Published in J Lipid Res on July 29, 2010
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (2010) 1.29
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem (2011) 1.27
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest (2010) 1.17
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One (2011) 1.14
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicol Sci (2011) 1.12
Intestinal transport and metabolism of bile acids. J Lipid Res (2014) 1.08
Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology (2012) 1.02
Specific bile acids inhibit hepatic fatty acid uptake in mice. Hepatology (2012) 1.01
Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One (2012) 1.00
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol (2012) 0.91
Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis. J Biol Chem (2013) 0.90
Oleanolic acid alters bile acid metabolism and produces cholestatic liver injury in mice. Toxicol Appl Pharmacol (2013) 0.90
Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.89
Loss of organic anion transporting polypeptide 1a1 increases deoxycholic acid absorption in mice by increasing intestinal permeability. Toxicol Sci (2011) 0.88
Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. Toxicol Lett (2014) 0.88
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Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci (2014) 0.86
Gender-divergent profile of bile acid homeostasis during aging of mice. PLoS One (2012) 0.84
Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicol Sci (2012) 0.84
Increased bile acids in enterohepatic circulation by short-term calorie restriction in male mice. Toxicol Appl Pharmacol (2013) 0.83
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. Am J Physiol Gastrointest Liver Physiol (2012) 0.81
Characterization of animal models for primary sclerosing cholangitis (PSC). J Hepatol (2014) 0.81
Atorvastatin induces bile acid-synthetic enzyme Cyp7a1 by suppressing FXR signaling in both liver and intestine in mice. J Lipid Res (2014) 0.80
H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.79
Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior. Front Behav Neurosci (2015) 0.79
Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism. PLoS One (2016) 0.79
Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice. Drug Metab Dispos (2015) 0.79
Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol (2015) 0.79
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure. Am J Pathol (2015) 0.78
Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. Am J Physiol Gastrointest Liver Physiol (2016) 0.77
Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis. Am J Physiol Gastrointest Liver Physiol (2016) 0.76
Activation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver. Toxicol Sci (2016) 0.76
Induction of FXR signaling in germ-free mice colonized with a human microbiota. J Lipid Res (2016) 0.75
Dose-response effect of berberine on bile acid profile and gut microbiota in mice. BMC Complement Altern Med (2016) 0.75
Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol (2017) 0.75
Berberine-induced Inactivation of Signal Transducer and Activator of Transcription 5 Signaling Promotes Male-specific Expression of a Bile Acid Uptake Transporter. J Biol Chem (2017) 0.75
Understanding mouse bile acid formation: Is it time to unwind why mice and rats make unique bile acids? J Lipid Res (2016) 0.75
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Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.42
Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol (2003) 1.36
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Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway. Hepatology (2007) 2.11
NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet. J Pharmacol Exp Ther (2008) 2.05
Differential expression of mouse hepatic transporter genes in response to acetaminophen and carbon tetrachloride. Toxicol Sci (2004) 1.98
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver. Drug Metab Dispos (2005) 1.90
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology (2012) 1.77
Tissue distribution and ontogeny of sulfotransferase enzymes in mice. Toxicol Sci (2006) 1.69
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med (2013) 1.67
Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice. Drug Metab Dispos (2005) 1.61
Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2. Toxicol Appl Pharmacol (2007) 1.60
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos (2005) 1.55
Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species. Toxicol Sci (2009) 1.54
Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice. Drug Metab Dispos (2006) 1.53
Introducing the "TCDD-inducible AhR-Nrf2 gene battery". Toxicol Sci (2009) 1.50
Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps). Drug Metab Dispos (2005) 1.49
Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenet Genomics (2007) 1.49
Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicol Sci (2007) 1.46
Structure, function, expression, genomic organization, and single nucleotide polymorphisms of human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) efflux transporters. Int J Toxicol (2006) 1.43
Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice. Drug Metab Dispos (2012) 1.43
Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 1.42
Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol Sci (2011) 1.41
Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos (2005) 1.40
Effect of bile duct ligation on bile acid composition in mouse serum and liver. Liver Int (2011) 1.34
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J Pharmacol Exp Ther (2010) 1.32
Rat and mouse differences in gender-predominant expression of organic anion transporter (Oat1-3; Slc22a6-8) mRNA levels. Drug Metab Dispos (2004) 1.31
Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2. Drug Metab Dispos (2007) 1.29
Organic anion-transporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: Studies in Oatp1b2-null mice. Hepatology (2010) 1.29
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem (2011) 1.27
Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol (2010) 1.26
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicol Sci (2009) 1.26
Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug Metab Dispos (2006) 1.25
Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis. Cell Stress Chaperones (2006) 1.23
CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes. Toxicol Appl Pharmacol (2009) 1.23
Oxidative stress and the pathogenesis of cholestasis. Semin Liver Dis (2010) 1.22
Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice. Biochem Biophys Res Commun (2005) 1.22
Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci (2008) 1.22
Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice. J Pharmacol Exp Ther (2010) 1.21
Oleanolic acid activates Nrf2 and protects from acetaminophen hepatotoxicity via Nrf2-dependent and Nrf2-independent processes. Biochem Pharmacol (2009) 1.21
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport. Drug Metab Dispos (2007) 1.21
Nrf2- and PPAR alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic acid and perfluorodecanoic acid. Toxicol Sci (2008) 1.20
ANIT-induced intrahepatic cholestasis alters hepatobiliary transporter expression via Nrf2-dependent and independent signaling. Toxicol Sci (2009) 1.18
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther (2002) 1.18
Circadian expression profiles of drug-processing genes and transcription factors in mouse liver. Drug Metab Dispos (2008) 1.17
Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metab Dispos (2008) 1.15
Gender-specific and developmental influences on the expression of rat organic anion transporters. J Pharmacol Exp Ther (2002) 1.15
Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS One (2011) 1.14
Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia. Cell Metab (2011) 1.14
Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci (2011) 1.13
Testicular toxicity of di-(2-ethylhexyl)phthalate in young Sprague-Dawley rats. Toxicology (2002) 1.13
Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice. J Pharmacol Exp Ther (2007) 1.12
Dose-response of five bile acids on serum and liver bile Acid concentrations and hepatotoxicty in mice. Toxicol Sci (2011) 1.12
Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor. Mol Pharmacol (2002) 1.12
Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metab Dispos (2009) 1.11
Nrf2 activation prevents cadmium-induced acute liver injury. Toxicol Appl Pharmacol (2012) 1.11
Regulation of hepatic bile acid transporters Ntcp and Bsep expression. Biochem Pharmacol (2007) 1.10
Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol Pharmacol (2009) 1.09
Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice. Toxicol Sci (2007) 1.09
Tissue distribution, gender-divergent expression, ontogeny, and chemical induction of multidrug resistance transporter genes (Mdr1a, Mdr1b, Mdr2) in mice. Drug Metab Dispos (2008) 1.09
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab Dispos (2003) 1.09
The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos (2008) 1.08
Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos (2004) 1.08
Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev (2013) 1.07
Bromobenzene-induced hepatotoxicity at the transcriptome level. Toxicol Sci (2004) 1.07
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile. Drug Metab Dispos (2003) 1.06
Endocrine regulation of gender-divergent mouse organic anion-transporting polypeptide (Oatp) expression. Mol Pharmacol (2006) 1.06
Molecular targets of epigenetic regulation and effectors of environmental influences. Toxicol Appl Pharmacol (2010) 1.05
Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicol Sci (2009) 1.04
Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers. Toxicol Sci (2008) 1.04
Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis. Biochim Biophys Acta (2006) 1.04
Diurnal variation of hepatic antioxidant gene expression in mice. PLoS One (2012) 1.04
The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. Toxicol Sci (2007) 1.04
Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats. Toxicol Sci (2002) 1.03
The presence of xenobiotic transporters in rat placenta. Drug Metab Dispos (2003) 1.03
Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis. Toxicol Appl Pharmacol (2011) 1.03
Tissue distribution, ontogeny and induction of the transporters Multidrug and toxin extrusion (MATE) 1 and MATE2 mRNA expression levels in mice. Life Sci (2008) 1.02
Coordinated induction of Nrf2 target genes protects against iron nitrilotriacetate (FeNTA)-induced nephrotoxicity. Toxicol Appl Pharmacol (2008) 1.01
ChIPing the cistrome of PXR in mouse liver. Nucleic Acids Res (2010) 1.01
Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology (2006) 1.01
Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice. PLoS One (2012) 1.00
Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One (2012) 0.99
Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Drug Metab Dispos (2009) 0.99
Th2 skewing by activation of Nrf2 in CD4(+) T cells. J Immunol (2012) 0.99
Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation. Toxicol Appl Pharmacol (2012) 0.99
Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol (2006) 0.99
Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. Toxicol Appl Pharmacol (2012) 0.98
Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha. J Pharmacol Exp Ther (2006) 0.98
Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett (2004) 0.97
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor. Drug Metab Dispos (2003) 0.97
Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults). Xenobiotica (2010) 0.97
Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4. J Pharmacol Exp Ther (2002) 0.95
Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. PLoS One (2013) 0.95
Tissue distribution and chemical induction of multiple drug resistance genes in rats. Drug Metab Dispos (2002) 0.94
Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female mice. Drug Metab Dispos (2012) 0.94
Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicol Sci (2011) 0.94
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways. Toxicol Sci (2002) 0.93
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology (2002) 0.93
RNA sequencing reveals dynamic changes of mRNA abundance of cytochromes P450 and their alternative transcripts during mouse liver development. Drug Metab Dispos (2012) 0.93
Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta. Drug Metab Dispos (2008) 0.93
Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors. Toxicol Sci (2008) 0.93
Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicol Sci (2012) 0.92