Purinergic signalling: from discovery to current developments.

PubWeight™: 1.08‹?› | Rank: Top 10%

🔗 View Article (PMC 4208685)

Published in Exp Physiol on September 27, 2013

Authors

Geoffrey Burnstock1

Author Affiliations

1: G. Burnstock: University College Medical School, Autonomic Neuroscience Centre, Rowland Hill Street, London NW3 2PF, UK and Department of Pharmacology, The University of Melbourne, Australia. g.burnstock@ucl.ac.uk.

Articles citing this

The purinergic neurotransmitter revisited: a single substance or multiple players? Pharmacol Ther (2014) 1.06

Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife (2016) 0.92

Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis. ACS Nano (2016) 0.83

The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders. Front Cell Neurosci (2013) 0.83

Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla. J Physiol (2015) 0.82

LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia. Purinergic Signal (2015) 0.80

LncRNA NONRATT021972 involved the pathophysiologic processes mediated by P2X7 receptors in stellate ganglia after myocardial ischemic injury. Purinergic Signal (2015) 0.78

Short- and long-term (trophic) purinergic signalling. Philos Trans R Soc Lond B Biol Sci (2016) 0.78

Extracellular purines, purinergic receptors and tumor growth. Oncogene (2016) 0.76

Interactions of Pannexin1 channels with purinergic and NMDA receptor channels. Biochim Biophys Acta (2017) 0.75

Upregulation of P2Y2 nucleotide receptor in human hepatocellular carcinoma cells. J Int Med Res (2016) 0.75

LncRNA NONRATT021972 siRNA attenuates P2X7 receptor expression and inflammatory cytokine production induced by combined high glucose and free fatty acids in PC12 cells. Purinergic Signal (2016) 0.75

Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats. Acta Physiol (Oxf) (2015) 0.75

Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal (2016) 0.75

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies. J Biol Chem (2016) 0.75

Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects. Dose Response (2017) 0.75

P2RX7: A receptor with a split personality in inflammation and cancer. Mol Cell Oncol (2015) 0.75

Diadenosine tetraphosphate (Ap4A) inhibits ATP-induced excitotoxicity: a neuroprotective strategy for traumatic spinal cord injury treatment. Purinergic Signal (2016) 0.75

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia. Mol Brain (2016) 0.75

Supportive or detrimental roles of P2Y receptors in brain pathology?-The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies. Purinergic Signal (2015) 0.75

The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation. Purinergic Signal (2016) 0.75

Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration. J Biol Chem (2016) 0.75

Inhibition of Neutrophils by Hypertonic Saline Involves Pannexin-1, CD39, CD73, and Other Ectonucleotidases. Shock (2015) 0.75

P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol (2017) 0.75

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway. PLoS One (2017) 0.75

Disruption of the ATP/Adenosine Balance in CD39-/- Mice is Associated with Handling-Induced Seizures. Immunology (2017) 0.75

Adenosine: Direct and Indirect Actions on Gastric Acid Secretion. Front Physiol (2017) 0.75

Leishmania infantum Parasites Subvert the Host Inflammatory Response through the Adenosine A2A Receptor to Promote the Establishment of Infection. Front Immunol (2017) 0.75

Articles cited by this

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart. J Physiol (1929) 23.79

Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61

Purinergic nerves. Pharmacol Rev (1972) 12.05

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev (2001) 9.90

Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol (1985) 9.20

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol (1970) 8.20

The transmission of excitation from autonomic nerve to smooth muscle. J Physiol (1961) 6.99

Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev (2007) 6.05

The inhibitory innervation of the taenia of the guinea-pig caecum. J Physiol (1966) 5.53

A method for studying the effects of ions and drugs on the resting and action potentials in smooth muscle with external electrodes. J Physiol (1958) 5.52

A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP. Nature (1994) 5.43

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature (1994) 4.61

ATP receptor-mediated synaptic currents in the central nervous system. Nature (1992) 4.57

Analysis of he responses of the isolated stomach to electrical stimulation and to drugs. J Physiol (1963) 4.56

