Published in Cancer Lett on June 18, 2013
PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell (2013) 1.52
Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci (2013) 1.21
Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol Cell (2016) 1.07
Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res (2014) 1.06
Targeting cancer cell metabolism in pancreatic adenocarcinoma. Oncotarget (2015) 1.05
Pyruvate kinase M2 at a glance. J Cell Sci (2015) 1.01
PKM2 as a biomarker for chemosensitivity to front-line platinum-based chemotherapy in patients with metastatic non-small-cell lung cancer. Br J Cancer (2014) 0.94
How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions? Oncogene (2014) 0.93
EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A (2015) 0.85
Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma. Oncotarget (2015) 0.84
Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell (2015) 0.83
PKM2 regulates Gli1 expression in hepatocellular carcinoma. Oncol Lett (2014) 0.80
PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma. Dig Dis Sci (2015) 0.80
Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res (2016) 0.80
c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function. PLoS One (2015) 0.79
Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS One (2015) 0.78
MiR-122 Reverses the Doxorubicin-Resistance in Hepatocellular Carcinoma Cells through Regulating the Tumor Metabolism. PLoS One (2016) 0.77
Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish. PLoS One (2016) 0.77
SURVIV for survival analysis of mRNA isoform variation. Nat Commun (2016) 0.77
Structural basis of PKM2 regulation. Protein Cell (2015) 0.76
PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun (2016) 0.75
FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells. Oncol Lett (2017) 0.75
AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth. Oncotarget (2016) 0.75
The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas. Oncotarget (2016) 0.75
Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies. Onco Targets Ther (2016) 0.75
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2. J Exp Clin Cancer Res (2016) 0.75
Energy metabolism in neurodevelopment and medulloblastoma. Transl Pediatr (2015) 0.75
MiR-338-3p targets pyruvate kinase M2 and affects cell proliferation and metabolism of ovarian cancer. Am J Transl Res (2016) 0.75
The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2. BMC Biochem (2015) 0.75
The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy. Oncotarget (2017) 0.75
miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer. Cell Death Dis (2017) 0.75
Chaperone-mediated autophagy substrate proteins in cancer. Oncotarget (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med (2004) 13.57
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature (2008) 9.77
Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer (2011) 9.68
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell (2011) 7.33
Cancer's molecular sweet tooth and the Warburg effect. Cancer Res (2006) 7.24
Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol (2007) 6.11
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (2011) 5.72
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal (2009) 5.57
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature (2011) 5.49
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature (2009) 5.48
Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol (2005) 5.25
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem (1991) 4.16
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell (2012) 3.98
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell (2011) 3.78
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol (2010) 3.72
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem (1986) 3.64
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry (2005) 3.57
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics (2004) 3.35
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature (2012) 3.01
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol (2012) 2.87
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem J (2005) 2.29
The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem (1987) 2.25
Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol (2011) 2.24
Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci (2012) 1.89
Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol (2009) 1.86
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog (1992) 1.82
L-serine in disease and development. Biochem J (2003) 1.79
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. Int J Cancer (2008) 1.72
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell (2012) 1.65
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res (2007) 1.64
Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem (2009) 1.61
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem (2010) 1.61
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene (2011) 1.52
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science (2012) 1.52
Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. J Biol Chem (2007) 1.50
Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro Oncol (2010) 1.41
Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis. Chin J Cancer (2011) 1.39
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett (2010) 1.37
Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem J (1999) 1.37
Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours. Ernst Schering Found Symp Proc (2007) 1.30
PKM2 functions as a histone kinase. Cell Cycle (2012) 1.24
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem (1998) 1.22
PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nat Commun (2012) 1.18
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2. J Cell Biochem (2009) 1.15
Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat. Virchows Arch B Cell Pathol Incl Mol Pathol (1981) 1.06
L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases. Virchows Arch (1994) 0.97
Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals. J Biol Chem (2013) 0.95
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett (2011) 0.94
Glucose regulates the promoter activity of aldolase A and pyruvate kinase M2 via dephosphorylation of Sp1. FEBS Lett (1997) 0.87
Transcriptional regulatory regions for expression of the rat pyruvate kinase M gene. Eur J Biochem (1994) 0.86
Role of the stimulatory proteins Sp1 and Sp3 in the regulation of transcription of the rat pyruvate kinase M gene. Eur J Biochem (1997) 0.85
Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity. Mol Cell Biochem (1985) 0.83
Purification and properties of pyruvate kinase from human lung. Biochim Biophys Acta (1976) 0.83
Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma. J Neurochem (1976) 0.82
Differences in DNA-binding efficiency of Sp1 to aldolase and pyruvate kinase promoter correlate with altered redox states in resting and proliferating rat thymocytes. FEBS Lett (1996) 0.79
Purification and properties of pyruvate kinase type M2 from rat lung. Biochim Biophys Acta (1982) 0.78
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature (2011) 5.49
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell (2012) 3.83
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol (2012) 2.87
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell (2012) 1.65
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell (2007) 1.40
PKM2 functions as a histone kinase. Cell Cycle (2012) 1.24
Nuclear PKM2 regulates the Warburg effect. Cell Cycle (2013) 1.18
Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. EMBO Rep (2012) 1.16
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol (2006) 1.12
p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol Cell Biol (2011) 1.08
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol Cell Biol (2011) 1.07
Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One (2011) 1.04
Paradoxical roles of FAK in tumor cell migration and metastasis. Cell Cycle (2009) 0.99
Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis. J Natl Cancer Inst (2014) 0.98
Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res (2011) 0.95
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One (2010) 0.94
Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene (2002) 0.94
Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion. J Biol Chem (2013) 0.93
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci U S A (2008) 0.90
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep (2012) 0.88
Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol (2009) 0.88
α-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of β-catenin transactivation. J Neurooncol (2010) 0.88
Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem (2013) 0.81
Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST). Chin J Cancer (2012) 0.80
Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus. Clin Rheumatol (2012) 0.79
The role of protein kinase CK2 in glioblastoma development. Clin Cancer Res (2013) 0.78
Corrigendum: A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol (2016) 0.75
Proceedings of the 1st International Conference for Cancer Metabolism and Therapy, October 14-17, 2016, Dalian, China. Pancreas (2017) 0.75
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis. Cell (2014) 0.75
Corrigendum: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature (2017) 0.75