Teaching the bioinformatics of signaling networks: an integrated approach to facilitate multi-disciplinary learning.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 23640570)

Published in Brief Bioinform on May 02, 2013

Authors

Tamas Korcsmaros1, Zsuzsanna A Dunai, Tibor Vellai, Peter Csermely

Author Affiliations

1: Department of Genetics, Eotvos Lorand University, H-1117 Budapest, Pázmány s. 1/C, Hungary. Tel.: +36302686590; korcsmaros@gmail.com.

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The role of structural disorder in the function of RNA and protein chaperones. FASEB J (2004) 2.98

Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol (2005) 2.86

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans. Autophagy (2008) 2.83

Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review. Pharmacol Ther (2004) 1.96

Community landscapes: an integrative approach to determine overlapping network module hierarchy, identify key nodes and predict network dynamics. PLoS One (2010) 1.74

Sequestration revisited: integrating traditional electron microscopy, de novo assembly and new results. Autophagy (2007) 1.55

SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks. BMC Syst Biol (2013) 1.30

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery. Bioinformatics (2010) 1.27

Learning and innovative elements of strategy adoption rules expand cooperative network topologies. PLoS One (2008) 1.19

Allo-network drugs: harnessing allostery in cellular networks. Trends Pharmacol Sci (2011) 1.17

Drug-therapy networks and the prediction of novel drug targets. J Biol (2008) 1.10

Large-scale functional organization of long-range chromatin interaction networks. Cell Rep (2012) 1.08

Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci (2007) 1.07

Transcriptional control of Notch signaling by a HOX and a PBX/EXD protein during vulval development in C. elegans. Dev Biol (2006) 1.06

Perturbation waves in proteins and protein networks: applications of percolation and game theories in signaling and drug design. Curr Protein Pept Sci (2009) 1.04

Network-based tools for the identification of novel drug targets. Sci Signal (2011) 1.03

Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics (2007) 1.01

A novel actin binding site of myosin required for effective muscle contraction. Nat Struct Mol Biol (2012) 1.00

Qualitative and quantitative characterization of autophagy in Caenorhabditis elegans by electron microscopy. Methods Enzymol (2008) 0.99

Speciation in Chlamydia: genomewide phylogenetic analyses identified a reliable set of acquired genes. J Mol Evol (2003) 0.98

Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins. FEBS Lett (2005) 0.97

Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation. PLoS Comput Biol (2011) 0.96

Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci (2011) 0.96

Hsp90 and developmental networks. Adv Exp Med Biol (2007) 0.95

DUK114, the Drosophila orthologue of bovine brain calpain activator protein, is a molecular chaperone. Biochem J (2004) 0.93

Complex regulation of autophagy in cancer - integrated approaches to discover the networks that hold a double-edged sword. Semin Cancer Biol (2013) 0.92

Nodes having a major influence to break cooperation define a novel centrality measure: game centrality. PLoS One (2013) 0.92

Toxicity of oxidized phospholipids in cultured macrophages. Lipids Health Dis (2012) 0.92

Allosteric conformational barcodes direct signaling in the cell. Structure (2013) 0.90

Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding. Biochim Biophys Acta (2008) 0.89

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1. Development (2009) 0.89

TRA-1/GLI controls the expression of the Hox gene lin-39 during C. elegans vulval development. Dev Biol (2009) 0.88

Autophagy in neuronal cell loss: a road to death. Bioessays (2006) 0.87

Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy. Nat Commun (2013) 0.87

Ageing as a price of cooperation and complexity: self-organization of complex systems causes the gradual deterioration of constituent networks. Bioessays (2009) 0.87

Distribution and evolution of short tandem repeats in closely related bacterial genomes. Gene (2007) 0.86

Signalogs: orthology-based identification of novel signaling pathway components in three metazoans. PLoS One (2011) 0.85

Autophagy in Caenorhabditis elegans. Methods Enzymol (2008) 0.84

The maintenance of sex in bacteria is ensured by its potential to reload genes. Genetics (2006) 0.84

The guanine-quadruplex structure in the human c-myc gene's promoter is converted into B-DNA form by the human poly(ADP-ribose)polymerase-1. PLoS One (2012) 0.83

Cancer-related networks: a help to understand, predict and change malignant transformation. Semin Cancer Biol (2013) 0.82

The C. elegans Hox gene ceh-13 regulates cell migration and fusion in a non-colinear way. Implications for the early evolution of Hox clusters. BMC Dev Biol (2010) 0.82

Autophagy Regulatory Network - a systems-level bioinformatics resource for studying the mechanism and regulation of autophagy. Autophagy (2015) 0.81

Identifying novel genes involved in both deer physiological and human pathological osteoporosis. Mol Genet Genomics (2008) 0.81

Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging. BMC Dev Biol (2012) 0.81

Perturbation centrality and turbine: a novel centrality measure obtained using a versatile network dynamics tool. PLoS One (2013) 0.81

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. Development (2013) 0.80

Autophagy and apoptosis are redundantly required for C. elegans embryogenesis. Autophagy (2011) 0.80

From allosteric drugs to allo-network drugs: state of the art and trends of design, synthesis and computational methods. Curr Top Med Chem (2013) 0.80

The mechanism of ageing: primary role of transposable elements in genome disintegration. Cell Mol Life Sci (2015) 0.80

Network strategies to understand the aging process and help age-related drug design. Genome Med (2009) 0.79

Rigidity and flexibility of biological networks. Brief Funct Genomics (2012) 0.78

Adaptation and learning of molecular networks as a description of cancer development at the systems-level: potential use in anti-cancer therapies. Semin Cancer Biol (2013) 0.77

Interaction of neuropeptide Y and Hsp90 through a novel peptide binding region. Biochemistry (2003) 0.76

Nucleoside diphosphate kinases (NDPKs) in animal development. Cell Mol Life Sci (2014) 0.76

The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development. Genomics (2004) 0.75

Potential application of network descriptions for understanding conformational changes and protonation states of ABC transporters. Curr Pharm Des (2013) 0.75

Heparin can liberate high molecular weight DNA from secondary necrotic cells. Cell Biol Int (2012) 0.75

Identification of novel cis-regulatory regions from the Notch receptor genes lin-12 and glp-1 of Caenorhabditis elegans. Gene Expr Patterns (2013) 0.75

Uniform curation protocol of metazoan signaling pathways to predict novel signaling components. Methods Mol Biol (2013) 0.75

Discovering cooperative biomarkers for heterogeneous complex disease diagnoses. Brief Bioinform (2017) 0.75