Published in J Clin Invest on August 01, 1990
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol (1992) 11.03
The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 6.84
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A (1993) 6.77
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci U S A (1997) 6.11
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A (1996) 5.69
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene. Proc Natl Acad Sci U S A (1991) 4.84
Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest (1991) 3.18
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene. Proc Natl Acad Sci U S A (1991) 2.67
Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci U S A (1995) 2.41
Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest (1996) 2.29
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J (2007) 2.20
Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest (1993) 2.14
Oxygen in wound healing--more than a nutrient. World J Surg (2004) 1.85
Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med (1995) 1.78
Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J Clin Invest (1995) 1.65
Angiogenesis in human coronary atherosclerotic plaques. Am J Pathol (1994) 1.65
A 24-base-pair sequence 3' to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer. Proc Natl Acad Sci U S A (1993) 1.57
Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen. J Clin Invest (1995) 1.36
Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. J Clin Invest (2013) 1.30
Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment. Lasers Surg Med (2010) 1.21
Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem (2009) 1.20
Hypoxia-inducible angiopoietin-2 expression is mimicked by iodonium compounds and occurs in the rat brain and skin in response to systemic hypoxia and tissue ischemia. Am J Pathol (2000) 1.16
Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J Exp Med (1994) 1.14
Regulation of cancer metastasis by stress pathways. Clin Exp Metastasis (2003) 1.07
Reactive oxygen species in pulmonary vascular remodeling. Compr Physiol (2013) 1.06
Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells. Angiogenesis (2009) 1.04
U19/Eaf2 binds to and stabilizes von hippel-lindau protein. Cancer Res (2009) 1.04
The Role of Elongin BC-Containing Ubiquitin Ligases. Front Oncol (2012) 1.04
Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling. Respir Res (2011) 1.03
Current status of targeted therapy for advanced renal cell carcinoma. Korean J Urol (2012) 1.02
Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture. J Clin Invest (1995) 1.02
Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. J Clin Invest (1992) 1.01
Lipopolysaccharide and interleukin 1 augment the effects of hypoxia and inflammation in human pulmonary arterial tissue. Proc Natl Acad Sci U S A (1996) 0.98
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica (2009) 0.97
Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol (1999) 0.96
mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. FASEB J (2013) 0.94
Molecular targeting therapy for renal cell carcinoma. Int J Clin Oncol (2006) 0.94
Targeted therapy for renal cell carcinoma: a new treatment paradigm. Proc (Bayl Univ Med Cent) (2007) 0.92
Antiangiogenic therapy for glioma. J Signal Transduct (2012) 0.89
Endothelial modulation and changes in endothelin pressor activity during hypoxia in the rat isolated perfused superior mesenteric arterial bed. Br J Pharmacol (1991) 0.88
Sequence of treatment in locally advanced and metastatic renal cell carcinoma. Transl Androl Urol (2015) 0.86
Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosis. J Thyroid Res (2011) 0.85
The erythropoietin/erythropoietin receptor signaling pathway promotes growth and invasion abilities in human renal carcinoma cells. PLoS One (2012) 0.83
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions. Cell Div (2016) 0.82
Identification of an oxygen-responsive element in the 5'-flanking sequence of the rat cytosolic phosphoenolpyruvate carboxykinase-1 gene, modulating its glucagon-dependent activation. Biochem J (1999) 0.82
Chronic hypoxia promotes pulmonary artery endothelial cell proliferation through H2O2-induced 5-lipoxygenase. PLoS One (2014) 0.81
Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells. Br J Pharmacol (1999) 0.81
Clinical application of development of nonantibiotic macrolides that correct inflammation-driven immune dysfunction in inflammatory skin diseases. Mediators Inflamm (2012) 0.80
Platelet-derived growth factor BB induces functional vascular anastomoses in vivo. Proc Natl Acad Sci U S A (1995) 0.79
