PubRank

Jeffrey Aubé

Author PubWeight™ 76.65‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Facile C-N cleavage in a series of bridged lactams. J Am Chem Soc 2005 1.37
2 Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine. J Org Chem 2005 1.31
3 Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem 2013 1.24
4 Cation-pi control of regiochemistry of intramolecular schmidt reactions en route to bridged bicyclic lactams. J Am Chem Soc 2007 1.18
5 Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem 2013 1.17
6 A combined intramolecular Diels-Alder/intramolecular schmidt reaction: formal synthesis of (+/-)-stenine. Angew Chem Int Ed Engl 2002 1.14
7 Domino reactions that combine an azido-Schmidt ring expansion with the Diels-Alder reaction. Org Lett 2004 1.14
8 Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction. J Am Chem Soc 2008 1.10
9 A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C. Org Lett 2010 1.09
10 An expeditious total synthesis of (+/-)-stenine. J Am Chem Soc 2005 1.08
11 Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals. Org Lett 2005 1.07
12 Medium-bridged lactams: a new class of non-planar amides. Org Biomol Chem 2010 1.05
13 Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence. J Comb Chem 2007 1.05
14 Minor withanolides of Physalis longifolia: structure and cytotoxicity. Chem Pharm Bull (Tokyo) 2012 1.04
15 Asymmetric total synthesis of dendrobatid alkaloid 251F. J Am Chem Soc 2002 0.99
16 Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction. J Am Chem Soc 2013 0.97
17 Stability of medium-bridged twisted amides in aqueous solutions. J Org Chem 2009 0.95
18 Asymmetric total synthesis of dendrobatid alkaloids: preparation of indolizidine 251F and its 3-desmethyl analogue using an intramolecular Schmidt reaction strategy. J Am Chem Soc 2004 0.95
19 Chemotype-selective modes of action of κ-opioid receptor agonists. J Biol Chem 2013 0.95
20 Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proc Natl Acad Sci U S A 2011 0.95
21 Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. ACS Chem Biol 2012 0.95
22 Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones. Org Lett 2003 0.94
23 Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification. J Comb Chem 2008 0.94
24 First asymmetric total synthesis of (+)-sparteine. Org Lett 2002 0.93
25 Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. J Comb Chem 2008 0.93
26 1,3-allylic strain as a strategic diversification element for constructing libraries of substituted 2-arylpiperidines. Angew Chem Int Ed Engl 2011 0.93
27 A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol 2012 0.92
28 Ring expansive routes to quinolizidine alkaloids: formal synthesis of (-)-lasubine II. Org Lett 2003 0.92
29 Asymmetric Schmidt reaction of hydroxyalkyl azides with ketones. J Am Chem Soc 2003 0.92
30 Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol 2015 0.92
31 Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. J Med Chem 2012 0.92
32 High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. J Biomol Screen 2011 0.91
33 Chemistry of bridged lactams and related heterocycles. Chem Rev 2013 0.91
34 Unusual tethering effects in the Schmidt reaction of hydroxyalkyl azides with ketones: cation-pi and steric stabilization of a pseudoaxial phenyl group. J Am Chem Soc 2003 0.90
35 Mechanism of the acid-promoted intramolecular schmidt reaction: theoretical assessment of the importance of lone pair-cation, cation-π, and steric effects in controlling regioselectivity. J Org Chem 2011 0.90
36 Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. J Med Chem 2014 0.89
37 Cation-n control of regiochemistry of intramolecular Schmidt reactions en route to bridged bicyclic lactams. Org Lett 2009 0.89
38 Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci 2012 0.89
39 N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. ACS Med Chem Lett 2010 0.88
40 Corey-Chaykovsky epoxidation of twisted amides: synthesis and reactivity of bridged spiro-epoxyamines. J Am Chem Soc 2009 0.88
41 Nucleophilic addition to iminium ethers in the preparation of functionalized N-alkyl heterocycles. J Org Chem 2007 0.88
42 Asymmetric total synthesis of alkaloids 223A and 6-epi-223A. Org Lett 2009 0.87
43 Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy. Org Lett 2009 0.87
44 Proximity effects in nucleophilic addition reactions to medium-bridged twisted lactams: remarkably stable tetrahedral intermediates. J Am Chem Soc 2010 0.86
45 Intramolecular and Intermolecular Schmidt Reactions of Alkyl Azides with Aldehydes. Tetrahedron 2007 0.86
46 (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. J Med Chem 2012 0.86
47 Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. J Org Chem 2010 0.85
