Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.

PubWeight™: 4.05‹?› | Rank: Top 1%

🔗 View Article (PMC 151145)

Published in J Clin Invest on October 01, 2002

Authors

Kristin Synnestvedt1, Glenn T Furuta, Katrina M Comerford, Nancy Louis, Jorn Karhausen, Holger K Eltzschig, Karl R Hansen, Linda F Thompson, Sean P Colgan

Author Affiliations

1: Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

(truncated to the top 100)

Hypoxia and inflammation. N Engl J Med (2011) 7.71

Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med (2004) 4.16

Purinergic signaling during inflammation. N Engl J Med (2012) 4.08

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90

Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71

Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol (2009) 3.24

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology (2008) 2.99

Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal (2006) 2.98

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A (2010) 2.67

A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest (2008) 2.62

HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med (2005) 2.35

Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev (2012) 2.24

Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23

Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol (2010) 2.18

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov (2009) 2.10

CD39 and CD73 in immunity and inflammation. Trends Mol Med (2013) 2.08

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity (2013) 2.08

Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta (2010) 2.00

Adenosine: an old drug newly discovered. Anesthesiology (2009) 1.99

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol (2006) 1.79

Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov (2013) 1.74

The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. Kidney Int (2013) 1.70

Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol (2009) 1.68

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood (2010) 1.65

Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood (2006) 1.65

Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J (2008) 1.63

Retracted Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver. Proc Natl Acad Sci U S A (2013) 1.59

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology (2008) 1.57

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A (2004) 1.56

CD73: a novel target for cancer immunotherapy. Cancer Res (2010) 1.52

A(2B) adenosine receptors in immunity and inflammation. Trends Immunol (2009) 1.48

Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor. J Immunol (2011) 1.48

Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. J Clin Invest (2007) 1.47

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol (2013) 1.45

Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci Transl Med (2015) 1.42

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun (2017) 1.38

Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol (2011) 1.36

Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med (2008) 1.36

PMNs facilitate translocation of platelets across human and mouse epithelium and together alter fluid homeostasis via epithelial cell-expressed ecto-NTPDases. J Clin Invest (2008) 1.35

SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol (2010) 1.31

Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology (2013) 1.30

Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells. Br J Pharmacol (2008) 1.30

Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol (2006) 1.30

Hypoxia and metabolic factors that influence inflammatory bowel disease pathogenesis. Gastroenterology (2011) 1.26

Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing. J Anat (2009) 1.24

The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta (2010) 1.23

Oxygen-independent stabilization of hypoxia inducible factor (HIF)-1 during RSV infection. PLoS One (2008) 1.22

Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid Redox Signal (2011) 1.21

Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits. J Neurosci (2010) 1.20

CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol (2012) 1.18

Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J (2008) 1.17

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov (2014) 1.17

Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol (2011) 1.16

Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol (2011) 1.14

Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov (2015) 1.12

Partial netrin-1 deficiency aggravates acute kidney injury. PLoS One (2011) 1.11

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J (2013) 1.10

Regulation of lymphocyte function by adenosine. Arterioscler Thromb Vasc Biol (2012) 1.09

Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia. FASEB J (2007) 1.08

Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07

The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity. Front Immunol (2013) 1.06

Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states. J Mol Med (Berl) (2013) 1.06

Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists. Cancer Immunol Res (2014) 1.06

Effect of zinc in enteropathogenic Escherichia coli infection. Infect Immun (2007) 1.05

Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets (2009) 1.04

Extracellular adenosine-mediated modulation of regulatory T cells. Front Immunol (2014) 1.04

Expression and clinical significance of CD73 and hypoxia-inducible factor-1α in gastric carcinoma. World J Gastroenterol (2013) 1.03

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol (2013) 1.03

Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. Future Med Chem (2013) 1.03

Adenosine signaling during acute and chronic disease states. J Mol Med (Berl) (2013) 1.02

Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell (2009) 1.01

Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape. J Biomed Biotechnol (2012) 1.01

CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth. J Biomed Biotechnol (2012) 1.00

Adenosine A2A receptors play an active role in mouse bone marrow-derived mesenchymal stem cell development. J Leukoc Biol (2008) 1.00

Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning. Proc Natl Acad Sci U S A (2012) 0.99

Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease. Nitric Oxide (2011) 0.99

Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response. J Immunol (2012) 0.98

Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance). Clin Cancer Res (2014) 0.97

Extracellular nucleotide and nucleoside signaling in vascular and blood disease. Blood (2014) 0.97

The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol (2011) 0.97

CD73 is critical for the resolution of murine colonic inflammation. J Biomed Biotechnol (2012) 0.97

Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine. J Immunol (2012) 0.96

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease. J Mol Med (Berl) (2012) 0.96