Vasotrophic regulation of age-dependent hypoxic cerebrovascular remodeling. Curr Vasc Pharmacol (2013) 0.76
Differential regulation of the inhibitor of apoptosis ch-IAP1 by v-rel and the proto-oncogene c-rel. J Virol (2002) 0.76
In vivo footprinting and functional analysis of the human c-sis/PDGF B gene promoter provides evidence for two binding sites for transcriptional activators. Nucleic Acids Res (1995) 0.75
Vascular endothelial growth factor: environmental controls and effects in angiogenesis. Br J Cancer Suppl (1996) 0.75
Angiogenic growth factors in myocardial infarction: a critical appraisal. Heart Fail Rev (2017) 0.75
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (1980) 40.02
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (1987) 35.44
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
The pathogenesis of atherosclerosis--an update. N Engl J Med (1986) 14.59
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature (1986) 4.81
Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis. N Engl J Med (1987) 2.62
Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J Cell Physiol (1982) 2.20
Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell (1985) 2.06
Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium. J Physiol (1985) 2.05
Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol (1985) 1.97
The molecular biology of platelet-derived growth factor. Cell (1983) 1.88
Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor. J Biol Chem (1989) 1.79
Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J Biol Chem (1986) 1.65
Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells. J Biol Chem (1988) 1.38
Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells. J Cell Biol (1986) 1.29
Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta. J Biol Chem (1987) 1.26
Deletions of specific regions of the simian sarcoma-associated virus genome are found in defective viruses and in the simian sarcoma virus. J Virol (1982) 1.25
Regulated expression of the platelet-derived growth factor A chain gene in microvascular endothelial cells. J Biol Chem (1987) 1.12
Serotonin uptake by bovine pulmonary artery endothelial cells in culture. II. Stimulation by hypoxia. Am J Physiol (1986) 1.04
Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor. J Biol Chem (1989) 1.04
Glycolytic activity and enhancement of serotonin uptake by endothelial cells exposed to hypoxia/anoxia. Circ Res (1987) 1.02
Effects of hypoxia and hyperoxia on proteoglycan production by bovine pulmonary artery endothelial cells. J Cell Physiol (1986) 1.00
Effect of ammonia on the glutamate dehydrogenase catalyzed oxidative deamination of L-glutamate. The steady state. Biochemistry (1979) 0.97
Roles of growth factor activities in oncogenesis. Blood (1984) 0.94
A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res (1991) 13.54
Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses. Proc Natl Acad Sci U S A (1978) 5.25
Development of an enterprise-wide clinical data repository: merging multiple legacy databases. Proc AMIA Annu Fall Symp (1997) 4.18
Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest (1991) 3.18
A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N Engl J Med (1993) 2.76
Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood (1999) 2.66
RNase T1-resistant oligonucleotides of B-tropic murine leukemia virus from BALB/c and five of its NB-tropic derivatives. J Virol (1977) 2.51
You bet-cha: a novel family of transcriptional regulators. Front Biosci (2001) 2.20
RNase T1-resistant oligonucleotides of Akv-1 and Akv-2 type C viruses of AKR mice. J Virol (1977) 2.17
Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest (1993) 2.14
RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ (2000) 2.13
Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol (1988) 1.88
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene (2012) 1.70
Retracted Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control. Oncogene (2008) 1.59
Adhesion of T lymphocytes to human endothelial cells is regulated by the LFA-1 membrane molecule. J Cell Physiol (1986) 1.57
Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. J Immunol (1985) 1.52
Oncogenic ras induces an inhibitor of double-stranded RNA-dependent eukaryotic initiation factor 2 alpha-kinase activation. J Biol Chem (1992) 1.50
T1 oligonucleotide maps of N-, B-, and B leads to NB-tropic murine leukemia viruses derived from BALB/c. J Virol (1978) 1.47
Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: one-year follow-up in five patients. Blood (1996) 1.42
