Published in IUBMB Life on July 11, 2013
Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms. Circ Res (2015) 1.45
Postmenopausal hypertension: role of the sympathetic nervous system in an animal model. Am J Physiol Regul Integr Comp Physiol (2013) 0.96
Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats. Am J Physiol Regul Integr Comp Physiol (2015) 0.87
Exaggerated sympathoexcitatory reflexes develop with changes in the rostral ventrolateral medulla in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol (2016) 0.77
Regulation of Blood Pressure, Appetite, and Glucose by Leptin After Inactivation of Insulin Receptor Substrate 2 Signaling in the Entire Brain or in Proopiomelanocortin Neurons. Hypertension (2015) 0.76
Differentially expressed circulating LncRNAs and mRNA identified by microarray analysis in obese patients. Sci Rep (2016) 0.75
ToxReporter: viewing the genome through the eyes of a toxicologist. Database (Oxford) (2016) 0.75
Cardiometabolic Features of Polycystic Ovary Syndrome: Role of Androgens. Physiology (Bethesda) (2017) 0.75
Linking Chronic Inflammation with Cardiovascular Disease: From Normal Aging to the Metabolic Syndrome. J Nat Sci (2017) 0.75
Role of the brain melanocortins in blood pressure regulation. Biochim Biophys Acta (2017) 0.75
Central nervous system control of food intake. Nature (2000) 15.85
Gut hormone PYY(3-36) physiologically inhibits food intake. Nature (2002) 8.30
Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell (2005) 7.04
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med (2002) 6.92
Genetics of obesity in humans. Endocr Rev (2006) 5.42
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med (2006) 4.22
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63
Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab (1999) 3.26
Prevalence of obesity among US preschool children in different racial and ethnic groups. Arch Pediatr Adolesc Med (2009) 3.16
Modulation of blood pressure by central melanocortinergic pathways. N Engl J Med (2008) 2.86
The kidney, hypertension, and obesity. Hypertension (2003) 2.79
Chronic leptin infusion increases arterial pressure. Hypertension (1998) 2.78
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nat Med (2006) 2.72
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem (2001) 2.65
The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem (1999) 2.63
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc Natl Acad Sci U S A (2004) 2.57
Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem (2010) 2.53
Central insulin action in energy and glucose homeostasis. J Clin Invest (2006) 2.51
IRS-2 pathways integrate female reproduction and energy homeostasis. Nature (2000) 2.45
The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest (2005) 2.40
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A (2004) 2.36
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest (2004) 2.34
Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes (2005) 2.24
Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest (2008) 2.07
Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats. Hypertension (2008) 1.98
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques. Diabetes (2012) 1.91
The sympathetic nervous system and the metabolic syndrome. J Hypertens (2007) 1.80
Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension (2006) 1.80
Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension (2005) 1.72
Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation (2009) 1.70
Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care (2000) 1.70
Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest (2000) 1.68
Obesity and hypertension: two epidemics or one? Am J Physiol Regul Integr Comp Physiol (2004) 1.68
Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension (2002) 1.63
Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation (1997) 1.60
Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem (2002) 1.57
Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension (1995) 1.53
Mechanisms of obesity-associated cardiovascular and renal disease. Am J Med Sci (2002) 1.51
Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens (2002) 1.45
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens (1999) 1.42
The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes (2002) 1.37
Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension (2010) 1.37
The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol (1997) 1.35
Sympathetic nervous system behavior in human obesity. Neurosci Biobehav Rev (2008) 1.35
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci (2010) 1.32
Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension (2002) 1.31
Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons. Hypertension (2011) 1.30
The role of the sympathetic nervous system in obesity-related hypertension. Curr Hypertens Rep (2009) 1.29
Mediators of sympathetic activation in metabolic syndrome obesity. Curr Hypertens Rep (2008) 1.29
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res (2011) 1.27
Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects. Am J Hypertens (2001) 1.13
Melanocortin signalling and the regulation of blood pressure in human obesity. J Neuroendocrinol (2011) 1.08
Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol (2008) 1.08
Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications. Hypertens Res (2011) 1.06
Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function. J Neuroendocrinol (2007) 1.05
The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J Endocrinol (2007) 1.04
Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. J Clin Endocrinol Metab (2010) 1.00
Oleic acid directly regulates POMC neuron excitability in the hypothalamus. J Neurophysiol (2009) 0.98
Activation of the central melanocortin system contributes to the increased arterial pressure in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol (2011) 0.93
Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin. Hypertension (2013) 0.91
Retracted Glucose regulates the effects of leptin on hypothalamic POMC neurons. Proc Natl Acad Sci U S A (2008) 0.84
Androgen regulation of proopiomelanocortin gene expression and peptide content in the basal hypothalamus. Endocrinology (1989) 0.79
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med (2006) 6.04
Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA (2012) 4.57
Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98
Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation (2012) 3.14
Rectal nonsteroidal anti-inflammatory drugs are superior to pancreatic duct stents in preventing pancreatitis after endoscopic retrograde cholangiopancreatography: a network meta-analysis. Clin Gastroenterol Hepatol (2013) 2.91
The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation (2011) 2.89
Recommendations for blood pressure measurement in humans: an AHA scientific statement from the Council on High Blood Pressure Research Professional and Public Education Subcommittee. J Clin Hypertens (Greenwich) (2005) 2.86
Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med (2009) 2.68
How to review a paper. Adv Physiol Educ (2003) 2.67
Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem (2010) 2.53
Heterogeneous aspirations promote cooperation in the prisoner's dilemma game. PLoS One (2010) 2.41
Relative abundance of EGFR mutations predicts benefit from gefitinib treatment for advanced non-small-cell lung cancer. J Clin Oncol (2011) 2.34
Patient engagement in research: a systematic review. BMC Health Serv Res (2014) 2.33
Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis. Proc Natl Acad Sci U S A (2014) 2.26
Wisdom of groups promotes cooperation in evolutionary social dilemmas. Sci Rep (2012) 2.22
Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China. J Thorac Oncol (2007) 2.15
Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA (2011) 2.13
Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats. Hypertension (2008) 1.98
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science (2012) 1.84
Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Arterioscler Thromb Vasc Biol (2005) 1.82
A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clin Cancer Res (2011) 1.82
Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol (2008) 1.81
Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension (2006) 1.80
How human location-specific contact patterns impact spatial transmission between populations? Sci Rep (2013) 1.74
Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension (2005) 1.72
Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure and evidence from new hypertension trials. Hypertension (2003) 1.71
p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J Biol Chem (2004) 1.70
Obesity and hypertension: two epidemics or one? Am J Physiol Regul Integr Comp Physiol (2004) 1.68
Pharmacologic interventions for painful diabetic neuropathy: An umbrella systematic review and comparative effectiveness network meta-analysis. Ann Intern Med (2014) 1.65
Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension (2002) 1.63
Clinical review: Drugs commonly associated with weight change: a systematic review and meta-analysis. J Clin Endocrinol Metab (2015) 1.63
Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer. Lung Cancer (2012) 1.61
Lung cancers with concomitant EGFR mutations and ALK rearrangements: diverse responses to EGFR-TKI and crizotinib in relation to diverse receptors phosphorylation. Clin Cancer Res (2014) 1.59
Case-fatality ratio and effectiveness of ribavirin therapy among hospitalized patients in china who had severe fever with thrombocytopenia syndrome. Clin Infect Dis (2013) 1.58
The use of allograft shell with intramedullary vascularized fibula graft for intercalary reconstruction after diaphyseal resection for lower extremity bony malignancy. J Surg Oncol (2010) 1.50
Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol (2012) 1.46
The matrix metalloproteinases as pharmacological target in osteoarthritis: statins may be of therapeutic benefit. Med Hypotheses (2007) 1.46
