Ubiquitin and drug discovery: challenges and opportunities.

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell (2003) 4.30

SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature (2002) 2.94

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci U S A (2006) 2.41

A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17

Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev Biol (2007) 2.13

BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Exp Cell Res (2003) 2.06

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer (2011) 2.06

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem (2008) 2.00

HECT and RING finger families of E3 ubiquitin ligases at a glance. J Cell Sci (2012) 1.95

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol Cell (2009) 1.83

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat Med (2007) 1.81

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J Biol Chem (2003) 1.79

Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS One (2009) 1.72

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. J Biol Chem (2006) 1.68

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J Biol Chem (2003) 1.67

Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion. Mol Biol Cell (2008) 1.66

RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64

The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer. Genes Cancer (2010) 1.55

Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47

Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Mol Cell (2012) 1.46

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Semin Cancer Biol (2003) 1.42

Regulating the p53 system through ubiquitination. Oncogene (2004) 1.39

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J Biol Chem (2003) 1.37

Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. J Cell Biol (2004) 1.33

Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J Biol Chem (2010) 1.18

E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells. Cancer Res (2006) 1.08

A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Mol Biol Cell (2009) 1.08

Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+. J Biol Chem (2003) 1.06

Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. J Biol Chem (2001) 1.06

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. EMBO J (2013) 1.05

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum. Biochem Biophys Res Commun (2009) 1.03

A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation. J Cell Sci (2009) 1.01

Dissecting the diverse functions of the metastasis suppressor CD82/KAI1. FEBS Lett (2011) 0.98

Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci (2011) 0.97

Expression, purification, and properties of the Ubc4/5 family of E2 enzymes. Methods Enzymol (2005) 0.96

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. Genes Cells (2005) 0.96

A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms. Mol Cell (2013) 0.95

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell (2012) 0.95

Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system. Proc Natl Acad Sci U S A (2010) 0.94

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Proc Natl Acad Sci U S A (2008) 0.93

Ubiquitylation in ERAD: reversing to go forward? PLoS Biol (2011) 0.92

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol Cancer Ther (2008) 0.92

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. J Biomol Screen (2008) 0.89

Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase. EMBO J (2013) 0.86

Expression and evaluation of RING finger proteins. Methods Enzymol (2005) 0.85

Studies of the ubiquitin proteasome system. Curr Protoc Cell Biol (2006) 0.84

Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains. Structure (2012) 0.84

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg Med Chem (2008) 0.82

Working on a chain: E3s ganging up for ubiquitylation. Nat Cell Biol (2010) 0.82

A ubiquitin-binding rhomboid protease aimed at ERADication. Dev Cell (2012) 0.76

Cullin RING ligases: glommed by glomulin. Mol Cell (2012) 0.75