Published in PLoS One on May 09, 2013
Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5. Front Immunol (2014) 1.21
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. Elife (2014) 1.09
Pattern recognition receptors and central nervous system repair. Exp Neurol (2014) 1.02
Sensing microbial RNA in the cytosol. Front Immunol (2013) 0.99
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. J Interferon Cytokine Res (2014) 0.91
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction. J Virol (2014) 0.90
Influenza virus activation of the interferon system. Virus Res (2015) 0.88
Intracellular detection of viral nucleic acids. Curr Opin Microbiol (2015) 0.88
Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp. J Immunol Res (2015) 0.85
The laboratory of genetics and physiology 2: emerging insights into the controversial functions of this RIG-I-like receptor. Biomed Res Int (2014) 0.84
Helicases in Antiviral Immunity: Dual Properties as Sensors and Effectors. Trends Biochem Sci (2015) 0.80
Comparative analysis of viral RNA signatures on different RIG-I-like receptors. Elife (2016) 0.80
Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition. J Virol (2014) 0.79
Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5. Mol Cell (2016) 0.78
Antiviral RNA recognition and assembly by RLR family innate immune sensors. Cytokine Growth Factor Rev (2014) 0.77
Negative regulators of the RIG-I-like receptor signaling pathway. Eur J Immunol (2017) 0.76
MDA-5 activation by cytoplasmic double-stranded RNA impairs endothelial function and aggravates atherosclerosis. J Cell Mol Med (2016) 0.75
Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic and In Vitro Cytomegalovirus Infection Reveal Plastic and Robust Immune Pathway Biology Responses. Front Immunol (2017) 0.75
Discrimination of Cytosolic Self and Non-Self RNA by RIG-I-like Receptors. J Biol Chem (2017) 0.75
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78
The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics (1996) 11.71
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol (2008) 8.85
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70
Immune signaling by RIG-I-like receptors. Immunity (2011) 5.02
The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. J Virol (1999) 4.99
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83
Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J (1995) 4.17
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A (2010) 2.90
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol (2007) 2.78
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. Virology (2006) 2.64
Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol (2009) 2.37
The beta-interferon promoter responds to priming through multiple independent regulatory elements. J Biol Chem (1994) 2.36
Sendai virus defective-interfering genomes and the activation of interferon-beta. Virology (2006) 2.28
RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J Virol (2006) 2.22
Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition. Proc Natl Acad Sci U S A (2011) 1.99
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J Biol Chem (2009) 1.78
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. J Biol Chem (2009) 1.78
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res (2009) 1.72
Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol (2011) 1.61
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J (2012) 1.57
Mechanism of mda-5 Inhibition by paramyxovirus V proteins. J Virol (2008) 1.55
Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I). J Biol Chem (2011) 1.54
MDA5 assembles into a polar helical filament on dsRNA. Proc Natl Acad Sci U S A (2012) 1.37
Cyclic AMP response element-binding protein and the catalytic subunit of protein kinase A are present in F9 embryonal carcinoma cells but are unable to activate the somatostatin promoter. Mol Cell Biol (1992) 1.29
The regulation of type I interferon production by paramyxoviruses. J Interferon Cytokine Res (2009) 1.27
The characteristics required for a Sendai virus preparation to induce high levels of interferon in human lymphoblastoid cells. J Gen Virol (1981) 1.20
Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction. J Virol (2012) 1.17
Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol (2010) 1.17
Deep sequencing analysis of defective genomes of parainfluenza virus 5 and their role in interferon induction. J Virol (2013) 1.12
Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist. Virology (2011) 1.04
ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem (2012) 1.00
Structural insights into RNA recognition and activation of RIG-I-like receptors. Curr Opin Struct Biol (2012) 0.99
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol (2008) 8.85
The multifunctional NS1 protein of influenza A viruses. J Gen Virol (2008) 6.87
The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta. Virology (2002) 3.02
mda-5, but not RIG-I, is a common target for paramyxovirus V proteins. Virology (2006) 2.64
Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A (2006) 2.63
Bunyamwera bunyavirus nonstructural protein NSs counteracts the induction of alpha/beta interferon. J Virol (2002) 2.50
Innate sensing of HIV-infected cells. PLoS Pathog (2011) 2.22
Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain. BMC Struct Biol (2008) 1.96
Viral immune modulators perturb the human molecular network by common and unique strategies. Nature (2012) 1.86
The NPro product of bovine viral diarrhea virus inhibits DNA binding by interferon regulatory factor 3 and targets it for proteasomal degradation. J Virol (2006) 1.84
Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. J Virol (2003) 1.67
Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J Virol (2002) 1.56
Structure of an avian influenza A virus NS1 protein effector domain. Virology (2008) 1.50
Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proc Natl Acad Sci U S A (2010) 1.34
The regulation of type I interferon production by paramyxoviruses. J Interferon Cytokine Res (2009) 1.27
CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology (2008) 1.26
Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. Nucleic Acids Res (2003) 1.25
Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction. J Virol (2012) 1.17
The amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling. J Virol (2003) 1.12
Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem (2007) 1.08
Role for bovine viral diarrhea virus Erns glycoprotein in the control of activation of beta interferon by double-stranded RNA. J Virol (2004) 1.08
A transient homotypic interaction model for the influenza A virus NS1 protein effector domain. PLoS One (2011) 1.07
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm. J Virol (2013) 1.06
Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K). Virology (2009) 1.03
The Npro product of classical swine fever virus and bovine viral diarrhea virus uses a conserved mechanism to target interferon regulatory factor-3. J Gen Virol (2007) 1.02
STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A (2013) 1.01
Differential activation of interferon regulatory factors-3 and -7 by non-cytopathogenic and cytopathogenic bovine viral diarrhoea virus. Vet Immunol Immunopathol (2004) 0.97
Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation. PLoS One (2012) 0.97
Genetic screen of a mutant poxvirus library identifies an ankyrin repeat protein involved in blocking induction of avian type I interferon. J Virol (2013) 0.94
Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5. J Virol (2006) 0.93
Stability of the parainfluenza virus 5 genome revealed by deep sequencing of strains isolated from different hosts and following passage in cell culture. J Virol (2014) 0.93
An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response. J Virol (2014) 0.86
Improved growth of enteric adenovirus type 40 in a modified cell line that can no longer respond to interferon stimulation. J Gen Virol (2007) 0.85
Activation of the interferon induction cascade by influenza a viruses requires viral RNA synthesis and nuclear export. J Virol (2014) 0.83
The classical swine fever virus Npro product is degraded by cellular proteasomes in a manner that does not require interaction with interferon regulatory factor 3. J Gen Virol (2009) 0.83
Genetic screen of a library of chimeric poxviruses identifies an ankyrin repeat protein involved in resistance to the avian type I interferon response. J Virol (2013) 0.80
Regulation of transcription of the Aedes albopictus cecropin A1 gene: A role for p38 mitogen-activated protein kinase. Insect Biochem Mol Biol (2011) 0.80