Matrix metalloproteinases: regulators of the tumor microenvironment.

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Published in Cell on April 02, 2010

Authors

Kai Kessenbrock1, Vicki Plaks, Zena Werb

Author Affiliations

1: Department of Anatomy and Biomedical Sciences Program, University of California, San Francisco, CA 94143-0452, USA.

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Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci (2006) 1.58

New functional roles for non-collagenous domains of basement membrane collagens. J Cell Sci (2002) 1.58

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med (2006) 1.54

Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell (2005) 1.53

Monitoring of vital signs for long-term survival of mice under anesthesia. Cold Spring Harb Protoc (2011) 1.50

Coevolution of cancer and stromal cellular responses. Cancer Cell (2005) 1.50

Preparation of mice for long-term intravital imaging of the mammary gland. Cold Spring Harb Protoc (2011) 1.50

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol (2013) 1.47

How proteases regulate bone morphogenesis. Ann N Y Acad Sci (2003) 1.47

Shedding light on sheddases: role in growth and development. Bioessays (2002) 1.47

Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol (2003) 1.43

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J (2006) 1.42

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J (2003) 1.42

Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39

Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev (2011) 1.36

Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol (2006) 1.36

Stromal regulation of vessel stability by MMP14 and TGFbeta. Dis Model Mech (2010) 1.35

Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev Dyn (2007) 1.35

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB J (2004) 1.34

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci (2012) 1.32

Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis. Am J Pathol (2002) 1.31

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One (2007) 1.29

Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation. J Immunol (2006) 1.27

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity. Proc Natl Acad Sci U S A (2012) 1.26

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. J Clin Invest (2005) 1.25

Role of c-kit/Kit ligand signaling in regulating vasculogenesis. Thromb Haemost (2003) 1.25

Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem (2004) 1.24