Published in Antimicrob Agents Chemother on August 26, 2013
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev (2015) 1.81
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes. Chem Biol (2015) 1.57
In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother (2013) 1.41
Antibiotics and bacterial resistance in the 21st century. Perspect Medicin Chem (2014) 1.41
Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: current and emerging therapeutic approaches. Expert Opin Pharmacother (2014) 1.19
Insights into Newer Antimicrobial Agents Against Gram-negative Bacteria. Microbiol Insights (2016) 1.13
Phase 2, randomized, double-blind study of the efficacy and safety of two dose regimens of eravacycline versus ertapenem for adult community-acquired complicated intra-abdominal infections. Antimicrob Agents Chemother (2013) 1.07
Antibiotics in the clinical pipeline at the end of 2015. J Antibiot (Tokyo) (2016) 1.04
Phase I, open-label, safety and pharmacokinetic study to assess bronchopulmonary disposition of intravenous eravacycline in healthy men and women. Antimicrob Agents Chemother (2014) 1.04
Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens. Infect Chemother (2014) 1.01
LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens. MBio (2014) 0.95
Carbapenemase-producing Klebsiella pneumoniae. F1000Prime Rep (2014) 0.91
Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother (2015) 0.90
Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor. Antimicrob Agents Chemother (2014) 0.89
Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City. Antimicrob Agents Chemother (2014) 0.87
Development of novel antibacterial drugs to combat multiple resistant organisms. Langenbecks Arch Surg (2015) 0.84
Eravacycline Pharmacokinetics and Challenges in Defining Humanized Exposure In Vivo. Antimicrob Agents Chemother (2016) 0.83
Eravacycline (TP-434) is active in vitro against biofilms formed by uropathogenic Escherichia coli. Antimicrob Agents Chemother (2015) 0.83
Fluorocycline TP-271 Is Potent against Complicated Community-Acquired Bacterial Pneumonia Pathogens. mSphere (2017) 0.82
Treatment for infections with carbapenem-resistant Enterobacteriaceae: what options do we still have? Crit Care (2014) 0.81
Breaking the Spell: Combating Multidrug Resistant 'Superbugs'. Front Microbiol (2016) 0.81
Editorial commentary: Polymyxin-resistant Acinetobacter baumannii: urgent action needed. Clin Infect Dis (2015) 0.79
Antibacterial Efficacy of Eravacycline In Vivo against Gram-Positive and Gram-Negative Organisms. Antimicrob Agents Chemother (2016) 0.79
In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline. J Antibiot (Tokyo) (2016) 0.78
Activity of Eravacycline against Escherichia coli Clinical Isolates Collected from U.S. Veterans in 2011 in Relation to Coresistance Phenotype and Sequence Type 131 Genotype. Antimicrob Agents Chemother (2015) 0.78
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens. ACS Med Chem Lett (2015) 0.77
Impact of the New Delhi metallo-beta-lactamase on beta-lactam antibiotics. Infect Drug Resist (2015) 0.77
Next-generation approaches to understand and combat the antibiotic resistome. Nat Rev Microbiol (2017) 0.75
Recent Advances in the Rational Design and Optimization of Antibacterial Agents. Medchemcomm (2016) 0.75
In Vitro Activity of Eravacycline against Carbapenem-Resistant Enterobacteriaceae and Acinetobacter baumannii. Antimicrob Agents Chemother (2016) 0.75
Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation. J Am Chem Soc (2014) 0.75
Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis (2009) 22.98
Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol (2002) 12.53
Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med (2005) 7.69
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones. J Bacteriol (1990) 7.61
Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother (2010) 6.98
Tracking a hospital outbreak of carbapenem-resistant Klebsiella pneumoniae with whole-genome sequencing. Sci Transl Med (2012) 6.63
Hospital-acquired infections due to gram-negative bacteria. N Engl J Med (2010) 6.61
Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother (2009) 6.33
Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis (2011) 5.58
Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship. Clin Infect Dis (2009) 4.87
Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis (2007) 3.73
Vital signs: carbapenem-resistant Enterobacteriaceae. MMWR Morb Mortal Wkly Rep (2013) 3.65
Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol (2010) 3.12
A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics. Science (2005) 3.03
"Stormy waters ahead": global emergence of carbapenemases. Front Microbiol (2013) 2.74
Inducible NorA-mediated multidrug resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1995) 2.52
Clinical and economic burden of antimicrobial resistance. Expert Rev Anti Infect Ther (2008) 2.22
Cost of Gram-negative resistance. Crit Care Med (2007) 2.05
Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn Microbiol Infect Dis (2013) 2.01
Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination. J Antimicrob Chemother (2010) 1.94
A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline. Antimicrob Agents Chemother (2005) 1.88
Antimicrobial resistance in gram-positive bacteria. Am J Med (2006) 1.71
Outcomes and genetic relatedness of carbapenem-resistant enterobacteriaceae at Detroit medical center. Infect Control Hosp Epidemiol (2011) 1.70
Multidrug resistance in Staphylococcus aureus due to overexpression of a novel multidrug and toxin extrusion (MATE) transport protein. Antimicrob Agents Chemother (2005) 1.66
Inclusion of 30-day postdischarge detection triples the incidence of hospital-onset methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol (2011) 1.63
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother (2012) 1.61
Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes. Expert Rev Pharmacoecon Outcomes Res (2010) 1.52
Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent. J Med Chem (2012) 1.48
Clinical characteristics of bacteraemia caused by extended-spectrum β-lactamase-producing Enterobacteriaceae in the era of CTX-M-type and KPC-type β-lactamases. Clin Microbiol Infect (2011) 1.39
Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options. Drugs (2007) 1.30
A hospital-based matched case-control study to identify clinical outcome and risk factors associated with carbapenem-resistant Klebsiella pneumoniae infection. BMC Infect Dis (2013) 1.20
Pharmacokinetic considerations regarding tigecycline for multidrug-resistant (MDR) Klebsiella pneumoniae or MDR Acinetobacter baumannii urosepsis. J Clin Microbiol (2009) 1.17
Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci, and other Gram-positives in healthcare. Curr Opin Infect Dis (2012) 1.11
Klebsiella pneumoniae antimicrobial drug resistance, United States, 1998-2010. Emerg Infect Dis (2013) 1.08
Unmet medical need in infectious diseases. Clin Infect Dis (2012) 1.00
Fluorocyclines. 2. Optimization of the C-9 side-chain for antibacterial activity and oral efficacy. J Med Chem (2012) 0.90
Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Appl Environ Microbiol (2000) 8.35
Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages. J Virol (1991) 3.28
The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism. J Virol (1992) 2.49
Geographical studies on rheumatoid arthritis. Ann Rheum Dis (1966) 2.09
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure (2000) 1.98
The Washington State Intergenerational Study of Birth Outcomes: methodology and some comparisons of maternal birthweight and infant birthweight and gestation in four ethnic groups. Paediatr Perinat Epidemiol (1999) 1.90
Appearances of the jejunal mucosa in acute tropical sprue in Singapore. Gut (1966) 1.79
Suppression of tumor growth by senescence in virally transformed human fibroblasts. Proc Natl Acad Sci U S A (1986) 1.70
Expression and isolation of antimicrobial small molecules from soil DNA libraries. J Mol Microbiol Biotechnol (2001) 1.60
Military tropical sprue from South-east Asia. Br Med J (1966) 1.57
Sequence analysis and functional characterization of the violacein biosynthetic pathway from Chromobacterium violaceum. J Mol Microbiol Biotechnol (2000) 1.54
Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men. Sex Transm Infect (2008) 1.41
Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes. Gene (1996) 1.33
Primary leiomyosarcoma of adrenal gland. Case report with immunohistochemical and ultrastructural study. Am J Surg Pathol (1991) 1.14
Killing of primary CD4+ T cells by non-syncytium-inducing macrophage-tropic human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1994) 1.12
Pseudoaneurysm complicating knee arthroscopy. Arthroscopy (1995) 1.12
Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase. Biochemistry (2001) 1.11
In vivo urea cycle flux distinguishes and correlates with phenotypic severity in disorders of the urea cycle. Proc Natl Acad Sci U S A (2000) 1.04
Kernel and nonlinear canonical correlation analysis. Int J Neural Syst (2000) 0.96
Physicians' knowledge and attitudes about suicide. JAMA (1973) 0.95
Hepatocyte gene therapy in a large animal: a neonatal bovine model of citrullinemia. Proc Natl Acad Sci U S A (1999) 0.92
Monophasic action potentials at discontinuation of cardiopulmonary bypass: evidence for contraction-excitation feedback in man. Circulation (1988) 0.92
The long-term prognosis in untreated cerebral aneurysms: II. Late morbidity and mortality. Ann Neurol (1978) 0.91
Comparison of characteristics of Q beta replicase-amplified assay with competitive PCR assay for Chlamydia trachomatis. J Clin Microbiol (1995) 0.89
Use of monophasic action potential recordings during routine coronary-artery bypass surgery as an index of localised myocardial ischaemia. Lancet (1986) 0.89
Pernicious anaemia among Asians in Singapore. Br Med J (1967) 0.89
Muscle protein breakdown during endotoxemia in rats and after treatment with interleukin-1 receptor antagonist (IL-1ra). Ann Surg (1992) 0.89
Structure-function studies of the Na,K-ATPase. Kidney Int Suppl (1994) 0.87
Prevention of anticardiolipin antibody-related pregnancy losses with prednisone and aspirin. Am J Med (1992) 0.86
Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist. Int J Biochem (1994) 0.84
Effect of abrupt changes in ventricular loading on repolarization induced by transient aortic occlusion in humans. Am J Physiol (1992) 0.84
Transient organic aciduria and methemoglobinemia with acute gastroenteritis. Pediatrics (1990) 0.82
Intestinal malabsorption in acute infection with Strongyloides stercoralis. Trans R Soc Trop Med Hyg (1975) 0.81
Megaloblastic anaemia in Asians in Singapore. Trans R Soc Trop Med Hyg (1966) 0.81
Bringing decision support to nurse managers. Comput Nurs (2000) 0.81
Scrotal enlargement following inguinal herniorrhaphy: ultrasound evaluation. Urol Radiol (1988) 0.81
Hospice and palliative care education in medical school: a module on the role of the physician in end-of-life care. J Cancer Educ (1997) 0.81
A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes. Diabet Med (2013) 0.81
Acute graded hypercapnia increases collateral coronary blood flow in a swine model of chronic coronary artery obstruction. Crit Care Med (1999) 0.81
Modelling multiple-cause structure using rectification constraints. Network (1998) 0.80
Production of secreted, soluble human two-domain CD4 protein in Escherichia coli. J Immunol Methods (1999) 0.80
Day case laparoscopic cholecystectomy is feasible. Ir J Med Sci (2001) 0.80
Cyclophosphamide vs. conservative treatment of rheumatoid arthritis. Arthritis Rheum (1968) 0.79
Acute military tropical sprue in Southeast Asia. Am J Clin Nutr (1968) 0.79
Required training in hospice and palliative care at the University of Maryland School of Medicine. J Cancer Educ (1999) 0.79
Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation. Surgery (2001) 0.79
A neural implementation of canonical correlation analysis. Neural Netw (1999) 0.79
Na,K-ATPase: structure-function studies. Ren Physiol Biochem (1994) 0.78
Effect of sepsis on mucosal protein synthesis in different parts of the gastrointestinal tract in rats. Clin Sci (Lond) (1994) 0.77
Defective monocyte cytotoxicity in rheumatoid arthritis: a correlation with disease activity and reversal by levamisole. Arthritis Rheum (1982) 0.77
Endoscopic stent configuration and bile flow rates in a variable diameter bile duct model. Surg Endosc (1990) 0.77
