Published in Proc Natl Acad Sci U S A on July 01, 2013
Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery. PLoS One (2014) 1.58
Novel technologies and emerging biomarkers for personalized cancer immunotherapy. J Immunother Cancer (2016) 1.22
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method. Nat Commun (2015) 1.11
Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med (2014) 1.09
Single-Cell Analysis in Cancer Genomics. Trends Genet (2015) 1.05
Open access to large scale datasets is needed to translate knowledge of cancer heterogeneity into better patient outcomes. PLoS Med (2015) 1.01
Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol (2015) 0.98
Imaging cycler microscopy. Proc Natl Acad Sci U S A (2014) 0.98
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest (2014) 0.98
Quantitative measurement of cancer tissue biomarkers in the lab and in the clinic. Lab Invest (2014) 0.92
Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Mol Syst Biol (2015) 0.92
High-dimensional single-cell cancer biology. Curr Top Microbiol Immunol (2014) 0.92
Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling. PLoS One (2015) 0.85
PD-L1 Expression in Lung Cancer. J Thorac Oncol (2016) 0.85
Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo. Proc Natl Acad Sci U S A (2015) 0.84
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci (2014) 0.83
On comparing heterogeneity across biomarkers. Cytometry A (2014) 0.83
Integrating single-molecule experiments and discrete stochastic models to understand heterogeneous gene transcription dynamics. Methods (2015) 0.83
Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Sci Signal (2016) 0.82
Emerging understanding of multiscale tumor heterogeneity. Front Oncol (2014) 0.82
Predictive biomarkers and companion diagnostics. The future of immunohistochemistry: "in situ proteomics," or just a "stain"? Appl Immunohistochem Mol Morphol (2014) 0.82
From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine. Cell Death Dis (2014) 0.82
Elution of High-affinity (>10-9 KD) Antibodies from Tissue Sections: Clues to the Molecular Mechanism and Use in Sequential Immunostaining. J Histochem Cytochem (2014) 0.81
The applications of single-cell genomics. Hum Mol Genet (2013) 0.80
Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis. Cytometry A (2015) 0.79
Normal cell phenotypes of breast epithelial cells provide the foundation of a breast cancer taxonomy. Expert Rev Anticancer Ther (2014) 0.79
Single cell-resolution western blotting. Nat Protoc (2016) 0.79
Dense transcript profiling in single cells by image correlation decoding. Nat Methods (2016) 0.79
A journey to uncharted territory: new technical frontiers in studying tumor-stromal cell interactions. Integr Biol (Camb) (2015) 0.79
Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism. JCI Insight (2016) 0.77
Systems immune monitoring in cancer therapy. Eur J Cancer (2016) 0.77
Changes in the Submandibular Salivary Gland Epithelial Cell Subpopulations During Progression of Sjögren's Syndrome-Like Disease in the NOD/ShiLtJ Mouse Model. Anat Rec (Hoboken) (2015) 0.77
madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy. Mol Biol Cell (2016) 0.77
High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. BMC Cancer (2016) 0.76
Aqueous two-phase system-mediated antibody micropatterning enables multiplexed immunostaining of cell monolayers and tissues. Biotechnol J (2014) 0.76
Reply to Schubert et al.: Regarding critique of highly multiplexed technologies. Proc Natl Acad Sci U S A (2014) 0.76
Multiscale analysis of the murine intestine for modeling human diseases. Integr Biol (Camb) (2015) 0.76
Multiplexed tissue biomarker imaging. J Immunother Cancer (2016) 0.75
Cross-Platform DNA Encoding for Single-Cell Imaging of Gene Expression. Angew Chem Int Ed Engl (2016) 0.75
Semi-Automated Digital Image Analysis of Pick's Disease and TDP-43 Proteinopathy. J Histochem Cytochem (2015) 0.75
Robust normalization protocols for multiplexed fluorescence bioimage analysis. BioData Min (2016) 0.75
Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers. J Pathol Inform (2016) 0.75
Versatile tissue lasers based on high-Q Fabry-Pérot microcavities. Lab Chip (2017) 0.75
A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. J Biomol Screen (2016) 0.75
The CA19-9 and Sialyl-TRA Antigens Define Separate Subpopulations of Pancreatic Cancer Cells. Sci Rep (2017) 0.75
