PubRank

Frederic J de Sauvage

Author PubWeight™ 182.55‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2002 14.34
2 Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 2008 12.68
3 Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010 10.83
4 The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature 2010 10.04
5 Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009 8.55
6 A paracrine requirement for hedgehog signalling in cancer. Nature 2008 8.16
7 Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009 7.23
8 Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006 6.82
9 A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 2011 5.45
10 Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009 5.40
11 Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006 5.30
12 Recurrent R-spondin fusions in colon cancer. Nature 2012 5.10
13 Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013 4.78
14 Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet 2012 4.70
15 Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell 2009 4.47
16 Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 2009 3.74
17 Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A 2009 3.13
18 A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol 2010 3.09
19 The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol 2009 2.63
20 Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res 2010 2.45
21 Paracrine Hedgehog signaling in cancer. Cancer Res 2009 2.21
22 The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res 2012 2.19
23 The hedgehog signaling pathway in cancer. Clin Cancer Res 2006 2.15
24 Oncogenic ERBB3 mutations in human cancers. Cancer Cell 2013 2.06
25 Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol 2010 1.93
26 Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol 2008 1.92
27 IL-27 limits IL-2 production during Th1 differentiation. J Immunol 2006 1.89
28 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol 2010 1.81
29 TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Sci Signal 2011 1.81
30 Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res 2011 1.72
31 Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers. Cancer Res 2005 1.69
32 Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 2009 1.61
33 Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology. Am J Pathol 2006 1.57
34 Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development 2010 1.55
35 Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol 2005 1.54
36 Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. J Immunol 2005 1.48
37 Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events. Genome Res 2012 1.47
38 Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res 2009 1.41
39 IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 2010 1.41
40 Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes. Blood 2008 1.39
41 Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol 2005 1.39
42 Suppressor of fused regulates Gli activity through a dual binding mechanism. Mol Cell Biol 2004 1.38
43 IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med 2007 1.34
44 Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction. Sci Signal 2008 1.33
45 Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells. Proc Natl Acad Sci U S A 2011 1.23
46 Structural ties between cholesterol transport and morphogen signaling. Cell 2009 1.18
47 A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. J Biol Chem 2002 1.17
48 miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer. Sci Signal 2011 1.16
49 The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol 2009 1.15
50 Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res 2002 1.15
51 Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J Biol Chem 2010 1.13
52 Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin Cancer Res 2011 1.10
53 Targeting superficial or nodular Basal cell carcinoma with topically formulated small molecule inhibitor of smoothened. Clin Cancer Res 2011 1.02
54 PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition. Cancer Res 2013 1.00
55 Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem 2009 0.96
56 Discovery and preclinical development of vismodegib. Expert Opin Drug Discov 2014 0.95
57 TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma. PLoS One 2011 0.93
58 Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway. Bioorg Med Chem Lett 2010 0.91
59 A tumor-specific stem cell. Nat Genet 2013 0.85
60 Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31. Exp Hematol 2007 0.84
61 Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials. Pancreatology 2011 0.82
62 Signaling: An oxysterol ligand for Smoothened. Nat Chem Biol 2012 0.81
63 Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly. Biochemistry 2006 0.80
64 Vive la science! Vive le hérisson! EMBO Rep 2010 0.75