Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).

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Published in J Med Chem on July 11, 2013

Authors

Brian A Johns1, Takashi Kawasuji, Jason G Weatherhead, Teruhiko Taishi, David P Temelkoff, Hiroshi Yoshida, Toshiyuki Akiyama, Yoshiyuki Taoda, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tanimoto, Jerry Jeffrey, Scott A Foster, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Matthew N Johnson, Edward P Garvey, Tamio Fujiwara

Author Affiliations

1: GlaxoSmithKline Research & Development , Infectious Diseases Therapeutic Area Unit, Five Moore Drive, Research Triangle Park, North Carolina 27709, United States.

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