Published in PLoS One on September 04, 2013
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Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Mol Cancer Ther (2008) 1.22
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A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network. Proc Natl Acad Sci U S A (2010) 1.11
Observing metabolic functions at the genome scale. Genome Biol (2007) 1.10
6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J Neurochem (2007) 1.07
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion. EMBO Rep (2012) 1.03
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Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). Exp Cell Res (2004) 1.00
Fen1 is induced p53 dependently and involved in the recovery from UV-light-induced replication inhibition. Oncogene (2005) 0.98
TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. Cancer Sci (2010) 0.95
Dynamics of p53 and NF-κB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention. BMC Syst Biol (2012) 0.94
Reconstruction and logical modeling of glucose repression signaling pathways in Saccharomyces cerevisiae. BMC Syst Biol (2009) 0.93
Erg and AP-1 as determinants of glucocorticoid response in acute lymphoblastic leukemia. Oncogene (2012) 0.91
Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. Cell Cycle (2012) 0.90
Selective control of the apoptosis signaling network in heterogeneous cell populations. PLoS One (2007) 0.90
A mathematical model for the detection mechanism of DNA double-strand breaks depending on autophosphorylation of ATM. PLoS One (2009) 0.88
A Boolean network model of the FA/BRCA pathway. Bioinformatics (2012) 0.87
Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2. J Biol Chem (2001) 0.86
Boolean network approach to negative feedback loops of the p53 pathways: synchronized dynamics and stochastic limit cycles. J Comput Biol (2009) 0.86
Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors. Oncogene (2001) 0.82
A CoD-based stationary control policy for intervening in large gene regulatory networks. BMC Bioinformatics (2011) 0.80
Retracted Ras puts the brake on doxorubicin-mediated cell death in p53-expressing cells. J Biol Chem (2010) 0.80
In vivo analyses of UV-irradiation-induced p53 promoter binding using a novel quantitative real-time PCR assay. Int J Oncol (2005) 0.76
Feature context-dependency and complexity-reduction in probability landscapes for integrative genomics. Theor Biol Med Model (2008) 0.75
Integration of metabolic databases for the reconstruction of genome-scale metabolic networks. BMC Syst Biol (2010) 1.44
A global view of drug-therapy interactions. BMC Pharmacol (2008) 1.34
A new effector pathway links ATM kinase with the DNA damage response. Nat Cell Biol (2004) 1.17
Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function. Mol Endocrinol (2008) 1.13
Acute or chronic stress induce cell compartment-specific phosphorylation of glucocorticoid receptor and alter its transcriptional activity in Wistar rat brain. J Endocrinol (2009) 1.06
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Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting BCR-ABL fusion gene in Chronic Myeloid Leukemia cells. J Control Release (2010) 0.93
Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res (2013) 0.93
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Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures. Mol Ecol (2014) 0.87
Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae. BMC Syst Biol (2009) 0.86
Regulation of glucocorticoid receptor activity by a stress responsive transcriptional cofactor. Mol Endocrinol (2010) 0.85
Effects of age and dexamethasone treatment on glucocorticoid response element and activating protein-1 binding activity in rat brain. J Gerontol A Biol Sci Med Sci (2003) 0.85
Streamlining the construction of large-scale dynamic models using generic kinetic equations. Bioinformatics (2010) 0.84
Modularity in protein complex and drug interactions reveals new polypharmacological properties. PLoS One (2012) 0.84
Molecular profiling of thyroid cancer subtypes using large-scale text mining. BMC Med Genomics (2014) 0.83
Quantitative analysis and modeling of glucocorticoid-controlled gene expression. Pharmacogenomics (2010) 0.83
Comprehensive modelling of the Neurospora circadian clock and its temperature compensation. PLoS Comput Biol (2012) 0.81
Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer. Int J Oncol (2013) 0.80
Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism. Psychoneuroendocrinology (2013) 0.79
A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. Psychiatry Res (2013) 0.79
The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Mol Cancer (2010) 0.77
The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. Int J Biochem Cell Biol (2009) 0.77
Site-specific and dose-dependent effects of glucocorticoid receptor phosphorylation in yeast Saccharomyces cerevisiae. Steroids (2010) 0.77
Exploring the genetic control of glycolytic oscillations in Saccharomyces cerevisiae. BMC Syst Biol (2012) 0.77
Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis. Proc Biol Sci (2014) 0.76
Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions. Int J Oncol (2012) 0.76
Constructing a molecular interaction network for thyroid cancer via large-scale text mining of gene and pathway events. BMC Syst Biol (2015) 0.75
Modeling the Mechanism of GR/c-Jun/Erg Crosstalk in Apoptosis of Acute Lymphoblastic Leukemia. Front Physiol (2012) 0.75
Disentangling the multigenic and pleiotropic nature of molecular function. BMC Syst Biol (2015) 0.75
Organising metabolic networks: Cycles in flux distributions. J Theor Biol (2010) 0.75
Identification of metabolic units induced by environmental signals. Bioinformatics (2006) 0.75
myo-Inositol esters of indomethacin as COX-2 inhibitors. Carbohydr Res (2012) 0.75