Large T1 oligonucleotides of Moloney leukemia virus missing in an env gene recombinant, HIX, are present on an intracellular 21S Moloney viral RNA species. Proc Natl Acad Sci U S A (1978) 1.39
Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor. J Clin Invest (1987) 1.36
Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals. Cell Growth Differ (1998) 1.28
Alpha and beta subunits of the LFA-1 membrane molecule are involved in human monocyte-endothelial cell adhesion. J Cell Physiol (1987) 1.26
RNase T1-resistant oligonucleotides of an N- and a B-tropic murine leukemia virus of BALB/c: evidence for recombination between these viruses. J Virol (1977) 1.25
Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. Immediate early gene induction. J Biol Chem (1995) 1.24
Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy. Blood (1998) 1.24
Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. Blood (1989) 1.23
Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching. Proc Natl Acad Sci U S A (1988) 1.22
Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. J Lab Clin Med (1998) 1.20
Short-chain fatty acid derivatives stimulate cell proliferation and induce STAT-5 activation. Blood (2001) 1.19
T1 oligonucleotides that segregate with tropism and with properties of gp70 in recombinants between N- and B-tropic murine leukemia viruses. J Virol (1978) 1.19
Cytotoxic T lymphocyte recognition of transfected cells expressing a cloned retroviral gene. Nature (1983) 1.16
Neutral amino acids in the brain: changes in response to food ingestion. J Neurochem (1978) 1.15
Delay in the fetal globin switch in infants of diabetic mothers. N Engl J Med (1985) 1.12
Spontaneous aggregation as a mechanism for human monocyte purification. Cell Immunol (1986) 1.11
Phosphorylation of Bcl-2 protein and association with p21Ras in Ras-induced apoptosis. J Biol Chem (1996) 1.11
Epstein--Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate. Transpl Infect Dis (2001) 1.10
Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated lymphoma. Blood Cells Mol Dis (1998) 1.10
Reprogramming of the SWI/SNF complex for co-activation or co-repression in prohibitin-mediated estrogen receptor regulation. Oncogene (2007) 1.08
Initial postoperative serum lactate levels predict survival in children after open heart surgery. Intensive Care Med (1996) 1.08
Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. Biochim Biophys Acta (1995) 1.06
Activation-induced nuclear translocation of RING3. J Cell Sci (2000) 1.06
Interferon-gamma induction of LFA-1-mediated homotypic adhesion of human monocytes. J Immunol (1986) 1.04
A mechanistic approach to anticancer therapy: targeting the cell cycle with histone deacetylase inhibitors. Curr Pharm Des (2005) 1.04
Platelet-derived growth factor production by human umbilical vein endothelial cells is regulated by basic fibroblast growth factor. J Biol Chem (1989) 1.04
Liposome encapsulation of retrovirus allows efficient superinfection of resistant cell lines. J Virol (1984) 1.04
P21 v-ras inhibits induction of c-myc and c-fos expression by platelet-derived growth factor. Mol Cell Biol (1988) 1.03
Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus. J Biol Chem (1988) 1.02
Sickle erythrocytes, after sickling, regulate the expression of the endothelin-1 gene and protein in human endothelial cells in culture. J Clin Invest (1995) 1.02
Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts. Mol Cell Biol (1995) 1.01
Endothelial cells synthesize basic fibroblast growth factor and transforming growth factor beta. Growth Factors (1988) 1.01
Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial cells. J Cell Physiol (1996) 0.97
T1 oligonucleotide maps of Moloney and HIX murine leukemia viruses. Virology (1978) 0.96
Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene (1995) 0.96
A transcript from the long terminal repeats of a murine retrovirus associated with trans activation of cellular genes. J Virol (1995) 0.96
Differential regulation of discrete apoptotic pathways by Ras. J Biol Chem (1998) 0.95
Murine retroviruses control class I major histocompatibility antigen gene expression via a trans effect at the transcriptional level. Mol Cell Biol (1987) 0.95
Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat. J Virol (1990) 0.94
Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. J Biol Chem (2000) 0.93
Butyrate derivatives. New agents for stimulating fetal globin production in the beta-globin disorders. Am J Pediatr Hematol Oncol (1994) 0.93
