PubRank

Bengt Fadeel

Author PubWeight™ 102.60‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nat Genet 2006 3.03
2 Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol 2010 2.26
3 Late-onset neutropenia following rituximab therapy in rheumatic diseases: association with B lymphocyte depletion and infections. Arthritis Rheum 2011 2.06
4 Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release. Part Fibre Toxicol 2014 1.77
5 A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol 2002 1.56
6 Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation. Biochim Biophys Acta 2010 1.48
7 Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicol Appl Pharmacol 2012 1.45
8 Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes. Blood 2005 1.44
9 Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PLoS One 2012 1.41
10 Macrophage clearance of neutrophil extracellular traps is a silent process. J Immunol 2013 1.37
11 Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice. PLoS One 2012 1.32
12 Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems. Annu Rev Pharmacol Toxicol 2010 1.27
13 Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS. Ann Neurol 2004 1.26
14 Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos. Part Fibre Toxicol 2012 1.21
15 Involvement of a functional NADPH oxidase in neutrophils and macrophages during programmed cell clearance: implications for chronic granulomatous disease. Am J Physiol Cell Physiol 2009 1.16
16 Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells. Toxicol Appl Pharmacol 2011 1.16
17 Phosphatidylserine targets single-walled carbon nanotubes to professional phagocytes in vitro and in vivo. PLoS One 2009 1.16
18 NADPH oxidase-dependent oxidation and externalization of phosphatidylserine during apoptosis in Me2SO-differentiated HL-60 cells. Role in phagocytic clearance. J Biol Chem 2002 1.12
19 Lipid antioxidant, etoposide, inhibits phosphatidylserine externalization and macrophage clearance of apoptotic cells by preventing phosphatidylserine oxidation. J Biol Chem 2003 1.12
20 Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure. ACS Nano 2011 1.11
21 Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors. Blood 2002 1.07
22 Safety assessment of nanomaterials: implications for nanomedicine. J Control Release 2012 1.07
23 Classification framework for graphene-based materials. Angew Chem Int Ed Engl 2014 1.06
24 Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation. J Biol Chem 2007 1.04
25 Adsorption of surfactant lipids by single-walled carbon nanotubes in mouse lung upon pharyngeal aspiration. ACS Nano 2012 1.04
26 Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential. Toxicology 2012 1.02
27 Gene expression profiling of immune-competent human cells exposed to engineered zinc oxide or titanium dioxide nanoparticles. PLoS One 2013 1.02
28 Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase. Small 2013 1.01
29 Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations. Pediatr Blood Cancer 2010 1.01
30 Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials. Acc Chem Res 2012 1.01
31 Microsomal glutathione transferase 1 protects against toxicity induced by silica nanoparticles but not by zinc oxide nanoparticles. ACS Nano 2012 0.98
32 Compound heterozygous HAX1 mutations in a Swedish patient with severe congenital neutropenia and no neurodevelopmental abnormalities. Pediatr Blood Cancer 2009 0.98
33 Induction of caspase- and reactive oxygen species-independent phosphatidylserine externalization in primary human neutrophils: role in macrophage recognition and engulfment. J Leukoc Biol 2008 0.98
34 Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes. ACS Nano 2011 0.97
35 Plasma membrane sequestration of apoptotic protease-activating factor-1 in human B-lymphoma cells: a novel mechanism of chemoresistance. Blood 2005 0.97
36 Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro. Cell Biochem Biophys 2013 0.95
37 The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells. Mol Immunol 2010 0.95
38 Neutrophil elastase and granulocyte colony-stimulating factor receptor mutation analyses and leukemia evolution in severe congenital neutropenia patients belonging to the original Kostmann family in northern Sweden. Haematologica 2006 0.95
39 Late-onset neutropenia associated with rituximab therapy: evidence for a maturation arrest at the (pro)myelocyte stage of granulopoiesis. Med Oncol 2008 0.95
40 Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D. Blood 2011 0.95