48 Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries. J Comb Chem 2008 0.84
49 Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction. J Am Chem Soc 2012 0.84
50 Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes. J Am Chem Soc 2006 0.84
51 Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues. ACS Med Chem Lett 2013 0.83
52 Modular synthesis of cyclic peptidomimetics inspired by gamma-turns. Org Lett 2005 0.83
53 Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett 2013 0.82
54 Nonbonded, attractive cation-pi interactions in azide-mediated asymmetric ring expansion reactions. J Org Chem 2008 0.82
55 A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. J Biomol Screen 2012 0.82
56 Base-promoted reactions of bridged ketones and 1,3- and 1,4-haloalkyl azides: competitive alkylation vs azidation reactions of ketone enolates. J Org Chem 2004 0.82
57 Parallel solid-phase synthesis of diaryltriazoles. Beilstein J Org Chem 2012 0.81
58 Double conjugate addition of a nitropropionate ester to a quinone monoketal: synthesis of an advanced intermediate to (+/-)-gelsemine. Org Lett 2007 0.81
59 Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. J Org Chem 2011 0.81
60 Synthesis and rearrangement of a bridged thioamide. Chem Commun (Camb) 2009 0.81
61 One-pot synthesis of lactams using domino reactions: combination of Schmidt reaction with Sakurai and aldol reactions. J Org Chem 2009 0.81
62 Synthesis of medium-bridged twisted lactams via cation-pi control of the regiochemistry of the intramolecular Schmidt reaction. J Org Chem 2010 0.81
63 Structural characterization of N-protonated amides: regioselective N-activation of medium-bridged twisted lactams. J Am Chem Soc 2010 0.80
64 The NIH's role in accelerating translational sciences. Nat Biotechnol 2012 0.79
65 Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorg Med Chem Lett 2005 0.79
66 Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity. J Med Chem 2014 0.79
67 Solution-phase parallel synthesis of a library of delta(2)-pyrazolines. J Comb Chem 2007 0.79
68 Synthesis and conformational studies of dipeptides constrained by disubstituted 3-(aminoethoxy)propionic acid linkers. J Org Chem 2004 0.78
69 Rearrangements of bicyclic nitrones to lactams: comparison of photochemical and modified Barton conditions. J Org Chem 2003 0.78
70 An efficient computational model to predict protonation at the amide nitrogen and reactivity along the C-N rotational pathway. Chem Commun (Camb) 2015 0.78
71 One-step synthesis of oxazoline and dihydrooxazine libraries. J Comb Chem 2007 0.78
72 Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones. J Org Chem 2013 0.77
73 Ab initio approach to understanding the stereoselectivity of reactions between hydroxyalkyl azides and ketones. J Org Chem 2004 0.77
74 In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format. Chemistry 2011 0.77
75 A concomitant allylic azide rearrangement/intramolecular azide-alkyne cycloaddition sequence. Org Lett 2014 0.77
76 Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users. Pharm Res 2013 0.77
77 Small-molecule libraries: naturally inspired oligomers. Nat Chem 2012 0.77
78 Use of a tandem Prins/Friedel-Crafts reaction in the construction of the indeno-tetrahydropyridine core of the haouamine alkaloids: formal synthesis of (-)-haouamine A. Org Lett 2011 0.77
79 High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. ACS Comb Sci 2015 0.76
80 Synthesis, structural analysis, and reactivity of bridged orthoamides by intramolecular Schmidt reaction. J Am Chem Soc 2010 0.76
81 Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds. J Org Chem 2012 0.76
82 Reactions of cyclopropanone acetals with alkyl azides: carbonyl addition versus ring-opening pathways. J Org Chem 2007 0.75
83 One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement. Org Biomol Chem 2016 0.75
84 Highly stereoselective ring expansion reactions mediated by attractive cation-n interactions. Angew Chem Int Ed Engl 2008 0.75
85 Automated three-component synthesis of a library of γ-lactams. Beilstein J Org Chem 2012 0.75
86 Resolution of carboxylic acids using copper(I)-promoted removal of propargylic esters under neutral conditions. J Org Chem 2011 0.75
87 The Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle. J Med Chem 2017 0.75
88 Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias". ACS Chem Neurosci 2017 0.75
89 Synthesis of enantiomerically enriched (R)-5-tert-butylazepan-2-one using a hydroxyalkyl azide mediated ring-expansion reaction. Nat Protoc 2008 0.75
90 Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides. Bioorg Med Chem Lett 2008 0.75
91 Stereoselectivity in nucleophilic additions to 3-azidoalkanals. J Org Chem 2011 0.75