Published in Front Physiol on August 16, 2013
The dark side of extracellular ATP in kidney diseases. J Am Soc Nephrol (2014) 0.80
P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells. Purinergic Signal (2016) 0.75
Functional and therapeutic importance of purinergic signaling in polycystic kidney disease. Am J Physiol Renal Physiol (2016) 0.75
Autosomal dominant polycystic kidney disease. Lancet (2007) 8.55
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
Polycystic kidney disease. Annu Rev Med (2009) 4.78
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest (2002) 4.05
ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes--a possible sensory mechanism? J Physiol (1997) 3.43
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet (2011) 3.18
PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell (2002) 3.09
Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease. Kidney Int (2009) 2.99
Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat. J Am Soc Nephrol (2005) 2.92
Purinergic signalling in the nervous system: an overview. Trends Neurosci (2008) 2.86
Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res (1992) 2.86
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med (2007) 2.85
Cilia and centrosomes: a unifying pathogenic concept for cystic kidney disease? Nat Rev Genet (2005) 2.55
The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J (1975) 2.46
Renal cystic diseases: a review. Adv Anat Pathol (2006) 2.27
Control of epithelial transport via luminal P2 receptors. Am J Physiol Renal Physiol (2003) 2.01
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol (2006) 1.95
Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury. Am J Transplant (2010) 1.74
Why kidneys fail in autosomal dominant polycystic kidney disease. Nat Rev Nephrol (2011) 1.65
Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro. Am J Physiol Renal Physiol (2006) 1.63
Hereditary polycystic kidney disease (adult form): a microdissection study of two cases at an early stage of the disease. Kidney Int (1978) 1.63
P2Y nucleotide receptors: promise of therapeutic applications. Drug Discov Today (2010) 1.62
Purines, purinergic receptors, and cancer. Cancer Res (2012) 1.61
Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion. J Mol Med (Berl) (2011) 1.54
Epithelial transport in polycystic kidney disease. Physiol Rev (1998) 1.45
A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert Opin Investig Drugs (2011) 1.39
Human plasma ATP concentration. Clin Chem (2006) 1.38
Molecular and cellular pathophysiology of autosomal recessive polycystic kidney disease (ARPKD). Cell Tissue Res (2006) 1.36
Role of polycystins in renal tubulogenesis. Trends Cell Biol (2003) 1.35
Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol (2009) 1.28
Nephronophthisis. Pediatr Nephrol (2010) 1.28
Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost (2005) 1.28
Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovasc Res (2012) 1.27
Loss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals. Purinergic Signal (2007) 1.27
Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling. Bone (2001) 1.26
The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice. Kidney Int (2006) 1.19
Extracellular nucleotide receptor inhibits AVP-stimulated water permeability in inner medullary collecting duct. Am J Physiol (1995) 1.17
ATP release mechanisms, ATP receptors and purinergic signalling along the nephron. Clin Exp Pharmacol Physiol (2001) 1.17
Cellular localization of P2Y(2) purinoceptor in rat renal inner medulla and lung. Am J Physiol Renal Physiol (2000) 1.12
ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys. J Am Soc Nephrol (1999) 1.12
Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys. Am J Physiol Renal Physiol (2002) 1.12
Apoptosis in polycystic kidney disease. Biochim Biophys Acta (2011) 1.10
P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 1.08
Polycystic kidney disease: etiology, pathogenesis, and treatment. Dis Mon (1995) 1.08
Epithelial cell polarity and disease. Am J Physiol (1997) 1.05
Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease. Biochim Biophys Acta (2011) 1.05
Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets (2009) 1.04
Cloning and functional characterization of two murine uridine nucleotide receptors reveal a potential target for correcting ion transport deficiency in cystic fibrosis gallbladder. J Pharmacol Exp Ther (2001) 1.03
Chemical modification of cell proliferation and fluid secretion in renal cysts. Kidney Int (1989) 1.03
The P2X7 ATP receptor in the kidney: a matter of life or death? Nephron Exp Nephrol (2005) 1.02
ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Mol Biol Cell (2004) 1.02
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol (2002) 1.01
Macrophages promote polycystic kidney disease progression. Kidney Int (2013) 1.01
The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry. Am J Physiol Renal Physiol (2003) 0.97
Purinergic signaling in the lumen of a normal nephron and in remodeled PKD encapsulated cysts. Purinergic Signal (2008) 0.97
P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis. J Leukoc Biol (2012) 0.92
Inhibition of the P2X7 receptor reduces cystogenesis in PKD. J Am Soc Nephrol (2011) 0.91
The P2X7 ATP receptor modulates renal cyst development in vitro. Biochem Biophys Res Commun (2004) 0.90
P2X(7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk/cpk mouse. Exp Nephrol (2002) 0.89
Calcium, cyclic AMP, and MAP kinases: dysregulation in polycystic kidney disease. Kidney Int (2008) 0.88
P2 receptors in the kidney. J Auton Nerv Syst (2000) 0.87
Role of interstitial inflammation in the pathogenesis of polycystic kidney disease. Nephrology (Carlton) (2013) 0.87
Multidrug therapy for polycystic kidney disease: a review and perspective. Am J Nephrol (2013) 0.86
Altered ATP-sensitive P2 receptor subtype expression in the Han:SPRD cy/+ rat, a model of autosomal dominant polycystic kidney disease. Cells Tissues Organs (2004) 0.86
The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells. Inflamm Bowel Dis (2010) 0.85
New treatments for autosomal dominant polycystic kidney disease. Br J Clin Pharmacol (2013) 0.85
The isolated C-terminus of polycystin-1 promotes increased ATP-stimulated chloride secretion in a collecting duct cell line. Clin Sci (Lond) (2003) 0.84
Extracellular ATP promotes cellular growth of renal inner medullary collecting duct cells mediated via P2u receptors. Nephron (1997) 0.84
ARPKD and ADPKD: first cousins or more distant relatives? J Am Soc Nephrol (2008) 0.81
Polycystic kidney disease: Tolvaptan in ADPKD-TEMPO 3:4 trial results. Nat Rev Nephrol (2012) 0.80
Caffeine-inducible ATP release is mediated by Ca2+-signal transducing system from the endoplasmic reticulum to mitochondria. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.80
Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease. Kidney Int (2002) 0.79
Observations on a polycystic kidney by microdissection. Aust N Z J Surg (1961) 0.76
The Gretchen question in autosomal-dominant polycystic kidney disease research. J Mol Med (Berl) (2011) 0.76