Published in Toxicol Appl Pharmacol on August 13, 2013
Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling. J Transl Med (2014) 0.85
Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats. Int J Clin Exp Med (2015) 0.80
Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway. Korean J Physiol Pharmacol (2016) 0.79
Effect of a controlled-release drug delivery system made of oleanolic acid formulated into multivesicular liposomes on hepatocellular carcinoma in vitro and in vivo. Int J Nanomedicine (2016) 0.79
Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury. Oxid Med Cell Longev (2016) 0.78
The evidence for natural therapeutics as potential anti-scarring agents in burn-related scarring. Burns Trauma (2016) 0.75
Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Toxicol Lett (2014) 0.75
Preserved Gut Microbial Diversity Accompanies Upregulation of TGR5 and Hepatobiliary Transporters in Bile Acid-Treated Animals Receiving Parenteral Nutrition. JPEN J Parenter Enteral Nutr (2016) 0.75
Atorvastatin alters the expression of genes related to bile acid metabolism and circadian clock in livers of mice. PeerJ (2017) 0.75
Oleanolic acid derivative DKS26 exerts antidiabetic and hepatoprotective effects in diabetic mice and promotes GLP-1 secretion and expression in intestinal cells. Br J Pharmacol (2017) 0.75
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Herbal hepatotoxicity. Clin Liver Dis (2007) 1.68
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol (2006) 1.63
Triterpenoids as new promising anticancer drugs. Anticancer Drugs (2009) 1.60
Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med (2009) 1.59
Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects. Am J Physiol Renal Physiol (2012) 1.54
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem Biophys Res Commun (2007) 1.49
Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res (2010) 1.45
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (2010) 1.29
The pathology of cholestasis. Semin Liver Dis (2004) 1.27
Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis (2010) 1.22
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci (2008) 1.22
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21
Hepatotoxic slimming aids and other herbal hepatotoxins. J Gastroenterol Hepatol (2008) 1.21
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci (2008) 1.20
Oleanolic acid. Phytochemistry (2012) 1.18
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicol Sci (2009) 1.18
Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol (2012) 1.11
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. Biochem Biophys Res Commun (2009) 1.11
Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. Zhongguo Yao Li Xue Bao (1995) 1.11
Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem Pharmacol (2007) 1.10
Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury. PLoS One (2011) 1.08
Nuclear receptor regulation of the adaptive response of bile acid transporters in cholestasis. Semin Liver Dis (2010) 1.07
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New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochem Pharmacol (2008) 1.03
Protective effects of oleanolic acid on acetaminophen-induced hepatotoxicity in mice. J Pharmacol Exp Ther (1993) 0.98
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Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports. Regul Toxicol Pharmacol (2011) 0.93
Oleanolic acid protects against cadmium hepatotoxicity by inducing metallothionein. J Pharmacol Exp Ther (1993) 0.92
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
Repeated oral administration of oleanolic acid produces cholestatic liver injury in mice. Molecules (2013) 0.91
Oleanolic acid is a selective farnesoid X receptor modulator. Phytother Res (2010) 0.90
Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae). J Pharmacol Exp Ther (2011) 0.90
Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.). Phytother Res (2011) 0.85
Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother (2010) 0.84
Hepatotoxicity and tumorigenicity induced by metabolic activation of pyrrolizidine alkaloids in herbs. Curr Drug Metab (2011) 0.84
Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited. Br J Clin Pharmacol (2012) 0.81
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Chemical and biological characterization of oleanane triterpenoids from soy. Molecules (2009) 0.80
Cholestasis induced by Chinese herbal remedy Xia-Ku-Hua-Tan-Pian. Liver Int (2011) 0.77
Disposition of lantadene A, the pentacyclic triterpenoid hepatotoxin, orally administered to guinea pigs. Toxicol Lett (1999) 0.76
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther (2008) 2.05
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicol Sci (2004) 1.98
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos (2005) 1.90
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (2012) 1.77
Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicol Sci (2006) 1.69
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med (2013) 1.67
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos (2005) 1.61
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol (2007) 1.60
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos (2005) 1.55
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci (2009) 1.54
Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos (2006) 1.53
Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicol Sci (2009) 1.50
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab Dispos (2005) 1.49
Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenet Genomics (2007) 1.49
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicol Sci (2007) 1.46
Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice. J Lipid Res (2010) 1.45
Human primary ductal carcinoma in situ (DCIS) subtype-specific pathology is preserved in a mouse intraductal (MIND) xenograft model. J Pathol (2011) 1.43
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol (2006) 1.43
Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metab Dispos (2012) 1.43
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.42
Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci (2011) 1.41
Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos (2005) 1.40
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J Pharmacol Exp Ther (2010) 1.32
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos (2004) 1.31
Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos (2007) 1.29
Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (2010) 1.29
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem (2011) 1.27
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol (2010) 1.26
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicol Sci (2009) 1.26
Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metab Dispos (2006) 1.25
A prospective, single-blind, randomized, controlled trial of EUS-guided FNA with and without a stylet. Gastrointest Endosc (2011) 1.23
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones (2006) 1.23
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol Appl Pharmacol (2009) 1.23
Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis (2010) 1.22
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun (2005) 1.22
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci (2008) 1.22
Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther (2010) 1.21
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos (2007) 1.21
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci (2008) 1.20
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicol Sci (2009) 1.18
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther (2002) 1.18
Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metab Dispos (2008) 1.17
Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol (2008) 1.17
Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Dispos (2008) 1.15
Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther (2002) 1.15
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One (2011) 1.14
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab (2011) 1.14
Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci (2011) 1.13
Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology (2002) 1.13
Reliability and validity of the screen for child anxiety related emotional disorders (SCARED) in Chinese children. J Anxiety Disord (2007) 1.13
Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. J Pharmacol Exp Ther (2007) 1.12
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicol Sci (2011) 1.12
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Mol Pharmacol (2002) 1.12
Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol (2012) 1.11
Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metab Dispos (2009) 1.11
Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem Pharmacol (2007) 1.10
Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol (2009) 1.09
Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxicol Sci (2007) 1.09
Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metab Dispos (2008) 1.09
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos (2003) 1.09
Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years. Ann Diagn Pathol (2009) 1.08
The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos (2008) 1.08
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos (2004) 1.08
Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev (2013) 1.07
Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicol Sci (2004) 1.07
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metab Dispos (2003) 1.06
Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol Pharmacol (2006) 1.06
Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicol Appl Pharmacol (2010) 1.05
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci (2009) 1.04
Diurnal variation of hepatic antioxidant gene expression in mice. PLoS One (2012) 1.04
Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts. Invest Ophthalmol Vis Sci (2012) 1.04
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicol Sci (2007) 1.04
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim Biophys Acta (2006) 1.04
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. Toxicol Sci (2008) 1.04
Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci (2002) 1.03
The presence of xenobiotic transporters in rat placenta. Drug Metab Dispos (2003) 1.03
New insights into generalized hepatoprotective effects of oleanolic acid: key roles of metallothionein and Nrf2 induction. Biochem Pharmacol (2008) 1.03
Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol (2011) 1.03
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sci (2008) 1.02
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicol Appl Pharmacol (2008) 1.01
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology (2006) 1.01
ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Res (2010) 1.01
Descemet membrane detachment after trabeculectomy. Int J Ophthalmol (2012) 1.00
Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One (2012) 1.00
Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One (2012) 0.99
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos (2009) 0.99
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol (2012) 0.99
Th2 skewing by activation of Nrf2 in CD4(+) T cells. J Immunol (2012) 0.99
Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol (2006) 0.99