Published in Cell on April 25, 2013
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol (2015) 1.62
Rho GTPases: masters of cell migration. Small GTPases (2014) 1.14
Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1. Nature (2013) 1.05
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem (2013) 1.04
An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Nat Commun (2014) 0.95
Protein prenylation: unique fats make their mark on biology. Nat Rev Mol Cell Biol (2016) 0.85
Function and regulation of Rnd proteins in cortical projection neuron migration. Front Neurosci (2015) 0.85
Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α. BMC Biochem (2014) 0.85
A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing. Proc Natl Acad Sci U S A (2016) 0.85
Targeting Cdc42 in cancer. Expert Opin Ther Targets (2013) 0.85
Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathy. Int J Clin Exp Pathol (2014) 0.84
Dynamic development of starch granules and the regulation of starch biosynthesis in Brachypodium distachyon: comparison with common wheat and Aegilops peregrina. BMC Plant Biol (2014) 0.84
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83
RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol (2015) 0.82
Structure of the RZZ complex and molecular basis of its interaction with Spindly. J Cell Biol (2017) 0.82
Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution. J Biol Chem (2014) 0.82
Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex. Neural Dev (2015) 0.82
Downregulation of urea transporter UT-A1 activity by 14-3-3 protein. Am J Physiol Renal Physiol (2015) 0.80
Genetic and physical interaction of Ssp1 CaMKK and Rad24 14-3-3 during low pH and osmotic stress in fission yeast. Open Biol (2014) 0.80
Rap1-dependent pathways coordinate cytokinesis in Dictyostelium. Mol Biol Cell (2014) 0.79
The N- and C-terminal ends of RPGR can bind to PDE6δ. EMBO Rep (2015) 0.78
Dynamic multiprotein assemblies shape the spatial structure of cell signaling. Prog Biophys Mol Biol (2014) 0.78
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
Physical view on migration modes. Cell Adh Migr (2015) 0.77
Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77
The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease. Front Pharmacol (2015) 0.77
The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties. J Biol Chem (2015) 0.76
Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides. J Biol Chem (2015) 0.75
Rnd3-induced cell rounding requires interaction with Plexin-B2. J Cell Sci (2016) 0.75
How do cells sense actin cortex-free membrane? Cell Cycle (2016) 0.75
Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem (2016) 0.75
Cell signalling: New G protein family rules. Nat Rev Mol Cell Biol (2013) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
The finer things in X-ray diffraction data collection. Acta Crystallogr D Biol Crystallogr (1999) 19.10
REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use. Acta Crystallogr D Biol Crystallogr (2004) 14.28
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell (1996) 7.81
The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol (2010) 6.91
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell (1990) 6.08
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J Cell Biol (2001) 5.05
A robust bulk-solvent correction and anisotropic scaling procedure. Acta Crystallogr D Biol Crystallogr (2005) 4.82
Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem (1997) 3.86
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol (2008) 3.30
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell (2000) 3.22
Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep (2009) 2.55
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol (1998) 2.36
Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol (2004) 2.31
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
JLigand: a graphical tool for the CCP4 template-restraint library. Acta Crystallogr D Biol Crystallogr (2012) 2.08
14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol Cell Biol (1998) 2.07
Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nat Chem Biol (2011) 2.00
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol (2011) 1.87
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol (2003) 1.84
RhoE regulates actin cytoskeleton organization and cell migration. Mol Cell Biol (1998) 1.80
Structural basis of 14-3-3 protein functions. Semin Cell Dev Biol (2011) 1.60
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity. J Biol Chem (2003) 1.45
Rap1A is a substrate for cyclic AMP-dependent protein kinase in human neutrophils. J Immunol (1991) 1.43
Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes. Biochem J (2002) 1.42
The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J Biol Chem (2002) 1.38
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO J (2007) 1.38
Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A. Science (1991) 1.33
Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci U S A (1995) 1.31
Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays (2010) 1.21
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. Biochem J (2009) 1.19
Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation. J Biol Chem (1999) 1.18
14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle (2004) 1.06
Facile synthesis of budding yeast a-factor and its use to synchronize cells of α mating type. Yeast (2012) 1.00
Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition. BMC Neurosci (2010) 0.89
Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol (2008) 8.99
Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol (2003) 8.68
A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nat Genet (2006) 4.59
Rho GTPases in cancer cell biology. FEBS Lett (2008) 4.47
Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J Exp Med (2003) 3.52
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nat Struct Mol Biol (2009) 3.37
Disruption of methylarginine metabolism impairs vascular homeostasis. Nat Med (2007) 3.28
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19
Lymphocyte transcellular migration occurs through recruitment of endothelial ICAM-1 to caveola- and F-actin-rich domains. Nat Cell Biol (2006) 3.08
Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol (2002) 2.88
Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res (2004) 2.83
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
F-actin is an evolutionarily conserved damage-associated molecular pattern recognized by DNGR-1, a receptor for dead cells. Immunity (2012) 2.72
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol (2006) 2.57
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. EMBO Rep (2009) 2.55
RhoE binds to ROCK I and inhibits downstream signaling. Mol Cell Biol (2003) 2.46
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol (2010) 2.41
Cholesterol binding by the bacterial type III translocon is essential for virulence effector delivery into mammalian cells. Mol Microbiol (2005) 2.32
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol (2010) 2.24
Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol (2009) 2.15
Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases. J Cell Biol (2003) 2.14
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep (2008) 2.09
Roles of Rho/ROCK and MLCK in TNF-alpha-induced changes in endothelial morphology and permeability. J Cell Physiol (2007) 2.03
Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00
Phosphoinositide 3-kinases in cell migration. Biol Cell (2009) 1.95
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. J Cell Biol (2003) 1.90
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2. Structure (2009) 1.89
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration. J Cell Sci (2004) 1.88
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein. J Biol Chem (2002) 1.88
Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology (2004) 1.82
The late endosome is essential for mTORC1 signaling. Mol Biol Cell (2010) 1.79
PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J (2005) 1.75
The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J (2008) 1.74
IQGAP1 promotes cell motility and invasion. J Biol Chem (2003) 1.72
Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem (2006) 1.72
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci (2006) 1.70
Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J (2003) 1.69
PKC epsilon controls the traffic of beta1 integrins in motile cells. EMBO J (2002) 1.67
Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res (2002) 1.63
The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc Natl Acad Sci U S A (2005) 1.62
A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol (2006) 1.61
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2. EMBO J (2006) 1.61
The regulated assembly of a PKCepsilon complex controls the completion of cytokinesis. Nat Cell Biol (2008) 1.61
RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell (2013) 1.60
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. Mol Biol Cell (2004) 1.57
Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain. J Biol Chem (2002) 1.54
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP. Mol Cell (2003) 1.53
Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol (2010) 1.52
A molecular explanation for the recessive nature of parkin-linked Parkinson's disease. Nat Commun (2013) 1.51
PKC controls HGF-dependent c-Met traffic, signalling and cell migration. EMBO J (2004) 1.51
Microtubules regulate migratory polarity through Rho/ROCK signaling in T cells. PLoS One (2010) 1.49
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation. J Cell Biol (2008) 1.48
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol (2009) 1.48
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J (2007) 1.48
Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol (2013) 1.46
RhoE inhibits cell cycle progression and Ras-induced transformation. Mol Cell Biol (2004) 1.41
Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J (2005) 1.39
The dual mechanism of separase regulation by securin. Curr Biol (2002) 1.39
Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages. J Cell Sci (2008) 1.39
Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Mol Cell (2003) 1.39
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol (2006) 1.37
Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell (2007) 1.36
Rho GTPases and leukocyte adhesion receptor expression and function in endothelial cells. Circ Res (2006) 1.35
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J Cell Biol (2010) 1.35
Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Mol Cell Biol (2002) 1.35
The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol (2004) 1.34
Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. J Biol Chem (2005) 1.34
Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis. Blood (2005) 1.34
PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics. J Cell Sci (2008) 1.32
Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. J Med Chem (2010) 1.32
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. PLoS One (2008) 1.31
Regulation of Listeria virulence: PrfA master and commander. Curr Opin Microbiol (2011) 1.30
Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol (2011) 1.30
Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer (2007) 1.30
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol (2010) 1.28
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Hydrophobic, aromatic, and electrostatic interactions play a central role in amyloid fibril formation and stability. Biochemistry (2011) 1.26
Intercellular adhesion molecule (ICAM)-1, but not ICAM-2, activates RhoA and stimulates c-fos and rhoA transcription in endothelial cells. J Immunol (2002) 1.25
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1. Exp Cell Res (2003) 1.25
Ethylene insensitivity conferred by the Green-ripe and Never-ripe 2 ripening mutants of tomato. Plant Physiol (2005) 1.24
PAK4 is activated via PI3K in HGF-stimulated epithelial cells. J Cell Sci (2002) 1.24
Cell migration in development and disease. Dev Cell (2002) 1.23
Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J (2008) 1.23
Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol. Structure (2004) 1.21
Rnd proteins: multifunctional regulators of the cytoskeleton and cell cycle progression. Bioessays (2010) 1.21