Published in Chemistry on July 27, 2011
Continuous flow organic synthesis under high-temperature/pressure conditions. Chem Asian J (2010) 1.43
A flow process for the multi-step synthesis of the alkaloid natural product oxomaritidine: a new paradigm for molecular assembly. Chem Commun (Camb) (2006) 1.35
Catalysis in capillaries by Pd thin films using microwave-assisted continuous-flow organic synthesis (MACOS). Angew Chem Int Ed Engl (2006) 1.12
Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations. Chemistry (2006) 1.11
Multistep synthesis using modular flow reactors: Bestmann-Ohira reagent for the formation of alkynes and triazoles. Angew Chem Int Ed Engl (2009) 1.10
Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent. Org Biomol Chem (2011) 1.08
A microreactor for microwave-assisted capillary (continuous flow) organic synthesis. J Am Chem Soc (2005) 1.06
Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis. J Comb Chem (2007) 1.05
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. Chemistry (2010) 1.02
Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous-flow organic synthesis (MACOS). Chemistry (2008) 0.97
Heterogeneous versus homogeneous palladium catalysts for ligandless mizoroki-heck reactions: a comparison of batch/microwave and continuous-flow processing. Chemistry (2009) 0.97
Diels-Alder cycloadditions by microwave-assisted, continuous flow organic synthesis (MACOS): the role of metal films in the flow tube. Chem Commun (Camb) (2007) 0.96
Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. Chemistry (2008) 0.95
Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones. Org Lett (2003) 0.94
Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions. Org Biomol Chem (2008) 0.94
Propargyl amine synthesis catalysed by gold and copper thin films by using microwave-assisted continuous-flow organic synthesis (MACOS). Chemistry (2010) 0.94
A modular flow reactor for performing Curtius rearrangements as a continuous flow process. Org Biomol Chem (2008) 0.93
Microwave reactions under continuous flow conditions. Comb Chem High Throughput Screen (2007) 0.93
[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor. Org Biomol Chem (2007) 0.92
A simple continuous flow microwave reactor. J Org Chem (2005) 0.87
A study of the synthesis of triazoles using microwave irradiation. Mol Divers (2003) 0.87
Intramolecular and Intermolecular Schmidt Reactions of Alkyl Azides with Aldehydes. Tetrahedron (2007) 0.86
Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor. Org Biomol Chem (2007) 0.82
Palladium complexes of N-heterocyclic carbenes as catalysts for cross-coupling reactions--a synthetic chemist's perspective. Angew Chem Int Ed Engl (2007) 2.11
Easily prepared air- and moisture-stable Pd-NHC (NHC=N-heterocyclic carbene) complexes: a reliable, user-friendly, highly active palladium precatalyst for the Suzuki-Miyaura reaction. Chemistry (2006) 1.55
Facile C-N cleavage in a series of bridged lactams. J Am Chem Soc (2005) 1.37
Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine. J Org Chem (2005) 1.31
The development of bulky palladium NHC complexes for the most-challenging cross-coupling reactions. Angew Chem Int Ed Engl (2012) 1.28
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem (2013) 1.24
Cation-pi control of regiochemistry of intramolecular schmidt reactions en route to bridged bicyclic lactams. J Am Chem Soc (2007) 1.18
Development of functionally selective, small molecule agonists at kappa opioid receptors. J Biol Chem (2013) 1.17
The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst. Org Lett (2005) 1.15
Domino reactions that combine an azido-Schmidt ring expansion with the Diels-Alder reaction. Org Lett (2004) 1.14
A combined intramolecular Diels-Alder/intramolecular schmidt reaction: formal synthesis of (+/-)-stenine. Angew Chem Int Ed Engl (2002) 1.14
Catalysis in capillaries by Pd thin films using microwave-assisted continuous-flow organic synthesis (MACOS). Angew Chem Int Ed Engl (2006) 1.12
Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction. J Am Chem Soc (2008) 1.10
A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C. Org Lett (2010) 1.09
An expeditious total synthesis of (+/-)-stenine. J Am Chem Soc (2005) 1.08
Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals. Org Lett (2005) 1.07
A microreactor for microwave-assisted capillary (continuous flow) organic synthesis. J Am Chem Soc (2005) 1.06
Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis. J Comb Chem (2007) 1.05
Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence. J Comb Chem (2007) 1.05
Medium-bridged lactams: a new class of non-planar amides. Org Biomol Chem (2010) 1.05
