Published in J Physiol on May 13, 2013
Treating hypertension by targeting orexin receptors: potential effects on the sleep-related blood pressure dipping profile. J Physiol (2013) 0.93
Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol (2014) 0.92
The orexinergic neurons receive synaptic input from C1 cells in rats. J Comp Neurol (2014) 0.82
Orexin, orexin receptor antagonists and central cardiovascular control. Front Neurosci (2013) 0.81
Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats. Neuropharmacology (2015) 0.78
An augmented CO2 chemoreflex and overactive orexin system are linked with hypertension in young and adult spontaneously hypertensive rats. J Physiol (2016) 0.78
Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR. Sci Rep (2016) 0.77
Arrhythmia: 100 years on from George Ralph Mines. J Physiol (2013) 0.77
Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states. Front Syst Neurosci (2015) 0.77
Orexin Neurons Respond Differentially to Auditory Cues Associated with Appetitive versus Aversive Outcomes. J Neurosci (2016) 0.76
Reply from Aihua Li, Charles C. T. Hindmarch, Eugene E. Nattie and Julian F. R. Paton. J Physiol (2013) 0.76
The role of orexin in post-stroke inflammation, cognitive decline, and depression. Mol Brain (2015) 0.76
Thermoregulation under pressure: a role for orexin neurons. Temperature (Austin) (2015) 0.75
Implicating the potential role of orexin in hypertension. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75
Neuroendocrine, Autonomic, and Metabolic Responses to an Orexin Antagonist, Suvorexant, in Psychiatric Patients with Insomnia. Innov Clin Neurosci (2017) 0.75
The Orexin System and Hypertension. Cell Mol Neurobiol (2017) 0.75
Role of orexin-A in the ventrolateral preoptic area on components of total energy expenditure. Int J Obes (Lond) (2017) 0.75
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA (2003) 97.28
Reporting ethical matters in the Journal of Physiology: standards and advice. J Physiol (2009) 10.92
Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci (1998) 9.88
The sympathetic control of blood pressure. Nat Rev Neurosci (2006) 6.44
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci (1983) 3.98
Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med (2007) 3.25
Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol (2003) 2.45
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A (1999) 2.39
Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol (2012) 1.69
A key role for orexin in panic anxiety. Nat Med (2009) 1.63
Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol (2008) 1.57
Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res (2009) 1.46
Autonomic nervous system and cardiovascular variability in rats: a spectral analysis approach. Am J Physiol (1991) 1.27
Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am J Physiol Regul Integr Comp Physiol (2000) 1.23
Hypocretin/orexin contributes to the expression of some but not all forms of stress and arousal. Eur J Neurosci (2009) 1.22
Functions of orexins in peripheral tissues. Acta Physiol (Oxf) (2008) 1.16
Antagonism of rat orexin receptors by almorexant attenuates central chemoreception in wakefulness in the active period of the diurnal cycle. J Physiol (2010) 1.12
Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors. J Pharmacol Exp Ther (2010) 1.11
Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Exp Physiol (2005) 1.08
Effects of systemic hypoxia on R-R interval and blood pressure variabilities in conscious rats. Am J Physiol (1998) 1.05
Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists. Mol Pharmacol (2009) 1.05
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol (2012) 1.05
Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol (2001) 1.00
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex. Br J Pharmacol (2012) 1.00
Effects of sleep on the cardiovascular and thermoregulatory systems: a possible role for hypocretins. J Appl Physiol (1985) (2010) 0.99
Cardiovascular effects of leptin and orexins. Am J Physiol Regul Integr Comp Physiol (2003) 0.98
Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension (2001) 0.96
Microinjection of orexin into the rat nucleus tractus solitarius causes increases in blood pressure. Brain Res (2002) 0.96
Respiration and autonomic regulation and orexin. Prog Brain Res (2012) 0.96
Brainstem catecholaminergic neurons modulate both respiratory and cardiovascular function. Adv Exp Med Biol (2008) 0.95
Circadian blood pressure: clinical implications based on the pathophysiology of its variability. Kidney Int (2007) 0.94
Neural regulation of blood pressure by leptin and the related peptides. Regul Pept (2003) 0.93
Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamus. J Physiol (2002) 0.89
A decade of hypocretins: past, present and future of the neurobiology of arousal. Acta Physiol (Oxf) (2009) 0.88
Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses. Am J Physiol Regul Integr Comp Physiol (2012) 0.83
Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci (2003) 4.82
Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA (2010) 2.55
The brainstem and serotonin in the sudden infant death syndrome. Annu Rev Pathol (2009) 2.03
Junctional adhesion molecule-1 is upregulated in spontaneously hypertensive rats: evidence for a prohypertensive role within the brain stem. Hypertension (2007) 1.73
Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat. J Physiol (2012) 1.69
Structural and functional architecture of respiratory networks in the mammalian brainstem. Philos Trans R Soc Lond B Biol Sci (2009) 1.68
Endothelial NO synthase activity in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats. Hypertension (2006) 1.68
Failed heart rate recovery at a critical age in 5-HT-deficient mice exposed to episodic anoxia: implications for SIDS. J Appl Physiol (1985) (2011) 1.67
Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity. J Physiol (2008) 1.66
Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics (2003) 1.62
Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci (2010) 1.62
Amplified respiratory-sympathetic coupling in the spontaneously hypertensive rat: does it contribute to hypertension? J Physiol (2008) 1.57
Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii. Exp Physiol (2006) 1.55
Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern generation. Prog Brain Res (2007) 1.54
Correction of respiratory disorders in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2010) 1.54
Maternal dietary tryptophan deficiency alters cardiorespiratory control in rat pups. J Appl Physiol (1985) (2010) 1.51
Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension. Hypertension (2011) 1.48
A functional analysis of the influence of β3-adrenoceptors on the rat micturition cycle. J Pharmacol Exp Ther (2013) 1.47
Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR. Circ Res (2009) 1.46
Carotid body removal for treatment of chronic systolic heart failure. Int J Cardiol (2013) 1.41
Brainstem respiratory networks: building blocks and microcircuits. Trends Neurosci (2012) 1.37
Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies. Eur J Neurosci (2003) 1.33
The carotid body as a putative therapeutic target for the treatment of neurogenic hypertension. Nat Commun (2013) 1.32
Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats. J Physiol (2005) 1.29
A decerebrate, artificially-perfused in situ preparation of rat: utility for the study of autonomic and nociceptive processing. J Neurosci Methods (2006) 1.28
Respiratory rhythm entrainment by somatic afferent stimulation. J Neurosci (2005) 1.19
Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness. J Physiol (2009) 1.18
Sympathetic-mediated hypertension of awake juvenile rats submitted to chronic intermittent hypoxia is not linked to baroreflex dysfunction. Exp Physiol (2009) 1.15
Late-expiratory activity: emergence and interactions with the respiratory CpG. J Neurophysiol (2010) 1.11
Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem. Exp Physiol (2004) 1.10
Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats. J Neurophysiol (2011) 1.10
Cardio-respiratory coupling depends on the pons. Respir Physiol Neurobiol (2009) 1.10
Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive rats. Cardiovasc Res (2007) 1.09
Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Exp Physiol (2005) 1.08
Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons. Am J Physiol Regul Integr Comp Physiol (2009) 1.06
Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata. Cardiovasc Res (2011) 1.06
Hierarchical recruitment of the sympathetic and parasympathetic limbs of the baroreflex in normotensive and spontaneously hypertensive rats. J Physiol (2006) 1.05
Processing of central and reflex vagal drives by rat cardiac ganglion neurones: an intracellular analysis. J Physiol (2011) 1.04
Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets. J Appl Physiol (1985) (2004) 1.04
Pontomedullary transection attenuates central respiratory modulation of sympathetic discharge, heart rate and the baroreceptor reflex in the in situ rat preparation. Exp Physiol (2008) 1.01
The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents. Exp Physiol (2002) 0.99
Postnatal loss of brainstem serotonin neurones compromises the ability of neonatal rats to survive episodic severe hypoxia. J Physiol (2011) 0.98
Role of pontile mechanisms in the neurogenesis of eupnea. Respir Physiol Neurobiol (2004) 0.98
Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla. Hypertension (2010) 0.98
Translational examination of changes in baroreflex function after renal denervation in hypertensive rats and humans. Hypertension (2013) 0.97
Chronic inhibition of endothelial nitric oxide synthase activity in nucleus tractus solitarii enhances baroreceptor reflex in conscious rats. J Physiol (2003) 0.97
Contributions of vascular inflammation in the brainstem for neurogenic hypertension. Respir Physiol Neurobiol (2011) 0.97
Bradycardia in serotonin-deficient Pet-1-/- mice: influence of respiratory dysfunction and hyperthermia over the first 2 postnatal weeks. Am J Physiol Regul Integr Comp Physiol (2010) 0.96
Do changes in the coupling between respiratory and sympathetic activities contribute to neurogenic hypertension? Clin Exp Pharmacol Physiol (2009) 0.95
Defining eupnea. Respir Physiol Neurobiol (2003) 0.95
Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii. FASEB J (2006) 0.94
Consequences of peripheral chemoreflex inhibition with low-dose dopamine in humans. J Physiol (2014) 0.94
