Published in Toxicol Sci on August 16, 2013
Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity. Clin Pharmacol Ther (2014) 1.52
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Mechanistic diversity in ATP-binding cassette (ABC) transporters. Nat Struct Mol Biol (2016) 0.95
Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metab Dispos (2013) 0.93
Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury. Front Pharmacol (2014) 0.93
Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury. J Pharmacol Exp Ther (2015) 0.86
Case Characterization, Clinical Features and Risk Factors in Drug-Induced Liver Injury. Int J Mol Sci (2016) 0.85
Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation. J Pharmacol Exp Ther (2016) 0.81
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™. Regul Toxicol Pharmacol (2015) 0.78
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors. Toxicol Sci (2016) 0.78
Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug-Induced Liver Injury. CPT Pharmacometrics Syst Pharmacol (2016) 0.77
Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. J Pharm Sci (2016) 0.77
Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors. Drug Metab Dispos (2015) 0.77
Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat. Drug Metab Dispos (2014) 0.76
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs. Sci Rep (2016) 0.76
Cellular imaging: a key phenotypic screening strategy for predictive toxicology. Front Pharmacol (2015) 0.76
Drug-Induced Liver Injury: Advances in Mechanistic Understanding that will Inform Risk Management. Clin Pharmacol Ther (2016) 0.75
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man. Arch Toxicol (2016) 0.75
Fasiglifam (TAK-875) alters bile acid homeostasis in rats and dogs: a potential cause of drug induced liver injury. Toxicol Sci (2017) 0.75
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Sci Rep (2016) 0.75
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury. Arch Toxicol (2017) 0.75
Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses. Gene Regul Syst Bio (2017) 0.75
Renal Drug Transporters and Drug Interactions. Clin Pharmacokinet (2017) 0.75
ABC gene-ranking for prediction of drug-induced cholestasis in rats. Toxicol Rep (2016) 0.75
Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics (2010) 15.90
Ensembl 2011. Nucleic Acids Res (2010) 14.68
Ensembl's 10th year. Nucleic Acids Res (2009) 10.82
An overview of Ensembl. Genome Res (2004) 10.35
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The DNA sequence of the human X chromosome. Nature (2005) 6.97
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
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Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc Natl Acad Sci U S A (2004) 4.19
Locus Reference Genomic sequences: an improved basis for describing human DNA variants. Genome Med (2010) 4.19
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Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
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Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet (2006) 3.00
SNP and haplotype mapping for genetic analysis in the rat. Nat Genet (2008) 2.96
Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. Am J Hum Genet (2008) 2.65
Gene expression analysis reveals chemical-specific profiles. Toxicol Sci (2002) 2.50
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol (2002) 2.49
Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. J Biol Chem (2005) 2.44
Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference. Bioinformatics (2003) 2.21
How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes. Acta Biochim Biophys Sin (Shanghai) (2008) 2.19
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. J Biol Chem (2005) 2.19
Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol (2003) 2.12
The intrinsic affinity between E2 and the Cys domain of E1 in ubiquitin-like modifications. Mol Cell (2007) 2.05
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proc Natl Acad Sci U S A (2012) 1.94
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer. Nat Med (2011) 1.93
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci (2004) 1.92
Integrating phenotypic and expression profiles to map arsenic-response networks. Genome Biol (2004) 1.90
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. Nat Struct Mol Biol (2004) 1.90
Curve analysis of the aging orbital aperture. Plast Reconstr Surg (2002) 1.87
Identification of putative gene based markers of renal toxicity. Environ Health Perspect (2004) 1.85
A calibrated human Y-chromosomal phylogeny based on resequencing. Genome Res (2012) 1.83
Prediction of compound signature using high density gene expression profiling. Toxicol Sci (2002) 1.82
Impact of the bag exchange procedure on risk of peritonitis. Perit Dial Int (2010) 1.80
Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure (2004) 1.78
Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Cephalalgia (2012) 1.78
Antibacterial activity of graphite, graphite oxide, graphene oxide, and reduced graphene oxide: membrane and oxidative stress. ACS Nano (2011) 1.78
Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression. Mol Cell (2012) 1.76
Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations. Toxicol Pathol (2002) 1.72
Mot1 activates and represses transcription by direct, ATPase-dependent mechanisms. Proc Natl Acad Sci U S A (2002) 1.72
Identification of a substrate recognition site on Ubc9. J Biol Chem (2002) 1.71
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. Biochemistry (2003) 1.70
Regulation of DNA replication fork genes by 17beta-estradiol. Mol Endocrinol (2002) 1.70
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. J Med Chem (2007) 1.70
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats. Nucleic Acids Res (2005) 1.70
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell (2004) 1.66
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A (2002) 1.52
Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Mol Cancer Res (2003) 1.48
Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy. Hepatology (2014) 1.48
EGFR mutation detection in NSCLC--assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Arch (2010) 1.45
Genetic basis of Y-linked hearing impairment. Am J Hum Genet (2013) 1.42
Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet (2010) 1.41
Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population. J Hum Genet (2009) 1.40
Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood (2008) 1.39
Downstream E-box-mediated regulation of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. Mol Biol Cell (2002) 1.36
A young Drosophila duplicate gene plays essential roles in spermatogenesis by regulating several Y-linked male fertility genes. PLoS Genet (2010) 1.35
Identification of platform-independent gene expression markers of cisplatin nephrotoxicity. Environ Health Perspect (2004) 1.30
Sharper and faster "nano darts" kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube. ACS Nano (2009) 1.29
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci (2010) 1.22
The DNA-binding properties of the ARID-containing subunits of yeast and mammalian SWI/SNF complexes. Nucleic Acids Res (2004) 1.21
A new permutation strategy of pathway-based approach for genome-wide association study. BMC Bioinformatics (2009) 1.19
Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. PLoS One (2011) 1.19
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density. Hum Mol Genet (2013) 1.17
Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/β-catenin signaling pathway in human lung cancer. Carcinogenesis (2012) 1.17
Sensitivity enhancement of multidimensional NMR experiments by paramagnetic relaxation effects. J Am Chem Soc (2006) 1.16
Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Toxicol Pathol (2005) 1.15
Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment. Environ Health Perspect (2004) 1.14
Alfuzosin delays cardiac repolarization by a novel mechanism. J Pharmacol Exp Ther (2007) 1.14
Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation. Genetics (2009) 1.13
Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. Neoplasia (2005) 1.13
The Cryptococcus neoformans transcriptome at the site of human meningitis. MBio (2014) 1.11
Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J Pharmacol Exp Ther (2012) 1.11
Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4. Drug Metab Dispos (2009) 1.10
Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. Int J Colorectal Dis (2012) 1.10
Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats. Biotechnol Lett (2010) 1.09
Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues. J Cancer Res Clin Oncol (2010) 1.09
Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells. Differentiation (2009) 1.09
Bupropion and venlafaxine responders differ in pretreatment regional cerebral metabolism in unipolar depression. Biol Psychiatry (2005) 1.09
Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability. Nat Cell Biol (2011) 1.08
Perturbation of microRNAs in rat heart during chronic doxorubicin treatment. PLoS One (2012) 1.08
FGFR1 expression and gene copy numbers in human lung cancer. Virchows Arch (2012) 1.07
Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. Gynecol Oncol (2002) 1.06
Oxidative stress and its role in skin disease. Antioxid Redox Signal (2002) 1.06
Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A (2004) 1.06
The evolution of bioinformatics in toxicology: advancing toxicogenomics. Toxicol Sci (2010) 1.06
A SNP map of the rat genome generated from cDNA sequences. Science (2004) 1.06
Insights into high affinity small ubiquitin-like modifier (SUMO) recognition by SUMO-interacting motifs (SIMs) revealed by a combination of NMR and peptide array analysis. J Biol Chem (2011) 1.06
Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma. J Clin Pathol (2011) 1.06
Toward the extraction of single species of single-walled carbon nanotubes using fluorene-based polymers. Nano Lett (2007) 1.05
Lateral dimension-dependent antibacterial activity of graphene oxide sheets. Langmuir (2012) 1.05
Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma. Hum Pathol (2012) 1.04
Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol Sci (2002) 1.04