The molecular biology of platelet-derived growth factor.

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. EMBO J (1985) 6.31

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol (1986) 3.77

A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase. Proc Natl Acad Sci U S A (1985) 3.02

Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest (1990) 2.94

Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells. J Cell Biol (1985) 2.26

Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences. Nucleic Acids Res (1987) 1.91

Posttranscriptional regulation of cellular gene expression by the c-myc oncogene. Mol Cell Biol (1989) 1.84

Stimulation of in vitro human skin collagenase expression by platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 1.65

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate. J Cell Biol (1985) 1.41

Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells. J Clin Invest (1984) 1.38

Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line. Proc Natl Acad Sci U S A (1984) 1.37

Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro. J Clin Invest (1985) 1.33

Production of platelet-derived growth factorlike protein by rat mesangial cells in culture. J Clin Invest (1987) 1.24

The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes. Proc Natl Acad Sci U S A (1986) 1.21

Structure and nucleotide sequence of the 5' region of the human and feline c-sis proto-oncogenes. Nucleic Acids Res (1986) 1.16

Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc Natl Acad Sci U S A (1995) 1.10

Constitutive and inducible secretion of platelet-derived growth factor analogs by human leukemic cell lines coexpressing erythroid and megakaryocytic markers. J Clin Invest (1987) 1.08

Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. J Cell Biol (1988) 1.07

Repression of platelet-derived growth factor beta-receptor expression by mitogenic growth factors and transforming oncogenes in murine 3T3 fibroblasts. Mol Cell Biol (1995) 1.01

Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor. Mol Cell Biol (1985) 0.98

Dissociation of the chemotactic and mitogenic activities of platelet-derived growth factor by human neutrophil elastase. J Cell Biol (1985) 0.95

Purification and biochemical properties of a human monocyte-derived growth factor. Proc Natl Acad Sci U S A (1988) 0.94

Healing of focal injury in the rat liver. Am J Pathol (1985) 0.93

Transformed and nontransformed cells differ in stability and cell cycle regulation of a binding activity to the murine thymidine kinase promoter. Proc Natl Acad Sci U S A (1990) 0.88

Platelet-derived growth factor and vascular endothelial growth factor expression in disc herniation tissue: and immunohistochemical study. Eur Spine J (1997) 0.88

Role of a tumor-suppressor gene in the negative control of anchorage-independent growth of Syrian hamster cells. Proc Natl Acad Sci U S A (1989) 0.85

Novel peripheral blood-derived human cell lines with properties of megakaryocytes. J Cell Biol (1985) 0.81

New and emerging strategies in platelet-rich plasma application in musculoskeletal regenerative procedures: general overview on still open questions and outlook. Biomed Res Int (2015) 0.81

Evidence for an intracellular precursor for human B-cell growth factor. Proc Natl Acad Sci U S A (1984) 0.75

Postreceptor signal transduction by cyclic adenosine monophosphate and the Ca2+-calmodulin complex. J Cell Biol (1984) 0.75

Tyrosyl kinases acquired from anchorage-independent cells by a membrane-enveloped virus. J Cell Biol (1984) 0.75

Growth control variant cell line having increased serum requirement and decreased response to platelet-derived growth factor: reversion by 5-azacytidine. J Cell Biol (1984) 0.75

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87

Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell (1983) 9.03

Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A (1977) 5.20

Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science (1984) 4.87

Purification of human platelet-derived growth factor. Proc Natl Acad Sci U S A (1979) 4.78

Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature (1984) 4.56

Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A (1979) 4.32

Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron (2000) 4.17

Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A (1988) 3.83

Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochim Biophys Acta (1979) 3.26

Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell (1985) 2.82

An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis. Proc Natl Acad Sci U S A (1978) 2.71

The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem (1989) 2.29

Platelet alpha granules contain a growth factor for fibroblasts. Blood (1979) 2.18

Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol (1978) 1.79

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer (1995) 1.69

Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development (2001) 1.62

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A (1991) 1.61

Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc Natl Acad Sci U S A (1987) 1.58

Serum-inducible genes. Adv Cancer Res (1989) 1.53

A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1. Mol Cell Biol (1995) 1.49

Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571. Oncogene (2000) 1.47

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res (2000) 1.39

The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors. J Cell Physiol (1979) 1.37

Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos. Science (1988) 1.37

Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor. Exp Cell Res (1984) 1.36

Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40. Cell (1979) 1.30

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol (1993) 1.29

Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A (2001) 1.29

Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J Cell Biol (1982) 1.28

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A (1994) 1.27

Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci (2001) 1.26

Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci (2001) 1.24

Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma. J Cell Physiol (1979) 1.24

Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci (1997) 1.22

Differential utilization of Trk autophosphorylation sites. J Biol Chem (1996) 1.22

Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor. Proc Natl Acad Sci U S A (1981) 1.19

Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res (1976) 1.19

Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A (1975) 1.18

Growth factors adherent to cell substrate are mitogenically active in situ. Nature (1982) 1.17

TrkA glycosylation regulates receptor localization and activity. J Neurobiol (1999) 1.17

Differential degradation of messenger RNAs in mammalian cells. Proc Natl Acad Sci U S A (1976) 1.14

Growth factor superfamilies and mammalian embryogenesis. Development (1988) 1.14

Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol (2001) 1.13

Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator. J Biol Chem (1996) 1.12

Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives. Int J Dev Neurosci (2001) 1.12

A novel 7-nucleotide motif located in 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene. Mol Cell Biol (1992) 1.11

PDGF and its receptors in the developing rodent retina and optic nerve. Development (1993) 1.11

Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci (1995) 1.10

Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci (1997) 1.10

Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers. J Biol Chem (1987) 1.08

Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem (1994) 1.08

A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron (2000) 1.07

Persistence of the mitogenic response to platelet-derived growth factor (competence) does not reflect a long-term interaction between the growth factor and the target cell. J Cell Biol (1983) 1.05

Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res (1976) 1.05

Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev (1990) 1.03

A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor. Science (1987) 1.02

Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res (1999) 1.02

Molecular cloning of gene sequences that are regulated by insulin-like growth factor I. J Biol Chem (1987) 1.01

Comparison of fibroblast and T-cell activation genes. Cell Immunol (1988) 1.00

Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol (1973) 0.98

Regulation of the Balb/c-3T3 cell cycle-effects of growth factors. J Supramol Struct (1980) 0.98

A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron (1997) 0.98

Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J Cell Physiol (1989) 0.98

Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta. J Cell Physiol (1989) 0.98

Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech Dev (1992) 0.97

Platelet-derived growth factor prevents G0 growth arrest. Nature (1979) 0.94

Cell cycle dependent genes inducible by different mitogens in cells from different species. Mol Cell Biochem (1986) 0.94

The biological role of oncogenes--insights from platelet-derived growth factor: Rhoads Memorial Award lecture. Cancer Res (1985) 0.93

Differential colony hybridization: molecular cloning from a zero data base. Methods Enzymol (1987) 0.91

Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci (2001) 0.90

Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol (1990) 0.89

Post-transcriptional control of protein synthesis in Balb/c-3T3 cells by platelet-derived growth factor and platelet-poor plasma. J Cell Physiol (1981) 0.89

Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A (1992) 0.88

Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA. Mol Cell Biol (1989) 0.87

Roles of the T antigens in transformation by SV40. Cold Spring Harb Symp Quant Biol (1980) 0.87

Degradation of messenger RNA in mammalian cells. Acta Endocrinol Suppl (Copenh) (1972) 0.87

Human keratinocyte growth-promoting activity on the surface of fibroblasts. J Cell Physiol (1991) 0.86

Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. Mol Cell Biol (1989) 0.86

Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements. Proc Natl Acad Sci U S A (1994) 0.85

Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci (1999) 0.84

Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem (1999) 0.83

Labile repressors are involved in the transcriptional control of PDGF-responsive genes. Oncogene Res (1989) 0.83

Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem (1990) 0.82

Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice. Gene Expr (1997) 0.82

Autocrine control of growth? Nature (1984) 0.82

Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res (1997) 0.82

Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. In Vitro Cell Dev Biol (1988) 0.81

Electroporation of peptides into adherent cells in situ. Biotechniques (1995) 0.80

The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression. Dev Genet (1993) 0.80

Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res (1979) 0.80

Platelet-derived growth factor generates at least two distinct intracellular signals that modulate gene expression. Cold Spring Harb Symp Quant Biol (1988) 0.79

Regulation of platelet-derived growth factor A messenger RNA translation in differentiating F9 teratocarcinoma cells. Cell Growth Differ (1993) 0.78

Transdominant negative mutations. Methods Enzymol (1995) 0.78

The PDGF-inducible 'competence genes': intracellular mediators of the mitogenic response. Ciba Found Symp (1985) 0.78

Effect of ouabain on growth regulation by serum components in Balb/c-3T3 cells: inhibition of entry into S phase by decreased protein synthesis. J Cell Physiol (1980) 0.78

The beta-interferon-mediated antimitogenic state resembles the anti-viral state. Oncogene Res (1990) 0.77

Applications of electroporation of adherent cells in situ, on a partly conductive slide. Mol Biotechnol (1995) 0.77

Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome. J Neurol Neurosurg Psychiatry (1995) 0.76

Regulation of the mammalian fibroblast cell cycle by a platelet-derived growth factor. Prog Clin Biol Res (1979) 0.75