Published in J Biol Chem on July 10, 1975
Spectral differences between the alpha and beta heme groups within human deoxyhemoglobin. Proc Natl Acad Sci U S A (1976) 0.95
Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin. Free Radic Biol Med (2014) 0.90
Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate. J Biol Chem (2012) 0.90
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med (2015) 0.87
α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. J Biol Chem (2012) 0.87
Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin. J Biol Chem (2014) 0.86
Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10). J Biol Chem (2015) 0.86
Tetramer-dimer dissociation of carboxyhemoglobin in the absence of dithionite. Biophys J (1981) 0.85
Laser photolysis study of conformational change rates for hemoglobin in viscous solutions. Biophys J (1983) 0.85
Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia. Redox Biol (2016) 0.78
Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)). Protein Sci (2012) 0.75
Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36
Dexamethasone therapy for children with bacterial meningitis. Meningitis Study Group. Pediatrics (1995) 2.98
High-resolution crystal structures of distal histidine mutants of sperm whale myoglobin. J Mol Biol (1993) 2.37
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nat Biotechnol (1998) 2.35
Mapping the pathways for O2 entry into and exit from myoglobin. J Biol Chem (2000) 2.31
Structural determinants of the stretching frequency of CO bound to myoglobin. Biochemistry (1994) 2.18
Nitric-oxide dioxygenase activity and function of flavohemoglobins. sensitivity to nitric oxide and carbon monoxide inhibition. J Biol Chem (2000) 2.13
The mechanism of action of xanthine oxidase. J Biol Chem (1974) 2.07
Rates of ligand binding to periplasmic proteins involved in bacterial transport and chemotaxis. J Biol Chem (1983) 2.06
The rate of oxygen uptake by human red blood cells. J Biol Chem (1979) 2.00
His64(E7)-->Tyr apomyoglobin as a reagent for measuring rates of hemin dissociation. J Biol Chem (1994) 1.87
Frequency and properties of naturally occurring adherent piliated strains of Haemophilus influenzae type b. Infect Immun (1985) 1.81
The association rate constant for heme binding to globin is independent of protein structure. Biochemistry (1996) 1.77
The effects of amino acid substitution at position E7 (residue 64) on the kinetics of ligand binding to sperm whale myoglobin. J Biol Chem (1990) 1.76
A novel site-directed mutant of myoglobin with an unusually high O2 affinity and low autooxidation rate. J Biol Chem (1992) 1.73
Two hemoglobin genes in Arabidopsis thaliana: the evolutionary origins of leghemoglobins. Proc Natl Acad Sci U S A (1997) 1.73
The mechanism of autooxidation of myoglobin. J Biol Chem (1993) 1.71
The reaction of xanthine oxidase with molecular oxygen. J Biol Chem (1974) 1.70
Renal scarring following reflux and nonreflux pyelonephritis in children: evaluation with 99mtechnetium-dimercaptosuccinic acid scintigraphy. J Urol (1992) 1.61
Discrimination between oxygen and carbon monoxide and inhibition of autooxidation by myoglobin. Site-directed mutagenesis of the distal histidine. J Biol Chem (1989) 1.59
Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-controlled study. J Am Geriatr Soc (2000) 1.50
Distal pocket residues affect picosecond ligand recombination in myoglobin. An experimental and molecular dynamics study of position 29 mutants. J Biol Chem (1992) 1.49
Role of adherence in the pathogenesis of Haemophilus influenzae type b infection in infant rats. Infect Immun (1983) 1.49
Characterization of recombinant soybean leghemoglobin a and apolar distal histidine mutants. J Mol Biol (1997) 1.48
Rice hemoglobins. Gene cloning, analysis, and O2-binding kinetics of a recombinant protein synthesized in Escherichia coli. Plant Physiol (1997) 1.44
Functional aspects of the subunit association-dissociation equilibria of hemoglobin. J Biol Chem (1970) 1.42
Non-anthrax Bacillus infections in children. Pediatr Infect Dis J (1987) 1.42
Ligand binding to heme proteins. An evaluation of distal effects. J Biol Chem (1983) 1.42
Quaternary structure regulates hemin dissociation from human hemoglobin. J Biol Chem (1997) 1.39
