Published in Mol Biol Cell on October 17, 2007
Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nat Cell Biol (2009) 1.99
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. Hepatology (2013) 1.48
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations. J Clin Invest (2009) 1.37
Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage. DNA Repair (Amst) (2009) 1.23
Cdk2 is required for p53-independent G2/M checkpoint control. PLoS Genet (2010) 1.21
Iron chelators of the di-2-pyridylketone thiosemicarbazone and 2-benzoylpyridine thiosemicarbazone series inhibit HIV-1 transcription: identification of novel cellular targets--iron, cyclin-dependent kinase (CDK) 2, and CDK9. Mol Pharmacol (2010) 1.21
Overall Cdk activity modulates the DNA damage response in mammalian cells. J Cell Biol (2009) 1.14
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol (2009) 1.12
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol (2009) 1.11
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2. Development (2008) 1.10
Checkpoint kinase 1 prevents cell cycle exit linked to terminal cell differentiation. Mol Cell Biol (2011) 0.98
AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells. Cell Cycle (2009) 0.95
Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells. Br J Cancer (2009) 0.95
Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells. PLoS Pathog (2009) 0.94
Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol Cell Biol (2009) 0.93
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet (2012) 0.92
Targeting cell cycle regulators in hematologic malignancies. Front Cell Dev Biol (2015) 0.92
Mechanisms of radiation toxicity in transformed and non-transformed cells. Int J Mol Sci (2013) 0.92
Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res (2014) 0.91
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS One (2011) 0.89
The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells. Gastroenterology (2011) 0.89
Increased Expression of GOLPH3 is Associated with the Proliferation of Prostate Cancer. J Cancer (2015) 0.88
Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition. Proc Natl Acad Sci U S A (2009) 0.88
Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways. Sci Rep (2015) 0.88
"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication. Front Physiol (2012) 0.88
CDK-mediated RNF4 phosphorylation regulates homologous recombination in S-phase. Nucleic Acids Res (2015) 0.86
Regulation of HIV-1 transcription at 3% versus 21% oxygen concentration. J Cell Physiol (2009) 0.85
Mitotic asynchrony induces transforming growth factor-β1 secretion from airway epithelium. Am J Respir Cell Mol Biol (2014) 0.82
Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate. J Cancer Res Clin Oncol (2012) 0.81
Regulation of the g1/s transition in hepatocytes: involvement of the cyclin-dependent kinase cdk1 in the DNA replication. Int J Hepatol (2012) 0.79
A dual role of Cdk2 in DNA damage response. Cell Div (2009) 0.79
AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts. Biochim Biophys Acta (2014) 0.79
Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2. Gene Ther Mol Biol (2009) 0.78
A haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity. Proc Natl Acad Sci U S A (2015) 0.78
Dynamics of DNA damage induced pathways to cancer. PLoS One (2013) 0.78
EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System. Mol Cancer Res (2015) 0.77
p27 is regulated independently of Skp2 in the absence of Cdk2. Biochim Biophys Acta (2013) 0.77
Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J (2015) 0.77
Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. J Virol (2015) 0.76
CHMP4C Disruption Sensitizes the Human Lung Cancer Cells to Irradiation. Int J Mol Sci (2015) 0.76
To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage. Aging (Albany NY) (2016) 0.75
Insulin-Like Growth Factor-1-Mediated DNA Repair in Irradiated Salivary Glands Is Sirtuin-1 Dependent. J Dent Res (2016) 0.75
The retinoblastoma protein and cell cycle control. Cell (1995) 20.21
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res (1988) 17.88
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem (2004) 14.93
Cell cycle checkpoints: preventing an identity crisis. Science (1996) 13.74
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
Cyclin-dependent kinases: engines, clocks, and microprocessors. Annu Rev Cell Dev Biol (1997) 9.87
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature (2004) 6.94
Mitotic forces control a cell-cycle checkpoint. Nature (1995) 6.93
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell (1988) 6.45
A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay. J Immunol Methods (1994) 5.34
Liver regeneration. J Hepatol (2000) 5.22
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat Genet (2003) 4.74
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell (2003) 4.32
Cdk2 knockout mice are viable. Curr Biol (2003) 3.92
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol (2001) 3.92
p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase. EMBO J (1989) 3.70
Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol (2005) 3.65
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol (1996) 3.50
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene (1999) 3.23
Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J (1995) 2.57
Control of pRB phosphorylation. Curr Opin Genet Dev (1998) 2.49
Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase. Mol Biol Cell (1993) 2.48
Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst) (2004) 2.39
Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III. Genes Dev (2002) 2.37
Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J Cell Biol (1998) 2.33
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. Oncogene (1999) 2.30
Cell cycle checkpoints. Curr Opin Cell Biol (1994) 2.26
Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation. Proc Natl Acad Sci U S A (1999) 2.10
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem (2003) 2.09
Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J Cell Sci (1992) 1.97
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell (2005) 1.78
p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res (1997) 1.77
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell (2006) 1.69
