1.25
Keratins as susceptibility genes for end-stage liver disease. Gastroenterology (2005) 1.24
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase. J Biol Chem (2002) 1.23
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury. Hepatology (2003) 1.21
Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs (2009) 1.20
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Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology (2004) 1.19
Cytoskeletal keratin glycosylation protects epithelial tissue from injury. Nat Cell Biol (2010) 1.18
Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon. Am J Physiol Gastrointest Liver Physiol (2003) 1.17
Gender dimorphic formation of mouse Mallory-Denk bodies and the role of xenobiotic metabolism and oxidative stress. Gastroenterology (2010) 1.14
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Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon. Am J Physiol Cell Physiol (2010) 1.11
Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10
Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells. Mol Biol Cell (2002) 1.09
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Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity. Hepatology (2009) 1.08
Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions. J Pharm Sci (2011) 1.07
The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury. Hepatology (2008) 1.07
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology (2007) 1.07
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology (2008) 1.07
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon. Am J Physiol Gastrointest Liver Physiol (2010) 1.06
Keratin 8 overexpression promotes mouse Mallory body formation. J Cell Biol (2005) 1.04
Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation. J Cell Sci (2004) 1.04
Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. J Cell Sci (2012) 1.04
Keratins modulate the shape and function of hepatocyte mitochondria: a mechanism for protection from apoptosis. J Cell Sci (2009) 1.04
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Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. J Biol Chem (2010) 1.00
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Keratin mutation primes mouse liver to oxidative injury. Hepatology (2005) 1.00
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. Clin Gastroenterol Hepatol (2007) 1.00
Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm Res (2011) 1.00
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Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. Proc Natl Acad Sci U S A (2003) 1.00
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Translational approaches for pharmacotherapy development for acute diarrhea. Gastroenterology (2012) 0.97
Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions. Pharm Res (2011) 0.97
Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis. Pharm Res (2010) 0.96
A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice. Exp Cell Res (2007) 0.96
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Three distinct mechanisms of HCO3- secretion in rat distal colon. Am J Physiol Cell Physiol (2004) 0.95
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. Am J Physiol Gastrointest Liver Physiol (2007) 0.95
Raf-1 activation disrupts its binding to keratins during cell stress. J Cell Biol (2004) 0.95
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Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon. Proc Natl Acad Sci U S A (2011) 0.94
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Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis. Hepatology (2014) 0.93
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Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties. Pharm Res (2014) 0.93
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Stimulated active potassium secretion in a patient with colonic pseudo-obstruction: a new mechanism of secretory diarrhea. Gastroenterology (2005) 0.92
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies. Exp Cell Res (2005) 0.91
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Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage. Hepatology (2011) 0.90
Mallory-Denk bodies are associated with outcomes and histologic features in patients with chronic hepatitis C. Clin Gastroenterol Hepatol (2011) 0.90
p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem (2010) 0.90
Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury. J Cell Sci (2003) 0.89
Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury. Am J Pathol (2008) 0.89
Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones. J Cell Sci (2009) 0.89
B cell lymphoma in HIV transgenic mice. Retrovirology (2013) 0.88
Reg-II is an exocrine pancreas injury-response product that is up-regulated by keratin absence or mutation. Mol Biol Cell (2007) 0.88
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner. J Cell Sci (2006) 0.88
Computational methods to predict therapeutic protein aggregation. Methods Mol Biol (2012) 0.88
Lamin aggregation is an early sensor of porphyria-induced liver injury. J Cell Sci (2013) 0.87
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