Published in Br J Cancer on July 16, 2013
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
Real-time measurements of amino acid and protein hydroperoxides using coumarin boronic acid. J Biol Chem (2014) 0.82
The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J (2016) 0.78
Targeting Cancer Metabolism - Revisiting the Warburg Effects. Toxicol Res (2016) 0.77
Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells. J Bioenerg Biomembr (2015) 0.77
Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta (2016) 0.76
Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration. J Bioenerg Biomembr (2015) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32
Glycolysis inhibition for anticancer treatment. Oncogene (2006) 6.55
Energy metabolism in tumor cells. FEBS J (2007) 5.16
Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 2.35
The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res (1998) 2.00
Guidelines for topical photodynamic therapy: update. Br J Dermatol (2008) 1.96
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer (2008) 1.55
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J (2009) 1.45
2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radic Biol Med (2007) 1.40
Glycolytic enzyme inhibitors in cancer treatment. Expert Opin Investig Drugs (2008) 1.28
3-Bromopyruvate: targets and outcomes. J Bioenerg Biomembr (2012) 1.27
Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore. Oncogene (1999) 1.26
A molecular view on signal transduction by the apoptosome. Cell Signal (2012) 1.23
Photodynamic therapy of tumors can lead to development of systemic antigen-specific immune response. PLoS One (2010) 1.12
Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Lett (2012) 1.08
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. PLoS One (2011) 1.06
Combination of photodynamic therapy with anti-cancer agents. Curr Med Chem (2008) 1.02
Mitochondrial dysfunction and cancer metastasis. J Bioenerg Biomembr (2012) 1.00
Altered energy metabolism in cancer: a unique opportunity for therapeutic intervention. Cancer Biol Ther (2012) 1.00
2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene (2011) 0.97
Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA. J Bioenerg Biomembr (2008) 0.97
Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro. J Cancer Res Ther (2009) 0.96
5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochem Photobiol (2001) 0.94
Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. Biochem Pharmacol (2011) 0.91
Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Rev Urol (2005) 0.90
Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment. Biochim Biophys Acta (2012) 0.89
Glycolytic pyruvate regulates P-Glycoprotein expression in multicellular tumor spheroids via modulation of the intracellular redox state. J Cell Biochem (2010) 0.87
5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase. Mol Cancer (2010) 0.87
Mitochondrial redox signaling and cancer invasiveness. J Bioenerg Biomembr (2012) 0.86
Failure of 2-deoxy-D-glucose in the treatment of experimental cutaneous and genital infections due to herpes simplex virus. J Infect Dis (1982) 0.84
Targeting the latest hallmark of cancer: another attempt at 'magic bullet' drugs targeting cancers' metabolic phenotype. Future Oncol (2012) 0.84
Bystander effects in cell death induced by photodynamic treatment UVA radiation and inhibitors of ATP synthesis. Photochem Photobiol (2001) 0.83
Apoptosis induction by different pathways with methylene blue derivative and light from mitochondrial sites in V79 cells. Int J Cancer (1998) 0.83
Glutamine depletion and glucose depletion trigger growth inhibition via distinctive gene expression reprogramming. Cell Cycle (2012) 0.83
How mainstream medicine sees photodynamic therapy in the United Kingdom. J Natl Compr Canc Netw (2012) 0.81
Single- and multiple dose pharmacokinetics of lonidamine in patients suffering from non-small-cell lung cancer. Arzneimittelforschung (1991) 0.80
Glucose is required to maintain high ATP-levels for the energy-utilizing steps during PDT-induced apoptosis. Photochem Photobiol (2002) 0.80
Combined chemotherapy and ALA-based photodynamic therapy in leukemic murine cells. Leuk Res (2012) 0.79
Effects of the inhibitors of energy metabolism, lonidamine and levamisole, on 5-aminolevulinic-acid-induced photochemotherapy. Int J Cancer (1996) 0.79
Correlation of death modes of photosensitized cells with intracellular ATP concentration. FEBS Lett (2003) 0.77
Midwife managed delivery unit: a randomised controlled comparison with consultant led care. BMJ (1994) 4.23
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol (1988) 4.20
Phytic acid and nutritional rickets in immigrants. Lancet (1972) 3.17
cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature (1993) 2.96
Expression of a polypeptide containing a dipeptide repeat is confined to the insect stage of Trypanosoma brucei. Nature (1987) 2.86
BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports. J Med Genet (2008) 2.79
Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature (1995) 2.78
A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med (1997) 2.76
The small subunit of HL-A antigens is beta 2-microglobulin. J Exp Med (1973) 2.68
Fire on an intensive care unit caused by an oxygen cylinder. Anaesthesia (2012) 2.61
Modulation of cytokine production by transforming growth factor-beta. J Immunol (1989) 2.42
The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J (1997) 2.34
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha. Clin Exp Immunol (1988) 2.06
Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol (2001) 2.03
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. Eur J Immunol (1990) 2.01
The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. Proc Natl Acad Sci U S A (1999) 1.98
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha. Eur J Immunol (1991) 1.87
Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene (1996) 1.77
The efficiency of multilocus DNA fingerprint probes for individualization and establishment of family relationships, determined from extensive casework. Am J Hum Genet (1991) 1.76
Neuropsychological dysfunction following repeat concussions in jockeys. J Neurol Neurosurg Psychiatry (2006) 1.71
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Dev Biol (2000) 1.61
Cytokine production in the rheumatoid joint: implications for treatment. Ann Rheum Dis (1990) 1.61
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56
Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr (1991) 1.55
Vasa previa: an avoidable obstetric tragedy. Obstet Gynecol Surv (1999) 1.55
New variant Creutzfeldt-Jakob disease: psychiatric features. Lancet (1997) 1.55
A randomized trial comparing heater probe plus thrombin with heater probe plus placebo for bleeding peptic ulcer. Gastroenterology (2003) 1.54
Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol (1997) 1.53
Schistosoma mekongi sp. n. from man and animals, compared with four geographic strains of Schistosoma japonicum. J Parasitol (1978) 1.52
Reducing the risk of retained throat packs after surgery. Br J Oral Maxillofac Surg (2012) 1.48
2.9 A resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei. J Mol Biol (1990) 1.48
Phase I/II study of vaccination with dendritic-like leukaemia cells for the immunotherapy of acute myeloid leukaemia. Br J Haematol (2006) 1.48
Two magnetoreception pathways in a migratory salamander. Science (1986) 1.45
Ulnar 'dive' identification of the median nerve in the forearm. Anaesthesia (2014) 1.45
Patent foramen ovale and decompression illness in divers. Lancet (1996) 1.44
Reduced anisotropy of action potential conduction in left ventricular hypertrophy. J Cardiovasc Electrophysiol (2001) 1.43
TAP blocks in breast reconstructions using abdominal wall tissue. Anaesthesia (2011) 1.41
Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein. Proc Natl Acad Sci U S A (1990) 1.40
Modeling of treatment response to erythropoiesis-stimulating agents as a function of center- and patient-related variables: results from the Anemia Cancer Treatment (ACT) study. Ann Oncol (2009) 1.39
A simple technique to control the hair and enhance draping for major head and neck surgery. Br J Oral Maxillofac Surg (2011) 1.38
Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Blood (1999) 1.35
Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies. Lancet (1988) 1.35
Variant specific glycoprotein of Trypanosoma brucei consists of two domains each having an independently conserved pattern of cysteine residues. J Mol Biol (1991) 1.31
Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol (1998) 1.28
Optimal mechanisms for finding and selecting mates: how threespine stickleback ( Gasterosteus aculeatus) should encode male throat colors. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2004) 1.27
zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly. Dev Cell (2001) 1.27
Continuing medical education using clinical algorithms. A controlled-trial assessment of effect on neonatal care. Am J Dis Child (1986) 1.26
CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity (1998) 1.25
Functional interactions between tumor and peripheral nerve: changes in excitability and morphology of primary afferent fibers in a murine model of cancer pain. J Neurosci (2001) 1.24
Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med (2001) 1.23
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7 TeV. Phys Rev Lett (2012) 1.23
Long-term hospitalization for tuberculosis control. Experience with a medical-psychosocial inpatient unit. JAMA (1997) 1.22
p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. J Clin Pathol (2003) 1.22
Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures. Clin Exp Immunol (1990) 1.21
Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. J Biol Chem (1999) 1.21
Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm: HMG-CoA reductase inhibitors, alpha-tocopherol, red yeast rice, and olive oil polyphenols. A review of the literature. Altern Med Rev (2001) 1.19
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV. Phys Rev Lett (2012) 1.19
Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76 TeV. Phys Rev Lett (2012) 1.19
Susceptibility and comparative pathology of ten species of primates exposed to infection with Schistosoma mansoni. Am J Trop Med Hyg (1966) 1.18
An analysis of injuries resulting from professional horse racing in France during 1991-2001: a comparison with injuries resulting from professional horse racing in Great Britain during 1992-2001. Br J Sports Med (2006) 1.17
Toxic effects following ingestion of C-4 plastic explosive. Arch Intern Med (1969) 1.16
Aneurysms of the portal vein and superior mesenteric vein. Abdom Imaging (1997) 1.14
Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6. Clin Exp Immunol (1989) 1.13
Observations on the pathogenesis of the pneumonitis associated with severe infections in other parts of the body. Ann Surg (1968) 1.13
Cannabinoids attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms. Pain (2001) 1.12
The usual medical care for irritable bowel syndrome. Aliment Pharmacol Ther (2004) 1.11
The release of prion protein from platelets during storage of apheresis platelets. Transfusion (2001) 1.11
The cellular and humoral immune response to Schistosoma mansoni infections in inbred rats. I. Mechanisms during initial exposure. Cell Immunol (1975) 1.11
A comparison of the responses of staphylococci and streptococci to teicoplanin and vancomycin. J Antimicrob Chemother (1987) 1.11
Extraocular magnetic compass in newts. Nature (1999) 1.11
Search for a W' or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7 TeV. Phys Rev Lett (2012) 1.10
Anthrax in humans in Zimbabwe. Cent Afr J Med (1980) 1.10
Sun safety: avoiding noonday sun, wearing protective clothing, and the use of sunscreen. J Natl Cancer Inst (1998) 1.09
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy. Phys Rev Lett (2012) 1.09
The United Kingdom Primary Immune Deficiency (UKPID) Registry: report of the first 4 years' activity 2008-2012. Clin Exp Immunol (2014) 1.08
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus. J Assoc Physicians India (2005) 1.08
Identification and characterization of cDNA clones encoding antigens of Eimeria tenella. Mol Biochem Parasitol (1988) 1.08
Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur J Immunol (1999) 1.08
MRI cisternography, and the localization of CSF fistulae. Br J Neurosurg (1994) 1.08
Application of a time-resolved fluoroimmunoassay for the analysis of normal prion protein in human blood and its components. Vox Sang (1999) 1.08
Pyridoxine dependent seizures--a wider clinical spectrum. Arch Dis Child (1983) 1.08
Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J (2000) 1.08
Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structures. Nature (1987) 1.07
Recommendations for patients with chronic respiratory disease considering air travel: a statement from the Canadian Thoracic Society. Can Respir J (1998) 1.06
Measurement of the Υ1S, Υ2S, and Υ3S polarizations in pp collisions at sqrt[s] = 7 TeV. Phys Rev Lett (2013) 1.05
Schistosomiasis mansoni in the chimpanzee: parasitologic, clinical, serologic, pathologic and radiologic observations. Am J Trop Med Hyg (1966) 1.04
Postnatal depression and elation among mothers and their partners: prevalence and predictors. Br J Psychiatry (1997) 1.04
Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta. Eur J Immunol (1989) 1.03
Cytokine assays: role in evaluation of the pathogenesis of autoimmunity. Immunol Rev (1991) 1.03
Community outbreak of adenovirus type 7a infections associated with a swimming pool. South Med J (1987) 1.02
6 A-resolution X-ray structure of a variable surface glycoprotein from Trypanosoma brucei. Nature (1984) 1.00
Hepatitis C: epidemiology and review of complementary/alternative medicine treatments. Altern Med Rev (1999) 0.99
Olfactory cues perceived at the home loft are not essential for the formation of a navigational map in pigeons. J Exp Biol (1991) 0.98
Characterization of non-neuronal elements within fibronectin mats implanted into the damaged adult rat spinal cord. Biomaterials (2005) 0.98
When to close a patent foramen ovale. Arch Dis Child (2007) 0.98
Biosynthesis of Trypanosoma brucei variant surface glycoproteins - analysis of carbohydrate heterogeneity and timing of post-translational modifications. Mol Biochem Parasitol (1983) 0.98
Handshaking, gender, personality, and first impressions. J Pers Soc Psychol (2000) 0.98
Point for doctors. Nurs Times (1977) 0.98
Career-ending injuries to professional jockeys in British horse racing (1991-2005). Br J Sports Med (2007) 0.98
Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis. Clin Exp Rheumatol (2007) 0.98