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. Am J Physiol Cell Physiol (2015) 0.96

Adenosine negative feedback on A2A adenosine receptors mediates hyporesponsiveness in chronically septic mice. Shock (2011) 0.96

Hypoxia signaling during intestinal ischemia and inflammation. Curr Opin Crit Care (2012) 0.95

Role of adenosine A(2B) receptors in inflammation. Adv Pharmacol (2011) 0.94

Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation. Mol Cell Biol (2014) 0.94

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest (2015) 0.94

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection. J Mol Med (Berl) (2014) 0.94

Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med (2013) 0.94

The inflammatory tissue microenvironment in IBD. Inflamm Bowel Dis (2013) 0.93

Feedback effects of host-derived adenosine on enteropathogenic Escherichia coli. FEMS Immunol Med Microbiol (2009) 0.93

Detecting adenosine triphosphate in the pericellular space. Interface Focus (2013) 0.92

Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. Am J Physiol Lung Cell Mol Physiol (2011) 0.92

An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J Immunol (2011) 0.92

Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J (2008) 0.92

Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. J Biol Chem (2009) 0.91

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J Biol Chem (2012) 0.91

Anti-CD73 in cancer immunotherapy: awakening new opportunities. Trends Cancer (2016) 0.90

Articles cited by this

A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61

Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol (1996) 72.84

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A (1995) 24.77

Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N Y) (1993) 22.41

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res (1998) 14.63

Purification and characterization of hypoxia-inducible factor 1. J Biol Chem (1995) 8.53

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science (2000) 6.26

HIF-1 and human disease: one highly involved factor. Genes Dev (2000) 5.41

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61

Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev (1998) 4.29

Transcriptional regulation by cyclic AMP. Annu Rev Biochem (1997) 3.81

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75

Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu Rev Pharmacol Toxicol (2001) 3.75

5'-Nucleotidase: molecular structure and functional aspects. Biochem J (1992) 3.08

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. J Clin Invest (1993) 3.02

Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia. J Exp Med (2001) 3.02

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature (1999) 2.88

A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol (1998) 2.74

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) J Clin Invest (2000) 2.57

Established intestinal cell lines as model systems for electrolyte transport studies. Methods Enzymol (1990) 2.48

Neutrophil-derived 5'-adenosine monophosphate promotes endothelial barrier function via CD73-mediated conversion to adenosine and endothelial A2B receptor activation. J Exp Med (1998) 2.33

Ecto-ATPases: identities and functions. Int Rev Cytol (1995) 2.26

Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J (2002) 1.90

Neutrophil migration across a cultured epithelial monolayer elicits a biphasic resistance response representing sequential effects on transcellular and paracellular pathways. J Cell Biol (1992) 1.89

Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest (2002) 1.80

CD39 is an ecto-(Ca2+,Mg2+)-apyrase. J Biol Chem (1996) 1.78

Surface expression, polarization, and functional significance of CD73 in human intestinal epithelia. J Clin Invest (1997) 1.75

Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol (2001) 1.62

Production and characterization of monoclonal antibodies to the glycosyl phosphatidylinositol-anchored lymphocyte differentiation antigen ecto-5'-nucleotidase (CD73). Tissue Antigens (1990) 1.57

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem (1990) 1.54

Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res (2000) 1.53

Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. J Physiol (1996) 1.52

The impact of femur fracture with associated soft tissue injury on immune function and intestinal permeability. Shock (1996) 1.46

Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia. Proc Natl Acad Sci U S A (2000) 1.46

Adenosine receptors. J Biol Chem (1992) 1.44

Role of VASP in reestablishment of epithelial tight junction assembly after Ca2+ switch. Am J Physiol Cell Physiol (2002) 1.43

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem (1987) 1.40

Regulation of endothelial CD73 by adenosine: paracrine pathway for enhanced endothelial barrier function. J Immunol (2000) 1.38

CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73. J Exp Med (1995) 1.37

Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha. J Biol Chem (1999) 1.35

Ecto-nucleotidases--molecular structures, catalytic properties, and functional roles in the nervous system. Prog Brain Res (1999) 1.34

Nucleotide metabolism by endothelium. Annu Rev Physiol (1985) 1.30

Stimulation of the mitogen-activated protein kinase via the A2A-adenosine receptor in primary human endothelial cells. J Biol Chem (1997) 1.30

Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem (2000) 1.17

Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: role of intracellular cAMP. J Cell Physiol (1998) 1.14

Intraoperative tissue oximetry in the human gastrointestinal tract. Am J Surg (1990) 1.11

Thrombosis and inflammation as multicellular processes: significance of cell-cell interactions. Thromb Haemost (1995) 1.09