Elevated serum chymotrypsin levels in a patient with junctional epidermolysis bullosa. Normalization after UVB therapy with good clinical response. Int J Dermatol (1987) 0.77
Alternans of epicardial repolarization as a localized phenomenon in man. Eur Heart J (1991) 0.77
Influence of maternal dietary protein and fat levels on fetal growth in mice. Growth (1981) 0.77
Educational program in palliative and hospice care at the University of Maryland School of Medicine. J Cancer Educ (1996) 0.77
Expanded clinical and molecular spectrum of guanidinoacetate methyltransferase (GAMT) deficiency. Mol Genet Metab (2008) 0.77
Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol (1999) 0.77
Auranofin: 1 mg or 9 mg? The search for the appropriate dose. J Rheumatol Suppl (1982) 0.77
Tropical sprue: a review. J R Soc Med (1979) 0.77
Ultrasonic assessment of skin and wounds with the scanning laser acoustic microscope. J Invest Dermatol (1987) 0.77
Spinal cord perfusion pressure in dogs after control of proximal aortic hypertension during thoracic aortic cross-clamping with esmolol or sodium nitroprusside. Anesthesiology (1993) 0.76
Computer-assisted analysis of radiographic neck lesions in chronic rheumatoid arthritis. Acta Radiol Diagn (Stockh) (1969) 0.76
High-level production of a secreted, heterodimeric alpha beta murine T-cell receptor in Escherichia coli. J Immunol Methods (1997) 0.76
Neuropsychological impairment and behavioral limitations exhibited within an alcohol treatment program. J Clin Exp Neuropsychol (1985) 0.76
Schistosoma mansoni infection with portal hypertension (Symmers' fibrosis). Proc R Soc Med (1974) 0.76
The effect of arginine or glycine supplementation on gastrointestinal function, muscle injury, serum amino acid concentrations and performance during a marathon run. Int J Sports Med (1999) 0.76
Aortic incompetence associated with ulcerative colitis and ankylosing spondylitis. Proc R Soc Med (1970) 0.75
Authors' reply to the commentary Maternal birthweight and newborn status. Paediatr Perinat Epidemiol (2000) 0.75
Dexamethasone effects on cerebral protein synthesis prior to and following hypoxia-ischemia in immature rat. Brain Res Bull (1999) 0.75
The fevers of the Great Famine. J Ir Coll Physicians Surg (1980) 0.75
An integrative approach to the electrophoresis of the reductase and dehydrogenase isozymes in respiring and fermenting yeasts. Microbios (1982) 0.75
Investigations of the horse conceptus via magnetic resonance imaging (MRI) and nitroxide spin labels as contrast agents. Free Radic Res Commun (1990) 0.75
The combined use of self-organizing maps and Andrews' Curves. Int J Neural Syst (2005) 0.75
Gooberphagia and anemia. Ann Intern Med (1969) 0.75
Roentgenographic findings during auranofin treatment. Am J Med (1983) 0.75
Past salt supplies in West Africa and blood pressures today. Lancet (1986) 0.75
A simple adjustable functional brace for tibial fractures. Injury (1986) 0.75
Intraoperative assessment of myocardial revascularisation for the relief of ischaemia using monophasic action potential recordings. Eur J Cardiothorac Surg (1988) 0.75
Antenatal predictors for Down's syndrome. Nurs Times (1991) 0.75
Health effects associated with exposure to radioactively contaminated gold rings. J Am Acad Dermatol (1984) 0.75
The diagnosis and treatment of tropical sprue. Trans R Soc Trop Med Hyg (1968) 0.75
Africanus Horton as a constitution-maker. J Commonw Comp Polit (1988) 0.75
The nature of program evaluation in mental health. Evaluation (1974) 0.75
Effects of two fluoride gels on fluoride uptake and phosphorus loss during artificial caries formation. J Dent Res (1986) 0.75
The diagnosis of tropical sprue. Trans R Soc Trop Med Hyg (1970) 0.75
Serum lipid profile determines platelet reactivity to native and modified LDL-cholesterol in humans. Thromb Haemost (1994) 0.75
The pregnant lupus patient who lost four fetuses. Hosp Pract (Off Ed) (1988) 0.75
The treatment of malaria. Practitioner (1975) 0.75
An interesting case presentation: peripartum meningococcal meningitis. J Perinatol (1992) 0.75
Stochastic ICA contrast maximisation using OJA's nonlinear PCA algorithm. Int J Neural Syst (1999) 0.75
Primary angiitis of the central nervous system with diffuse cerebral mass effect and giant cells. J Clin Neurosci (2010) 0.75