Published in J Med Chem on July 18, 2013
Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line. ACS Med Chem Lett (2013) 1.04
Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties. Acc Chem Res (2015) 0.95
Structural basis for the regulation of tubulin by vinblastine. Nature (2005) 3.10
Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin. Cancer Res (2006) 1.94
Evidence for an association of high levels of endogenous Acetyl-Ser-Asp-Lys-Pro, a potent mediator of angiogenesis, with acute myeloid leukemia development. Leuk Lymphoma (2006) 1.45
Identification of the minimal conserved structure of HIV-1 protease in the presence and absence of drug pressure. AIDS (2004) 1.37
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations. J Virol (2005) 1.24
The dual role of thymidine phosphorylase in cancer development and chemotherapy. Med Res Rev (2009) 1.22
Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes. J Virol (2006) 1.21
Development of a new family of conformationally restricted peptides as potent nucleators of beta-turns. Design, synthesis, structure, and biological evaluation of a beta-lactam peptide analogue of melanostatin. J Am Chem Soc (2003) 1.13
Application of the palladium-catalyzed borylation/Suzuki coupling (BSC) reaction to the synthesis of biologically active biaryl lactams. J Org Chem (2002) 1.12
The palladium-catalyzed C-H activation of benzylic gem-dialkyl groups. Angew Chem Int Ed Engl (2003) 1.09
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships. J Med Chem (2005) 1.06
Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines. Biochem Pharmacol (2009) 1.06
The tetrapeptide AcSDKP, an inhibitor of primitive hematopoietic cell proliferation, induces angiogenesis in vitro and in vivo. Blood (2002) 1.04
Leishmania infantum expresses a mitochondrial nuclease homologous to EndoG that migrates to the nucleus in response to an apoptotic stimulus. Mol Biochem Parasitol (2008) 1.03
ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr Med Chem (2004) 1.01
Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: a single mode of inhibition for the three HIV enzymes? Antiviral Res (2006) 0.99
Discovery of isoerianin analogues as promising anticancer agents. ChemMedChem (2011) 0.96
Optimization of taxane binding to microtubules: binding affinity dissection and incremental construction of a high-affinity analog of paclitaxel. Chem Biol (2008) 0.95
Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide. J Med Chem (2007) 0.95
Synthesis of novel macrocyclic docetaxel analogues. Influence of their macrocyclic ring size on tubulin activity. J Med Chem (2003) 0.93
Overexpression of the angiogenic tetrapeptide AcSDKP in human malignant tumors. Anticancer Res (2008) 0.93
Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents. Bioorg Med Chem (2006) 0.93
HIV protease inhibition: limited recent progress and advances in understanding current pitfalls. Curr Top Med Chem (2004) 0.93
In silico activation of Src tyrosine kinase reveals the molecular basis for intramolecular autophosphorylation. J Mol Graph Model (2004) 0.92
Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products. J Med Chem (2004) 0.92
Asymmetric synthesis of an axially chiral antimitotic biaryl via an atropo-enantioselective Suzuki cross-coupling. J Org Chem (2003) 0.91
XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinking-mimetic alkaloids. Chem Biol (2011) 0.91
Kingianin A: a new natural pentacyclic compound from Endiandra kingiana. Org Lett (2010) 0.90
Inhibitory effect of fucoidan on the adhesion of adenocarcinoma cells to fibronectin. Anticancer Res (2005) 0.90
Two novel series of allocolchicinoids with modified seven membered B-rings: design, synthesis, inhibition of tubulin assembly and cytotoxicity. Bioorg Med Chem (2005) 0.90
The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Mol Pharmacol (2005) 0.90
Insights into the interaction of discodermolide and docetaxel with tubulin. Mapping the binding sites of microtubule-stabilizing agents by using an integrated NMR and computational approach. ACS Chem Biol (2011) 0.90
Synthesis and biological evaluation of A-ring biaryl-carbamate analogues of rhazinilam. Bioorg Med Chem (2002) 0.89
Synthesis of C2-C3'N-linked macrocyclic taxoids. Novel docetaxel analogues with high tubulin activity. J Med Chem (2004) 0.89
Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations. Nucleic Acids Res (2011) 0.89
Binding of 5'-GMP to the GluR2 AMPA receptor: insight from targeted molecular dynamics simulations. Biochemistry (2005) 0.88
Overcoming the inadequacies or limitations of experimental structures as drug targets by using computational modeling tools and molecular dynamics simulations. ChemMedChem (2007) 0.88
VSDMIP 1.5: an automated structure- and ligand-based virtual screening platform with a PyMOL graphical user interface. J Comput Aided Mol Des (2011) 0.88
Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest. Phytochemistry (2009) 0.88