A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc Revasc Med (2006) 1.66
Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J (2003) 1.64
Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage. J Biol Chem (2004) 1.63
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J Cell Biol (1999) 1.60
Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem (1996) 1.44
The cyclin A1-CDK2 complex regulates DNA double-strand break repair. Mol Cell Biol (2004) 1.43
Cell-specific responses to loss of cyclin-dependent kinases. Oncogene (2007) 1.41
Mammalian G1 and G2 phase checkpoints. Cancer Surv (1997) 1.41
Liver regeneration after hepatectomy. Hepatogastroenterology (2001) 1.35
All aboard the cyclin train: subcellular trafficking of cyclins and their CDK partners. Trends Cell Biol (1999) 1.33
G2 damage checkpoints: what is the turn-on? J Cell Sci (2005) 1.29
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Res (2006) 1.27
Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regeneration. Hepatology (1997) 1.26
The p53 protein family and radiation sensitivity: Yes or no? Cancer Metastasis Rev (2004) 1.24
Cell cycle control, checkpoint mechanisms, and genotoxic stress. Environ Health Perspect (1999) 1.22
p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol (1998) 1.20
Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene (1995) 1.17
Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metastasis Rev (1995) 1.11
Cell-cycle signaling: Atm displays its many talents. Curr Biol (1997) 1.07
Modifications of alkaline microgel electrophoresis for sensitive detection of DNA damage. Int J Radiat Biol (1994) 1.07
Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities. J Biol Chem (1993) 1.02
Dominant mutants identify new roles for p34cdc2 in mitosis. EMBO J (1995) 1.01
Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle (2005) 0.98
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2. Mol Cell Biol (2007) 0.95
Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice. Cell Cycle (2004) 0.91
Role of p21(Waf-1) in regulating the G1 and G2/M checkpoints in ultraviolet-irradiated keratinocytes. J Invest Dermatol (2002) 0.89
Checking on the cell cycle. J Cell Biochem Suppl (1998) 0.79
Cdk2 knockout mice are viable. Curr Biol (2003) 3.92
Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell (2012) 3.92
Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat Cell Biol (2005) 3.65
Kinase-independent function of cyclin E. Mol Cell (2007) 3.03
Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development (2013) 2.89
Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest. Nat Cell Biol (2007) 2.76
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell (2006) 1.69
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J Mol Cell Cardiol (2008) 1.44
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone. J Cell Biol (2007) 1.41
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A (2011) 1.41
IL-7 promotes T cell proliferation through destabilization of p27Kip1. J Exp Med (2006) 1.40
TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types. Cancer Cell (2012) 1.34
Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem (2010) 1.30
Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res (2009) 1.27
Cell cycle-dependent phosphorylation of C/EBPbeta mediates oncogenic cooperativity between C/EBPbeta and H-RasV12. Mol Cell Biol (2004) 1.19
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells. Mol Cell Biol (2009) 1.12
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. Mol Cell Biol (2006) 1.12
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2. Development (2008) 1.10
PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes. Cancer Res (2006) 1.09
p27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice. Mol Endocrinol (2007) 1.09
CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion. Mol Cell Biol (2002) 1.07
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol (2006) 1.06
Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. Mol Cell Biol (2005) 1.04
Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. Mol Cell Biol (2005) 1.04
Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells. Stem Cells (2012) 1.03
Cdk1, but not Cdk2, is the sole Cdk that is essential and sufficient to drive resumption of meiosis in mouse oocytes. Hum Mol Genet (2012) 1.02
Cdk2 and Cdk4 cooperatively control the expression of Cdc2. Cell Div (2006) 0.99
Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Results Probl Cell Differ (2011) 0.97
Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter. Blood (2004) 0.97
Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo. Cell Cycle (2009) 0.97
CDK2 is required by MYC to induce apoptosis. Cell Cycle (2006) 0.96
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2. Mol Cell Biol (2007) 0.95
Cell biology. Enforcing the Greatwall in mitosis. Science (2010) 0.94
Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53. Mol Cell Biol (2009) 0.93
Cdk2 as a master of S phase entry: fact or fake? Cell Cycle (2004) 0.89
Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition. Proc Natl Acad Sci U S A (2009) 0.88
Mouse models of cell cycle regulators: new paradigms. Results Probl Cell Differ (2006) 0.88
Biochemical characterization of Cdk2-Speedy/Ringo A2. BMC Biochem (2005) 0.87
Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Cell Mol Life Sci (2012) 0.87
Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis. Neoplasia (2011) 0.86
Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116. Cell Rep (2013) 0.86
CDK2 is dispensable for adult hippocampal neurogenesis. Cell Cycle (2007) 0.86
Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1. Open Biol (2014) 0.85
p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. FEBS Lett (2006) 0.85
RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood (2010) 0.84
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer Res (2008) 0.79
A dual role of Cdk2 in DNA damage response. Cell Div (2009) 0.79
Cyclin E1 regulates hematopoietic stem cell quiescence. Cell Cycle (2013) 0.77
Cell cycle transitions and Cdk inhibition in melanoma therapy: cyclin' through the options. Cell Cycle (2011) 0.76
Genetic mouse models to investigate cell cycle regulation. Transgenic Res (2009) 0.75