Minor withanolides of Physalis longifolia: structure and cytotoxicity. Chem Pharm Bull (Tokyo) (2012) 1.04
Scaling out by microwave-assisted, continuous flow organic synthesis (MACOS): multi-gram synthesis of bromo- and fluoro-benzofused sultams benzthiaoxazepine-1,1-dioxides. Chemistry (2010) 1.02
Structure-activity relationship analysis of Pd-PEPPSI complexes in cross-couplings: a close inspection of the catalytic cycle and the precatalyst activation model. Chemistry (2010) 1.01
Application of 6,7-indole aryne cycloaddition and Pd(0)-catalyzed Suzuki-Miyaura and Buchwald-Hartwig cross-coupling reactions for the preparation of annulated indole libraries. ACS Comb Sci (2011) 1.00
Asymmetric total synthesis of dendrobatid alkaloid 251F. J Am Chem Soc (2002) 0.99
A microcapillary system for simultaneous, parallel microwave-assisted synthesis. Chemistry (2005) 0.98
Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction. J Am Chem Soc (2013) 0.97
Gold-film-catalysed hydrosilylation of alkynes by microwave-assisted, continuous-flow organic synthesis (MACOS). Chemistry (2008) 0.97
Regioselective cross-coupling of allylboronic acid pinacol ester derivatives with aryl halides via Pd-PEPPSI-IPent. J Am Chem Soc (2012) 0.97
Pd-PEPPSI-IPent(Cl): a highly effective catalyst for the selective cross-coupling of secondary organozinc reagents. Angew Chem Int Ed Engl (2012) 0.96
Diels-Alder cycloadditions by microwave-assisted, continuous flow organic synthesis (MACOS): the role of metal films in the flow tube. Chem Commun (Camb) (2007) 0.96
Chemotype-selective modes of action of κ-opioid receptor agonists. J Biol Chem (2013) 0.95
Stability of medium-bridged twisted amides in aqueous solutions. J Org Chem (2009) 0.95
Asymmetric total synthesis of dendrobatid alkaloids: preparation of indolizidine 251F and its 3-desmethyl analogue using an intramolecular Schmidt reaction strategy. J Am Chem Soc (2004) 0.95
Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proc Natl Acad Sci U S A (2011) 0.95
Pd PEPPSI-IPr-mediated reactions in metal-coated capillaries under MACOS: the synthesis of indoles by sequential aryl amination/Heck coupling. Chemistry (2008) 0.95
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. ACS Chem Biol (2012) 0.95
Lewis acid-mediated reactions of alkyl azides with alpha,beta-unsaturated ketones. Org Lett (2003) 0.94
Propargyl amine synthesis catalysed by gold and copper thin films by using microwave-assisted continuous-flow organic synthesis (MACOS). Chemistry (2010) 0.94
Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification. J Comb Chem (2008) 0.94
Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. J Comb Chem (2008) 0.93
1,3-allylic strain as a strategic diversification element for constructing libraries of substituted 2-arylpiperidines. Angew Chem Int Ed Engl (2011) 0.93
First asymmetric total synthesis of (+)-sparteine. Org Lett (2002) 0.93
Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow. Synthesis (Stuttg) (2011) 0.92
Ring expansive routes to quinolizidine alkaloids: formal synthesis of (-)-lasubine II. Org Lett (2003) 0.92
A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. ACS Chem Biol (2012) 0.92
Asymmetric Schmidt reaction of hydroxyalkyl azides with ketones. J Am Chem Soc (2003) 0.92
Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol (2015) 0.92
Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. J Med Chem (2012) 0.92
High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity. J Biomol Screen (2011) 0.91
Chemistry of bridged lactams and related heterocycles. Chem Rev (2013) 0.91
Automated synthesis of a 184-member library of thiadiazepan-1,1-dioxide-4-ones. ACS Comb Sci (2011) 0.91
Unusual tethering effects in the Schmidt reaction of hydroxyalkyl azides with ketones: cation-pi and steric stabilization of a pseudoaxial phenyl group. J Am Chem Soc (2003) 0.90
Mechanism of the acid-promoted intramolecular schmidt reaction: theoretical assessment of the importance of lone pair-cation, cation-π, and steric effects in controlling regioselectivity. J Org Chem (2011) 0.90
Cation-n control of regiochemistry of intramolecular Schmidt reactions en route to bridged bicyclic lactams. Org Lett (2009) 0.89
Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. J Med Chem (2014) 0.89
Higher-order zincates as transmetalators in alkyl-alkyl negishi cross-coupling. Angew Chem Int Ed Engl (2012) 0.89
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci (2012) 0.89
Nucleophilic addition to iminium ethers in the preparation of functionalized N-alkyl heterocycles. J Org Chem (2007) 0.88