Structural and functional effects of apolar mutations of the distal valine in myoglobin. J Mol Biol (1995) 1.37
Crystal structure of a nonsymbiotic plant hemoglobin. Structure (2000) 1.36
Kinetic studies of inducer binding to lac repressor.operator complex. J Biol Chem (1980) 1.35
The stability of holomyoglobin is determined by heme affinity. Biochemistry (1996) 1.33
The dissociation of the first oxygen molecule from some mammalian oxyhemoglobins. J Biol Chem (1971) 1.30
The effects of E7 and E11 mutations on the kinetics of ligand binding to R state human hemoglobin. J Biol Chem (1989) 1.29
The mechanism of sugar binding to the periplasmic receptor for galactose chemotaxis and transport in Escherichia coli. J Biol Chem (1980) 1.25
Stopped-flow, rapid mixing measurements of ligand binding to hemoglobin and red cells. Methods Enzymol (1981) 1.24
Spectral transitions of nitrosyl hemes during ligand binding to hemoglobin. J Biol Chem (1979) 1.23
Stability of myoglobin: a model for the folding of heme proteins. Biochemistry (1994) 1.23
Equilibrium binding of alkyl isocyanides to human hemoglobin. J Biol Chem (1980) 1.21
Steady-state and transient kinetics of Escherichia coli nitric-oxide dioxygenase (flavohemoglobin). The B10 tyrosine hydroxyl is essential for dioxygen binding and catalysis. J Biol Chem (2000) 1.20
Analysis of the kinetic barriers for ligand binding to sperm whale myoglobin using site-directed mutagenesis and laser photolysis techniques. J Biol Chem (1990) 1.19
Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase. J Biol Chem (1997) 1.18
Prediction of oxygen transport rates in blood flowing in large capillaries. Microvasc Res (1989) 1.17
Rate constants for O2 and CO binding to the alpha and beta subunits within the R and T states of human hemoglobin. J Biol Chem (1998) 1.17
Structure of myoglobin-ethyl isocyanide. Histidine as a swinging door for ligand entry. J Mol Biol (1989) 1.15
The role of Val68(E11) in ligand binding to sperm whale myoglobin. Site-directed mutagenesis of a synthetic gene. J Biol Chem (1990) 1.15
Treatment of intracranial abscesses associated with sinusitis in children and adolescents. J Pediatr (1988) 1.13
Nitric oxide myoglobin: crystal structure and analysis of ligand geometry. Proteins (1998) 1.11
Structural factors governing hemin dissociation from metmyoglobin. Biochemistry (1996) 1.10
The reaction of n-butyl isocyanide with human hemoglobin. II. The ligand-binding properties of the and chains within deoxyhemoglobin. J Biol Chem (1972) 1.10
Urinary interleukin-6 and interleukin-8 in children with urinary tract infection. Pediatr Nephrol (2000) 1.06
The reaction of n-butyl isocyanide with human hemoglobin. I. Determination of the kinetic parameters involved in the last step in ligand binding. J Biol Chem (1971) 1.05
Waterproofing the heme pocket. Role of proximal amino acid side chains in preventing hemin loss from myoglobin. J Biol Chem (2000) 1.05
A comparison of the geminate recombination kinetics of several monomeric heme proteins. J Biol Chem (1988) 1.03
A cyanobacterial hemoglobin with unusual ligand binding kinetics and stability properties. Biochemistry (1999) 1.03
Determination of the rate and equilibrium constants for oxygen and carbon monoxide binding to R-state human hemoglobin cross-linked between the alpha subunits at lysine 99. J Biol Chem (1991) 1.01
Transmembrane movement of heme. J Biol Chem (1990) 1.00
Antibiotic rashes in children: a survey in a private practice setting. Arch Dermatol (2000) 1.00
The reaction of reduced xanthine oxidase with oxygen. Kinetics of peroxide and superoxide formation. J Biol Chem (1981) 1.00
L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase. J Biol Chem (1994) 1.00
Alteration of axial coordination by protein engineering in myoglobin. Bisimidazole ligation in the His64-->Val/Val68-->His double mutant. J Biol Chem (1995) 0.99
Kinetics of ligand binding to Pseudoterranova decipiens and Ascaris suum hemoglobins and to Leu-29-->Tyr sperm whale myoglobin mutant. J Biol Chem (1993) 0.98
Chain equivalence in reaction of nitric oxide with hemoglobin. J Biol Chem (1977) 0.98
A quantitative description in three dimensions of oxygen uptake by human red blood cells. Biophys J (1984) 0.98
