Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation.

One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68

Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42

Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (2011) 3.19

Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol (2011) 2.28

Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates. J Cell Biol (2010) 1.85

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol Cell (2009) 1.83

Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol (2011) 1.68

RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J Cell Biol (2009) 1.48

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. J Cell Biol (2009) 1.45

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A (2011) 1.38

Arabidopsis ubiquitin conjugase UBC32 is an ERAD component that functions in brassinosteroid-mediated salt stress tolerance. Plant Cell (2012) 1.29

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol (2010) 1.29

An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors. J Biol Chem (2009) 1.26

Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25

Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.22

Regulation of HMG-CoA reductase in mammals and yeast. Prog Lipid Res (2011) 1.22

The ERAD inhibitor Eeyarestatin I is a bifunctional compound with a membrane-binding domain and a p97/VCP inhibitory group. PLoS One (2010) 1.21

Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J Biol Chem (2010) 1.18

Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem (2011) 1.17

How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha. Mol Cell Biol (2008) 1.11

Increased endoplasmic reticulum stress and decreased proteasomal function in lafora disease models lacking the phosphatase laforin. PLoS One (2009) 1.10

Degradation of the bile salt export pump at endoplasmic reticulum in progressive familial intrahepatic cholestasis type II. Hepatology (2008) 1.07

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. J Cell Biol (2009) 1.07

Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast. J Biol Chem (2009) 1.07

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. Arch Biochem Biophys (2008) 1.06

Viral and cellular MARCH ubiquitin ligases and cancer. Semin Cancer Biol (2008) 1.05

RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin. Mol Biol Cell (2010) 1.05

A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem (2011) 1.04

Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.04

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum. Biochem Biophys Res Commun (2009) 1.03

Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. PLoS One (2010) 1.02

A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation. J Cell Sci (2009) 1.01

When worlds collide: IP(3) receptors and the ERAD pathway. Cell Calcium (2009) 1.00

Endoplasmic reticulum (ER) stress response and its physiological roles in plants. Int J Mol Sci (2013) 0.97

Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. Mol Biol Cell (2009) 0.96

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell (2012) 0.95

Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP). J Biol Chem (2009) 0.93

Intracellular events regulating cross-presentation. Front Immunol (2012) 0.93

Ubiquitin on the move: the ubiquitin modification system plays diverse roles in the regulation of endoplasmic reticulum- and plasma membrane-localized proteins. Plant Physiol (2012) 0.93

Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. J Biol Chem (2010) 0.92

Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope. Crit Rev Biochem Mol Biol (2014) 0.92

ATL9, a RING zinc finger protein with E3 ubiquitin ligase activity implicated in chitin- and NADPH oxidase-mediated defense responses. PLoS One (2010) 0.92

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I. Proc Natl Acad Sci U S A (2014) 0.91

Endoplasmic reticulum-mediated protein quality control in Arabidopsis. Front Plant Sci (2014) 0.91

The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits. Mol Biol Cell (2010) 0.91

Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. Proteins (2010) 0.91

Deglycosylation-dependent fluorescent proteins provide unique tools for the study of ER-associated degradation. Proc Natl Acad Sci U S A (2013) 0.90

Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. J Biol Chem (2011) 0.90

Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication. Mol Biol Cell (2010) 0.88

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins. J Cell Biol (2014) 0.88

E2 enzymes: more than just middle men. Cell Res (2016) 0.87

Selective targeting of proteins within secretory pathway for endoplasmic reticulum-associated degradation. J Biol Chem (2012) 0.87

Importin beta interacts with the endoplasmic reticulum-associated degradation machinery and promotes ubiquitination and degradation of mutant alpha1-antitrypsin. J Biol Chem (2011) 0.87

Liver cytochrome P450 3A endoplasmic reticulum-associated degradation: a major role for the p97 AAA ATPase in cytochrome P450 3A extraction into the cytosol. J Biol Chem (2010) 0.86

Bifunctional apoptosis regulator (BAR), an endoplasmic reticulum (ER)-associated E3 ubiquitin ligase, modulates BI-1 protein stability and function in ER Stress. J Biol Chem (2010) 0.85

Ume6p is required for germination and early colony development of yeast ascospores. FEMS Yeast Res (2010) 0.84

Cln6 mutants associated with neuronal ceroid lipofuscinosis are degraded in a proteasome-dependent manner. Biosci Rep (2009) 0.83

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB. Hum Mol Genet (2013) 0.82

Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD). J Biol Chem (2013) 0.82

Ube2g2-gp78-mediated HERP polyubiquitylation is involved in ER stress recovery. J Cell Sci (2014) 0.81

