Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76

Hypoxia, notch signalling, and prostate cancer. Nat Rev Urol (2013) 2.24

The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev (2009) 1.82

Molecular signaling pathways that regulate prostate gland development. Differentiation (2008) 1.47

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung. J Biol Chem (2008) 1.40

EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma. Cancer Res (2008) 1.38

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol (2007) 1.26

Prostate cancer stem cells. J Pathol (2009) 1.26

Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy. Am J Pathol (2011) 1.24

Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res (2008) 1.19

Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling. Genes Dev (2012) 1.17

Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling. PLoS One (2008) 1.16

Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell (2012) 1.16

Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells. Mol Oncol (2010) 1.11

Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction. Endocr Rev (2008) 1.10

Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers. Am J Transl Res (2013) 1.03

Identification of Notch-1 expression in the limbal basal epithelium. Mol Vis (2007) 1.02

Molecular pathways and targets in prostate cancer. Oncotarget (2014) 1.00

Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol (2008) 1.00

Hedgehog pathway activity in the LADY prostate tumor model. Mol Cancer (2007) 0.99

Notch signaling in prostate cancer: a moving target. Prostate (2014) 0.98

Activation of c-MET induces a stem-like phenotype in human prostate cancer. PLoS One (2011) 0.98

Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells (2011) 0.97

The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways. Am J Pathol (2009) 0.97

Lgr4 is a key regulator of prostate development and prostate stem cell differentiation. Stem Cells (2013) 0.97

Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem (2009) 0.96

Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism. Dev Biol (2011) 0.96

Notch signaling modulates hypoxia-induced neuroendocrine differentiation of human prostate cancer cells. Mol Cancer Res (2011) 0.93

Androgen deprivation and stem cell markers in prostate cancers. Int J Clin Exp Pathol (2009) 0.93

Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways. PLoS One (2010) 0.92

FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions. Acta Neuropathol (2015) 0.92

Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies. Endocr Rev (2008) 0.92

Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint. Cancer Res (2013) 0.89

Disruption of prostate epithelial differentiation pathways and prostate cancer development. Front Oncol (2013) 0.89

LEF1 identifies androgen-independent epithelium in the developing prostate. Mol Endocrinol (2011) 0.88

Genetic regulation of prostate development. J Androl (2010) 0.87

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation. Neoplasia (2014) 0.83

NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer. Nat Rev Urol (2014) 0.83

Castration-resistant prostate cancer: potential targets and therapies. Biologics (2012) 0.81

Predicting the functions of long noncoding RNAs using RNA-seq based on Bayesian network. Biomed Res Int (2015) 0.80

Essential roles of epithelial bone morphogenetic protein signaling during prostatic development. Endocrinology (2014) 0.80

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression. Mol Cancer (2014) 0.79

Mini-review: Does Notch promote or suppress cancer? New findings and old controversies. Am J Clin Exp Urol (2015) 0.79

Early human prostate adenocarcinomas harbor androgen-independent cancer cells. PLoS One (2013) 0.79

Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation. F1000Res (2014) 0.79

Sonic Hedgehog pathway activity in prostate cancer. Oncol Lett (2010) 0.78

REST reduction is essential for hypoxia-induced neuroendocrine differentiation of prostate cancer cells by activating autophagy signaling. Oncotarget (2016) 0.78

Notch signaling in prostate cancer: refining a therapeutic opportunity. Histol Histopathol (2015) 0.77

Notch signaling in the prostate: critical roles during development and in the hallmarks of prostate cancer biology. J Cancer Res Clin Oncol (2015) 0.76

Dual tumor suppressing and promoting function of Notch1 signaling in human prostate cancer. Oncotarget (2016) 0.75

Prostate organogenesis: tissue induction, hormonal regulation and cell type specification. Development (2017) 0.75

Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate. PLoS One (2015) 0.75

Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes. BMC Cancer (2016) 0.75

Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports (2016) 0.75

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A (2016) 0.75

Synergistic Activity with NOTCH Inhibition and Androgen Ablation in ERG-positive Prostate Cancer Cells. Mol Cancer Res (2017) 0.75

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell (2006) 21.66

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem (2002) 14.34

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med (2008) 12.68

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83

The mutation spectrum revealed by paired genome sequences from a lung cancer patient. Nature (2010) 10.04

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med (2009) 8.55

A paracrine requirement for hedgehog signalling in cancer. Nature (2008) 8.16

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med (2009) 7.23

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol (2006) 6.82

Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature (2011) 5.45

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science (2009) 5.40

Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov (2006) 5.30

Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol (2013) 5.21

Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10

Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res (2005) 4.94

Influence of tumour micro-environment heterogeneity on therapeutic response. Nature (2013) 4.78

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet (2012) 4.70

Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 4.56

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47

The External RNA Controls Consortium: a progress report. Nat Methods (2005) 4.24

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat Med (2009) 3.86

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci (2009) 3.74

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression. Cancer Res (2009) 3.72

Transcription factor RORα is critical for nuocyte development. Nat Immunol (2012) 3.72

PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell (2009) 3.71

Generation of a prostate from a single adult stem cell. Nature (2008) 3.46

A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell (2010) 3.34

Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol (2011) 3.23

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med (2004) 3.16

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A (2009) 3.13

Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res (2006) 3.12

A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol (2010) 3.09

Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08

The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol (2007) 3.06

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03

Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus. PLoS One (2009) 2.98

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Cancer Res (2006) 2.84

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity (2002) 2.83

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes. Proc Natl Acad Sci U S A (2010) 2.77

Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res (2011) 2.71

Loss of the tumor suppressor BAP1 causes myeloid transformation. Science (2012) 2.69

Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers. Mol Cancer Res (2009) 2.65

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol (2009) 2.63

Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A (2003) 2.54

The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell (2005) 2.53

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res (2010) 2.45

Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44

MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res (2008) 2.33

Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29

Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28

Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology (2007) 2.26

Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence. Cancer Discov (2011) 2.22

Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 2.21

Paracrine Hedgehog signaling in cancer. Cancer Res (2009) 2.21

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J (2012) 2.21

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res (2012) 2.19

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17

The hedgehog signaling pathway in cancer. Clin Cancer Res (2006) 2.15

Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett (2006) 2.14

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13

Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06

Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood (2007) 2.06

Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity (2008) 2.05

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol (2011) 1.95

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93

Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol (2010) 1.93

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol (2008) 1.92

Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91

IL-27 limits IL-2 production during Th1 differentiation. J Immunol (2006) 1.89

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples. BMC Med Genomics (2011) 1.84

Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell (2009) 1.84

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2010) 1.84

COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature (2011) 1.83

Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation. Mol Cell Biol (2010) 1.81

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer. Clin Cancer Res (2008) 1.81

TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Sci Signal (2011) 1.81

Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78

Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75

Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology (2005) 1.73

Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J Exp Med (2007) 1.73

Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. J Neurosci (2010) 1.72

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res (2011) 1.72