Published in Proc Natl Acad Sci U S A on January 08, 2010
Immune signaling by RIG-I-like receptors. Immunity (2011) 5.02
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med (2011) 4.51
Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature (2013) 3.39
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
Structural insights into RNA recognition by RIG-I. Cell (2011) 3.25
Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol (2012) 3.11
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity (2011) 2.59
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol (2012) 2.48
The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain. Structure (2010) 2.29
The airway epithelium: soldier in the fight against respiratory viruses. Clin Microbiol Rev (2011) 2.05
Expanding role of ubiquitination in NF-κB signaling. Cell Res (2010) 1.89
The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome. Immunity (2013) 1.78
Newly described pattern recognition receptors team up against intracellular pathogens. Nat Rev Immunol (2013) 1.69
Induction and function of type I and III interferon in response to viral infection. Curr Opin Virol (2011) 1.61
MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J (2012) 1.57
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Mol Cell Biol (2011) 1.52
Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown. PLoS One (2015) 1.44
Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med (2011) 1.42
The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness. Immunity (2012) 1.39
RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity. Curr Opin Virol (2011) 1.38
Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses. Cytokine Growth Factor Rev (2011) 1.35
A structure-based model of RIG-I activation. RNA (2012) 1.33
Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate. Nucleic Acids Res (2010) 1.25
Intracellular pathogen detection by RIG-I-like receptors. Adv Immunol (2013) 1.25
SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One (2013) 1.25
The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. Cell Host Microbe (2012) 1.24
Mechanisms of MAVS regulation at the mitochondrial membrane. J Mol Biol (2013) 1.24
Interplay between innate immunity and negative-strand RNA viruses: towards a rational model. Microbiol Mol Biol Rev (2011) 1.22
Interferons and viruses: an evolutionary arms race of molecular interactions. Trends Immunol (2015) 1.22
Innate immune detection of microbial nucleic acids. Trends Microbiol (2013) 1.21
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med (2014) 1.18
Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2. J Virol (2011) 1.18
Paramyxovirus V proteins interact with the RNA Helicase LGP2 to inhibit RIG-I-dependent interferon induction. J Virol (2012) 1.17
Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol (2010) 1.15
The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Mol Cell (2014) 1.13
Activation of RIG-I-like receptor signal transduction. Crit Rev Biochem Mol Biol (2011) 1.13
The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication. J Virol (2011) 1.13
Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing. RNA Biol (2012) 1.10
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. Elife (2014) 1.09
Postinfluenza bacterial pneumonia: host defenses gone awry. J Interferon Cytokine Res (2010) 1.09
Intracellular nucleic acid sensors and autoimmunity. J Interferon Cytokine Res (2011) 1.07
Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors. Cold Spring Harb Perspect Biol (2014) 1.07
Expression and functional characterization of the RIG-I-like receptors MDA5 and LGP2 in Rainbow trout (Oncorhynchus mykiss). J Virol (2011) 1.06
Innate immune responses in hepatitis C virus infection. Semin Immunopathol (2012) 1.06
Cytosolic surveillance and antiviral immunity. Curr Opin Virol (2011) 1.06
The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor. J Biol Chem (2012) 1.06
Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system. J Virol (2013) 1.04
RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice. J Clin Invest (2011) 1.04
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One (2010) 1.04
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol (2010) 1.04
Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol Mol Biol Rev (2012) 1.04
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol (2013) 1.01
ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). J Biol Chem (2012) 1.00
LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. PLoS One (2013) 0.99
Sensing microbial RNA in the cytosol. Front Immunol (2013) 0.99
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA. Elife (2015) 0.98
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways. Int Rev Immunol (2013) 0.98
RIG-I in RNA virus recognition. Virology (2015) 0.98
MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation. PLoS One (2013) 0.97
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells. PLoS Pathog (2014) 0.97
Innate sensing of viruses by pattern recognition receptors in birds. Vet Res (2013) 0.96
Induction of type I interferon by adenovirus-encoded small RNAs. Proc Natl Acad Sci U S A (2010) 0.95
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines. Viruses (2013) 0.95
Type I interferons: diversity of sources, production pathways and effects on immune responses. Curr Opin Virol (2011) 0.95
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. J Biol Chem (2012) 0.94
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1. Cell (2015) 0.94
dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity. Immunol Rev (2011) 0.93
RNA helicases: emerging roles in viral replication and the host innate response. RNA Biol (2010) 0.93
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B. Hepatology (2013) 0.93
