TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B.

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Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol (2002) 3.57

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Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest (2007) 2.42

Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab (2009) 2.27

Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17

Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood (2005) 2.17

Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism. J Virol (2006) 2.02

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell (2003) 1.79

Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest (2010) 1.66

Protein tyrosine phosphatases in the JAK/STAT pathway. Front Biosci (2008) 1.63

Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation. J Physiol (2006) 1.56

Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol Cell Biol (2004) 1.55

Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol (2004) 1.46

PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP. Mol Cell Biol (2003) 1.44

Signaling by STATs. Arthritis Res Ther (2004) 1.35

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell (2011) 1.34

Conformation-sensing antibodies stabilize the oxidized form of PTP1B and inhibit its phosphatase activity. Cell (2011) 1.34

Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol (2007) 1.34

Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling. Mol Cell Biol (2003) 1.32

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32

Biology and significance of the JAK/STAT signalling pathways. Growth Factors (2012) 1.29

Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production. Infect Immun (2006) 1.29

Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology (2006) 1.26

Alternative activation of tumor-associated macrophages by IL-4: priming for protumoral functions. Cell Cycle (2010) 1.22

Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol (2003) 1.22

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21

Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms. Am J Physiol Endocrinol Metab (2008) 1.16

Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. J Biol Chem (2008) 1.15

Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2. Biochemistry (2011) 1.13

Host cell signalling and leishmania mechanisms of evasion. J Trop Med (2011) 1.13

Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol (2009) 1.12

Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor. Mol Cell Biol (2006) 1.12

Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity. Invest Ophthalmol Vis Sci (2008) 1.10

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis. Diabetes (2010) 1.03

Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling. Proc Natl Acad Sci U S A (2006) 1.02

Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. Blood (2007) 1.02

Large-scale identification of disease genes involved in acute myeloid leukemia. J Virol (2004) 1.02

T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. Mol Cell Biol (2006) 1.02

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol (2012) 1.02

Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs). J Biol Chem (2012) 1.00

Adiponectin inhibits leptin signalling via multiple mechanisms to exert protective effects against hepatic fibrosis. Biochem J (2011) 0.99

Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1). Immunology (2009) 0.98

Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci (2013) 0.96

Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors. J Cancer (2011) 0.95

PTP1B suppresses prolactin activation of Stat5 in breast cancer cells. Am J Pathol (2010) 0.95

The molecular regulation of Janus kinase (JAK) activation. Biochem J (2014) 0.95

Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J Biol Chem (2011) 0.95

PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem (2010) 0.95

Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation. Proc Natl Acad Sci U S A (2014) 0.95

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. Biochem Biophys Res Commun (2005) 0.94

Identification of YB-1 as a regulator of PTP1B expression: implications for regulation of insulin and cytokine signaling. EMBO J (2003) 0.94

Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection. J Immunol (2011) 0.91

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor. Mol Metab (2014) 0.91

Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab (2012) 0.91

Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3. J Virol (2014) 0.91

Phosphatase inhibitor, sodium stibogluconate, in combination with interferon (IFN) alpha 2b: phase I trials to identify pharmacodynamic and clinical effects. Oncotarget (2011) 0.90

Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. Infect Immun (2010) 0.90

Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. Biochem J (2006) 0.90

The insulin receptor: both a prototypical and atypical receptor tyrosine kinase. Cold Spring Harb Perspect Biol (2013) 0.90

Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. Am J Physiol Endocrinol Metab (2011) 0.90

Control of metabolic and cardiovascular function by the leptin-brain melanocortin pathway. IUBMB Life (2013) 0.90

Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface. J Cell Sci (2011) 0.90

Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38. Biochem J (2004) 0.89

The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency. J Obes (2012) 0.89

C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal (2011) 0.89

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis. Cell Commun Signal (2014) 0.88

Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling. Proc Natl Acad Sci U S A (2009) 0.88

Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells. PLoS One (2013) 0.88

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge. Cell Death Dis (2014) 0.88

Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proc Natl Acad Sci U S A (2012) 0.87

New pharmacological perspectives for the leptin receptor in the treatment of obesity. Front Endocrinol (Lausanne) (2014) 0.86

PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol (2011) 0.85

Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin. Int J Obes (Lond) (2013) 0.85

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. Protein Sci (2002) 0.85

Innate immunity in pluripotent human cells: attenuated response to interferon-β. J Biol Chem (2013) 0.84

Protein-tyrosine phosphatases are involved in interferon resistance associated with insulin resistance in HepG2 cells and obese mice. J Biol Chem (2012) 0.84

CUEDC2 (CUE domain-containing 2) and SOCS3 (suppressors of cytokine signaling 3) cooperate to negatively regulate Janus kinase 1/signal transducers and activators of transcription 3 signaling. J Biol Chem (2011) 0.83

Endothelial cell PTP1B regulates leukocyte recruitment during allergic inflammation. Am J Physiol Lung Cell Mol Physiol (2012) 0.83

The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity. J Exp Med (2014) 0.83

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome. Oncotarget (2016) 0.82

Protein-tyrosine phosphatase 1B substrates and metabolic regulation. Semin Cell Dev Biol (2014) 0.82

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice. Diabetologia (2011) 0.82

Leptin therapy, insulin sensitivity, and glucose homeostasis. Indian J Endocrinol Metab (2012) 0.81

Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. J Biol Chem (2014) 0.81

Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm. J Cell Mol Med (2013) 0.81

Protein tyrosine phosphatase 1B participates in the down-regulation of erythropoietin receptor signalling. Biochem J (2004) 0.80

Differential expression of proteins in naïve and IL-2 stimulated primary human NK cells identified by global proteomic analysis. J Proteomics (2013) 0.80

Protein tyrosine phosphatases as wardens of STAT signaling. JAKSTAT (2014) 0.80

The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity. Mol Cell Biol (2013) 0.80

Organization of F-actin via concerted regulation of Kette by PTP61F and dAbl. Mol Cell Biol (2009) 0.79

Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase. J Biol Chem (2015) 0.79

Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease. Sci Rep (2016) 0.78

Liraglutide, leptin and their combined effects on feeding: additive intake reduction through common intracellular signalling mechanisms. Diabetes Obes Metab (2015) 0.78

The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development. Immunology (2009) 0.78

Involvement of phosphatases in proliferation, maturation, and hemoglobinization of developing erythroid cells. J Signal Transduct (2011) 0.78

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature (1990) 7.94

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84

The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98

Tissue- and species-specific expression of sp56, a mouse sperm fertilization protein. Science (1995) 6.56

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The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J (1998) 5.61

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Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science (1990) 4.36

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A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell (1994) 4.05

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The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med (1995) 3.86

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Failed intubation and failed oxygenation in a child. Anaesth Intensive Care (2012) 2.16

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