Published in Biochem Pharmacol on January 07, 2007
Beyond reverse pharmacology: Mechanism-based screening of Ayurvedic drugs. J Ayurveda Integr Med (2010) 1.60
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther (2009) 1.56
Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology (2008) 1.49
TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro. Arthritis Res Ther (2012) 1.30
IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One (2011) 1.27
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther (2010) 1.23
Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol (2013) 1.21
Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2011) 1.15
Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol (2007) 1.13
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS One (2012) 1.02
Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res (2009) 1.00
Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK. Arch Oral Biol (2013) 0.99
Recent advances in the investigation of curcuminoids. Chin Med (2008) 0.98
Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes. J Biol Chem (2012) 0.97
Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus (2013) 0.95
Current nutraceuticals in the management of osteoarthritis: a review. Ther Adv Musculoskelet Dis (2012) 0.94
Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer. Cancer Lett (2008) 0.92
Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr (2010) 0.91
The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. J Biol Chem (2012) 0.91
Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes. Osteoarthritis Cartilage (2010) 0.91
Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci (2012) 0.90
Intersection of inflammation and herbal medicine in the treatment of osteoarthritis. Curr Rheumatol Rep (2012) 0.90
Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS One (2011) 0.90
Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress. Lab Invest (2009) 0.89
Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis. Int J Mol Sci (2013) 0.88
Adaptive cellular stress pathways as therapeutic targets of dietary phytochemicals: focus on the nervous system. Pharmacol Rev (2014) 0.87
Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese mice. Diabetes (2011) 0.87
The effect of co-delivery of paclitaxel and curcumin by transferrin-targeted PEG-PE-based mixed micelles on resistant ovarian cancer in 3-D spheroids and in vivo tumors. Eur J Pharm Biopharm (2014) 0.87
Curcumin attenuates radiation-induced inflammation and fibrosis in rat lungs. Korean J Physiol Pharmacol (2013) 0.85
Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes Nutr (2011) 0.84
Pilot study of oral administration of a curcumin-phospholipid formulation for treatment of central serous chorioretinopathy. Clin Ophthalmol (2012) 0.83
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs. Arthritis Res Ther (2011) 0.83
Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complement Altern Med (2014) 0.83
A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations. Mediators Inflamm (2014) 0.82
Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development. Sci Rep (2015) 0.82
Immune modulation to improve tissue engineering outcomes for cartilage repair in the osteoarthritic joint. Tissue Eng Part B Rev (2014) 0.81
Modulation of inflammatory signaling pathways by phytochemicals in ovarian cancer. Genes Nutr (2011) 0.81
Management of chronic anterior uveitis relapses: efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin Ophthalmol (2010) 0.81
Saponin-rich fraction from Clematis chinensis Osbeck roots protects rabbit chondrocytes against nitric oxide-induced apoptosis via preventing mitochondria impairment and caspase-3 activation. Cytotechnology (2012) 0.81
Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. PLoS One (2014) 0.80
Curcumin inhibits the AKT/NF-κB signaling via CpG demethylation of the promoter and restoration of NEP in the N2a cell line. AAPS J (2014) 0.80
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther (2016) 0.80
Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation. Int J Nanomedicine (2015) 0.79
Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis. Arthritis Res Ther (2013) 0.79
Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes. Arthritis Res Ther (2013) 0.79
Plant polyphenols as inhibitors of NF-κB induced cytokine production-a potential anti-inflammatory treatment for Alzheimer's disease? Front Mol Neurosci (2015) 0.79
Regulation of biomechanical signals by NF-kappaB transcription factors in chondrocytes. Biorheology (2008) 0.78
Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evid Based Complement Alternat Med (2012) 0.78
Oral administration of nano-emulsion curcumin in mice suppresses inflammatory-induced NFκB signaling and macrophage migration. PLoS One (2014) 0.78
UP1304, a Botanical Composition Containing Two Standardized Extracts of Curcuma longa and Morus alba, Mitigates Pain and Inflammation in Adjuvant-induced Arthritic Rats. Pharmacognosy Res (2016) 0.78
The spice for joint inflammation: anti-inflammatory role of curcumin in treating osteoarthritis. Drug Des Devel Ther (2016) 0.76
Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Mol Med Rep (2016) 0.76
Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells. PLoS One (2015) 0.76
Curcumin inhibits AP-2γ-induced apoptosis in the human malignant testicular germ cells in vitro. Acta Pharmacol Sin (2013) 0.76
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9. Immunology (2008) 0.76
Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms. Acta Pharmacol Sin (2013) 0.75
