Have We Hatched the Addiction Egg: Reward Deficiency Syndrome Solution System™

PubWeight™: 0.84‹?›

🔗 View Article (PMID 24077767)

Published in J Genet Syndr Gene Ther on June 03, 2013

Authors

Bw Downs1, M Oscar-Berman, Rl Waite, Ma Madigan, J Giordano, T Beley, S Jones, T Simpatico, M Hauser, J Borsten, F Marcelo, Er Braverman, R Lohmann, K Dushaj, M Helman, D Barh, St Schoenthaler, D Han, K Blum

Author Affiliations

1: Department of Nutrigenomics, LifeGen, Inc., Austin, Texas, USA.

Articles cited by this

Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation. JAMA (2000) 14.17

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet (2013) 13.17

Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA (1990) 5.04

Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry (1991) 2.30

The D2 dopamine receptor gene as a determinant of reward deficiency syndrome. J R Soc Med (1996) 1.98

Weight gain is associated with reduced striatal response to palatable food. J Neurosci (2010) 1.94

The process addictions and the new ASAM definition of addiction. J Psychoactive Drugs (2012) 1.82

Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. Pharmacogenetics (1996) 1.43

The addictive brain: all roads lead to dopamine. J Psychoactive Drugs (2012) 1.16

Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine D₂ agonist therapy: part 2. Postgrad Med (2010) 1.09

Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males. Eur Neuropsychopharmacol (2008) 1.06

Population frequencies of the A1 allele at the dopamine D2 receptor locus. Biol Psychiatry (1993) 1.03

Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map. J Psychoactive Drugs (2011) 0.99

Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map? Med Hypotheses (2009) 0.90

Articles by these authors

(truncated to the top 100)

CATH--a hierarchic classification of protein domain structures. Structure (1997) 29.95

The genome of black cottonwood, Populus trichocarpa (Torr. & Gray). Science (2006) 21.03

A physical map of the human genome. Nature (2001) 12.39

Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial. Lancet (2009) 7.96

A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99

Takayasu arteritis. Ann Intern Med (1994) 5.94

A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85

Acute myocardial infarction: home and hospital treatment. Br Med J (1971) 5.21

Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet (1987) 4.20

The two distinct phospholipases C of Listeria monocytogenes have overlapping roles in escape from a vacuole and cell-to-cell spread. Infect Immun (1995) 4.02

Processing of complex sounds in the macaque nonprimary auditory cortex. Science (1995) 3.98

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A (1998) 3.60

Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity (2001) 3.27

The value of feedback in teaching interviewing skills to medical students. Psychol Med (1978) 3.24

Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science (1998) 3.04

Extended resections for hilar cholangiocarcinoma. Ann Surg (1999) 2.93

Equity, waiting times, and NHS reforms: retrospective study. BMJ (2009) 2.86

Association of alkaline phosphatase with an autoantigen recognised by circulating anti-neutrophil antibodies in systemic vasculitis. Lancet (1987) 2.85

A comparative evaluation of three accelerometry-based physical activity monitors. Med Sci Sports Exerc (2000) 2.75

Comparison of effects of a self management booklet and audiocassette for patients with asthma. BMJ (1988) 2.66

Tobacco point of sale advertising increases positive brand user imagery. Tob Control (2002) 2.65

A novel method of applying a split cast. Injury (2005) 2.64

Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog Brain Res (2000) 2.58

An investigation of the acute behavioural effects of styrene on factory workers. Br J Ind Med (1980) 2.44

Cost implications of the British Pacing and Electrophysiology Group's recommendations for pacing. BMJ (1992) 2.42

Risk of sudden infant death syndrome in subsequent siblings. J Pediatr (1990) 2.31

Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry (1991) 2.30

Arsenic and mercury intoxication due to Indian ethnic remedies. BMJ (1993) 2.24

Rheumatology manpower in the 1990s. Br J Rheumatol (1991) 2.17

Survey of practice annual reports. J R Coll Gen Pract (1989) 2.14

Glutamate does not play a major role in controlling bone growth. J Bone Miner Res (2001) 2.12

Prion protein conformation in a patient with sporadic fatal insomnia. N Engl J Med (1999) 2.04

Spinocerebellar degeneration associated with a selective defect of vitamin E absorption. N Engl J Med (1985) 1.99

Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator. Microbiology (1995) 1.98

Prediction of elementary school children's externalizing problem behaviors from attentional and behavioral regulation and negative emotionality. Child Dev (2001) 1.95

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. Gene Ther (2008) 1.94

Appropriateness of paediatric admission. Arch Dis Child (1994) 1.87

Aniridia-associated cytogenetic rearrangements suggest that a position effect may cause the mutant phenotype. Hum Mol Genet (1995) 1.86

Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action. Genes Dev (2001) 1.84

Using larvae in modern wound management. J Wound Care (1996) 1.84

Partial leptin deficiency and human adiposity. Nature (2001) 1.83

Genome-wide scan for adult onset primary open angle glaucoma. Hum Mol Genet (2000) 1.82

The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. Int J Geriatr Psychiatry (2012) 1.82

Discovery of very-high-energy gamma-rays from the Galactic Centre ridge. Nature (2006) 1.81

Histological appearances of the gastric mucosa 15--27 years after partial gastrectomy. J Clin Pathol (1979) 1.79

Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. J Cell Physiol (2000) 1.76

Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. MBio (2011) 1.76

The risks of ignoring insurance risk management. Health Aff (Millwood) (1994) 1.75

PANNOTATOR: an automated tool for annotation of pan-genomes. Genet Mol Res (2013) 1.74

Catamenial hemoptysis. Diagnosis with MRI. Chest (1997) 1.74

Management of older patients with hypertension in primary care: improvement on the rule of halves. Age Ageing (2001) 1.72

Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth (2002) 1.70

Protein folds and functions. Structure (1998) 1.69

Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med (1991) 1.69

The hospital standardised mortality ratio: a powerful tool for Dutch hospitals to assess their quality of care? Qual Saf Health Care (2010) 1.69

The nature of forensic science opinion--a possible framework to guide thinking and practice in investigations and in court proceedings. Sci Justice (2006) 1.67

Radio imaging of the very-high-energy gamma-ray emission region in the central engine of a radio galaxy. Science (2009) 1.66

T-cell-derived lymphokines that induce IgM and IgG secretion in activated murine B cells. Immunol Rev (1984) 1.65

The quality of self-monitoring of blood glucose. Diabet Med (1990) 1.62

The sensitivity, specificity and predictive values of raised plasma metal ion levels in the diagnosis of adverse reaction to metal debris in symptomatic patients with a metal-on-metal arthroplasty of the hip. J Bone Joint Surg Br (2012) 1.62

Multiple cognitive deficits during the transition to Alzheimer's disease. J Intern Med (2004) 1.59

Development and use of a population based injury surveillance system: the all Wales Injury Surveillance System (AWISS). Inj Prev (2002) 1.56

Substance abuse vulnerability and D2 receptor genes. Trends Neurosci (1993) 1.55

Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity. J Biol Chem (1978) 1.55

High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation (2001) 1.54

Improving the standard of operation notes in orthopaedic and trauma surgery: the value of a proforma. Injury (2004) 1.54

Acute ureteric dilatation for ureteroscopy. An experimental study. Br J Urol (1988) 1.53

Strain and substrain differences in context- and tone-dependent fear conditioning of inbred mice. Behav Brain Res (1999) 1.53

Identifying home advantage in international tennis and golf tournaments. J Sports Sci (1997) 1.52

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein. J Virol (2000) 1.52

A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis. Eur J Neurol (2012) 1.51

Comparative neuropsychology and Korsakoff's syndrome. I.--Spatial and visual reversal learning. Neuropsychologia (1980) 1.50

p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A. Proc Natl Acad Sci U S A (1999) 1.49

The impact of viewing a hysteroscopy on a screen on the patient's experience: a randomised trial. BJOG (2009) 1.48

Determinants of genital human papillomavirus infection in low-income women in Washington, D.C. Sex Transm Dis (1993) 1.48

Patterns of burns and scalds in children. Arch Dis Child (2014) 1.48

Contemporaneous and longitudinal prediction of children's social functioning from regulation and emotionality. Child Dev (1997) 1.47

Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy. J Pediatr Ophthalmol Strabismus (1995) 1.47

Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr Biol (1996) 1.46

Radiologic diagnosis and management of complications related to central venous access. Acta Radiol (2003) 1.46

Adverse reactions to duck embryo rabies vaccine. Range and incidence. Ann Intern Med (1973) 1.44

Infrainguinal aneurysm formation in arterialized autologous saphenous vein grafts. J Vasc Surg (1998) 1.44

A low level of extragalactic background light as revealed by gamma-rays from blazars. Nature (2006) 1.44

Contrast cine left ventriculography: comparison of two pigtail catheter shapes and analysis of factors determining the final quality. Cathet Cardiovasc Diagn (1996) 1.44

Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones. J Physiol (1994) 1.42

Flesh quality of market-size farmed and wild British Columbia salmon. Environ Sci Technol (2007) 1.41

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. J Physiol (2007) 1.40

Measuring implementation of evidence-based guidance on promoting workers' health. Occup Med (Lond) (2012) 1.40

Palliative care in terminal cardiac failure. BMJ (1995) 1.40

Fast variability of tera-electron volt gamma rays from the radio galaxy M87. Science (2006) 1.39

Prevalence of hepatitis C among injection drug users in England and Wales: is harm reduction working? Am J Public Health (2001) 1.39

Perception, ontology, and naming in young children: commentary on Soja, Carey, and Spelke. Cognition (1992) 1.39

The sobering D2 story. Science (1994) 1.39

The varied appearances of starch particles in smears and paraffin sections. Histopathology (1988) 1.39

Analysis and prediction of carbohydrate binding sites. Protein Eng (2000) 1.39

'Appropriateness of referral to urologists': can it be defined for symptoms of benign prostatic obstruction and used as a quality measure? . BJU Int (1999) 1.38

Care of central venous catheters for total parenteral nutrition. Nutr Clin Pract (1996) 1.38

Discovery of very high energy gamma rays associated with an x-ray binary. Science (2005) 1.38

New approach to patency and flow assessment after left internal thoracic artery hypoperfusion syndrome with additional saphenous vein graft to the left anterior descending artery with phase-contrast magnetic resonance angiography. J Thorac Cardiovasc Surg (1997) 1.38

Managing a pluralist health system. Health Aff (Millwood) (1991) 1.38