Energetic response of coronary endothelial cells to hypoxia. Am J Physiol (1990) 1.07

Hypoxia induces phosphorylation of the cyclic AMP response element-binding protein by a novel signaling mechanism. J Biol Chem (1998) 1.06

Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun (1994) 1.00

Adenosine and cardioprotection in the diseased heart. Jpn Circ J (1999) 0.96

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci U S A (1996) 0.95

Isolation and characterization of the promoter of the human 5'-nucleotidase (CD73)-encoding gene. Gene (1995) 0.94

N(G)-monomethyl-L-arginine inhibits erythropoietin gene expression by stimulating GATA-2. Blood (2000) 0.93

A2-adenosine receptor stimulation increases macromolecule permeability of coronary endothelial cells. Am J Physiol (1992) 0.92

Cardioprotection due to preconditioning correlates with increased ecto-5'-nucleotidase activity. Am J Physiol (1996) 0.91

A novel assay for 5'-nucleotidase using 1,N6-etheno-AMP as substrate, and comments on the properties of the reaction product, ethenoadenosine. Biochem J (1988) 0.88

Characterization of the adenosine receptor in microvascular coronary endothelial cells. Eur J Pharmacol (1994) 0.87

Cardioprotection by ischemic preconditioning. Role of adenosine and glycogen. Adv Exp Med Biol (1998) 0.85

Articles by these authors

Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol (2011) 12.48

Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med (2002) 7.99

Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol (2010) 5.55

ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol (2013) 5.09

Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med (2004) 4.16

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci U S A (2006) 4.08

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J Clin Invest (2004) 3.90

Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc (2005) 3.82

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res (2002) 3.75

Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71

Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation (2007) 3.65

Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem (2007) 3.28

Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol (2009) 3.24

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation (2008) 3.13

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med (2012) 3.03

Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol (2006) 3.03

Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology (2008) 2.99

Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal (2006) 2.98

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol (2010) 2.98

Eosinophils in the esophagus--peptic or allergic eosinophilic esophagitis? Case series of three patients with esophageal eosinophilia. Am J Gastroenterol (2006) 2.92

Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood (2004) 2.80

A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood (2007) 2.70

A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest (2008) 2.62

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood (2008) 2.52

Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology (2002) 2.52

HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J (2006) 2.46

Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics (2010) 2.45

The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med (2008) 2.43

HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med (2005) 2.35

Utility of intraoperative transesophageal echocardiography for diagnosis of pulmonary embolism. Anesth Analg (2004) 2.26

ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res (2006) 2.23

Concern Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest (2012) 2.23

Cardiac output monitoring using indicator-dilution techniques: basics, limits, and perspectives. Anesth Analg (2010) 2.23

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol (2003) 2.23

CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med (2002) 2.22

Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning. Gastroenterology (2008) 2.18

Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. Am J Respir Crit Care Med (2014) 2.13

CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res (2010) 2.13

CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation (2007) 2.09

Hypoxia and gastrointestinal disease. J Mol Med (Berl) (2007) 2.06

Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol (2007) 2.03

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci U S A (2002) 2.01

Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol (2008) 1.93

Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol (2007) 1.90

Role of vasodilator-stimulated phosphoprotein in PKA-induced changes in endothelial junctional permeability. FASEB J (2002) 1.90

A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol (2009) 1.85

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84

Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J (2007) 1.84

CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest (2011) 1.82

Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol (2011) 1.82

Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology (2008) 1.80

Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood (2008) 1.79

High-resolution EUS in children with eosinophilic "allergic" esophagitis. Gastrointest Endosc (2003) 1.77

Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS One (2007) 1.77

Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J (2008) 1.75

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A (2008) 1.75

Adenosine receptors as drug targets--what are the challenges? Nat Rev Drug Discov (2013) 1.74

Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology (2011) 1.73

Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood (2012) 1.72

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A (2012) 1.70

Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol (2010) 1.70

Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol (2009) 1.68

Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension. Circ Res (2013) 1.68

Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol (2006) 1.68

Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J (2007) 1.67

Safety of transesophageal echocardiography. J Am Soc Echocardiogr (2010) 1.67

Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med (2015) 1.65

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood (2010) 1.65

Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood (2006) 1.65

Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. J Immunol (2009) 1.63

Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury. FASEB J (2008) 1.63

Feeding dysfunction in children with eosinophilic gastrointestinal diseases. Pediatrics (2010) 1.62

Retracted Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver. Proc Natl Acad Sci U S A (2013) 1.59

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci U S A (2004) 1.56

Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc (2002) 1.56

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun (2008) 1.55

Detrimental effects of adenosine signaling in sickle cell disease. Nat Med (2010) 1.54

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A (2003) 1.52