Obesity and diabetes as accelerators of functional decline: can lifestyle interventions maintain functional status in high risk older adults?

PubWeight™: 0.95‹?› | Rank: Top 15%

🔗 View Article (PMC 3817488)

Published in Exp Gerontol on July 04, 2013

Authors

Stephen D Anton1, Christy Karabetian, Kelly Naugle, Thomas W Buford

Author Affiliations

1: Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. santon@ufl.edu

Associated clinical trials:

Dose Response of Eccentric Exercise on Glycemic Control in Type II Diabetes Mellitus | NCT04790526

Articles citing this

Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr (2015) 0.93

Educational disparities in the burden of disability: contributions of disease prevalence and disabling impact. Am J Public Health (2014) 0.87

Successful aging: Advancing the science of physical independence in older adults. Ageing Res Rev (2015) 0.86

Effect of resistance training on neuromuscular junctions of young and aged muscles featuring different recruitment patterns. J Neurosci Res (2014) 0.80

Healthy behavior change and cardiovascular outcomes in newly diagnosed type 2 diabetic patients: a cohort analysis of the ADDITION-Cambridge study. Diabetes Care (2014) 0.79

Muscle Weakness Is Associated With Diabetes in Older Mexicans: The Mexican Health and Aging Study. J Am Med Dir Assoc (2016) 0.78

Moving beyond cardio: the value of resistance training, balance training, and other forms of exercise in the management of diabetes. Diabetes Spectr (2015) 0.77

Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity. Am J Physiol Regul Integr Comp Physiol (2016) 0.76

Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis. Diabetol Metab Syndr (2016) 0.75

Explanators of Sarcopenia in Individuals With Diabesity: A Cross-sectional Analysis. J Geriatr Phys Ther (2015) 0.75

Nutrition for Sarcopenia. J Clin Med Res (2015) 0.75

Application of a Web-Enabled Leg Training System for the Objective Monitoring and Quantitative Analysis of Exercise-Induced Fatigue. JMIR Res Protoc (2016) 0.75

Combined Interval Training and Post-exercise Nutrition in Type 2 Diabetes: A Randomized Control Trial. Front Physiol (2017) 0.75

How can clinical practices pragmatically increase physical activity for patients with type 2 diabetes? A systematic review. Transl Behav Med (2017) 0.75

A Chinese Chan-based Mind-Body Intervention Improves Memory of Older Adults. Front Aging Neurosci (2017) 0.75

Articles cited by this

(truncated to the top 100)

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 101.79

Prevalence and trends in obesity among US adults, 1999-2008. JAMA (2010) 50.58

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01

Gait speed and survival in older adults. JAMA (2011) 15.01

Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care (2007) 14.35

American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc (2009) 8.89

Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc (2002) 8.28

Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul Health Metr (2010) 7.70

Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum (2004) 6.46

Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med (2011) 6.04

Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study. J Appl Physiol (1985) (2001) 5.35

The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc (2004) 4.84

Physical frailty and body composition in obese elderly men and women. Obes Res (2004) 4.61

A prospective study of long-term care institutionalization among the aged. Am J Public Health (1982) 4.54

Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol (2010) 4.53

Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr (2009) 3.44

An objective measure of physical function of elderly outpatients. The Physical Performance Test. J Am Geriatr Soc (1990) 3.19

Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes (2006) 3.02

A longitudinal study of functional change and mortality in the United States. J Gerontol (1988) 3.01

Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med (2006) 2.94

A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care (2002) 2.91

Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med (2012) 2.90

Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care (2007) 2.87

Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol A Biol Sci Med Sci (2000) 2.81

Sarcopenic obesity predicts instrumental activities of daily living disability in the elderly. Obes Res (2004) 2.76

Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes Care (2009) 2.68

Psychological and metabolic stress: a recipe for accelerated cellular aging? Hormones (Athens) (2009) 2.61

Prevalence of self-reported physically active adults--United States, 2007. MMWR Morb Mortal Wkly Rep (2008) 2.56

The obesity pandemic: where have we been and where are we going? Obes Res (2004) 2.24

Functional transitions among the elderly: patterns, predictors, and related hospital use. Am J Public Health (1994) 2.20

The Framingham Disability Study: I. Social disability among the aging. Am J Public Health (1981) 2.14

Comorbidities and impairments explaining the association between diabetes and lower extremity disability: The Women's Health and Aging Study. Diabetes Care (2002) 2.03

Obesity and mobility disability in the older adult. Obes Rev (2009) 1.99

Association of diabetes, comorbidities, and A1C with functional disability in older adults: results from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. Diabetes Care (2010) 1.92

Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study. J Gerontol A Biol Sci Med Sci (1998) 1.92

Dietary weight loss and exercise effects on insulin resistance in postmenopausal women. Am J Prev Med (2011) 1.90

Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med (2009) 1.85

Physical activity, falls, and fractures among older adults: a review of the epidemiologic evidence. J Am Geriatr Soc (2000) 1.81

Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial. Obesity (Silver Spring) (2010) 1.78

Diabetes is associated with subclinical functional limitation in nondisabled older individuals: the Health, Aging, and Body Composition study. Diabetes Care (2003) 1.77

Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr (2009) 1.77

Reduced physical activity increases intermuscular adipose tissue in healthy young adults. Am J Clin Nutr (2007) 1.72

Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis. Obesity (Silver Spring) (2006) 1.72

Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean Sarcopenic Obesity Study (KSOS). Diabetes Care (2010) 1.72

Obesity, physical function, and mortality in older adults. J Am Geriatr Soc (2008) 1.61

The case for low carbohydrate diets in diabetes management. Nutr Metab (Lond) (2005) 1.61

The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. Int J Obes (Lond) (2009) 1.52

Diabetes, sarcopenia, and frailty. Clin Geriatr Med (2008) 1.50

Obesity, intentional weight loss and physical disability in older adults. Obes Rev (2010) 1.49

Weighty concerns: the growing prevalence of obesity among older adults. J Am Diet Assoc (2009) 1.46

Physical disability in older Americans. J Gerontol (1993) 1.35

Role of muscle mass and muscle quality in the association between diabetes and gait speed. Diabetes Care (2012) 1.33

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Res Rev (2010) 1.31

Does the amount of fat mass predict age-related loss of lean mass, muscle strength, and muscle quality in older adults? J Gerontol A Biol Sci Med Sci (2011) 1.30

Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance. Am J Physiol Endocrinol Metab (2011) 1.28

The cardiometabolic syndrome and sarcopenic obesity in older persons. J Cardiometab Syndr (2007) 1.28

Predictors of weight change in men: results from the Health Professionals Follow-up Study. Int J Obes Relat Metab Disord (1998) 1.25

Progression of lower-extremity disability in older women with diabetes: the Women's Health and Aging Study. Diabetes Care (2003) 1.24

Adult obesity and the burden of disability throughout life. Obes Res (2004) 1.24

Dynapenic-obesity and physical function in older adults. J Gerontol A Biol Sci Med Sci (2009) 1.24

Impact of diabetes on physical function in older people. Diabetes Care (2007) 1.23

Functional impact of relative versus absolute sarcopenia in healthy older women. J Am Geriatr Soc (2007) 1.23

Weight loss intervention for obese older women: improvements in performance and function. Obes Res (2004) 1.22

Signaling pathways weigh in on decisions to make or break skeletal muscle. Curr Opin Clin Nutr Metab Care (2004) 1.21

Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study. Diabetes Care (2006) 1.20

Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. Eur Heart J (1999) 1.20

Effect of moderate intensity resistance training during weight loss on body composition and physical performance in overweight older adults. Eur J Appl Physiol (2010) 1.19

Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci (2010) 1.17

A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults. J Nutr (2011) 1.17

Obesity, disability, and mortality: a puzzling link. Arch Intern Med (2007) 1.15

Ability of fat and fat-free mass percentages to predict functional disability in older men and women. J Am Geriatr Soc (2001) 1.12

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial. Clin Interv Aging (2011) 1.12

Effects of exercise on mobility in obese and nonobese older adults. Obesity (Silver Spring) (2009) 1.10

Summary health statistics for U.S. adults: National Health Interview Survey, 2000. Vital Health Stat 10 (2003) 1.10

Impact of weight loss on physical function with changes in strength, muscle mass, and muscle fat infiltration in overweight to moderately obese older adults: a randomized clinical trial. J Obes (2010) 1.09

Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci (2012) 1.09

The gait and balance of patients with diabetes can be improved: a randomised controlled trial. Diabetologia (2009) 1.08

Type 2 diabetes and risk for functional decline and disability in older persons. Curr Diabetes Rev (2010) 1.08

Does high-intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes? Osteoporos Int (2005) 1.06

Impact of resistance training with or without caloric restriction on physical capacity in obese older women. Menopause (2009) 1.05

Association of muscle strength with functional status of elderly people. Age Ageing (1990) 1.03

Promoting and prescribing exercise for the elderly. Am Fam Physician (2002) 1.02

The aging musculoskeletal system and obesity-related considerations with exercise. Ageing Res Rev (2012) 1.01