Prolonged survival with imatinib mesylate combined with chemotherapy and allogeneic stem cell transplantation in de novo Ph+ acute myeloid leukemia. Acta Haematol (2012) 1.43
Low Discrepancy Between Tissue Biopsy Plus Magnifying Endoscopy With Narrow-Band Imaging and Endoscopic Resection in the Diagnosis of Gastric Epithelial Neoplasia (STROBE). Medicine (Baltimore) (2015) 1.43
A potential probe set of fluorescence in situ hybridization for detection of lung cancer in bronchial brushing specimens. J Cancer Res Clin Oncol (2012) 1.43
Inhibitor κB kinase 2 is a myosin light chain kinase in vascular smooth muscle. Circ Res (2013) 1.42
If players are sparse social dilemmas are too: Importance of percolation for evolution of cooperation. Sci Rep (2012) 1.42
The incremental benefit of functional imaging in pheochromocytoma/paraganglioma: a systematic review. Endocrine (2015) 1.41
Attack robustness and centrality of complex networks. PLoS One (2013) 1.40
Role of Gα(12)- and Gα(13)-protein subunit linkage of D(3) dopamine receptors in the natriuretic effect of D(3) dopamine receptor in kidney. Hypertens Res (2011) 1.40
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex. Nat Struct Mol Biol (2012) 1.40
Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function. Hypertension (2002) 1.40
Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin. Hypertension (2004) 1.39
Pathophysiology and treatment of obesity hypertension. Curr Pharm Des (2004) 1.37
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain. Genome Res (2011) 1.35
Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury. Kidney Int (2011) 1.33
Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol (2013) 1.33
ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn (2013) 1.30
Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat Commun (2012) 1.30
Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study. Neuroimage (2010) 1.30
Control of blood pressure, appetite, and glucose by leptin in mice lacking leptin receptors in proopiomelanocortin neurons. Hypertension (2011) 1.30
The role of the sympathetic nervous system in obesity-related hypertension. Curr Hypertens Rep (2009) 1.29
Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation. Hypertension (2004) 1.29
Obstructive sleep apnea and risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies. Int J Cardiol (2013) 1.29
Comparative effectiveness of therapies for Graves' hyperthyroidism: a systematic review and network meta-analysis. J Clin Endocrinol Metab (2013) 1.29
Spontaneous scale-free structure in adaptive networks with synchronously dynamical linking. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 1.28
Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol (2014) 1.28
Racial and ethnic differences in blood pressure: biology and sociology. Circulation (2006) 1.27
microRNA-92a promotes lymph node metastasis of human esophageal squamous cell carcinoma via E-cadherin. J Biol Chem (2010) 1.27
An approach for identifying cytokines based on a novel ensemble classifier. Biomed Res Int (2013) 1.27
miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer. Gut (2012) 1.25
Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide. Nephrol Dial Transplant (2011) 1.24
Coherent temporal oscillations of macroscopic quantum states in a Josephson junction. Science (2002) 1.22
MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma. Biochem Biophys Res Commun (2012) 1.20
Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. J Pharm Biomed Anal (2009) 1.19
Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury. Am J Physiol Renal Physiol (2011) 1.19
Hypertension: physiology and pathophysiology. Compr Physiol (2012) 1.18
Chronic antidiabetic and cardiovascular actions of leptin: role of CNS and increased adrenergic activity. Am J Physiol Regul Integr Comp Physiol (2006) 1.18
Obesity-associated hypertension and kidney disease. Curr Opin Nephrol Hypertens (2003) 1.18
A systematic review of approaches for engaging patients for research on rare diseases. J Gen Intern Med (2014) 1.18
The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials (2002) 1.17
Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice. PLoS One (2012) 1.17
Cooperation and age structure in spatial games. Phys Rev E Stat Nonlin Soft Matter Phys (2012) 1.15
Crohn's disease in mainland China: a systematic analysis of 50 years of research. Chin J Dig Dis (2005) 1.15
Interface-confined ferrous centers for catalytic oxidation. Science (2010) 1.15
Integrin-mediated axoglial interactions initiate myelination in the central nervous system. J Cell Biol (2009) 1.15
Arabidopsis enhanced drought tolerance1/HOMEODOMAIN GLABROUS11 confers drought tolerance in transgenic rice without yield penalty. Plant Physiol (2013) 1.15
Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration. Hypertension (2003) 1.14
Impact of obesity on renal structure and function in the presence and absence of hypertension: evidence from melanocortin-4 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol (2009) 1.13