Published in Sci Signal on July 23, 2013
High-sensitivity measurements of multiple kinase activities in live single cells. Cell (2014) 1.76
Frequency modulation of ERK activation dynamics rewires cell fate. Mol Syst Biol (2015) 1.11
Optimization of ERK activity biosensors for both ratiometric and lifetime FRET measurements. Sensors (Basel) (2014) 0.99
Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell Adh Migr (2014) 0.98
ERK as a model for systems biology of enzyme kinetics in cells. Curr Biol (2013) 0.94
A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells. PLoS One (2013) 0.92
A new genetically encoded single-chain biosensor for Cdc42 based on FRET, useful for live-cell imaging. PLoS One (2014) 0.90
Toward understanding RhoGTPase specificity: structure, function and local activation. Small GTPases (2014) 0.89
A growth factor-induced, spatially organizing cytoskeletal module enables rapid and persistent fibroblast migration. Dev Cell (2014) 0.88
Biophysical Tools for Cellular and Subcellular Mechanical Actuation of Cell Signaling. Biophys J (2016) 0.86
Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. Sci Rep (2015) 0.83
Engineering genetically encoded FRET sensors. Sensors (Basel) (2014) 0.82
CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget (2016) 0.81
Visualising apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time. J Biophotonics (2016) 0.80
Visualizing and manipulating temporal signaling dynamics with fluorescence-based tools. Sci Signal (2014) 0.80
Development of FRET biosensors for mammalian and plant systems. Protoplasma (2013) 0.79
Dynamic single cell measurements of kinase activity by synthetic kinase activity relocation sensors. BMC Biol (2015) 0.79
Fluorescent Protein Based FRET Pairs with Improved Dynamic Range for Fluorescence Lifetime Measurements. PLoS One (2015) 0.79
Endothelial cell-cell adhesion during zebrafish vascular development. Cell Adh Migr (2014) 0.79
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration. Oncotarget (2016) 0.78
Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT). Proc Natl Acad Sci U S A (2016) 0.78
Fluorescent protein biosensors applied to microphysiological systems. Exp Biol Med (Maywood) (2015) 0.78
Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics. Sci Rep (2016) 0.78
Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation. Mediators Inflamm (2015) 0.78
Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. J Cell Biol (2016) 0.76
Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway. Proc Natl Acad Sci U S A (2016) 0.76
Biosensor architectures for high-fidelity reporting of cellular signaling. Biophys J (2014) 0.75
CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma. Cancer Cell Int (2016) 0.75
Mitochondrial Ca(2+) uptake controls actin cytoskeleton dynamics during cell migration. Sci Rep (2016) 0.75
PAK4 suppresses PDZ-RhoGEF activity to drive invadopodia maturation in melanoma cells. Oncotarget (2016) 0.75
Multiplexing PKA and ERK1&2 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM. Sci Rep (2017) 0.75
Large Scale Bacterial Colony Screening of Diversified FRET Biosensors. PLoS One (2015) 0.75
Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev (2016) 0.75
The dynamics of spatio-temporal Rho GTPase signaling: formation of signaling patterns. F1000Res (2016) 0.75
Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor. Mol Pharmacol (2017) 0.75
FRAP, FLIM, and FRET: Detection and analysis of cellular dynamics on a molecular scale using fluorescence microscopy. Mol Reprod Dev (2015) 0.75
A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity. Curr Protoc Cell Biol (2014) 0.75
Live-cell imaging: new avenues to investigate retinal regeneration. Neural Regen Res (2017) 0.75
Characterization of a spectrally diverse set of fluorescent proteins as FRET acceptors for mTurquoise2. Sci Rep (2017) 0.75
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15
Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods (2008) 4.13
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation. J Cell Biol (2009) 2.90
Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nat Genet (2009) 2.23
A comparison of donor-acceptor pairs for genetically encoded FRET sensors: application to the Epac cAMP sensor as an example. PLoS One (2008) 2.23
A transcriptional network in polycystic kidney disease. EMBO J (2004) 2.21
Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia. Blood (2009) 2.11
Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis. Curr Biol (2002) 2.06
Integrins control motile strategy through a Rho-cofilin pathway. J Cell Biol (2005) 2.04
Cell motility and cytoskeletal regulation in invasion and metastasis. J Mammary Gland Biol Neoplasia (2007) 2.03
Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis. Sci Transl Med (2012) 2.02
MicroRNA-24 regulates vascularity after myocardial infarction. Circulation (2011) 1.98
Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafish. Circ Res (2007) 1.95
Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. Hum Mutat (2009) 1.90
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proc Natl Acad Sci U S A (2006) 1.89
Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell (2011) 1.86
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
Development of the zebrafish lymphatic system requires VEGFC signaling. Curr Biol (2006) 1.78
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Early endocardial morphogenesis requires Scl/Tal1. PLoS Genet (2007) 1.73
Female extrapair mating behavior can evolve via indirect selection on males. Proc Natl Acad Sci U S A (2011) 1.70
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape. Immunity (2005) 1.64
Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Circulation (2012) 1.60
Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans. Nat Genet (2009) 1.59
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J (2013) 1.58
Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk. Development (2010) 1.57
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries. Development (2009) 1.51
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen. Proc Natl Acad Sci U S A (2012) 1.50
Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development (2002) 1.50
ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish. Hum Mol Genet (2008) 1.47
Zebrafish development and regeneration: new tools for biomedical research. Int J Dev Biol (2009) 1.46
Zebrafish VEGF receptors: a guideline to nomenclature. PLoS Genet (2008) 1.46
Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev (2007) 1.45
Flt1 acts as a negative regulator of tip cell formation and branching morphogenesis in the zebrafish embryo. Development (2011) 1.44
Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling. Development (2009) 1.42
Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development (2008) 1.42
Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: changes in mobility, conformation and mapping of contact regions. J Mol Biol (2002) 1.40
CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo. Circ Res (2011) 1.39
LRRC50, a conserved ciliary protein implicated in polycystic kidney disease. J Am Soc Nephrol (2008) 1.38
Dendra2 photoswitching through the Mammary Imaging Window. J Vis Exp (2009) 1.36
Intravital microscopy: new insights into metastasis of tumors. J Cell Sci (2011) 1.36
Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol (2010) 1.35
8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem (2008) 1.32
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev (2004) 1.30
Rapid BAC selection for tol2-mediated transgenesis in zebrafish. Development (2011) 1.27
Regulation of connexin43 gap junctional communication by phosphatidylinositol 4,5-bisphosphate. J Cell Biol (2007) 1.25
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation. EMBO J (2005) 1.23
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22
Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell (2007) 1.22
Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods Cell Biol (2008) 1.20
Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Dev Cell (2008) 1.20
Surgical implantation of an abdominal imaging window for intravital microscopy. Nat Protoc (2013) 1.19
Intravital imaging of fluorescent markers and FRET probes by DNA tattooing. BMC Biotechnol (2007) 1.19
Direct spatial control of Epac1 by cyclic AMP. Mol Cell Biol (2009) 1.17
miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo. Mol Cell Biol (2010) 1.15
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. Am J Hum Genet (2012) 1.10
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J (2012) 1.09
Intravital imaging of cancer stem cell plasticity in mammary tumors. Stem Cells (2013) 1.07
A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Hum Mol Genet (2010) 1.05
Zebrafish neuropilins are differentially expressed and interact with vascular endothelial growth factor during embryonic vascular development. Dev Dyn (2004) 1.04
GSK-3 is activated by the tyrosine kinase Pyk2 during LPA1-mediated neurite retraction. Mol Biol Cell (2006) 1.04
Mutation in vascular endothelial growth factor-C, a ligand for vascular endothelial growth factor receptor-3, is associated with autosomal dominant milroy-like primary lymphedema. Circ Res (2013) 1.03
von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish. Dis Model Mech (2010) 1.03
Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy. PLoS One (2013) 1.03
Apelin enhances cardiac neovascularization after myocardial infarction by recruiting aplnr+ circulating cells. Circ Res (2012) 1.02
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development (2014) 1.02
Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria. RNA (2008) 1.01
Not all bones are created equal - using zebrafish and other teleost species in osteogenesis research. Methods Cell Biol (2011) 1.00
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. J Biol Chem (2005) 1.00
Control of endothelial sprouting by a Tel-CtBP complex. Nat Cell Biol (2010) 0.99
Growth promoting signaling by tenascin-C [corrected]. Cancer Res (2004) 0.99
Functional proteometrics for cell migration. Cytometry A (2006) 0.99
Chirped arrays of refractive ellipsoidal microlenses for aberration correction under oblique incidence. Opt Express (2005) 0.99
The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein. Dev Biol (2003) 0.99
Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (2014) 0.98
Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Mol Cell Biol (2010) 0.98
E-cadherin is a ligand for integrin alpha2beta1. Matrix Biol (2002) 0.96
Growth cone MKK7 mRNA targeting regulates MAP1b-dependent microtubule bundling to control neurite elongation. PLoS Biol (2012) 0.96
A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol (2006) 0.96
Structure/function relationships in the minicollagen of Hydra nematocysts. J Biol Chem (2002) 0.96
Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method. Dev Dyn (2004) 0.95
p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells. Exp Cell Res (2009) 0.95
Two distinct filopodia populations at the growth cone allow to sense nanotopographical extracellular matrix cues to guide neurite outgrowth. PLoS One (2010) 0.95
Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering. Mol Biol Cell (2009) 0.94