Measuring the impact of diabetes on life expectancy and disability-free life expectancy among older adults in Mexico. J Gerontol B Psychol Sci Soc Sci (2009) 0.99

Effects of an exercise program on balance and trunk proprioception in older adults with diabetic neuropathies. Diabetes Technol Ther (2011) 0.99

Health benefits of Tai Chi for older patients with type 2 diabetes: the "Move It For Diabetes study"--a randomized controlled trial. Clin Interv Aging (2007) 0.96

Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment. Altern Med Rev (2002) 0.94

Burden of diabetes in an aging population: prevalence, incidence, mortality, characteristics and quality of care. Diabetes Metab (2005) 0.94

Obesity in the elderly diabetic patient: is weight loss beneficial? No. Diabetes Care (2009) 0.93

The shape of things to come: obesity, aging, and disability. LDI Issue Brief (2008) 0.93

Diabetes mellitus in a subgroup of older Mexicans: prevalence, association with cardiovascular risk factors, functional and cognitive impairment, and mortality. J Am Geriatr Soc (2002) 0.93

Summarizing amount of difficulty in ADLs: a refined characterization of disability. Results from the women's health and aging study. Aging (Milano) (2001) 0.92

Obesity and physical inactivity: the relevance of reconsidering the notion of sedentariness. Obes Facts (2009) 0.91

Reduction of skeletal muscle, especially in lower limbs, in Japanese type 2 diabetic patients with insulin resistance and cardiovascular risk factors. Metab Syndr Relat Disord (2010) 0.91

Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders. J Gerontol A Biol Sci Med Sci (2012) 0.89

Sarcopenic obesity: an emerging cause of frailty in older adults. Geriatr Nurs (2009) 0.89

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity. J Aging Res (2011) 0.86

Effect of diabetes mellitus on muscle size and strength in patients receiving dialysis therapy. Am J Kidney Dis (2006) 0.86

Diabetes-related change in physical disability from midlife to older adulthood: evidence from 1996-2003 Survey of Health and Living Status of the Elderly in Taiwan. Diabetes Res Clin Pract (2010) 0.84

Independence of elderly patients with arterial hypertension in fulfilling their needs, in the aspect of functional assessment and quality of life (QoL). Arch Gerontol Geriatr (2010) 0.83

Articles by these authors

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol (2013) 1.38

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell (2012) 1.29

Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. PLoS One (2012) 1.02

Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr) (2010) 0.92

Blood flow restriction enhances post-resistance exercise angiogenic gene expression. Med Sci Sports Exerc (2012) 0.89

Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc (2013) 0.89

Use of a computerized tracking system to monitor and provide feedback on dietary goals for calorie-restricted diets: the POUNDS LOST study. J Diabetes Sci Technol (2012) 0.88

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity. J Aging Res (2011) 0.86

Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study. J Gerontol A Biol Sci Med Sci (2013) 0.81

Sedentary individuals as "controls" in human studies: the correct approach? Proc Natl Acad Sci U S A (2010) 0.81

Growth hormone responses to acute resistance exercise with vascular restriction in young and old men. Growth Horm IGF Res (2012) 0.79

Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise. Med Sci Sports Exerc (2015) 0.78

Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age (Dordr) (2012) 0.78

Commentaries on Viewpoint: Muscle atrophy is not always sarcopenia. J Appl Physiol (1985) (2012) 0.78

The renin-angiotensin system and prevention of age-related functional decline: where are we now? Age (Dordr) (2015) 0.78

Atenolol induced HDL-C change in the pharmacogenomic evaluation of antihypertensive responses (PEAR) study. PLoS One (2013) 0.77

Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males. Eur J Appl Physiol (2014) 0.75

Protein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following Immobilization. J Nutr Metab (2011) 0.75

Bilateral comparison of barbell kinetics and kinematics during a weightlifting competition. Int J Sports Physiol Perform (2007) 0.75

Greater Functional Aerobic Capacity Predicts More Effective Pain Modulation In Older Adults: 1155 June 1, 3: 30 PM - 3: 45 PM. Med Sci Sports Exerc (2016) 0.75

Nutrition and Exercise in Sarcopenia. Curr Protein Pept Sci (2016) 0.75

Effects of Blood Flow Restriction on Biomarkers of Myogenesis Among Healthy Young Adults: 3700 Board #139 June 4, 9: 30 AM - 11: 00 AM. Med Sci Sports Exerc (2016) 0.75

Active Gaming as a Method to Improve Pressure Pain Sensitivity: 1570 Board #223 June 2, 8: 00 AM - 9: 30 AM. Med Sci Sports Exerc (2016) 0.75