Lessons to be Learned from Natural Control of HIV - Future Directions, Therapeutic, and Preventive Implications.

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Published in Front Immunol on June 25, 2013

Authors

David Shasha1, Bruce D Walker

Author Affiliations

1: The Ragon Institute of MGH, MIT and Harvard , Cambridge, MA , USA.

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Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. J Virol (2010) 1.81

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