MYC, FBXW7 and TP53 copy number variation and expression in gastric cancer.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 3851138)

Published in BMC Gastroenterol on September 23, 2013

Authors

Danielle Queiroz Calcagno1, Vanessa Morais Freitas, Mariana Ferreira Leal, Carolina Rosal Teixeira de Souza, Samia Demachki, Raquel Montenegro, Paulo Pimentel Assumpção, André Salim Khayat, Marília de Arruda Cardoso Smith, Andrea Kely Campos Ribeiro dos Santos, Rommel Rodriguez Burbano

Author Affiliations

1: Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brasil. danicalcagno@gmail.com.

Articles citing this

Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer. BMC Gastroenterol (2015) 1.00

Discovery of co-occurring driver pathways in cancer. BMC Bioinformatics (2014) 0.84

BET inhibition as a new strategy for the treatment of gastric cancer. Oncotarget (2016) 0.81

Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients. Clin Exp Med (2014) 0.80

The role of piRNA and its potential clinical implications in cancer. Epigenomics (2015) 0.79

Fbxw7 Tumor Suppressor: A Vital Regulator Contributes to Human Tumorigenesis. Medicine (Baltimore) (2016) 0.78

Ubiquitin proteasome system research in gastrointestinal cancer. World J Gastrointest Oncol (2016) 0.78

Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis. PLoS One (2015) 0.78

CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. Int J Oncol (2015) 0.77

Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer. Gastric Cancer (2015) 0.76

Inferring pathway dysregulation in cancers from multiple types of omic data. Genome Med (2015) 0.76

Integrated Analysis of Genome-Wide Copy Number Alterations and Gene Expression Profiling of Lung Cancer in Xuanwei, China. PLoS One (2017) 0.75

Association Between Amplification and Expression of C-MYC Gene and Clinicopathological Characteristics of Stomach Cancer. Iran Red Crescent Med J (2016) 0.75

YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process. Oncotarget (2016) 0.75

Role of E3 ubiquitin ligases in gastric cancer. World J Gastroenterol (2015) 0.75

Nuclear receptor retinoid-related orphan receptor alpha promotes apoptosis but is reduced in human gastric cancer. Oncotarget (2016) 0.75

Copy Number Gains at 8q24 and 20q11-q13 in Gastric Cancer Are More Common in Intestinal-Type than Diffuse-Type. PLoS One (2015) 0.75

Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines. World J Gastroenterol (2016) 0.75

Study of C-MYC amplification and expression in Iranian gastric cancer samples using CISH and IHC methods. Adv Biomed Res (2015) 0.75

Progression inference for somatic mutations in cancer. Heliyon (2017) 0.75

Deregulation of MYC and TP53 through genetic and epigenetic alterations in gallbladder carcinomas. Clin Exp Med (2014) 0.75

CDKN1A histone acetylation and gene expression relationship in gastric adenocarcinomas. Clin Exp Med (2015) 0.75

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

p53 mutations in human cancers. Science (1991) 31.96

THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO-CALLED INTESTINAL-TYPE CARCINOMA. AN ATTEMPT AT A HISTO-CLINICAL CLASSIFICATION. Acta Pathol Microbiol Scand (1965) 22.65

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature (1986) 14.56

Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03

Clinical implications of the p53 tumor-suppressor gene. N Engl J Med (1993) 7.29

The c-Myc target gene network. Semin Cancer Biol (2006) 5.98

Modelling Myc inhibition as a cancer therapy. Nature (2008) 5.81

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35

Gastric adenocarcinoma: review and considerations for future directions. Ann Surg (2005) 3.83

FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res (2007) 3.79

Epidemiology of stomach cancer. Methods Mol Biol (2009) 3.72

Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell (1986) 3.70

Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol (2005) 3.08

Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori? Trends Microbiol (1997) 2.33

The ins and outs of MYC regulation by posttranslational mechanisms. J Biol Chem (2006) 1.96

Implications of the p53 tumor-suppressor gene in clinical oncology. J Clin Oncol (1995) 1.85

Cellular and molecular aspects of gastric cancer. World J Gastroenterol (2006) 1.84

Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives. EMBO J (1985) 1.76

The many faces of c-MYC. Arch Biochem Biophys (2003) 1.74

Tumor suppressor genetics. Carcinogenesis (2005) 1.66

Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64

p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases. Cancer Res (2009) 1.37

Cytogenetic and molecular aspects of gastric cancer: clinical implications. Cancer Lett (2008) 1.30

Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies. Cancer Res (2005) 1.29

Rapid fingerprinting of Helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol (1993) 1.26

MYC and gastric adenocarcinoma carcinogenesis. World J Gastroenterol (2008) 1.17

Base transitions are the most frequent genetic changes at P53 in gastric cancer. Cancer Res (1993) 1.15

Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma. World J Gastroenterol (2006) 1.14

Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice. Cell Cycle (2008) 1.11

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization. Cancer Sci (2005) 1.08

Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy. Cancer Res (2005) 1.07

C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil. Anticancer Res (2006) 1.06

MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res (2009) 1.05

Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer. Br J Cancer (2006) 1.03

Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma. Anticancer Res (2005) 1.02

Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma. Cancer Genet Cytogenet (2008) 0.98

Establishment and conventional cytogenetic characterization of three gastric cancer cell lines. Cancer Genet Cytogenet (2009) 0.94

Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. World J Gastroenterol (2010) 0.92

New concepts of molecular biology on gastric carcinogenesis. Hepatogastroenterology (2005) 0.91

MYC, TP53, and chromosome 17 copy-number alterations in multiple gastric cancer cell lines and in their parental primary tumors. J Biomed Biotechnol (2011) 0.91

Aberrant ubiquitin-mediated proteolysis of cell cycle regulatory proteins and oncogenesis. Adv Cancer Res (2003) 0.89

MYC quantitation in cell-free plasma DNA by real-time PCR for gastric cancer diagnosis. Clin Chem Lab Med (2009) 0.87

Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma. BMC Gastroenterol (2009) 0.86

p53 alterations in gastric carcinoma: a study of 56 primary tumors and 204 nodal metastases. Cancer Genet Cytogenet (1994) 0.80

[The expression of integrinανβ6 and MMP-9 in gastric cancer and the correlation with clinicopathologic characteristic]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2011) 0.78

Adenocarcinoma of the cardia in a young man: detection of somatic p53 mutation by immunohistochemistry and automated direct sequencing. Pathol Res Pract (1995) 0.77

Articles by these authors

Interrelationship between chromosome 8 aneuploidy, C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma. World J Gastroenterol (2006) 1.14

C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil. Anticancer Res (2006) 1.06

MYC insertions in diffuse-type gastric adenocarcinoma. Anticancer Res (2009) 1.05

Epigenetic mechanisms in gastric cancer. Epigenomics (2012) 1.05

Interleukin-1 and TNF-alpha polymorphisms and Helicobacter pylori in a Brazilian Amazon population. World J Gastroenterol (2009) 1.04

DNA and histone methylation in gastric carcinogenesis. World J Gastroenterol (2013) 1.03

Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma. Anticancer Res (2005) 1.02

Interrelationship between MYC gene numerical aberrations and protein expression in individuals from northern Brazil with early gastric adenocarcinoma. Cancer Genet Cytogenet (2008) 0.98

MYC deregulation in gastric cancer and its clinicopathological implications. PLoS One (2013) 0.96

Apolipoprotein A1 gene polymorphisms as risk factors for hypertension and obesity. Clin Exp Med (2009) 0.96

Clinical and pathological importance of vacA allele heterogeneity and cagA status in peptic ulcer disease in patients from North Brazil. Mem Inst Oswaldo Cruz (2006) 0.95

Reference genes for quantitative RT-PCR data in gastric tissues and cell lines. World J Gastroenterol (2013) 0.95

Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. Acta Trop (2006) 0.94

Establishment and conventional cytogenetic characterization of three gastric cancer cell lines. Cancer Genet Cytogenet (2009) 0.94

Titanium pigment in tissues of drug addicts: report of 5 necropsied cases. Rev Hosp Clin Fac Med Sao Paulo (2004) 0.94