Solution and crystal structures of a sperm whale myoglobin triple mutant that mimics the sulfide-binding hemoglobin from Lucina pectinata. J Biol Chem (1998) 0.98
Thermodynamic analysis of the lactose repressor-operator DNA interaction. Biochemistry (1986) 0.97
Phe-46(CD4) orients the distal histidine for hydrogen bonding to bound ligands in sperm whale myoglobin. Proteins (1995) 0.96
Studies on ligand binding to hemoglobins from teleosts and elasmobranchs. J Biol Chem (1973) 0.96
Enhancement of recombinant hemoglobin production in Escherichia coli BL21(DE3) containing the Plesiomonas shigelloides heme transport system. Appl Environ Microbiol (2008) 0.96
Assignment of rate constants for O2 and CO binding to alpha and beta subunits within R- and T-state human hemoglobin. Methods Enzymol (1994) 0.95
Spectral differences between the alpha and beta heme groups within human deoxyhemoglobin. Proc Natl Acad Sci U S A (1976) 0.95
The kinetics of O2 release by human red blood cells in the presence of external sodium dithionite. J Biol Chem (1984) 0.95
The D-helix in myoglobin and in the beta subunit of hemoglobin is required for the retention of heme. Biochemistry (1995) 0.95
Functional effects of heme orientational disorder in sperm whale myoglobin. J Biol Chem (1987) 0.93
Mechanism of hydrogen cyanide binding to myoglobin. Biochemistry (1996) 0.93
The oxygen and carbon monoxide reactions of heme oxygenase. J Biol Chem (1998) 0.93
Distal pocket polarity in ligand binding to myoglobin: deoxy and carbonmonoxy forms of a threonine68(E11) mutant investigated by X-ray crystallography and infrared spectroscopy. Biochemistry (1993) 0.92
Reactions of sperm whale myoglobin with hydrogen peroxide. Effects of distal pocket mutations on the formation and stability of the ferryl intermediate. J Biol Chem (1999) 0.92
The stabilities of mammalian apomyoglobins vary over a 600-fold range and can be enhanced by comparative mutagenesis. J Biol Chem (2000) 0.92
Imidazole is a sensitive probe of steric hindrance in the distal pockets of oxygen-binding heme proteins. Biochemistry (1998) 0.92
Aerotolerant Clostridium tertium brain abscess following a lawn dart injury. J Clin Microbiol (1990) 0.92
Morphological and physiological factors affecting oxygen uptake and release by red blood cells. J Biol Chem (1984) 0.92
A kinetic description of ligand binding to sperm whale myoglobin. J Biol Chem (1986) 0.91
Effects of solvent composition and viscosity on the rates of CO binding to heme proteins. J Biol Chem (1981) 0.91
Disruption of the heme iron-proximal histidine bond requires unfolding of deoxymyoglobin. Biochemistry (1998) 0.91
Relationship among vesicoureteral reflux, P-fimbriated Escherichia coli, and acute pyelonephritis in children with febrile urinary tract infection. J Pediatr (1991) 0.91
High resolution crystal structures of the deoxy, oxy, and aquomet forms of cobalt myoglobin. J Biol Chem (1996) 0.90
Contributions of residue 45(CD3) and heme-6-propionate to the biomolecular and geminate recombination reactions of myoglobin. Biochemistry (1991) 0.90
Binding of inositol hexaphosphate to human methemoglobin. J Biol Chem (1976) 0.90
Nitric oxide recombination to double mutants of myoglobin: role of ligand diffusion in a fluctuating heme pocket. Biochemistry (1994) 0.90
Heme transfer between phospholipid membranes and uptake by apohemoglobin. J Biol Chem (1985) 0.89
Rates of isonitrile binding to the isolated alpha and beta subunits of human hemoglobin. J Biol Chem (1980) 0.89
Numerical analysis of kinetic ligand binding data. Methods Enzymol (1981) 0.89
Ligand diffusion in the distal heme pocket of myoglobin. A primary determinant of geminate rebinding. J Biol Chem (1993) 0.89
Prevalence and significance of cryptosporidiosis in children. Pediatr Infect Dis (1985) 0.88
Aggregation of deoxyhemoglobin subunits. J Biol Chem (1976) 0.88
A double mutant of sperm whale myoglobin mimics the structure and function of elephant myoglobin. J Biol Chem (1995) 0.88
The assignment of carbon monoxide association rate constants to the alpha and beta subunits in native and mutant human deoxyhemoglobin tetramers. J Biol Chem (1991) 0.88
Interaction of lac repressor with inducer, kinetic and equilibrium measurements. J Mol Biol (1977) 0.88