Muscimol inhibition of medullary raphé neurons decreases the CO2 response and alters sleep in newborn piglets. Respir Physiol Neurobiol (2002) 0.94
Specific respiratory neuron types have increased excitability that drive presympathetic neurones in neurogenic hypertension. Hypertension (2014) 0.93
Transcription factor CREB3L1 regulates vasopressin gene expression in the rat hypothalamus. J Neurosci (2014) 0.93
Effect of baroreceptor stimulation on the respiratory pattern: insights into respiratory-sympathetic interactions. Respir Physiol Neurobiol (2010) 0.93
Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain. J Gene Med (2008) 0.93
An arterially perfused decerebrate preparation of Suncus murinus (house musk shrew) for the study of emesis and swallowing. Exp Physiol (2002) 0.92
Astroglia are a possible cellular substrate of angiotensin(1-7) effects in the rostral ventrolateral medulla. Cardiovasc Res (2010) 0.92
Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous. Forensic Sci Med Pathol (2012) 0.91
Maintenance of eupnea of in situ and in vivo rats following riluzole: a blocker of persistent sodium channels. Respir Physiol Neurobiol (2006) 0.91
Nociception attenuates parasympathetic but not sympathetic baroreflex via NK1 receptors in the rat nucleus tractus solitarii. J Physiol (2003) 0.91
Adaptive transcriptional dynamics of A2 neurons and central cardiovascular control pathways. Exp Physiol (2011) 0.90
Genetic and pharmacological dissection of pathways involved in the angiotensin II-mediated depression of baroreflex function. FASEB J (2002) 0.90
Location and properties of respiratory neurones with putative intrinsic bursting properties in the rat in situ. J Physiol (2009) 0.90
Area-specific differences in transmitter release in central catecholaminergic neurons of spontaneously hypertensive rats. Hypertension (2008) 0.90
Chronic fluoxetine microdialysis into the medullary raphe nuclei of the rat, but not systemic administration, increases the ventilatory response to CO2. J Appl Physiol (1985) (2004) 0.89
Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats. Respir Physiol Neurobiol (2005) 0.89
IL-6 microinjected in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats. Am J Physiol Regul Integr Comp Physiol (2009) 0.89
Inhibitory synaptic mechanisms regulating upper airway patency. Respir Physiol Neurobiol (2002) 0.89
Control of cardiac contractility in the rat working heart-brainstem preparation. Exp Physiol (2009) 0.89
Optical imaging of medullary ventral respiratory network during eupnea and gasping in situ. Eur J Neurosci (2006) 0.88
Brainstem serotonin deficiency in the neonatal period: autonomic dysregulation during mild cold stress. J Physiol (2011) 0.88
Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex. Eur J Neurosci (2002) 0.88
Dissociation between blood pressure and heart rate response to hypoxia after bilateral carotid body removal in men with systolic heart failure. Exp Physiol (2013) 0.88
Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. Hypertension (2012) 0.88
Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt. Hypertension (2010) 0.88
Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord. Brain Res (2003) 0.88
Specific inflammatory condition in nucleus tractus solitarii of the SHR: novel insight for neurogenic hypertension? Auton Neurosci (2008) 0.87
Switching control of sympathetic activity from forebrain to hindbrain in chronic dehydration. J Physiol (2011) 0.87
Dominant role of aortic baroreceptors in the cardiac baroreflex of the rat in situ. Auton Neurosci (2008) 0.87
Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat. Hypertension (2008) 0.87
Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link? Curr Hypertens Rep (2012) 0.87
Uncoupling of rhythmic hypoglossal from phrenic activity in the rat. Exp Physiol (2004) 0.86
Potential switch from eupnea to fictive gasping after blockade of glycine transmission and potassium channels. Am J Physiol Regul Integr Comp Physiol (2002) 0.86
Temporal analysis of the spontaneous baroreceptor reflex during mild emotional stress in the rat. Stress (2010) 0.86
Disinhibition of the cardiac limb of the arterial baroreflex in rat: a role for metabotropic glutamate receptors in the nucleus tractus solitarii. J Physiol (2006) 0.86
Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats. J Appl Physiol (1985) (2011) 0.86
Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development. J Appl Physiol (1985) (2012) 0.85
Evidence of specific inflammatory condition in nucleus tractus solitarii of spontaneously hypertensive rats. Exp Physiol (2009) 0.85
Respiratory-modulated neuronal activities of the rostral medulla which may generate gasping. Respir Physiol Neurobiol (2003) 0.85
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat. Hypertension (2013) 0.84
Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat. Am J Physiol Regul Integr Comp Physiol (2002) 0.84
Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat. Auton Neurosci (2008) 0.84
Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology. Hypertens Res (2011) 0.83
The transcriptome of the medullary area postrema: the thirsty rat, the hungry rat and the hypertensive rat. Exp Physiol (2011) 0.83
Down-regulation of chemokine Ccl5 gene expression in the NTS of SHR may be pro-hypertensive. J Hypertens (2011) 0.83