41 Mapping the surface adsorption forces of nanomaterials in biological systems. ACS Nano 2011 0.95
42 Broaden the discussion. Nat Nanotechnol 2013 0.94
43 Mechanisms of carbon nanotube-induced toxicity: focus on pulmonary inflammation. Adv Drug Deliv Rev 2013 0.94
44 Incidence of Langerhans cell histiocytosis in children: a population-based study. Pediatr Blood Cancer 2008 0.94
45 Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells. Blood 2004 0.93
46 VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice. Biochem Biophys Res Commun 2007 0.93
47 Efficient internalization of mesoporous silica particles of different sizes by primary human macrophages without impairment of macrophage clearance of apoptotic or antibody-opsonized target cells. Toxicol Appl Pharmacol 2009 0.92
48 Water-soluble superparamagnetic magnetite nanoparticles with biocompatible coating for enhanced magnetic resonance imaging. ACS Nano 2011 0.92
49 Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Haematologica 2009 0.91
50 Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations. Clin Cancer Res 2005 0.90
51 In search of the Holy Grail: Folate-targeted nanoparticles for cancer therapy. Biochem Pharmacol 2011 0.90
52 Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice. Cancer Res 2007 0.90
53 Kostmann syndrome or infantile genetic agranulocytosis, part two: Understanding the underlying genetic defects in severe congenital neutropenia. Acta Paediatr 2007 0.90
54 Solution-engineered palladium nanoparticles: model for health effect studies of automotive particulate pollution. ACS Nano 2011 0.90
55 An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. Blood 2004 0.90
56 Interactions of engineered nanoparticles with organs protected by internal biological barriers. Small 2012 0.89
57 Langerhans-cell histiocytosis: neoplasia or unbridled inflammation? Trends Immunol 2003 0.89
58 Syntaxin-11 is expressed in primary human monocytes/macrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG-opsonized target cells. Br J Haematol 2008 0.88
59 Kostmann syndrome or infantile genetic agranulocytosis, part one: celebrating 50 years of clinical and basic research on severe congenital neutropenia. Acta Paediatr 2006 0.88
60 MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters: implications for nephrogenesis and the development of renal cancer. PLoS One 2012 0.87
61 Stromal-derived factor-1 abolishes constitutive apoptosis of WHIM syndrome neutrophils harbouring a truncating CXCR4 mutation. Br J Haematol 2006 0.87
62 Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition. Cancer Lett 2012 0.86
63 Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells. Small 2012 0.85
64 Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes. Nanoscale 2014 0.84
65 Fantastic voyage and opportunities of engineered nanomaterials: what are the potential risks of occupational exposures? J Occup Environ Med 2010 0.84
66 Fas-triggered phosphatidylserine exposure is modulated by intracellular ATP. FEBS Lett 2002 0.84
67 Fat(al) attraction: oxidized lipids act as "eat-me" signals. HFSP J 2007 0.83
68 Combined spectral karyotyping, comparative genomic hybridization, and in vitro apoptyping of a panel of Burkitt's lymphoma-derived B cell lines reveals an unexpected complexity of chromosomal aberrations and a recurrence of specific abnormalities in chemoresistant cell lines. Int J Oncol 2006 0.83
69 Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses. Inhal Toxicol 2009 0.83
70 Epstein-Barr virus-encoded latent membrane protein 1 promotes stress-induced apoptosis upstream of caspase-2-dependent mitochondrial perturbation. Int J Cancer 2005 0.83
71 Epstein-Barr virus-encoded LMP1 promotes cisplatin-induced caspase activation through JNK and NF-kappaB signaling pathways. Biochem Biophys Res Commun 2007 0.83
72 Extracellular entrapment and degradation of single-walled carbon nanotubes. Nanoscale 2014 0.83
73 Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines. Part Fibre Toxicol 2014 0.83
74 Differentiation-promoting culture of competent and noncompetent keratinocytes identifies biomarkers for head and neck cancer. Am J Pathol 2011 0.82
75 NanoMiner - integrative human transcriptomics data resource for nanoparticle research. PLoS One 2013 0.82
76 Apoptosis modulation of Epstein-Barr virus-encoded latent membrane protein 1 in the epithelial cell line HeLa is stimulus-dependent. Virology 2002 0.82
77 Incidence of severe congenital neutropenia in Sweden and risk of evolution to myelodysplastic syndrome/leukaemia. Br J Haematol 2012 0.81
