Published in Science on February 26, 2009
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
Recurrent R-spondin fusions in colon cancer. Nature (2012) 5.10
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. Nature (2012) 3.23
Making sense of cancer genomic data. Genes Dev (2011) 3.01
Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature (2012) 2.96
A hyperactive piggyBac transposase for mammalian applications. Proc Natl Acad Sci U S A (2011) 2.68
Harnessing transposons for cancer gene discovery. Nat Rev Cancer (2010) 2.44
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Genes Dev (2010) 2.37
Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. BMC Cancer (2009) 2.32
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science (2010) 2.31
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
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High-throughput insertional mutagenesis screens in mice to identify oncogenic networks. Nat Rev Cancer (2009) 2.06
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A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res (2009) 1.86
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2012) 1.82
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All y'all need to know 'bout retroelements in cancer. Semin Cancer Biol (2010) 1.52
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Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med Genomics (2012) 1.39
Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumors. PLoS One (2011) 1.38
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality. Cancer Res (2009) 1.34
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Global methylation in exposure biology and translational medical science. Environ Health Perspect (2011) 1.28
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Sleeping beauty transposition from nonintegrating lentivirus. Mol Ther (2009) 1.18
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A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. Proc Natl Acad Sci U S A (2012) 1.12
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A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis. Proc Natl Acad Sci U S A (2011) 1.09
Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer. Nat Methods (2013) 1.08
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Colorectal cancer. Nat Rev Dis Prim (2015) 1.07
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Murine models of colorectal cancer. Mamm Genome (2009) 1.03
Regulation of CUG-binding protein 1 (CUGBP1) binding to target transcripts upon T cell activation. J Biol Chem (2011) 1.02
The role of KCNQ1 in mouse and human gastrointestinal cancers. Oncogene (2013) 1.02
Chromatin landscapes of retroviral and transposon integration profiles. PLoS Genet (2014) 1.02
Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy. Transl Res (2013) 1.01
TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data. BMC Bioinformatics (2012) 1.01
Genetic reconstitution of tumorigenesis in primary intestinal cells. Proc Natl Acad Sci U S A (2013) 1.00
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Animal models of colorectal cancer. Cancer Metastasis Rev (2013) 0.99
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev (2014) 0.98
Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas. Cancer Res (2010) 0.98
New methods for finding common insertion sites and co-occurring common insertion sites in transposon- and virus-based genetic screens. Nucleic Acids Res (2012) 0.98
The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice. Nucleic Acids Res (2014) 0.97
Unexpectedly high copy number of random integration but low frequency of persistent expression of the Sleeping Beauty transposase after trans delivery in primary human T cells. Hum Gene Ther (2010) 0.97
L1 retrotransposons, cancer stem cells and oncogenesis. FEBS J (2013) 0.97
Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A (2012) 0.96
piggyBac transposon somatic mutagenesis with an activated reporter and tracker (PB-SMART) for genetic screens in mice. PLoS One (2011) 0.95
Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups. Proc Natl Acad Sci U S A (2013) 0.95
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors. Cancer Res (2012) 0.94
Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis. BMC Genomics (2011) 0.94
Mobilizing diversity: transposable element insertions in genetic variation and disease. Mob DNA (2010) 0.93
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Proc Natl Acad Sci U S A (2014) 0.93
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin. EMBO Rep (2013) 0.93
Transposon-based screens for cancer gene discovery in mouse models. Semin Cancer Biol (2010) 0.93
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Retroviral vectors: post entry events and genomic alterations. Viruses (2011) 0.92
Computational identification of insertional mutagenesis targets for cancer gene discovery. Nucleic Acids Res (2011) 0.92
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease. Nat Chem Biol (2015) 0.90
Oocyte-derived R-spondin2 promotes ovarian follicle development. FASEB J (2013) 0.89
Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis. Am J Pathol (2013) 0.89
Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. J Hematol Oncol (2014) 0.88
Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR. Hepatology (2012) 0.88
Cancer gene discovery: exploiting insertional mutagenesis. Mol Cancer Res (2013) 0.88
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Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. Oncogene (2014) 0.87
Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer. J Cancer Res Clin Oncol (2013) 0.86
Enhancing diagnosis, prognosis, and therapeutic outcome prediction of gliomas using genomics. OMICS (2012) 0.86
EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation. Proc Natl Acad Sci U S A (2013) 0.86
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia. Oncogene (2015) 0.86
Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathol Commun (2013) 0.85
Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res (2015) 0.85
Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PLoS One (2011) 0.85
Genetic screens using the piggyBac transposon. Methods (2010) 0.84
New approaches for modelling sporadic genetic disease in the mouse. Dis Model Mech (2009) 0.84
Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model. Proc Natl Acad Sci U S A (2013) 0.83
Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice. PLoS One (2014) 0.83
LGR4 and Its Role in Intestinal Protection and Energy Metabolism. Front Endocrinol (Lausanne) (2015) 0.83
CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene (2016) 0.83
RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens. Genome Res (2015) 0.82
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature (2008) 6.24
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature (2005) 6.20
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Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations. Cancer Res (2007) 1.56
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Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene (2007) 1.28
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature (2011) 13.30
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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
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