TGF-β signaling protects retinal neurons from programmed cell death during the development of the mammalian eye.

PubWeight™: 0.84‹?›

🔗 View Article (PMID 23986258)

Published in J Neurosci on August 28, 2013

Authors

Barbara M Braunger1, Stefan Pielmeier, Cora Demmer, Victoria Landstorfer, Daniela Kawall, Natalie Abramov, Marco Leibinger, Ingo Kleiter, Dietmar Fischer, Herbert Jägle, Ernst R Tamm

Author Affiliations

1: Institute of Human Anatomy and Embryology, University of Regensburg, D-93053 Regensburg, Germany.

Articles by these authors

Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients. J Neuroinflammation (2012) 3.12

A broad role for melanopsin in nonvisual photoreception. J Neurosci (2003) 2.78

CNGB3 mutations account for 50% of all cases with autosomal recessive achromatopsia. Eur J Hum Genet (2005) 2.37

Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci (2003) 2.26

Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients. J Neurol Neurosurg Psychiatry (2013) 2.23

Gene targeting reveals a widespread role for the high-mobility-group transcription factor Sox11 in tissue remodeling. Mol Cell Biol (2004) 2.23

Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation. Brain (2007) 2.15

Markers distinguishing mesenchymal stem cells from fibroblasts are downregulated with passaging. Stem Cells Dev (2010) 2.12

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases. Bioessays (2004) 1.96

Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS). J Neurol (2013) 1.79

Reorganization of human cortical maps caused by inherited photoreceptor abnormalities. Nat Neurosci (2002) 1.69

Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor. J Neurosci (2009) 1.63

Taxol facilitates axon regeneration in the mature CNS. J Neurosci (2011) 1.62

Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol (2010) 1.48

The role of TGF-β in the pathogenesis of primary open-angle glaucoma. Cell Tissue Res (2011) 1.47

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF. Mol Cell Neurosci (2009) 1.46

Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy. JAMA Neurol (2013) 1.30

Modulation of extracellular matrix turnover in the trabecular meshwork. Exp Eye Res (2009) 1.29

Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2007) 1.26

Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease. Brain (2010) 1.24

Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am J Pathol (2012) 1.22

Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells. Exp Eye Res (2009) 1.22

Cone dystrophy with supernormal rod response is strictly associated with mutations in KCNV2. Invest Ophthalmol Vis Sci (2008) 1.20

Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities. Mech Dev (2002) 1.20

Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders. Mult Scler (2011) 1.19

Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma. Cancer (2004) 1.19

Identification of pax6-dependent gene regulatory networks in the mouse lens. PLoS One (2009) 1.19

Risk perception in natalizumab-treated multiple sclerosis patients and their neurologists. Mult Scler (2010) 1.18

Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease. J Neurol Neurosurg Psychiatry (2012) 1.17

Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination. Dev Cell (2012) 1.17

The molecular basis of dichromatic color vision in males with multiple red and green visual pigment genes. Hum Mol Genet (2002) 1.16

Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res (2009) 1.14

Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments. Invest Ophthalmol Vis Sci (2002) 1.14

Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanylate cyclase. Hum Mutat (2009) 1.14

Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/beta-catenin signaling pathway and the induction of neuroprotective growth factors in Muller cells. J Neurosci (2010) 1.13

A luminous efficiency function, V*(lambda), for daylight adaptation. J Vis (2005) 1.12

Fingolimod reduces recurrence of disease activity after natalizumab withdrawal in multiple sclerosis. J Neurol (2012) 1.11

Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. J Neurosci (2005) 1.10

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin (2010) 1.10

Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve. Glia (2011) 1.09

Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro. Exp Eye Res (2004) 1.09

Promoting optic nerve regeneration. Prog Retin Eye Res (2012) 1.07

Long-term follow-up of retinitis pigmentosa patients with multifocal electroretinography. Invest Ophthalmol Vis Sci (2008) 1.07

Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet (2005) 1.06

Large deletions of the KCNV2 gene are common in patients with cone dystrophy with supernormal rod response. Hum Mutat (2011) 1.06

The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination. Mol Cell Biol (2005) 1.05

The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes. PLoS Genet (2013) 1.05

Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11. Exp Eye Res (2008) 1.05

Donor corneoscleral buttons: a new source of trabecular meshwork for research. Exp Eye Res (2003) 1.04

Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages. Exp Neurol (2007) 1.04

Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci (2009) 1.03

ABCA4 gene analysis in patients with autosomal recessive cone and cone rod dystrophies. Eur J Hum Genet (2008) 1.02

Norrin: molecular and functional properties of an angiogenic and neuroprotective growth factor. Prog Retin Eye Res (2012) 1.02

Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes. Invest Ophthalmol Vis Sci (2003) 1.01

Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice. Invest Ophthalmol Vis Sci (2005) 1.00

Glaucoma and optic nerve repair. Cell Tissue Res (2013) 1.00

Different collagen types define two types of idiopathic epiretinal membranes. Histopathology (2011) 0.98

Elevated amounts of myocilin in the aqueous humor of transgenic mice cause significant changes in ocular gene expression. Exp Eye Res (2008) 0.97

Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn (2002) 0.96

Update on biomarkers in neuromyelitis optica. Neurol Neuroimmunol Neuroinflamm (2015) 0.96

Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro. Hum Mol Genet (2010) 0.95

Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation. Neurobiol Dis (2012) 0.94

Repair of full-thickness tendon injury using connective tissue progenitors efficiently derived from human embryonic stem cells and fetal tissues. Tissue Eng Part A (2010) 0.94

Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol (2009) 0.93

Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium. Pflugers Arch (2012) 0.93

Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells. Histochem Cell Biol (2008) 0.92

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage. Neurobiol Dis (2012) 0.92

Facilitating axon regeneration in the injured CNS by microtubules stabilization. Commun Integr Biol (2011) 0.92

Transgenic studies on the role of optineurin in the mouse eye. Exp Eye Res (2006) 0.92

Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. J Neurosci (2010) 0.92

Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism. FASEB J (2005) 0.91

Evidence-based patient information programme in early multiple sclerosis: a randomised controlled trial. J Neurol Neurosurg Psychiatry (2013) 0.90

Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves. Glia (2003) 0.90

The role of plasmalemma vesicle-associated protein (PLVAP) in endothelial cells of Schlemm's canal and ocular capillaries. Exp Eye Res (2012) 0.89

Perfusion with the olfactomedin domain of myocilin does not affect outflow facility. Invest Ophthalmol Vis Sci (2003) 0.88

Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis. J Neuroinflammation (2008) 0.87

Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice. J Histochem Cytochem (2009) 0.87

Molecular basis of an inherited form of incomplete achromatopsia. J Neurosci (2004) 0.87

Lack of endothelial diaphragms in fenestrae and caveolae of mutant Plvap-deficient mice. Histochem Cell Biol (2012) 0.87

Gyrate atrophy: clinical and genetic findings in a female without arginine-restricted diet during her first 39 years of life and report of a new OAT gene mutation. Doc Ophthalmol (2012) 0.87

Management of strabismus with hemianopic visual field defects. Graefes Arch Clin Exp Ophthalmol (2012) 0.87

A comparison of the performance of three visual evoked potential-based methods to estimate visual acuity. Doc Ophthalmol (2012) 0.87

The different functions of Norrin. Adv Exp Med Biol (2012) 0.86

Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. PLoS One (2013) 0.86

Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells. J Mol Cell Biol (2013) 0.86

Bridging, switching or drug holidays - how to treat a patient who stops natalizumab? Ther Clin Risk Manag (2013) 0.85

A method for preparing primary retinal cell cultures for evaluating the neuroprotective and neuritogenic effect of factors on axotomized mature CNS neurons. Curr Protoc Neurosci (2010) 0.85

Psychophysically determined full-field stimulus thresholds (FST) in retinitis pigmentosa: relationships with electroretinography and visual field outcomes. Doc Ophthalmol (2013) 0.85

Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma. Hum Mol Genet (2010) 0.84

The role of bestrophin-1 in intracellular Ca(2+) signaling. Adv Exp Med Biol (2014) 0.84

Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice. PLoS One (2009) 0.84

Hyperoxia, hyperglycemia, and photoreceptor sensitivity in normal and diabetic subjects. Vis Neurosci (2006) 0.84

GUCY2D- or GUCA1A-related autosomal dominant cone-rod dystrophy: is there a phenotypic difference? Retina (2014) 0.84

BAP1 germline mutation in two first grade family members with uveal melanoma. Br J Ophthalmol (2013) 0.84