A nuclear ubiquitin-proteasome pathway targets the inner nuclear membrane protein Asi2 for degradation. J Cell Sci (2014) 0.81

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem (2013) 0.81

Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy. BMC Med (2012) 0.81

Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexes. J Biol Chem (2014) 0.81

KF-1 Ubiquitin Ligase: An Anxiety Suppressor. Front Neurosci (2009) 0.81

Terminating protein ubiquitination: Hasta la vista, ubiquitin. Cell Cycle (2011) 0.80

Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation. J Biol Chem (2009) 0.79

Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation. J Biol Chem (2014) 0.78

EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Proc Natl Acad Sci U S A (2015) 0.78

Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D. Hum Mol Genet (2014) 0.78

The C-terminal amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human cytomegalovirus US11-induced MHC-I degradation. PLoS One (2013) 0.78

Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition? IUBMB Life (2014) 0.77

In silico analysis of ubiquitin/ubiquitin-like modifiers and their conjugating enzymes in Entamoeba species. Parasitol Res (2012) 0.77

p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Mol Biol Cell (2015) 0.77

Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. Drug Metab Rev (2016) 0.75

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy. Autophagy (2017) 0.75

Comparative sequence analysis reveals regulation of genes in developing schistosomula of Schistosoma mansoni exposed to host portal serum. PLoS One (2017) 0.75

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev (2002) 16.10

Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol (2001) 8.68

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature (2001) 7.59

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature (2004) 6.37

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell (1999) 6.04

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell (2006) 5.54

A membrane protein required for dislocation of misfolded proteins from the ER. Nature (2004) 5.39

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor. Cell (1993) 5.05

A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J (2000) 4.48

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell (2001) 4.41

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol (2001) 4.28

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell (1996) 4.19

Role of Cue1p in ubiquitination and degradation at the ER surface. Science (1997) 4.18

A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell (2006) 4.08

Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol (2002) 4.06

Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J Cell Biol (2004) 3.83

A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev (2001) 3.82

The biochemistry of Parkinson's disease. Annu Rev Biochem (2005) 3.79

AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol (2002) 3.77

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell (2006) 3.73

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci U S A (2001) 3.39

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J (1996) 3.34

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell (1998) 3.33

Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell (2003) 3.04

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J Biol Chem (2003) 2.96

Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol (2000) 2.88

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Nature (2007) 2.82

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A (2005) 2.81

N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol (2004) 2.81

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J (2006) 2.58

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell (2002) 2.53

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol (2007) 2.53

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Mol Cell (2005) 2.51

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway. Cell (1998) 2.48

A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. Nat Cell Biol (2006) 2.41

Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem (2004) 2.41

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci U S A (2006) 2.41

Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen. Mol Cell (2005) 2.38

Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell (2003) 2.25

Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol (2005) 2.12

Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD. Mol Cell (2005) 2.12

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation. J Biol Chem (2004) 2.07

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol (2005) 2.06

Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem (2001) 2.04

The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol (2005) 2.04

Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD. J Biol Chem (2003) 1.99

Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol Cell (2005) 1.97

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci U S A (1998) 1.86

TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Biochem J (2005) 1.84

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. EMBO J (2006) 1.83

Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature (2006) 1.78

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev (2003) 1.76

Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI). J Biol Chem (2005) 1.68

Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet (2006) 1.66

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev (2003) 1.63

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. J Cell Sci (1999) 1.62

Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome. J Biol Chem (1998) 1.61

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. J Biol Chem (2003) 1.60

Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. J Biol Chem (2006) 1.54

Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J (2001) 1.50

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J (2006) 1.45

Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation. EMBO Rep (2004) 1.40

A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett (2004) 1.40

A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun (2003) 1.37

An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci U S A (2006) 1.35

The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol Biol Cell (2007) 1.33

Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation. J Cell Sci (2006) 1.30

Essential role of synoviolin in embryogenesis. J Biol Chem (2004) 1.28

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. J Biol Chem (2003) 1.27

A role for mammalian Ubc6 homologues in ER-associated protein degradation. J Cell Sci (2002) 1.26

Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells. Int Immunol (2004) 1.24

Structural insights into the p97-Ufd1-Npl4 complex. Proc Natl Acad Sci U S A (2007) 1.22

The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett (1999) 1.21

Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair. Mol Cell Biol (2000) 1.18

Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates. EMBO Rep (2005) 1.12

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J Biol Chem (1991) 1.12

A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. FEBS Lett (1999) 1.10

Ubiquitin ligase gp78 increases solubility and facilitates degradation of the Z variant of alpha-1-antitrypsin. Biochem Biophys Res Commun (2006) 1.08

Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet (2006) 1.06

Der1p, a protein required for degradation of malfolded soluble proteins of the endoplasmic reticulum: topology and Der1-like proteins. FEMS Yeast Res (2004) 1.05

A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem (2006) 1.03

RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. Oncogene (2006) 1.01

Expression of autocrine motility factor (AMF) and its receptor, AMFR, in human breast cancer. J Histochem Cytochem (2005) 1.00

A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. J Biol Chem (2006) 0.99

The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene (2002) 0.96

Expression of autocrine motility factor receptor in colorectal cancer as a predictor for disease recurrence. Cancer (1994) 0.95

Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells. Int J Mol Med (2006) 0.92

Substrate recognition in ER-associated degradation mediated by Eps1, a member of the protein disulfide isomerase family. EMBO J (2003) 0.92

Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation. Clin Exp Metastasis (2003) 0.84

Improved prognosis assessment for patients with bladder carcinoma. Am J Pathol (1997) 0.81

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell (2003) 4.30

SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals. Nature (2002) 2.94

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat Struct Mol Biol (2006) 2.85

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. Cancer Res (2007) 2.60

The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci U S A (2006) 2.41

A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17

BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. Exp Cell Res (2003) 2.06

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer (2011) 2.06

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem (2008) 2.00

HECT and RING finger families of E3 ubiquitin ligases at a glance. J Cell Sci (2012) 1.95

Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78. Mol Cell (2009) 1.83

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation. Nat Med (2007) 1.81

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation. J Biol Chem (2003) 1.79

Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS One (2009) 1.72

The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. J Biol Chem (2006) 1.68

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J Biol Chem (2003) 1.67

Ubiquitin-proteasome-dependent degradation of a mitofusin, a critical regulator of mitochondrial fusion. Mol Biol Cell (2008) 1.66

RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Biophys Acta (2013) 1.64

The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and Cancer. Genes Cancer (2010) 1.55

Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med (2014) 1.47

Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Mol Cell (2012) 1.46

RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular targets in cancer. Semin Cancer Biol (2003) 1.42

Regulating the p53 system through ubiquitination. Oncogene (2004) 1.39

Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells. J Biol Chem (2003) 1.37

Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. J Cell Biol (2004) 1.33

Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulum-associated degradation of the unassembled protein. J Biol Chem (2010) 1.18

E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells. Cancer Res (2006) 1.08

A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Mol Biol Cell (2009) 1.08

Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+. J Biol Chem (2003) 1.06

Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase. J Biol Chem (2001) 1.06

Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. EMBO J (2013) 1.05

Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1: cross-talk between E3s in the endoplasmic reticulum. Biochem Biophys Res Commun (2009) 1.03

A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation. J Cell Sci (2009) 1.01

Dissecting the diverse functions of the metastasis suppressor CD82/KAI1. FEBS Lett (2011) 0.98

Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. J Cell Sci (2011) 0.97

Expression, purification, and properties of the Ubc4/5 family of E2 enzymes. Methods Enzymol (2005) 0.96

Multiple roles of Rbx1 in the VBC-Cul2 ubiquitin ligase complex. Genes Cells (2005) 0.96

A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms. Mol Cell (2013) 0.95

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell (2012) 0.95

Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system. Proc Natl Acad Sci U S A (2010) 0.94

EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Proc Natl Acad Sci U S A (2008) 0.93

Ubiquitylation in ERAD: reversing to go forward? PLoS Biol (2011) 0.92

Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol Cancer Ther (2008) 0.92

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen. J Biomol Screen (2008) 0.89

Compact Parkin only: insights into the structure of an autoinhibited ubiquitin ligase. EMBO J (2013) 0.86

Expression and evaluation of RING finger proteins. Methods Enzymol (2005) 0.85

Anterior thalamic mediation of experimental seizures: selective EEG spectral coherence. Epilepsia (2003) 0.85

Studies of the ubiquitin proteasome system. Curr Protoc Cell Biol (2006) 0.84

Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains. Structure (2012) 0.84

Working on a chain: E3s ganging up for ubiquitylation. Nat Cell Biol (2010) 0.82

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg Med Chem (2008) 0.82

Sinusoidal modeling of ictal activity along a thalamus-to-cortex seizure pathway I: new coherence approaches. Ann Biomed Eng (2004) 0.81

An improved in vitro and in vivo Sindbis virus expression system through host and virus engineering. Virus Res (2009) 0.79

A ubiquitin-binding rhomboid protease aimed at ERADication. Dev Cell (2012) 0.76

Cullin RING ligases: glommed by glomulin. Mol Cell (2012) 0.75

Ubiquitin and drug discovery: challenges and opportunities. Cell Biochem Biophys (2013) 0.75