Published in Blood on September 12, 2013
Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood (2015) 1.48
Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Blood (2015) 0.85
LDL electronegativity index: a potential novel index for predicting cardiovascular disease. Vasc Health Risk Manag (2015) 0.85
Non-invasive in vivo characterization of human carotid plaques with acoustic radiation force impulse ultrasound: comparison with histology after endarterectomy. Ultrasound Med Biol (2015) 0.81
Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovasc Diabetol (2014) 0.79
Bad cholesterol breaking really bad. Blood (2013) 0.78
Low-density lipoprotein electronegativity is a novel cardiometabolic risk factor. PLoS One (2014) 0.77
Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease. Sci Rep (2017) 0.75
Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. J Lipid Res (2016) 0.75
Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury. J Neuroinflammation (2017) 0.75
Prothrombotic lipoprotein patterns in stroke. Blood (2016) 0.75
Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science (1992) 4.75
Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med (2005) 4.57
Platelets in inflammation and atherogenesis. J Clin Invest (2005) 4.10
The combined role of P- and E-selectins in atherosclerosis. J Clin Invest (1998) 2.53
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci U S A (1995) 2.37
Activation of platelet function through G protein-coupled receptors. Circ Res (2006) 2.13
Early and late effects of clopidogrel in patients with acute coronary syndromes. Circulation (2003) 2.05
Pro-coagulant state resulting from high levels of soluble P-selectin in blood. Proc Natl Acad Sci U S A (2000) 1.90
Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res (2009) 1.83
Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes. Circulation (2001) 1.83
The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med (1999) 1.76
The impact of blood coagulability on atherosclerosis and cardiovascular disease. J Thromb Haemost (2012) 1.63
P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med (2000) 1.61
A revised model of platelet aggregation. J Clin Invest (2000) 1.54
Mapping the glycoprotein Ib-binding site in the von willebrand factor A1 domain. J Biol Chem (2000) 1.43
Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia. Blood (2002) 1.33
Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J Exp Med (1992) 1.28
Platelet-leukocyte interactions in cardiovascular disease and beyond. Arterioscler Thromb Vasc Biol (2010) 1.23
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation (2004) 1.16
Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem Med (1983) 1.13
Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation (2003) 1.12
Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets. J Biol Chem (2009) 1.09
Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J (2009) 1.07
Vitronectin receptor (alpha(v)beta3) mediates platelet adhesion to the luminal aspect of endothelial cells: implications for reperfusion in acute myocardial infarction. Circulation (1997) 1.06
Arrestin-2 differentially regulates PAR4 and ADP receptor signaling in platelets. J Biol Chem (2010) 1.02
Electronegative low-density lipoprotein. Curr Opin Lipidol (2004) 1.02
Platelet glycoprotein IIb/IIIa receptor antagonists in cardiovascular disease. JAMA (1999) 0.99
Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res (2007) 0.96
Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arterioscler Thromb Vasc Biol (2003) 0.95
Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes (2007) 0.95
Activation-dependent surface expression of LOX-1 in human platelets. Biochem Biophys Res Commun (2001) 0.93
A novel role for CD36 in VLDL-enhanced platelet activation. Diabetes (2003) 0.92
Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling. J Pharmacol Exp Ther (2007) 0.92
Thrombin and vascular inflammation. Mol Cell Biochem (2011) 0.91
Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: a novel cytoprotective role of aspirin in acute myocardial infarction. Cardiovasc Res (2013) 0.90
The roles and mechanisms of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced platelet aggregation. Br J Pharmacol (2010) 0.89
Regulation of endothelial cell tissue factor expression by minimally oxidized LDL and lipopolysaccharide. Arterioscler Thromb (1993) 0.88
Cytokines and thrombosis. J Cardiovasc Pharmacol (1995) 0.88
Pro-apoptotic low-density lipoprotein subfractions in type II diabetes. Atherosclerosis (2006) 0.84
Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines. Apoptosis (2012) 0.83
Chemical composition-oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein. Pure Appl Chem (2011) 0.80
The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells. J Vasc Res (2012) 0.79
Variations in platelet proteins associated with ST-elevation myocardial infarction: novel clues on pathways underlying platelet activation in acute coronary syndromes. Arterioscler Thromb Vasc Biol (2011) 0.79
Apoptosis, a major determinant of atherothrombosis. Arch Mal Coeur Vaiss (2003) 0.79
Baseline platelet reactivity in acute myocardial infarction treated with primary angioplasty--influence on myocardial reperfusion, left ventricular performance, and clinical events. Am Heart J (2007) 0.77
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res (2007) 2.87
Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization. Heart Rhythm (2013) 2.61
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity (2002) 2.47
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest (2008) 2.43
Association of a programmed death 1 gene polymorphism with the development of rheumatoid arthritis, but not systemic lupus erythematosus. Arthritis Rheum (2004) 2.18
Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood (2002) 2.15
Effectiveness and safety of antiplatelet in stroke patients with end-stage renal disease undergoing dialysis. Int J Stroke (2014) 2.00
Lipid paradox in acute myocardial infarction-the association with 30-day in-hospital mortality. Crit Care Med (2015) 1.99
Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis. Arterioscler Thromb Vasc Biol (2003) 1.91
Evaluation of microalbuminuria after non-ionic radiocontrast medium exposure in patients undergoing coronary angiography. Int J Cardiol (2007) 1.91
Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res (2009) 1.83
Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer (2004) 1.82
Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res (2008) 1.78
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther (2002) 1.74
ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem (2003) 1.65
LOX index, a novel predictive biochemical marker for coronary heart disease and stroke. Clin Chem (2010) 1.65
Conformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol (2006) 1.64
Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion. Hypertension (2008) 1.58
Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71. J Med Virol (2006) 1.58
A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function. J Hypertens (2009) 1.58
Influence of biologic markers on the outcome of Hodgkin's lymphoma: a study by the Spanish Hodgkin's Lymphoma Study Group. J Clin Oncol (2004) 1.50
LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens (2010) 1.49
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation. Clin Chem (2011) 1.46
Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease. Am J Hypertens (2010) 1.46
Validation of a new index for estimating arterial stiffness: measurement of the QPV interval by Doppler ultrasound. Clin Cardiol (2006) 1.44
Cilostazol for primary prevention of stroke in peripheral artery disease: a population-based longitudinal study in Taiwan. Thromb Res (2013) 1.41
LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation (2003) 1.40
Usefulness of time interval between end of diastolic mitral annular velocity pattern and onset of QRS for predicting left ventricular end-diastolic pressure. Am J Cardiol (2006) 1.39
Antioxidative and hepatoprotective effects of Antrodia camphorata extract. J Agric Food Chem (2003) 1.37
Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol (2004) 1.35
Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett (2005) 1.34
Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation (2008) 1.34
A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes. Diabetes (2011) 1.33
Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Proc Natl Acad Sci U S A (2003) 1.29
SNPs in BRAP associated with risk of myocardial infarction in Asian populations. Nat Genet (2009) 1.29
Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13. Blood (2009) 1.27
Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res (2005) 1.27
C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res (2004) 1.23
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis (2005) 1.21
Structural basis of von Willebrand factor activation by the snake toxin botrocetin. Structure (2002) 1.21
Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med (2002) 1.20
Lox-1: the multifunctional receptor underlying cardiovascular dysfunction. Circ J (2009) 1.19
Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation. J Hypertens (2005) 1.18
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. PLoS One (2009) 1.17
Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation. Circ Res (2004) 1.17
Kinetics of GPIbalpha-vWF-A1 tether bond under flow: effect of GPIbalpha mutations on the association and dissociation rates. Biophys J (2003) 1.17
Septum hematoma: a complication of retrograde wiring in chronic total occlusion. Int J Cardiol (2006) 1.16
Measuring left ventricular peak longitudinal systolic strain from a single beat in atrial fibrillation: validation of the index beat method. J Am Soc Echocardiogr (2012) 1.16
Haemoglobin blocks von Willebrand factor proteolysis by ADAMTS-13: a mechanism associated with sickle cell disease. Thromb Haemost (2009) 1.15
Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase. J Lipid Res (2006) 1.14
Association of peripheral total and differential leukocyte counts with metabolic syndrome and risk of ischemic cardiovascular diseases in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev (2007) 1.13
The discovery of LOX-1, its ligands and clinical significance. Cardiovasc Drugs Ther (2011) 1.12
Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation (2003) 1.12
Higher seroprevalence of Entamoeba histolytica infection is associated with human immunodeficiency virus type 1 infection in Taiwan. Am J Trop Med Hyg (2006) 1.11
Genotyping of Chlamydia trachomatis from clinical specimens in Taiwan. J Med Microbiol (2006) 1.11
Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Biochem Biophys Res Commun (2003) 1.11
Mycobacterium abscessus endocarditis: a case report and literature review. Kaohsiung J Med Sci (2008) 1.11
C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood (2005) 1.10
Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. J Pharmacol Exp Ther (2002) 1.10
Altered homeostasis of CD4(+) FoxP3(+) regulatory T-cell subpopulations in systemic lupus erythematosus. Immunology (2008) 1.09
Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with non-valvular atrial fibrillation. Thromb Haemost (2010) 1.08
LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.08
Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. J Physiol (2011) 1.08
Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors. Endocrinology (2004) 1.08
Impact of remote magnetic catheter navigation on ablation fluoroscopy and procedure time. Pacing Clin Electrophysiol (2008) 1.07
Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbalpha. Biophys J (2009) 1.07
Association of ORAI1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis. PLoS One (2011) 1.07
Splenic marginal zone lymphoma: clinical characteristics and prognostic factors in a series of 60 patients. Blood (2002) 1.07
Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress. J Biol Chem (2010) 1.07
Effects of clopidogrel on mortality, cardiovascular and bleeding outcomes in patients with chronic kidney disease - data from Taiwan acute coronary syndrome full spectrum registry. PLoS One (2013) 1.07
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells. Cardiovasc Res (2009) 1.07
Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study. J Atheroscler Thromb (2012) 1.05
An outbreak of typhoid Fever in Florida associated with an imported frozen fruit. J Infect Dis (2002) 1.05
The role of applied epidemiology methods in the disaster management cycle. Am J Public Health (2014) 1.04
Traumatic tricuspid insufficiency with chordae tendinae rupture: a case report and literature review. Kaohsiung J Med Sci (2006) 1.04
Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology (2007) 1.03
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS One (2012) 1.03
Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina. Arch Ophthalmol (2002) 1.03
Acute carbon monoxide poisoning resulting in ST elevation myocardial infarction: a rare case report. Kaohsiung J Med Sci (2010) 1.03
Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging (2011) 1.02