Published in Drug Discov Today on August 15, 2004
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82
Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology (2008) 1.57
Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1. J Biol Chem (2005) 1.54
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem J (2005) 1.45
The human side of hypoxia-inducible factor. Br J Haematol (2008) 1.41
Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A (2006) 1.39
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Mol Cell Proteomics (2008) 1.36
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. J Physiol (2013) 1.35
Hypoxia-Inducible Factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia. Yale J Biol Med (2007) 1.23
A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1 alpha. J Cell Sci (2006) 1.20
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res (2009) 1.12
A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients. Mol Cancer (2010) 1.10
Structural integration in hypoxia-inducible factors. Nature (2015) 1.09
Hypoxia-inducible factor expression in human RPE cells. Br J Ophthalmol (2007) 1.02
Three autocrine feedback loops determine HIF1 alpha expression in chronic hypoxia. Biochim Biophys Acta (2007) 0.97
Cellular oxygen sensing in health and disease. Pediatr Nephrol (2007) 0.97
Hypoxia inducible factor-1 as a target for neurodegenerative diseases. Curr Med Chem (2011) 0.91
Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1). Curr Pharm Des (2006) 0.91
A truncated Ah receptor blocks the hypoxia and estrogen receptor signaling pathways: a viable approach for breast cancer treatment. Mol Pharm (2006) 0.90
Ritonavir inhibits HIF-1α-mediated VEGF expression in retinal pigment epithelial cells in vitro. Eye (Lond) (2013) 0.89
The second coordination sphere of FIH controls hydroxylation. Biochemistry (2011) 0.89
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors. J Med Chem (2013) 0.89
Screening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH). J Inorg Biochem (2012) 0.87
Uncoupled O2-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species. J Inorg Biochem (2011) 0.86
Wound healing improvement with PHD-2 silenced fibroblasts in diabetic mice. PLoS One (2013) 0.83
Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway. Cell Mol Neurobiol (2009) 0.83
Neuroprotective effects of multifaceted hybrid agents targeting MAO, cholinesterase, iron and β-amyloid in ageing and Alzheimer's disease. Br J Pharmacol (2015) 0.80
Effect of conjugated linoleic acid on inhibition of prolyl hydroxylase 1 in hearts of mice. Lipids Health Dis (2012) 0.80
Analysis of HIF-1a and its regulator, PHD2, in retroperitoneal sarcomas: clinico-pathologic implications. Cancer Biol Ther (2009) 0.80
Treatment with an activator of hypoxia-inducible factor 1, DMOG provides neuroprotection after traumatic brain injury. Neuropharmacology (2016) 0.79
Targeting angiogenesis in melanoma: prospects for the future. Ther Adv Med Oncol (2010) 0.79
(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Mol Pharmacol (2008) 0.79
Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim. J Neural Transm (Vienna) (2011) 0.79
Post-translational hydroxylation by 2OG/Fe(II)-dependent oxygenases as a novel regulatory mechanism in bacteria. Front Microbiol (2015) 0.78
A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor protein. Nucleic Acids Res (2007) 0.78
Targeting HIF-alpha: when a magic arrow hits the bull's eye. Drug Discov Today (2004) 0.77
Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines. Front Oncol (2014) 0.77
Increased Turnover at Limiting O2 Concentrations by the Thr(387) → Ala Variant of HIF-Prolyl Hydroxylase PHD2. Biochemistry (2015) 0.77
Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target. Cancer Res (2016) 0.77
Betaine inhibits vascularization via suppression of Akt in the retinas of streptozotocin-induced hyperglycemic rats. Mol Med Rep (2015) 0.76
Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Org Biomol Chem (2012) 0.76
Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase. Biochem Pharmacol (2011) 0.75
Prolyl 4 hydroxylase: a critical target in the pathophysiology of diseases. Korean J Physiol Pharmacol (2013) 0.75
The antitumor efficacy of anti-p21Ras scFv mediated by the dual-promoter-regulated recombinant adenovirus KGHV300. Gene Ther (2016) 0.75
Drug discovery in the HIF pathway: where do we go now? Drug Discov Today (2004) 0.75
Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress. Int J Med Sci (2017) 0.75
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol (2008) 4.52
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem (2002) 3.91
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem (2006) 3.08
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (2009) 2.59
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem (2002) 2.29
Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol (2009) 2.28
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A (2006) 2.17
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci (2010) 2.12
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J (2008) 1.95
Inhibition of 2-oxoglutarate dependent oxygenases. Chem Soc Rev (2011) 1.90
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Elimination of Rhodnius prolixus in Central America. Parasit Vectors (2012) 1.87
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem (2007) 1.84
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Structure (2002) 1.82
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem (2006) 1.75
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem (2008) 1.74
Structural studies on human 2-oxoglutarate dependent oxygenases. Curr Opin Struct Biol (2010) 1.72
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One (2010) 1.71
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep (2010) 1.62
Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chem Biol (2010) 1.62