Eliminating Size-Associated Diffusion Constraints for Rapid On-Surface Bioassays with Nanoparticle Probes. Small (2016) 0.75
Deciphering tumor heterogeneity from FFPE tissues: Its promise and challenges. Mol Cell Oncol (2016) 0.75
Multiplexed Single-Cell Imaging: Past, Present, and Future. Assay Drug Dev Technol (2016) 0.75
Key regulators of apoptosis execution as biomarker candidates in melanoma. Mol Cell Oncol (2014) 0.75
Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging. Curr Protoc Chem Biol (2016) 0.75
Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity. Oxid Med Cell Longev (2017) 0.75
Superresolution Imaging of Clinical Formalin Fixed Paraffin Embedded Breast Cancer with Single Molecule Localization Microscopy. Sci Rep (2017) 0.75
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data. Nat Methods (2017) 0.75
Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D). Proc Natl Acad Sci U S A (2017) 0.75
Universal Super-Resolution Multiplexing by DNA Exchange. Angew Chem Int Ed Engl (2017) 0.75
Biologically Relevant Heterogeneity: Metrics and Practical Insights. SLAS Discov (2017) 0.75
Multiplex Staining by Sequential Immunostaining and Antibody Removal on Routine Tissue Sections. J Histochem Cytochem (2017) 0.75
Cellular-level characterization of B cells infiltrating pulmonary MALT lymphoma tissues. Virchows Arch (2016) 0.75
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Integrated genomic analyses of ovarian carcinoma. Nature (2011) 47.72
Comprehensive molecular portraits of human breast tumours. Nature (2012) 47.39
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 39.09
Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 18.90
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A (2008) 6.84
Analyzing proteome topology and function by automated multidimensional fluorescence microscopy. Nat Biotechnol (2006) 4.71
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov (2009) 3.64
Systems biology in drug discovery. Nat Biotechnol (2004) 3.29
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest (2007) 3.01
Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res (2009) 2.59
Cell and tissue autofluorescence research and diagnostic applications. Biotechnol Annu Rev (2005) 2.53
The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annu Rev Biochem (2011) 1.80
Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition. J Histochem Cytochem (2000) 1.79
Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. J Clin Oncol (2006) 1.70
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival. Cancer Res (2009) 1.58
What brown cannot do for you. Nat Biotechnol (2006) 1.51
Sequential immunofluorescence staining and image analysis for detection of large numbers of antigens in individual cell nuclei. Cytometry (2002) 1.45
Fluorescence detection of protein clusters in individual cells and tissue sections by using toponome imaging system: sample preparation and measuring procedures. Nat Protoc (2007) 1.44
SIMPLE: a sequential immunoperoxidase labeling and erasing method. J Histochem Cytochem (2009) 1.39
Antibody elution method for multiple immunohistochemistry on primary antibodies raised in the same species and of the same subtype. J Histochem Cytochem (2009) 1.37
A novel five-antibody immunohistochemical test for subclassification of lung carcinoma. Mod Pathol (2009) 1.35
The relative distribution of membranous and cytoplasmic met is a prognostic indicator in stage I and II colon cancer. Clin Cancer Res (2008) 1.34
Chemosensitivity and stratification by a five monoclonal antibody immunohistochemistry test in the NSABP B14 and B20 trials. Clin Cancer Res (2008) 1.13
Toponome mapping in prostate cancer: detection of 2000 cell surface protein clusters in a single tissue section and cell type specific annotation by using a three symbol code. J Proteome Res (2009) 1.01
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission. N Engl J Med (2008) 8.19
Histopathological image analysis: a review. IEEE Rev Biomed Eng (2009) 6.86
Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans. Eur Heart J (2010) 5.04
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75
Fibronectin requirement in branching morphogenesis. Nature (2003) 3.41
CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res (2008) 3.40
Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology (2014) 3.40
Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci (2008) 3.30
Statistical methods for testing effects on "maximum lifespan". Mech Ageing Dev (2004) 3.26
Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy--an intergroup study. J Clin Oncol (2002) 3.25
Prospectively gated transverse coronary CT angiography versus retrospectively gated helical technique: improved image quality and reduced radiation dose. Radiology (2008) 3.18
Optimization of sensing and feedback control for vibration/flutter of rotating disk by PZT actuators via air coupled pressure. Sensors (Basel) (2011) 2.84
Synthesis, characterization, and structures of a persistent aniline radical cation. Angew Chem Int Ed Engl (2012) 2.59
Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One (2008) 2.51
Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circ Res (2003) 2.49
Oct4 pseudogenes are transcribed in cancers. Biochem Biophys Res Commun (2005) 2.34
Postnatal HIV-1 transmission after cessation of infant extended antiretroviral prophylaxis and effect of maternal highly active antiretroviral therapy. J Infect Dis (2009) 2.26
Rare genetic variation at Zea mays crtRB1 increases beta-carotene in maize grain. Nat Genet (2010) 2.25
Frequency of gastroenteritis and gastroenteritis-associated mortality with early weaning in HIV-1-uninfected children born to HIV-infected women in Malawi. J Acquir Immune Defic Syndr (2010) 2.19
Median-based robust algorithms for tracing neurons from noisy confocal microscope images. IEEE Trans Inf Technol Biomed (2003) 2.15
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr (2006) 2.06
Characterization of the bell-shaped vibratory angular rate gyro. Sensors (Basel) (2013) 2.04
Prediction of on-road driving performance in patients with early Alzheimer's disease. J Am Geriatr Soc (2005) 2.03
FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development (2005) 1.98
Postexposure prophylaxis of breastfeeding HIV-exposed infants with antiretroviral drugs to age 14 weeks: updated efficacy results of the PEPI-Malawi trial. J Acquir Immune Defic Syndr (2011) 1.96
c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations. Blood (2005) 1.96
Atypical presentations among Medicare beneficiaries with unstable angina pectoris. Am J Cardiol (2002) 1.92
Mammographic density as a surrogate marker for the effects of hormone therapy on risk of breast cancer. Cancer Epidemiol Biomarkers Prev (2006) 1.91
Tissue-specific dysregulation of DNA methylation in aging. Aging Cell (2010) 1.90
Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis. J Gastroenterol Hepatol (2011) 1.86
Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol Lett (2004) 1.86
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis (2009) 1.85
Quasi-ballistic thermal transport from nanoscale interfaces observed using ultrafast coherent soft X-ray beams. Nat Mater (2009) 1.83
Epigenetic and genetic influences on DNA methylation variation in maize populations. Plant Cell (2013) 1.83
N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. Int J Cancer (2003) 1.75
Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell (2010) 1.74
Fertility intentions of HIV-1 infected and uninfected women in Malawi: a longitudinal study. AIDS Behav (2009) 1.73
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature (2009) 1.72
Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. J Immunol (2004) 1.68
Research on bell-shaped vibratory angular rate gyro's character of resonator. Sensors (Basel) (2013) 1.66
Precision of GE Lunar iDXA for the measurement of total and regional body composition in nonobese adults. J Clin Densitom (2012) 1.63
Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development (2002) 1.62
Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes (2007) 1.62
Regulation of aurora B expression by the bromodomain protein Brd4. Mol Cell Biol (2009) 1.60
Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity. J Infect Dis (2002) 1.59
The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. Proc Natl Acad Sci U S A (2013) 1.59
A facile approach to anhydrogalactosucrose derivatives from chlorinated sucrose. Carbohydr Res (2004) 1.59
Development of receptor for advanced glycation end products-directed imaging of atherosclerotic plaque in a murine model of spontaneous atherosclerosis. Circ Cardiovasc Imaging (2008) 1.58
Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab (2009) 1.57
Stage specific assessment of Candida albicans phagocytosis by macrophages identifies cell wall composition and morphogenesis as key determinants. PLoS Pathog (2012) 1.54
