Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.

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Published in Haematologica on August 30, 2013

Authors

Husheng Ding1, Jennifer S McDonald, Seongseok Yun, Paula A Schneider, Kevin L Peterson, Karen S Flatten, David A Loegering, Ann L Oberg, Shaun M Riska, Shengbing Huang, Frank A Sinicrope, Alex A Adjei, Judith E Karp, X Wei Meng, Scott H Kaufmann

Author Affiliations

1: Kaufmann.scott@mayo.edu.

Associated clinical trials:

Tipifarnib and Etoposide in Treating Older Patients With Newly Diagnosed, Previously Untreated Acute Myeloid Leukemia | NCT00602771

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