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem J (2002) 1.61
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. Bioorg Med Chem Lett (2003) 1.59
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J (2007) 1.58
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev (2011) 1.46
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet (2009) 1.44
Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. J Biol Chem (2009) 1.44
The selectivity and inhibition of AlkB. J Biol Chem (2003) 1.43
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J Biol Chem (2011) 1.42
Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma. PLoS Negl Trop Dis (2008) 1.34
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem (2011) 1.31
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angew Chem Int Ed Engl (2012) 1.30
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. J Biol Chem (2005) 1.29
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst) (2007) 1.27
A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst (2009) 1.27
Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Org Biomol Chem (2008) 1.26
Crystal structure of carbapenem synthase (CarC). J Biol Chem (2003) 1.24
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc (2014) 1.23
Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. J Med Chem (2012) 1.23
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate. Mol Biosyst (2005) 1.22
Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. J Neurochem (2002) 1.22
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen. FEBS J (2010) 1.20
Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proc Natl Acad Sci U S A (2014) 1.19
Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases. Curr Opin Struct Biol (2012) 1.18
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J Biol Chem (2007) 1.17
Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents. Biochem J (2010) 1.17
Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements. FEBS Lett (2002) 1.17
Selective inhibition of factor inhibiting hypoxia-inducible factor. J Am Chem Soc (2005) 1.15
Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb) (2013) 1.13
The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorg Med Chem Lett (2002) 1.11
Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme. Chem Biol (2004) 1.11
Evidence for a stereoelectronic effect in human oxygen sensing. Angew Chem Int Ed Engl (2009) 1.11
Mechanisms of human histone and nucleic acid demethylases. Curr Opin Chem Biol (2012) 1.11
Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors. Mol Biol Rep (2011) 1.10
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. EMBO Rep (2012) 1.09
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem (2012) 1.09
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). PLoS One (2011) 1.09
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. Biochem J (2004) 1.08
The enzymology of clavam and carbapenem biosynthesis. Chem Commun (Camb) (2005) 1.07
The human oxygen sensing machinery and its manipulation. Chem Soc Rev (2008) 1.07
OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proc Natl Acad Sci U S A (2014) 1.06
Inhibition of the histone lysine demethylase JMJD2A by ejection of structural Zn(II). Chem Commun (Camb) (2009) 1.06
Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure. J Med Chem (2009) 1.05
Therapeutic manipulation of the HIF hydroxylases. Antioxid Redox Signal (2010) 1.05
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J Biol Chem (2010) 1.04
Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Mol Biosyst (2008) 1.04
Research needs for Chagas disease prevention. Acta Trop (2010) 1.04
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol (2013) 1.04
Dynamic states of the DNA repair enzyme AlkB regulate product release. EMBO Rep (2008) 1.03
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem (2008) 1.03
Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis: anthocyanidin synthase, flavonol synthase, and flavanone 3beta-hydroxylase. J Biol Chem (2003) 1.03
The enzymes of β-lactam biosynthesis. Nat Prod Rep (2013) 1.02
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity. Eur J Biochem (2002) 1.02
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. Bioorg Med Chem Lett (2003) 1.02
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6. J Mol Biol (2010) 1.02
Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro. FEBS Lett (2006) 1.02
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline. Chembiochem (2009) 1.02
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. FEBS J (2011) 1.01
Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans. FEBS Lett (2005) 1.01
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proc Natl Acad Sci U S A (2014) 1.00
Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J Biol Chem (2012) 1.00
On the histone lysine methyltransferase activity of fungal metabolite chaetocin. J Med Chem (2013) 0.99
Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic Res Cardiol (2012) 0.99
Assay platform for clinically relevant metallo-β-lactamases. J Med Chem (2013) 0.99
X-ray structure of a serine protease acyl-enzyme complex at 0.95-A resolution. J Biol Chem (2002) 0.99
Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates. Org Biomol Chem (2010) 0.97
Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde. Chembiochem (2010) 0.97
2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2. Bioorg Med Chem Lett (2009) 0.96
Structural analyses on intermediates in serine protease catalysis. J Biol Chem (2006) 0.96
The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues. Chembiochem (2011) 0.96
Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. PLoS One (2010) 0.95
Glyco- and peptidomimetics from three-component Joullié-Ugi coupling show selective antiviral activity. J Am Chem Soc (2005) 0.95
Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocr Relat Cancer (2010) 0.95