Recapitulation of the hepatitis C virus life-cycle in engineered murine cell lines. Virology (2013) 0.93
Control of antiviral immunity by pattern recognition and the microbiome. Immunol Rev (2012) 0.93
International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev (2015) 0.92
RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge. J Virol (2013) 0.92
Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses. Am J Clin Exp Immunol (2013) 0.92
Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling. Cytokine (2013) 0.92
Homologous RIG-I-like helicase proteins direct RNAi-mediated antiviral immunity in C. elegans by distinct mechanisms. Proc Natl Acad Sci U S A (2013) 0.91
Functions of the influenza A virus NS1 protein in antiviral defense. Curr Opin Virol (2015) 0.91
Sensing of viral nucleic acids by RIG-I: from translocation to translation. Eur J Cell Biol (2011) 0.91
dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effects. J Interferon Cytokine Res (2014) 0.91
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction. J Virol (2014) 0.90
Impaired cellular responses to cytosolic DNA or infection with Listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein. PLoS One (2011) 0.89
Paramyxovirus evasion of innate immunity: Diverse strategies for common targets. World J Virol (2013) 0.89
The role of type I interferons in intestinal infection, homeostasis, and inflammation. Immunol Rev (2014) 0.89
LGP2: positive about viral sensing. Proc Natl Acad Sci U S A (2010) 0.89
NLRs, inflammasomes, and viral infection. J Leukoc Biol (2012) 0.88
Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke. Sci Rep (2013) 0.88
Influenza virus activation of the interferon system. Virus Res (2015) 0.88
The essential adaptors of innate immune signaling. Protein Cell (2012) 0.88
Positive evolutionary selection on the RIG-I-like receptor genes in mammals. PLoS One (2013) 0.88
Ambivalent role of the innate immune response in rabies virus pathogenesis. J Virol (2011) 0.87
Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection. Future Microbiol (2011) 0.87
Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiol (2010) 0.87
DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. PLoS Pathog (2013) 0.87
LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. J Virol (2012) 0.87
A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PLoS Pathog (2014) 0.86
Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus. Immunogenetics (2013) 0.85
Ancient origins of vertebrate-specific innate antiviral immunity. Mol Biol Evol (2013) 0.84
Exposing viruses: RNA patterns sensed by RIG-I-like receptors. J Clin Immunol (2010) 0.84
Interferon induction by RNA viruses and antagonism by viral pathogens. Viruses (2014) 0.84
The laboratory of genetics and physiology 2: emerging insights into the controversial functions of this RIG-I-like receptor. Biomed Res Int (2014) 0.84
Pathogen recognition and innate immunity. Cell (2006) 44.14
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. Science (2006) 16.00
RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell (2009) 10.11
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Innate immunity to virus infection. Immunol Rev (2009) 7.04
RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol (2009) 6.97
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity (2006) 5.36
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell (2008) 5.35
Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses. Mol Cell (2008) 5.20
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83
Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. Science (2009) 4.00
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
Viral RNA replication in association with cellular membranes. Curr Top Microbiol Immunol (2005) 3.18
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I. Proc Natl Acad Sci U S A (2009) 3.05
Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity (2008) 2.81
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol (2007) 2.78
Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1. J Virol (2007) 2.59
RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. J Virol (2006) 2.22
The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA. J Biol Chem (2009) 1.78
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA. Nucleic Acids Res (2009) 1.72
Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors. J Biol Chem (2009) 1.68
Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor-induced apoptosis. J Exp Med (2001) 0.88
Pathogen recognition and innate immunity. Cell (2006) 44.14
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Toll-like receptors. Annu Rev Immunol (2001) 26.06
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
Pattern recognition receptors and inflammation. Cell (2010) 21.05
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10
Toll-like receptors in innate immunity. Int Immunol (2005) 12.24
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Innate immune recognition of viral infection. Nat Immunol (2006) 9.59
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol (2005) 9.11
TLR signaling pathways. Semin Immunol (2004) 9.08
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87
TLR signaling. Semin Immunol (2007) 8.16
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50
Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
Innate immunity to virus infection. Immunol Rev (2009) 7.04
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98
Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95
Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A (2005) 5.64
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48
Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41
The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell (2008) 5.35
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21