Prognostic and predictive significance of MYC and KRAS alterations in breast cancer from women treated with neoadjuvant chemotherapy. PLoS One (2013) 0.94

Numerical aberrations of chromosome 8 detected by conventional cytogenetics and fluorescence in situ hybridization in individuals from northern Brazil with gastric adenocarcinoma. Cancer Genet Cytogenet (2006) 0.93

cagA vacA alelles and babA2 genotypes of Helicobacter pylori associated with gastric disease in Brazilian adult patients. Diagn Microbiol Infect Dis (2005) 0.93

hTERT methylation and expression in gastric cancer. Biomarkers (2009) 0.93

Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil. World J Gastroenterol (2010) 0.92

MCF-7 cells as a three-dimensional model for the study of human breast cancer. Tissue Eng Part C Methods (2011) 0.92

MYC, TP53, and chromosome 17 copy-number alterations in multiple gastric cancer cell lines and in their parental primary tumors. J Biomed Biotechnol (2011) 0.91

Assessing interethnic admixture using an X-linked insertion-deletion multiplex. Am J Hum Biol (2009) 0.89

Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. J Alzheimers Dis (2008) 0.89

MYC in gastric carcinoma and intestinal metaplasia of young adults. Cancer Genet Cytogenet (2010) 0.88

Chromosome X aneuploidy in Brazilian schizophrenic patients. In Vivo (2010) 0.88

Genomic alterations in diffuse-type gastric cancer as shown by high-resolution comparative genomic hybridization. Cancer Genet Cytogenet (2009) 0.88

Differential proteomic analysis of noncardia gastric cancer from individuals of northern Brazil. PLoS One (2012) 0.88

Anti-angiogenic and anti-metastatic activity of synthetic phosphoethanolamine. PLoS One (2013) 0.88

hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions. BMC Gastroenterol (2012) 0.88

Clinical implication of 14-3-3 epsilon expression in gastric cancer. World J Gastroenterol (2012) 0.86

Interrelationship between TP53 gene deletion, protein expression and chromosome 17 aneusomy in gastric adenocarcinoma. BMC Gastroenterol (2009) 0.86

CagA positive Helicobacter pylori in Brazilian children related to chronic gastritis. Braz J Infect Dis (2006) 0.86

Differential expression of histone deacetylase and acetyltransferase genes in gastric cancer and their modulation by trichostatin A. Tumour Biol (2014) 0.85

Occurrence of Helicobacter pylori and Epstein-Barr virus infection in endoscopic and gastric cancer patients from Northern Brazil. BMC Gastroenterol (2014) 0.85

Low frequency of human papillomavirus detection in prostate tissue from individuals from Northern Brazil. Mem Inst Oswaldo Cruz (2009) 0.84

Human Papilloma Virus: Prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma. Int Braz J Urol (2013) 0.84

Helicobacter pylori detection in gastric biopsies, saliva and dental plaque of Brazilian dyspeptic patients. Mem Inst Oswaldo Cruz (2010) 0.83

In vitro evaluation of the cytotoxic and genotoxic effects of artemether, an antimalarial drug, in a gastric cancer cell line (PG100). J Appl Toxicol (2011) 0.83

Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population. Clin Exp Med (2010) 0.83

Experimental gastric carcinogenesis in Cebus apella nonhuman primates. PLoS One (2011) 0.83

Association of PPARalpha gene polymorphisms and lipid serum levels in a Brazilian elderly population. Exp Mol Pathol (2009) 0.81

Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications. BMC Gastroenterol (2014) 0.81

Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels. Clin Chem Lab Med (2007) 0.81

Reduced mRNA expression levels of MBD2 and MBD3 in gastric carcinogenesis. Tumour Biol (2013) 0.81

Insulin-like growth factor binding protein-3 gene methylation and protein expression in gastric adenocarcinoma. Growth Horm IGF Res (2010) 0.81

c -MYC amplification and expression in astrocytic tumors. Acta Neuropathol (2008) 0.81

Association of cytokine gene polymorphisms and serum concentrations with the outcome of chronic hepatitis B. Cytokine (2013) 0.81