78 Elevated serum levels of the decoy receptor osteoprotegerin in children with Langerhans cell histiocytosis. Pediatr Res 2006 0.81
79 Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia. Br J Haematol 2007 0.81
80 Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid. Toxicol Lett 2013 0.80
81 AIF and Scythe (Bat3) regulate phosphatidylserine exposure and macrophage clearance of cells undergoing Fas (APO-1)-mediated apoptosis. PLoS One 2012 0.80
82 N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1. J Biol Chem 2009 0.80
83 Graphene oxide attenuates Th2-type immune responses, but augments airway remodeling and hyperresponsiveness in a murine model of asthma. ACS Nano 2014 0.80
84 Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii. Part Fibre Toxicol 2012 0.80
85 Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines. Int J Cancer 2006 0.79
86 Vitamin D fails to prevent serum starvation- or staurosporine-induced apoptosis in human and rat osteosarcoma-derived cell lines. Biochem Biophys Res Commun 2005 0.79
87 Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers. Biomaterials 2011 0.79
88 Nanotoxicology: no small matter. Nanoscale 2010 0.78
89 Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis. Hum Genet 2002 0.78
90 Requirement of apoptotic protease-activating factor-1 for bortezomib-induced apoptosis but not for Fas-mediated apoptosis in human leukemic cells. Mol Pharmacol 2012 0.78
91 Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis. J Pediatr Hematol Oncol 2005 0.78
92 Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis. FEBS Lett 2012 0.78
93 Cytotoxic and Pro-inflammatory Effects of Metal-based Nanoparticles on THP-1 Monocytes Characterized by Combined Proteomics Approaches. J Proteome Res 2016 0.78
94 Ovarian failure in HAX1-deficient patients: is there a gender-specific difference in pubertal development in severe congenital neutropenia or Kostmann disease? Acta Paediatr 2013 0.77
95 Bortezomib and IL-12 produce synergetic anti-multiple myeloma effects with reduced toxicity to natural killer cells. Anticancer Drugs 2014 0.77
96 Brief cross-linking of Fas/APO-1 (CD95) triggers engulfment of pre-apoptotic target cells. FEBS Lett 2008 0.77
97 Phosphatidylserine externalization in cardiolipin-deficient cells. Blood 2004 0.76
98 Phosphatidylserine exposure in Fas type I cells is mitochondria-dependent. FEBS Lett 2003 0.76
99 Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells. ACS Nano 2014 0.76
100 The importance of size: nanomedicine for delivery of anticancer drugs in solid tumors. Nanomedicine (Lond) 2012 0.75
101 Perinatal nanomedicine: dendrimer-based therapy for neuroinflammatory disorders. Nanomedicine (Lond) 2012 0.75
102 Research highlights: Highlights from the last year in nanomedicine. Nanomedicine (Lond) 2014 0.75
103 DNA origami: self-assembled nucleic acid nanoparticles for siRNA delivery. Nanomedicine (Lond) 2012 0.75
104 "But many that are first shall be last; and the last shall be first". FASEB J 2009 0.75
105 Towards the clinic: intelligent design of nanomedicines for cancer treatment. Nanomedicine (Lond) 2012 0.75
106 Geoengineering: perilous particles. Science 2013 0.75
107 Trimodal imaging of brain tumors using multifunctional nanoparticles. Nanomedicine (Lond) 2012 0.75
108 Double de novo mutations of ELANE (ELA2) in a patient with severe congenital neutropenia requiring high-dose G-CSF therapy. Br J Haematol 2009 0.75
109 Retraction. Neutrophil elastase mutations in severe congenital neutropenia patients of the original Kostmann family. Blood 2003 0.75
110 VR-3848, a novel peptide derived from Euphobiaceae, induces mitochondria-dependent apoptosis in human leukemia cells. Cancer Lett 2004 0.75
111 Normal levels of constitutive and death receptor-mediated apoptosis of peripheral blood neutrophils from patients with chronic idiopathic neutropenia. Clin Immunol 2006 0.75
112 [Kostmann's syndrome largely elucidated--by Swedish research. 50 years since Rolf Kostmann's pioneering work on severe congenital neutropenia]. Lakartidningen 2006 0.75
113 Systems biology in nanosafety research. Nanomedicine (Lond) 2015 0.75
114 Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2008 0.75
115 Multiple inherited sequence variations in two disease-causing genes in familial haemophagocytic lymphohistiocytosis. Br J Haematol 2009 0.75
116 Meeting report: BBRC Symposium on Trends in Biochemistry and Biophysics. Biochem Biophys Res Commun 2015 0.75
117 Morphological properties of nanoporous folic acid materials and in vitro assessment of their biocompatibility. Nanomedicine (Lond) 2011 0.75