The antioxidant activity of some curcuminoids and chalcones. Inflammopharmacology (2016) 0.75
Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion. BMC Complement Altern Med (2015) 0.75
Protective effect of curcumin on experimentally induced arthritic rats: detailed histopathological study of the joints and white blood cell count. EXCLI J (2012) 0.75
Increased activity of chondrocyte translational apparatus accompanies osteoarthritis. Arthritis Rheumatol (2016) 0.75
Nutraceutical Supplements in the Management and Prevention of Osteoarthritis. Int J Mol Sci (2016) 0.75
Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy. Oncotarget (2017) 0.75
Marine Diterpenoids as Potential Anti-Inflammatory Agents. Mediators Inflamm (2015) 0.75
A Chemically Modified Curcumin (CMC 2.24) Inhibits Nuclear Factor κB Activation and Inflammatory Bone Loss in Murine Models of LPS-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis. Inflammation (2017) 0.75
Malvidin attenuates pain and inflammation in rats with osteoarthritis by suppressing NF-κB signaling pathway. Inflamm Res (2017) 0.75
Curcumin-loaded poly lactic-co-glycolic acid nanoparticles effects on mono-iodoacetate -induced osteoarthritis in rats. Vet Res Forum (2017) 0.75
Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model. Inflammopharmacology (2017) 0.75
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy (2007) 2.01
Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res Ther (2009) 1.56
Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem Pharmacol (2008) 1.37
Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol (2004) 1.36
IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway. PLoS One (2011) 1.27
Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J Leukoc Biol (2008) 1.26
Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther (2010) 1.23
The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol (2009) 1.19
Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem (2011) 1.15
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Exp Neurol (2006) 1.14
The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet J (2007) 1.14
Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem (2011) 1.11
Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes. J Biol Chem (2012) 1.10
Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-κB and Src protein kinase signaling pathways. PLoS One (2013) 1.10
Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. J Cell Physiol (2010) 1.09
Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann N Y Acad Sci (2007) 1.09
Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Res Ther (2009) 1.08
The emerging chondrocyte channelome. Front Physiol (2010) 1.08
Loss of chondrogenic potential in dedifferentiated chondrocytes correlates with deficient Shc-Erk interaction and apoptosis. Osteoarthritis Cartilage (2004) 1.06
Apoptosis and the loss of chondrocyte survival signals contribute to articular cartilage degradation in osteoarthritis. Vet J (2003) 1.04
Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann N Y Acad Sci (2009) 1.04
Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther (2012) 1.03
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS One (2012) 1.02
Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat (2005) 1.02
Pitfalls and complications in the treatment of cervical spine fractures in patients with ankylosing spondylitis. Patient Saf Surg (2008) 1.01
Redox regulation of apoptosis by members of the TNF superfamily. Antioxid Redox Signal (2005) 1.01
Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology. OMICS (2013) 1.00
Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes. J Orthop Res (2010) 1.00
Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells. FASEB J (2002) 0.99
Interleukin-10 and articular cartilage: experimental therapeutical approaches in cartilage disorders. Curr Gene Ther (2009) 0.99
Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes. Ann N Y Acad Sci (2004) 0.98
Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain. Arthritis Rheumatol (2014) 0.98
High throughput proteomic analysis of the secretome in an explant model of articular cartilage inflammation. J Proteomics (2011) 0.97
Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes. J Biol Chem (2012) 0.97
Glucose transporter Glut-1 is detectable in peri-necrotic regions in many human tumor types but not normal tissues: Study using tissue microarrays. Ann Anat (2010) 0.96
Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells. J Orthop Res (2011) 0.95
Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus (2013) 0.95
Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem Pharmacol (2006) 0.93
The role of the membrane potential in chondrocyte volume regulation. J Cell Physiol (2011) 0.93
Matrix metalloproteinases in inflammatory pathologies of the horse. Vet J (2008) 0.93
Carprofen inhibits the release of matrix metalloproteinases 1, 3, and 13 in the secretome of an explant model of articular cartilage stimulated with interleukin 1β. Arthritis Res Ther (2013) 0.93
Nutraceutical therapies for degenerative joint diseases: a critical review. Crit Rev Food Sci Nutr (2005) 0.92
ATPase pumps in osteoclasts and osteoblasts. Int J Biochem Cell Biol (2002) 0.91
Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy. Am J Hypertens (2002) 0.91
Curcumin synergizes with resveratrol to stimulate the MAPK signaling pathway in human articular chondrocytes in vitro. Genes Nutr (2010) 0.91
Tenocytes, pro-inflammatory cytokines and leukocytes: a relationship? Muscles Ligaments Tendons J (2012) 0.91
Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion. J Mol Med (Berl) (2005) 0.90
Current concepts in the treatment of proximal humeral fractures. Orthopedics (2008) 0.90
Biphasic onset of splenic apoptosis following hemorrhagic shock: critical implications for Bax, Bcl-2, and Mcl-1 proteins. Crit Care (2008) 0.87
Identification of PSF as a protein kinase Calpha-binding protein in the cell nucleus. J Cell Biochem (2002) 0.87
RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3. Biochem Biophys Res Commun (2008) 0.87
Effects of hypoxia on glucose transport in primary equine chondrocytes in vitro and evidence of reduced GLUT1 gene expression in pathologic cartilage in vivo. J Orthop Res (2009) 0.87
Expression of Transient Receptor Potential Vanilloid (TRPV) channels in different passages of articular chondrocytes. Int J Mol Sci (2012) 0.86
Errors in handling and manufacturing of orthopaedic implants: the tip of the iceberg of an unrecognized system problem? Patient Saf Surg (2007) 0.85
Physicochemical and biomechanical stimuli in cell-based articular cartilage repair. Curr Rheumatol Rep (2015) 0.84
The impact of maternal protein restriction during rat pregnancy upon renal expression of angiotensin receptors and vasopressin-related aquaporins. Reprod Biol Endocrinol (2010) 0.83
Differential regulation of the GLUT1 and GLUT3 glucose transporters by growth factors and pro-inflammatory cytokines in equine articular chondrocytes. Vet J (2005) 0.83
Equine transcriptome quantification using human GeneChip arrays can be improved using genomic DNA hybridisation and probe selection. Vet J (2009) 0.83
Extracellular matrix expression of human tenocytes in three-dimensional air-liquid and PLGA cultures compared with tendon tissue: implications for tendon tissue engineering. J Orthop Res (2010) 0.82
On some aspects of the thermodynamic of membrane recycling mediated by fluid phase endocytosis: evaluation of published data and perspectives. Cell Biochem Biophys (2010) 0.82
Low doses of 2,3,7,8-tetrachlorodibenzo- p-dioxin increase transforming growth factor beta and cause myocardial fibrosis in marmosets ( Callithrix jacchus). Arch Toxicol (2002) 0.82
Differential cellular expression of FXYD1 (phospholemman) and FXYD2 (gamma subunit of Na, K-ATPase) in normal human tissues: a study using high density human tissue microarrays. Ann Anat (2009) 0.82
Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology (2003) 0.82
Healing parameters in a rabbit partial tendon defect following tenocyte/biomaterial implantation. Biomaterials (2011) 0.81
The biology of equine mesenchymal stem cells: phenotypic characterization, cell surface markers and multilineage differentiation. Front Biosci (Landmark Ed) (2012) 0.81
Effects of simulated microgravity on thyroid carcinoma cells. J Gravit Physiol (2002) 0.80
Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis. Arthritis Res Ther (2013) 0.79
Complement gene expression is regulated by pro-inflammatory cytokines and the anaphylatoxin C3a in human tenocytes. Mol Immunol (2012) 0.79
Expression of the plasma membrane markers aquaporin 1 (AQP1), glucose transporter 1 (GLUT1) and Na, K-ATPase in canine mammary glands and mammary tumours. Vet J (2010) 0.79
Intraluminal application of vascular endothelial growth factor enhances healing of microvascular anastomosis in a rat model. J Vasc Res (2005) 0.79
Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities. BMC Res Notes (2013) 0.79
Longterm conditions of mimicked weightlessness influences the cytoskeleton in thyroid cells. J Gravit Physiol (2004) 0.79
Voltage-dependent calcium channels in chondrocytes: roles in health and disease. Curr Rheumatol Rep (2015) 0.79
Human hamstring tenocytes survive when seeded into a decellularized porcine Achilles tendon extracellular matrix. Connect Tissue Res (2013) 0.78
Selectivity in bone targeting with multivalent dendritic polyanion dye conjugates. Adv Healthc Mater (2013) 0.78
Anaphylatoxin receptors and complement regulatory proteins in human articular and non-articular chondrocytes: interrelation with cytokines. Cell Tissue Res (2012) 0.78
Heterotopic autologous chondrocyte transplantation--a realistic approach to support articular cartilage repair? Tissue Eng Part B Rev (2010) 0.78
Applications of proteomics in cartilage biology and osteoarthritis research. Front Biosci (Landmark Ed) (2011) 0.78
A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data. BMC Genomics (2015) 0.78
HLA-B27-restricted antigen presentation by human chondrocytes to CD8+ T cells: potential contribution to local immunopathologic processes in ankylosing spondylitis. Arthritis Rheum (2009) 0.78
Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes. Evid Based Complement Alternat Med (2012) 0.78
A hypothesis for the origin and pathogenesis of rheumatoid diseases. Rheumatol Int (2005) 0.78
Influence of fiber orientation in electrospun polymer scaffolds on viability, adhesion and differentiation of articular chondrocytes. Clin Hemorheol Microcirc (2012) 0.78
Expression and function of K(ATP) channels in normal and osteoarthritic human chondrocytes: possible role in glucose sensing. J Cell Biochem (2013) 0.78
Expression and distribution of Na, K-ATPase isoforms in the human uterus. Reprod Sci (2010) 0.77
Heterotopic and orthotopic autologous chondrocyte implantation using a minipig chondral defect model. Ann Anat (2013) 0.77
Detection of differential mitotic cell age in bone marrow CD34(+) cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature. Exp Hematol (2010) 0.77