3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem (2010) 0.87
The molecular basis of resilience to the effect of the Lys103Asn mutation in non-nucleoside HIV-1 reverse transcriptase inhibitors studied by targeted molecular dynamics simulations. J Am Chem Soc (2005) 0.87
Synthesis and biological evaluation of B-ring analogues of (-)-rhazinilam. Bioorg Med Chem (2005) 0.87
Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors. J Nat Prod (2011) 0.87
Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity. Cancer Res (2011) 0.87
New antitubulin derivatives in the combretastatin A4 series: synthesis and biological evaluation. Bioorg Med Chem (2005) 0.86
Eudesmane derivatives and other sesquiterpenes from Laggera alata. J Nat Prod (2003) 0.86
Assessment by molecular dynamics simulations of the structural determinants of DNA-binding specificity for transcription factor Sp1. J Mol Biol (2003) 0.86
Tubulin-based structure-affinity relationships for antimitotic Vinca alkaloids. Anticancer Agents Med Chem (2012) 0.86
Pentacyclic polyketides from Endiandra kingiana as inhibitors of the Bcl-xL/Bak interaction. Phytochemistry (2011) 0.85
Quantitative analysis of substrate specificity of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26. Biochemistry (2005) 0.85
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae). Phytochemistry (2008) 0.85
Relevance of the Fanconi anemia pathway in the response of human cells to trabectedin. Mol Cancer Ther (2008) 0.85
Synthesis and antitumor activity of benzils related to combretastatin A-4. Bioorg Med Chem Lett (2008) 0.85
New C5-alkylated indolobenzazepinones acting as inhibitors of tubulin polymerization: cytotoxic and antitumor activities. J Med Chem (2008) 0.85
Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product. J Med Chem (2003) 0.85
Mitochondrial thymidine kinase inhibitors. Curr Top Med Chem (2005) 0.84
Antiviral agents: structural basis of action and rational design. Subcell Biochem (2013) 0.84
Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations. Nucleic Acids Res (2005) 0.84
Biologically active tetralones from New Caledonian Zygogynum spp. Phytochemistry (2008) 0.84
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication. J Nat Prod (2012) 0.84
Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata. J Nat Prod (2004) 0.83
The role of Thr139 in the human immunodeficiency virus type 1 reverse transcriptase sensitivity to (+)-calanolide A. Mol Pharmacol (2005) 0.83
Antiplasmodial, antitrypanosomal, and cytotoxic activities of prenylated flavonoids isolated from the stem bark of Artocarpus styracifolius. Planta Med (2010) 0.83
Tetrapeptide AcSDKP induces postischemic neovascularization through monocyte chemoattractant protein-1 signaling. Arterioscler Thromb Vasc Biol (2006) 0.83
Novel C2-C3' N-peptide linked macrocyclic taxoids. Part 2: synthesis and biological activities of docetaxel analogues with a peptide side chain at C2 and their macrocyclic derivatives. Bioorg Med Chem (2006) 0.83
Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae). Phytochemistry (2010) 0.83
Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora. J Nat Prod (2005) 0.82
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri. Phytochemistry (2012) 0.82
Structure of human glycolate oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.82
In vitro oxidative metabolism study of (-)-rhazinilam. Bioorg Med Chem (2005) 0.82
Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations. Biochemistry (2004) 0.82
The tetrapeptide acetyl-serine-aspartyl-lysine-proline improves skin flap survival and accelerates wound healing. Wound Repair Regen (2006) 0.82
Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4. Eur J Med Chem (2010) 0.82
Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications. Curr Pharm Des (2012) 0.82
Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia (2012) 0.81
Rationale for the opposite stereochemistry of the major monoadducts and interstrand crosslinks formed by mitomycin C and its decarbamoylated analogue at CpG steps in DNA and the effect of cytosine modification on reactivity. Org Biomol Chem (2012) 0.81
Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA. J Med Chem (2006) 0.81
TSAO compounds: the comprehensive story of a unique family of HIV-1 specific inhibitors of reverse transcriptase. Curr Top Med Chem (2004) 0.81
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. ChemMedChem (2008) 0.81
Elaboration of simplified vinca alkaloids and phomopsin hybrids. Chem Biol Drug Des (2010) 0.81
Synthesis, biological evaluation of 1,1-diarylethylenes as a novel class of antimitotic agents. ChemMedChem (2009) 0.81
A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2. J Biomol Screen (2012) 0.81
Comparison of ultra-fast 2D and 3D ligand and target descriptors for side effect prediction and network analysis in polypharmacology. Br J Pharmacol (2013) 0.81