PubRank

Neil Q McDonald

Author PubWeight™ 81.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Disruption of methylarginine metabolism impairs vascular homeostasis. Nat Med 2007 3.28
2 A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol 2006 2.57
3 Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep 2009 2.55
4 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell 2013 1.90
5 Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 2006 1.72
6 The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc Natl Acad Sci U S A 2005 1.62
7 A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol 2006 1.61
8 Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J 2005 1.39
9 The dual mechanism of separase regulation by securin. Curr Biol 2002 1.39
10 Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell 2007 1.36
11 The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol 2004 1.34
12 Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J 2008 1.23
13 Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol. Structure 2004 1.21
14 Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator. Sci Signal 2011 1.17
15 Protein kinase C intervention: the state of play. Curr Opin Cell Biol 2009 1.11
16 Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J Biol Chem 2008 1.10
17 Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism. J Biol Chem 2011 1.09
18 Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. Structure 2002 1.01
19 G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci 2012 0.96
20 Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution. Genome Biol 2014 0.92
21 Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J Biol Chem 2011 0.92
22 Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474. Endocr Relat Cancer 2008 0.89
23 Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J 2013 0.88
24 Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition. Nucleic Acids Res 2012 0.87
25 Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations. Nat Struct Mol Biol 2010 0.87
26 Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg Med Chem 2010 0.86
27 Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex. Structure 2013 0.81
28 A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif. Sci Signal 2013 0.80
29 Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity. Structure 2012 0.80
30 A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes. Nucleic Acids Res 2013 0.79
31 Functional implications of assigned, assumed and assembled PKC structures. Biochem Soc Trans 2014 0.75
32 Crystallization and preliminary X-ray diffraction analysis of vaccinia virus H1L phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.75
33 Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. J Med Chem 2020 0.75