Corey-Chaykovsky epoxidation of twisted amides: synthesis and reactivity of bridged spiro-epoxyamines. J Am Chem Soc (2009) 0.88
N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. ACS Med Chem Lett (2010) 0.88
Selective formation of angular tricyclic compounds by ruthenium-mediated ring-rearrangement metathesis. Chem Commun (Camb) (2011) 0.88
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. J Med Chem (2005) 0.87
Asymmetric total synthesis of alkaloids 223A and 6-epi-223A. Org Lett (2009) 0.87
Direct synthesis of medium-bridged twisted amides via a transannular cyclization strategy. Org Lett (2009) 0.87
Use of olefin templates in queued chemical transformations using late transition metal catalysis. Total synthesis of cis and trans bupleurynol via a single multireaction sequence. Org Lett (2004) 0.87
Intramolecular and Intermolecular Schmidt Reactions of Alkyl Azides with Aldehydes. Tetrahedron (2007) 0.86
(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a small molecule inhibitor probe for the study of respiratory syncytial virus infection. J Med Chem (2012) 0.86
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem (2006) 0.86
Proximity effects in nucleophilic addition reactions to medium-bridged twisted lactams: remarkably stable tetrahedral intermediates. J Am Chem Soc (2010) 0.86
Reaction discovery using microfluidic-based multidimensional screening of polycyclic iminium ethers. J Org Chem (2010) 0.85
Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy. ACS Comb Sci (2012) 0.85
Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent. Chem Commun (Camb) (2011) 0.85
Synthesis of amino-benzothiaoxazepine-1,1-dioxides utilizing a microwave-assisted, S(N)Ar protocol. ACS Comb Sci (2011) 0.84
Remote control of diastereoselectivity in intramolecular reactions of chiral allylsilanes. J Am Chem Soc (2006) 0.84
Three-component synthesis of 1,4-diazepin-5-ones and the construction of gamma-turn-like peptidomimetic libraries. J Comb Chem (2008) 0.84
Stereocontrol in a combined allylic azide rearrangement and intramolecular Schmidt reaction. J Am Chem Soc (2012) 0.84
Synthesis and Cytotoxicity of Semisynthetic Withalongolide A Analogues. ACS Med Chem Lett (2013) 0.83
Amination with Pd-NHC complexes: rate and computational studies on the effects of the oxidative addition partner. Chemistry (2011) 0.83
Block copolypeptides prepared by N-carboxyanhydride ring-opening polymerization. Macromol Rapid Commun (2012) 0.83
Modular synthesis of cyclic peptidomimetics inspired by gamma-turns. Org Lett (2005) 0.83
The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques. Chemistry (2010) 0.83
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett (2013) 0.82
Room-temperature Negishi cross-coupling of unactivated alkyl bromides with alkyl organozinc reagents utilizing a Pd/N-heterocyclic carbene catalyst. J Org Chem (2005) 0.82
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. J Biomol Screen (2012) 0.82
Base-promoted reactions of bridged ketones and 1,3- and 1,4-haloalkyl azides: competitive alkylation vs azidation reactions of ketone enolates. J Org Chem (2004) 0.82
An efficient low-temperature Stille-Migita cross-coupling reaction for heteroaromatic compounds by Pd-PEPPSI-IPent. Chemistry (2010) 0.82
Nonbonded, attractive cation-pi interactions in azide-mediated asymmetric ring expansion reactions. J Org Chem (2008) 0.82
High yielding alkylations of unactivated sp3 and sp2 centres with alkyl-9-BBN reagents using an NHC-based catalyst: Pd-PEPPSI-IPrf. Chem Commun (Camb) (2008) 0.82
Synthesis of natural products containing the pyrrolic ring. Nat Prod Rep (2010) 0.81
Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols. J Org Chem (2013) 0.81
Synthesis and rearrangement of a bridged thioamide. Chem Commun (Camb) (2009) 0.81
One-pot synthesis of lactams using domino reactions: combination of Schmidt reaction with Sakurai and aldol reactions. J Org Chem (2009) 0.81
Parallel solid-phase synthesis of diaryltriazoles. Beilstein J Org Chem (2012) 0.81
Double conjugate addition of a nitropropionate ester to a quinone monoketal: synthesis of an advanced intermediate to (+/-)-gelsemine. Org Lett (2007) 0.81
Synthesis of medium-bridged twisted lactams via cation-pi control of the regiochemistry of the intramolecular Schmidt reaction. J Org Chem (2010) 0.81
Synthesis and reactivity of bicyclo[3.2.1]octanoid-derived cyclopropanes. J Org Chem (2011) 0.81
Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro. Anticancer Res (2012) 0.80
Structural characterization of N-protonated amides: regioselective N-activation of medium-bridged twisted lactams. J Am Chem Soc (2010) 0.80