Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes.

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Published in Antimicrob Agents Chemother on August 01, 2011

Authors

Kendra E Hightower1, Ruolan Wang, Felix Deanda, Brian A Johns, Kurt Weaver, Yingnian Shen, Ginger H Tomberlin, H Luke Carter, Timothy Broderick, Scott Sigethy, Takahiro Seki, Masanori Kobayashi, Mark R Underwood

Author Affiliations

1: Infectious Diseases MDD, 3.2104 GlaxoSmithKline, 5 Moore Dr., Research Triangle Park, NC 27709, USA.

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