A theoretical model to predict both horizontal displacement and vertical displacement for electromagnetic induction-based deep displacement sensors. Sensors (Basel) (2011) 1.53
Racial differences in thoracic aorta atherosclerosis among ischemic stroke patients. Stroke (2003) 1.53
Integration of light and abscisic acid signaling during seed germination and early seedling development. Proc Natl Acad Sci U S A (2008) 1.52
Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng (2007) 1.52
Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J Immunol (2009) 1.52
Observation of intermolecular charge transfer in a quasi-one-dimensional molecular alloy system. J Phys Chem A (2008) 1.50
Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury. Circulation (2006) 1.48
The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults. J Nutr (2003) 1.47
Acidic preconditioning protects against ischemia-induced brain injury. Neurosci Lett (2012) 1.45
An examination of the dynamic changes in prostate-specific antigen occurring in a population-based cohort of men over time. BJU Int (2012) 1.42
Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis. Dev Biol (2009) 1.41
Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. J Surg Res (2011) 1.41
Imaging of receptors for advanced glycation end products in experimental myocardial ischemia and reperfusion injury. JACC Cardiovasc Imaging (2012) 1.40
Retracted Rebamipide plus proton pump inhibitor versus proton pump inhibitor alone in the treatment of endoscopic submucosal dissection-induced gastric ulcer: a meta-analysis of randomized controlled trials. Medicine (Baltimore) (2014) 1.40
Asymmetric somatic stem cells division plays a critical role in cell senescence. Med Hypotheses (2006) 1.38
Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clin Gastroenterol Hepatol (2005) 1.38
Terminal phosphate labeled nucleotides: synthesis, applications, and linker effect on incorporation by DNA polymerases. Nucleosides Nucleotides Nucleic Acids (2005) 1.38
Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr Biol (2007) 1.37
Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males. Clin Chim Acta (2006) 1.34
The relative distribution of membranous and cytoplasmic met is a prognostic indicator in stage I and II colon cancer. Clin Cancer Res (2008) 1.34
Simple and robust image-based autofocusing for digital microscopy. Opt Express (2008) 1.32
A randomized trial of dietary intervention for breast cancer prevention. Cancer Res (2011) 1.32
beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clin Pharmacol Ther (2006) 1.31
Nitrogen-doped graphene: beyond single substitution and enhanced molecular sensing. Sci Rep (2012) 1.31
Mitogen-activated protein kinases and retinal ischemia. Invest Ophthalmol Vis Sci (2003) 1.31
Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem (2002) 1.30
Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure. J Biol Chem (2012) 1.30
Micro magnetic stir-bar mixer integrated with parylene microfluidic channels. Lab Chip (2004) 1.29
High-field magnetic resonance imaging of brain iron in Alzheimer disease. Top Magn Reson Imaging (2006) 1.29
Bactericidal activity in whole blood as a potential surrogate marker of immunity after vaccination against tuberculosis. Clin Diagn Lab Immunol (2002) 1.29
RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol (2008) 1.29
Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant. Mol Cell Biol (2004) 1.28
Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer. BMC Gastroenterol (2013) 1.27
Spatio-temporal cell cycle phase analysis using level sets and fast marching methods. Med Image Anal (2008) 1.26
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A (2010) 1.25
Nutrition and bone growth and development. Proc Nutr Soc (2006) 1.25
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog (2011) 1.25
Influenza A virus N5 neuraminidase has an extended 150-cavity. J Virol (2011) 1.25
Do local opinion leaders augment hospital quality improvement efforts? A randomized trial to promote adherence to unstable angina guidelines. Med Care (2003) 1.24
Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina. J Physiol (2004) 1.24
Neonatal loss of gamma-aminobutyric acid pathway expression after human perinatal brain injury. J Neurosurg (2006) 1.23
Genetic analysis and characterization of a new maize association mapping panel for quantitative trait loci dissection. Theor Appl Genet (2010) 1.23