Published in Arthritis Res Ther on January 01, 2013
Obesity and inflammatory arthritis: impact on occurrence, disease characteristics and therapeutic response. RMD Open (2015) 0.93
Does lipopolysaccharide-mediated inflammation have a role in OA? Nat Rev Rheumatol (2015) 0.83
Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation. J Inflamm (Lond) (2015) 0.79
Evaluation of tool-like receptor-2 and 4 and interleukin-6 gene expressions in Turkish rheumatoid arthritis patients. Clin Rheumatol (2016) 0.76
Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation. Osteoarthritis Cartilage (2016) 0.75
Detection of human antibodies binding with smooth and rough LPSs from Proteus mirabilis O3 strains S1959, R110, R45. Antonie Van Leeuwenhoek (2017) 0.75
Missing pieces in the NF-kappaB puzzle. Cell (2002) 17.83
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med (1997) 14.51
Evolving concepts of rheumatoid arthritis. Nature (2003) 14.31
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature (1995) 11.61
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med (1999) 9.23
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature (1999) 8.42
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature (1999) 8.23
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol (1995) 6.99
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol (2001) 5.59
Collagens, modifying enzymes and their mutations in humans, flies and worms. Trends Genet (2004) 5.47
Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol (1999) 4.03
Nuclear factor-kappaB: its role in health and disease. J Mol Med (Berl) (2004) 4.01
Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab (2006) 3.84
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem (2002) 3.05
Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest (1976) 2.84
Scavenger receptors in innate immunity. Curr Opin Immunol (2002) 2.62
Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum (1996) 2.07
The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum (1997) 2.07
Immunopathogenesis of collagen arthritis. Springer Semin Immunopathol (2003) 1.89
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87
How antirheumatic drugs protect joints from damage in rheumatoid arthritis. Arthritis Rheum (2008) 1.74
Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol (2007) 1.73
The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models. Connect Tissue Res (1999) 1.67
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res (2008) 1.58
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther (2009) 1.56
Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. J Biol Chem (1997) 1.50
The catabolic pathway mediated by Toll-like receptors in human osteoarthritic chondrocytes. Arthritis Rheum (2006) 1.46
Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. J Leukoc Biol (2002) 1.44
Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J (2003) 1.41
Molecules and mechanisms operating in septic shock: lessons from knockout mice. Immunol Today (1997) 1.38
Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol (2008) 1.37
Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-kappa B activation. J Immunol (2000) 1.32
Inhibition of mitogen-activated protein kinase kinase induces apoptosis of human chondrocytes. J Biol Chem (2001) 1.23
Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2011) 1.15
Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes. Biochimie (2009) 1.12
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci U S A (2011) 1.12
Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes. J Biol Chem (2012) 1.10
The role of resident synovial cells in destructive arthritis. Best Pract Res Clin Rheumatol (2008) 1.10
Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum (2003) 1.08
The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem (2001) 1.06
Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes. J Immunol (2007) 1.04
Inhibition of chondrogenesis by integrin antibody in vitro. Exp Cell Res (1998) 1.04
Molecular targets of rheumatoid arthritis. Inflamm Allergy Drug Targets (2008) 1.02
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling. J Invest Dermatol (2010) 1.01
Signal transduction by beta1 integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor. Biochem J (1999) 1.00
Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem (2009) 0.98
An outbreak of respiratory diseases among workers at a water-damaged building--a case report. Indoor Air (2000) 0.97
Epigenetics in rheumatoid arthritis. Clin Rev Allergy Immunol (2010) 0.96
Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy. Curr Pharm Des (2005) 0.93
Glycosaminoglycans reduced inflammatory response by modulating toll-like receptor-4 in LPS-stimulated chondrocytes. Arch Biochem Biophys (2009) 0.91
Rheumatoid arthritis is more than cytokines: autoimmunity and rheumatoid arthritis. Arthritis Rheum (2001) 0.89
Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action. J Inflamm (1997) 0.87
Differential effect of molecular mass hyaluronan on lipopolysaccharide-induced damage in chondrocytes. Innate Immun (2009) 0.87
Integrins in ageing cartilage tissue in vitro. Histol Histopathol (1993) 0.86
Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide. Osteoarthritis Cartilage (2012) 0.86
Purified human plasma glycosaminoglycans reduced NF-kappaB activation, pro-inflammatory cytokine production and apoptosis in LPS-treated chondrocytes. Innate Immun (2008) 0.85
Changes in integrin expression during chondrogenesis in vitro: an immunomorphological study. J Histochem Cytochem (1995) 0.84
Does endotoxaemia contribute to osteoarthritis in obese patients? Clin Sci (Lond) (2012) 0.84
Complement reduction impairs the febrile response of guinea pigs to endotoxin. Am J Physiol (1998) 0.84
Why does rheumatoid arthritis involve the joints? N Engl J Med (2007) 0.83
Changes in pro-inflammatory cytokines in association with exposure to moisture-damaged building microbes. Eur Respir J (2001) 0.82
A hypothesis for the origin and pathogenesis of rheumatoid diseases. Rheumatol Int (2005) 0.78
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy (2007) 2.01
Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol (2007) 1.73
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther (2009) 1.56
Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem Pharmacol (2007) 1.51
Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol (2008) 1.37
Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol (2004) 1.36
Electron microscopic findings in BAL of a fire-eater after petroleum aspiration. Chest (2003) 1.29
IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One (2011) 1.27
Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. J Clin Invest (2008) 1.27
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther (2010) 1.23
Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation (2008) 1.17
Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2011) 1.15
The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet J (2007) 1.14
In utero and lactational exposures to low doses of polybrominated diphenyl ether-47 alter the reproductive system and thyroid gland of female rat offspring. Environ Health Perspect (2008) 1.12
Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem (2011) 1.11
Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain. Endocrinology (2003) 1.10
Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes. J Biol Chem (2012) 1.10
Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One (2013) 1.10
Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. J Cell Physiol (2010) 1.09
Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci (2007) 1.09
Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res Ther (2009) 1.08
The emerging chondrocyte channelome. Front Physiol (2010) 1.08
Loss of chondrogenic potential in dedifferentiated chondrocytes correlates with deficient Shc-Erk interaction and apoptosis. Osteoarthritis Cartilage (2004) 1.06
Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet J (2003) 1.04
Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann N Y Acad Sci (2009) 1.04
Ultrastructural changes observed in rat ovaries following in utero and lactational exposure to low doses of a polybrominated flame retardant. Toxicol Lett (2005) 1.03
Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther (2012) 1.03
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS One (2012) 1.02
Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat (2005) 1.02
Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology. OMICS (2013) 1.00
Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB J (2002) 0.99
Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci (2004) 0.98
Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain. Arthritis Rheumatol (2014) 0.98
High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. J Proteomics (2011) 0.97
Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells. Toxicology (2005) 0.97
Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes. J Biol Chem (2012) 0.97
Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays. Ann Anat (2010) 0.96
Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells. Cell Tissue Res (2006) 0.96
Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells. J Orthop Res (2011) 0.95
Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus (2013) 0.95
Accelerated mitochondrial adenosine diphosphate/adenosine triphosphate transport improves hypertension-induced heart disease. Circulation (2007) 0.95
Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines. Adv Anat Embryol Cell Biol (2008) 0.94
Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem Pharmacol (2006) 0.93
The role of the membrane potential in chondrocyte volume regulation. J Cell Physiol (2011) 0.93
Matrix metalloproteinases in inflammatory pathologies of the horse. Vet J (2008) 0.93
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β. Arthritis Res Ther (2013) 0.93
Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr (2005) 0.92
Synergistic effects of dexamethasone and quinolones on human-derived tendon cells. Int J Antimicrob Agents (2010) 0.92
ATPase pumps in osteoclasts and osteoblasts. Int J Biochem Cell Biol (2002) 0.91
Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr (2010) 0.91
Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy. Am J Hypertens (2002) 0.91
Expression of aquaporin 1 (AQP1) in human synovitis. Ann Anat (2010) 0.90
Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion. J Mol Med (Berl) (2005) 0.90
Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci (2012) 0.90
Cryopreservation of human vascular umbilical cord cells under good manufacturing practice conditions for future cell banks. J Transl Med (2012) 0.89
Midkine acts as proangiogenic cytokine in hypoxia-induced angiogenesis. Am J Physiol Heart Circ Physiol (2012) 0.89
Effects of the Des-F(6)-quinolone garenoxacin (BMS-284756), in comparison to those of ciprofloxacin and ofloxacin, on joint cartilage in immature rats. Antimicrob Agents Chemother (2002) 0.87
Tissue engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg (2006) 0.87
Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J Orthop Res (2009) 0.87
Expression of Transient Receptor Potential Vanilloid (TRPV) channels in different passages of articular chondrocytes. Int J Mol Sci (2012) 0.86
Rab7 silencing prevents μ-opioid receptor lysosomal targeting and rescues opioid responsiveness to strengthen diabetic neuropathic pain therapy. Diabetes (2012) 0.84
Anabolic actions of IGF-I and TGF-beta1 on Interleukin-1beta-treated human articular chondrocytes: evaluation in two and three dimensional cultures. Histol Histopathol (2009) 0.84
Regulation of 2-deoxy-D-glucose transport, lactate metabolism, and MMP-2 secretion by the hypoxia mimetic cobalt chloride in articular chondrocytes. Ann N Y Acad Sci (2006) 0.84
The transmembrane domains of L-selectin and CD44 regulate receptor cell surface positioning and leukocyte adhesion under flow. J Biol Chem (2010) 0.84
Use of human umbilical cord blood-derived progenitor cells for tissue-engineered heart valves. Ann Thorac Surg (2010) 0.84
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. Curr Rheumatol Rep (2015) 0.84
Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes. Vet J (2005) 0.83
The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins. Reprod Biol Endocrinol (2010) 0.83
Equine transcriptome quantification using human GeneChip arrays can be improved using genomic DNA hybridisation and probe selection. Vet J (2009) 0.83
Effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin on the extracellular matrix of the thymus in juvenile marmosets (Callithrix jacchus). Toxicology (2006) 0.83
On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives. Cell Biochem Biophys (2010) 0.82
Low doses of 2,3,7,8-tetrachlorodibenzo- p-dioxin increase transforming growth factor beta and cause myocardial fibrosis in marmosets ( Callithrix jacchus). Arch Toxicol (2002) 0.82
Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology (2003) 0.82
Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: a study using high density human tissue microarrays. Ann Anat (2009) 0.82
The biology of equine mesenchymal stem cells: phenotypic characterization, cell surface markers and multilineage differentiation. Front Biosci (Landmark Ed) (2012) 0.81
Vascular endothelial growth factor inhibits programmed cell death of endothelial cells induced by clinorotation. J Gravit Physiol (2004) 0.80
Effects of simulated microgravity on thyroid carcinoma cells. J Gravit Physiol (2002) 0.80
Reduced number, G protein coupling, and antinociceptive efficacy of spinal mu-opioid receptors in diabetic rats are reversed by nerve growth factor. J Pain (2013) 0.80