Published in Br J Pharmacol on January 01, 2014
Motivational activation: a unifying hypothesis of orexin/hypocretin function. Nat Neurosci (2014) 1.09
Orexin/hypocretin receptor signalling: a functional perspective. Br J Pharmacol (2014) 0.92
Orexin/hypocretin role in reward: implications for opioid and other addictions. Br J Pharmacol (2014) 0.92
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. Front Neurosci (2013) 0.82
Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy. Front Neurosci (2013) 0.82
Resuscitation therapy for traumatic brain injury-induced coma in rats: mechanisms of median nerve electrical stimulation. Neural Regen Res (2015) 0.79
Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103. Sci Rep (2015) 0.78
Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. ACS Chem Neurosci (2015) 0.77
Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human. Front Cell Neurosci (2015) 0.77
Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach. PLoS One (2015) 0.76
Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus. Addict Biol (2015) 0.75
Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization. J Neurosci (2016) 0.75
Impact of Orexin-A Treatment on Food Intake, Energy Metabolism and Body Weight in Mice. PLoS One (2017) 0.75
Cerebrospinal Fluid Orexin A Levels and Autonomic Function in Kleine-Levin Syndrome. Sleep (2016) 0.75
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell (1998) 12.66
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A (1998) 9.32
TRP channels. Annu Rev Biochem (2007) 8.09
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov (2010) 5.76
Endocannabinoid-mediated control of synaptic transmission. Physiol Rev (2009) 5.56
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron (2006) 4.39
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02
Mitogenic signaling pathways induced by G protein-coupled receptors. J Cell Physiol (2007) 2.97
Protein kinase C: poised to signal. Am J Physiol Endocrinol Metab (2009) 2.81
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol (2009) 2.72
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci (2010) 2.69
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol Sci (2005) 2.63
G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function. Br J Pharmacol (2009) 2.60
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48
Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci (1998) 2.45
Fine-tuning of GPCR activity by receptor-interacting proteins. Nat Rev Mol Cell Biol (2009) 2.39
Phosphoinositide 3-kinase signalling--which way to target? Trends Pharmacol Sci (2003) 2.35
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. Mol Pharmacol (2008) 2.24
Regulation of ion transport proteins by membrane phosphoinositides. Nat Rev Neurosci (2007) 2.21
Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv (2002) 2.19
Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J Neurosci (1999) 2.17
Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system. Neuron (2002) 2.08
Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Biochem J (2007) 2.05
Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci (2009) 2.02
Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab (2011) 2.01
Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells. Cell Signal (2005) 1.95
Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci (2001) 1.81
Inhibition of a background potassium channel by Gq protein alpha-subunits. Proc Natl Acad Sci U S A (2006) 1.63
Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J Neurosci (2002) 1.63
Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors. J Physiol (2006) 1.58
Optimization of halopemide for phospholipase D2 inhibition. Bioorg Med Chem Lett (2007) 1.58
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
A role for orexin in central vestibular motor control. Neuron (2011) 1.48
Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). J Neurosci (2002) 1.47
Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J Biol Chem (2006) 1.43
The hypocretins/orexins: integrators of multiple physiological functions. Br J Pharmacol (2014) 1.42
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br J Pharmacol (1999) 1.38
Pharmacological analysis of intracellular Ca2+ signalling: problems and pitfalls. Trends Pharmacol Sci (1998) 1.35
Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy. J Neurosci (2002) 1.30
Selective enhancement of synaptic inhibition by hypocretin (orexin) in rat vagal motor neurons: implications for autonomic regulation. J Neurosci (2003) 1.28
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci (2004) 1.21
Arachidonic acid, ARC channels, and Orai proteins. Cell Calcium (2009) 1.21
The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J Neurosci (2005) 1.20
Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci (2005) 1.20
The Na+/Ca2+ exchange inhibitor KB-R7943 potently blocks TRPC channels. Biochem Biophys Res Commun (2007) 1.19
Muscarinic acetylcholine receptors (mAChRs) in the nervous system: some functions and mechanisms. J Mol Neurosci (2010) 1.18
Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron (2003) 1.16
Discovery and development of orexin receptor antagonists as therapeutics for insomnia. Br J Pharmacol (2014) 1.14
Hypersensitization of the Orexin 1 receptor by the CB1 receptor: evidence for cross-talk blocked by the specific CB1 antagonist, SR141716. J Biol Chem (2003) 1.13
Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger. J Neurosci (2003) 1.12
Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone. Biochem J (2002) 1.11
Gating of GIRK channels: details of an intricate, membrane-delimited signaling complex. Neuron (2003) 1.11
The orexin OX1 receptor activates a novel Ca2+ influx pathway necessary for coupling to phospholipase C. J Biol Chem (2000) 1.09
Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons. J Neurosci (2004) 1.09
G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX). Toxins (Basel) (2011) 1.08
Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. Am J Physiol Cell Physiol (2012) 1.05
Lateral hypothalamus: early developmental expression and response to hypocretin (orexin). J Comp Neurol (2001) 1.04
OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling. Mol Endocrinol (2005) 1.03
OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms. J Biol Chem (2004) 1.03
Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis. J Biol Chem (2004) 1.02
Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. Eur J Neurosci (2008) 1.01
Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. J Neurophysiol (2008) 1.01
Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab (2001) 1.00
G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. J Biol Chem (2005) 0.99
Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition. J Neurosci (2002) 0.99
The closing and opening of TRPC channels by Homer1 and STIM1. Acta Physiol (Oxf) (2011) 0.99
Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition. J Neurosci (2011) 0.98
The signalling profile of recombinant human orexin-2 receptor. Cell Signal (2008) 0.98
Neuroendocrine proopiomelanocortin neurons are excited by hypocretin/orexin. J Neurosci (2009) 0.98
Probing the regulation of TASK potassium channels by PI4,5P₂ with switchable phosphoinositide phosphatases. J Physiol (2011) 0.96
Visualizing differences in ligand-induced beta-arrestin-GFP interactions and trafficking between three recently characterized G protein-coupled receptors. J Neurochem (2001) 0.96
Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J Neurophysiol (2004) 0.95
Effects of orexin (hypocretin) on GIRK channels. J Neurophysiol (2003) 0.93
Heteromultimerization of cannabinoid CB(1) receptor and orexin OX(1) receptor generates a unique complex in which both protomers are regulated by orexin A. J Biol Chem (2011) 0.93
Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro. Peptides (2005) 0.93
Orexin-A-induced Ca2+ entry: evidence for involvement of trpc channels and protein kinase C regulation. J Biol Chem (2004) 0.93
Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B. J Endocrinol (2009) 0.93
Orexin/hypocretin receptor signalling: a functional perspective. Br J Pharmacol (2014) 0.92
Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regul Pept (2002) 0.92
Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. J Clin Endocrinol Metab (2001) 0.92
Food deprivation differentially modulates orexin receptor expression and signaling in rat hypothalamus and adrenal cortex. Am J Physiol Endocrinol Metab (2005) 0.92
The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. J Neurosci (2006) 0.92
Selective enhancement of excitatory synaptic activity in the rat nucleus tractus solitarius by hypocretin 2. Neuroscience (2002) 0.91
Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases. Acta Physiol (Oxf) (2009) 0.91
A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism. FASEB J (2008) 0.91
Regulation of OX1 orexin/hypocretin receptor-coupling to phospholipase C by Ca2+ influx. Br J Pharmacol (2006) 0.91
Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. J Clin Endocrinol Metab (2001) 0.91
Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells. Infect Immun (2007) 0.90
Muscarinic cholinergic receptors and the canine model of narcolepsy. Sleep (1986) 0.90
Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging. Br J Pharmacol (2011) 0.90
Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1. Biochem Pharmacol (2006) 0.90
Orexin-induced apoptosis: the key role of the seven-transmembrane domain orexin type 2 receptor. Endocrinology (2006) 0.90
Orexin signaling in recombinant neuron-like cells. FEBS Lett (2002) 0.89
Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes. Diabetologia (2011) 0.88
Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci (2010) 0.88
Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis. FASEB J (2009) 0.88
Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse. Proc Natl Acad Sci U S A (1985) 3.23
Function of specific K(+) channels in sustained high-frequency firing of fast-spiking neocortical interneurons. J Neurophysiol (1999) 2.17
Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking Kv3.2 K+ channel proteins. J Neurosci (2000) 1.38
Spatial organization of visual messages of the rabbit's cerebellar flocculus. II. Complex and simple spike responses of Purkinje cells. J Neurophysiol (1988) 1.14
Spike train encoding by regular-spiking cells of the visual cortex. J Neurophysiol (1996) 1.13
Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. J Neurophysiol (2008) 1.01
Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons. Eur J Neurosci (2010) 0.88
The accessory optic system of rabbit. II. Spatial organization of direction selectivity. J Neurophysiol (1988) 0.85
Recovery of cable properties through active and passive modeling of subthreshold membrane responses from laterodorsal tegmental neurons. J Neurophysiol (1998) 0.85
The accessory optic system. Analyzer of self-motion. Ann N Y Acad Sci (1988) 0.81
Voltage-clamp analysis and computer simulation of a novel cesium-resistant A-current in guinea pig laterodorsal tegmental neurons. J Neurophysiol (1998) 0.80
The rostral dorsal cap and ventrolateral outgrowth of the rabbit inferior olive receive a GABAergic input from dorsal group Y and the ventral dentate nucleus. J Comp Neurol (1994) 0.78
NMDA-receptor-mediated synaptic currents in guinea pig laterodorsal tegmental neurons in vitro. J Neurophysiol (1996) 0.78
NMDA receptor-mediated synaptic input to nitric oxide synthase-containing neurons of the guinea pig mesopontine tegmentum in vitro. Neurosci Lett (1994) 0.77
Quantitative morphology of physiologically identified and intracellularly labeled neurons from the guinea-pig laterodorsal tegmental nucleus in vitro. Neuroscience (1996) 0.76
Representations of ocular rotations in the cerebellar flocculus of the rabbit. Prog Brain Res (1989) 0.76
The Immunizing Effect in the Action of Trypanocidal Agents. Science (1946) 0.75
Preservation of ultrastructure and antigenicity for EM immunocytochemistry following intracellular recording and labeling of single cortical neurons in brain slices. J Neurosci Methods (1998) 0.75
Plasma amino acids in full-term infants. Am J Clin Nutr (1966) 0.75
Lack of Influence of Thiosulfate and Metabisulfite on the Antibiotic Activity of Penicillin. Science (1946) 0.75