A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression. J Biol Chem (2000) 0.92
Inhibition of platelet-derived growth factor-mediated signal transduction by transforming ras. Suppression of receptor autophosphorylation. J Biol Chem (1991) 0.92
Endogenous inhibitors of the dsRNA-dependent eIF-2 alpha protein kinase PKR in normal and ras-transformed cells. Biochimie (1994) 0.92
Interleukin-1, tumor necrosis factor, and the production of colony-stimulating factors by cultured mesenchymal cells. Blood (1988) 0.91
Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol (2011) 0.91
The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis. Cell Growth Differ (2001) 0.91
Detection of monoclonal microsatellite alterations in atypical breast hyperplasia. J Clin Invest (1996) 0.90
Isobutyramide, an orally bioavailable butyrate analogue, stimulates fetal globin gene expression in vitro and in vivo. Br J Haematol (1994) 0.89
The long terminal repeats of a murine retrovirus encode a trans-activator for cellular genes. J Biol Chem (1994) 0.89
Tryptophan concentrations in rat brain. Failure to correlate with free serum tryptophan or its ratio to the sum of other serum neutral amino acids. Biochem J (1976) 0.89
Characterization of a hypoxia-responsive adhesion molecule for leukocytes on human endothelial cells. J Immunol (1995) 0.89
T cell hybridomas define the class II MHC-restricted response to vesicular stomatitis virus infection. Microb Pathog (1988) 0.88
Protection from apoptosis in human neutrophils is determined by the surface of adhesion. Am J Physiol (1997) 0.88
The immune response to Moloney murine leukemia virus-induced tumors: induction of cytolytic T lymphocytes specific for both viral and tumor-associated antigens. J Immunol (1986) 0.87
A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J Biol Chem (1997) 0.87
Feline leukemia virus long terminal repeat activates collagenase IV gene expression through AP-1. J Virol (1999) 0.87
Microsatellite alterations indicating monoclonality in atypical hyperplasias associated with breast cancer. Hum Pathol (1997) 0.86
Distinct effects of interferon-gamma and MHC class I surface antigen levels on resistance of the K562 tumor cell line to natural killer-mediated lysis. Cell Immunol (1990) 0.86
Intercellular adhesion molecule-1 (ICAM-1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line. J Cell Physiol (1988) 0.86
Cardiac operations in patients aged 70 years and over: mortality, length of stay, and hospital charge. Ann Thorac Surg (1995) 0.86
The Moloney leukemia retroviral long terminal repeat trans-activates AP-1-inducible genes and AP-1 transcription factor binding. J Biol Chem (1995) 0.86
Butryic acid analogues augment gamma globin gene expression in neonatal erythroid progenitors. Biochem Biophys Res Commun (1987) 0.86
Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras. Mol Cell Biol (1996) 0.85
Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis. Ann N Y Acad Sci (1998) 0.85
Selective inhibition of protein kinase C isozymes by Fas ligation. J Biol Chem (1999) 0.85
Erythroid progenitor proliferation is stimulated by phenoxyacetic and phenylalkyl acids. Blood Cells Mol Dis (1996) 0.85
Hypoxia affects tumor cell invasiveness in vitro: the role of hypoxia-activated ligand HAL1/13 (Ku86 autoantigen). Cancer Lett (2000) 0.84
trans-Activation of genes encoding activation-associated human T lymphocyte surface proteins by murine retroviral sequences. J Immunol (1991) 0.84
Hematopoietic hormones: from cloning to clinic. Am J Pediatr Hematol Oncol (1989) 0.84
Redox control of retinoic acid receptor activity: a novel mechanism for retinoic acid resistance in melanoma cells. Endocrinology (2001) 0.84
A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding. J Biol Chem (1995) 0.84
Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro. Am J Physiol Cell Physiol (2001) 0.84
Immunoblastic lymphoma of donor origin in the allograft after lung transplantation. Transplantation (1996) 0.83
Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblasts. J Biol Chem (1996) 0.83
Oxygen tension regulates neutrophil adhesion to human endothelial cells via an LFA-1-dependent mechanism. J Cell Physiol (1993) 0.83
Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras. Cell Death Differ (1998) 0.83
Regulation of platelet-derived growth factor signaling by activated p21Ras. Front Biosci (1999) 0.83
The combination of propranolol and magnesium does not prevent postoperative atrial fibrillation. Ann Thorac Surg (2000) 0.83
Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids. Blood Cells Mol Dis (1997) 0.83