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature (2009) 4.18

Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther (1994) 3.93

Purine and pyrimidine receptors. Cell Mol Life Sci (2007) 3.79

Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A (1993) 3.68

The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol (1982) 3.52

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochim Biophys Acta (2008) 3.51

Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett (1993) 3.38

The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol (1959) 3.36

Inhibition of excitatory junction potentials in guinea-pig vas deferens by alpha, beta-methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters. Eur J Pharmacol (1984) 3.24

P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels. EMBO J (1998) 3.23

INNERVATION OF THE GUINEA-PIG TAENIA COLI: ARE THERE INTRINSIC INHIBITORY NERVES WHICH ARE DISTINCT FROM SYMPATHETIC NERVES? Int J Neuropharmacol (1964) 3.11

The action of adrenaline on excitability and membrane potential in the taenia coli of the guinea-pig and the effect of DNP on this action and on the action of acetylcholine. J Physiol (1958) 2.91

ATP mediates fast synaptic transmission in mammalian neurons. Nature (1992) 2.87

Purinergic signalling in the nervous system: an overview. Trends Neurosci (2008) 2.86

Purinergic innervation of the guinea-pig urinary bladder. Br J Pharmacol (1978) 2.61

The effects of acetylcholine on membrane potential, spike frequency, conduction velocity and excitability in the taenia coli of the guinea-pig. J Physiol (1958) 2.60

Do some nerve cells release more than one transmitter? Neuroscience (1976) 2.54

Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov (2008) 2.40

Purinergic signalling: ATP release. Neurochem Res (2001) 2.33

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury. Glia (2004) 2.13

The birth and postnatal development of purinergic signalling. Acta Physiol (Oxf) (2010) 2.06

Purinergic signaling and vascular cell proliferation and death. Arterioscler Thromb Vasc Biol (2002) 1.97

Purinergic signalling: pathophysiological roles. Jpn J Pharmacol (1998) 1.94

Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J Anat (1999) 1.94

P2 receptors in cardiovascular regulation and disease. Purinergic Signal (2007) 1.91

P2 receptors and cancer. Trends Pharmacol Sci (2006) 1.80

Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol (2011) 1.76

Regulation of platelet functions by P2 receptors. Annu Rev Pharmacol Toxicol (2006) 1.71

An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature (2007) 1.66

Extracellular ATP in plants. Visualization, localization, and analysis of physiological significance in growth and signaling. Plant Physiol (2006) 1.64

P2 receptor subtypes in the cardiovascular system. Biochem J (1998) 1.60

Is ATP a signaling agent in plants? Plant Physiol (2003) 1.58

[3H]adenosine triphosphate: release during stimulation of enteric nerves. Science (1971) 1.54

Autonomic nerve-smooth muscle transmission. Nature (1960) 1.49

Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal (2012) 1.49

Evolutionary origins of the purinergic signalling system. Acta Physiol (Oxf) (2009) 1.46

A unifying purinergic hypothesis for the initiation of pain. Lancet (1996) 1.45

Adenosine receptors. Adv Cyclic Nucleotide Protein Phosphorylation Res (1985) 1.45

Purinergic signalling and bone remodelling. Curr Opin Pharmacol (2010) 1.43

Functional characterization of a P2X receptor from Schistosoma mansoni. J Biol Chem (2004) 1.43

The changing face of autonomic neurotransmission. Acta Physiol Scand (1986) 1.41

Purinergic mechanosensory transduction and visceral pain. Mol Pain (2009) 1.36

Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future. Bioessays (2012) 1.24

P2 purinoceptors: historical perspective and classification. Ciba Found Symp (1996) 1.22

Permeation properties of a P2X receptor in the green algae Ostreococcus tauri. J Biol Chem (2008) 1.22

Trophic functions of nucleotides in the central nervous system. Trends Neurosci (2009) 1.21

Comparison of the effects of ultraviolet light and purinergic nerve stimulation on the guinea-pig taenia coli. Br J Pharmacol (1978) 1.20

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death. Cell Death Dis (2010) 1.19

Purinergic signalling and cancer. Purinergic Signal (2013) 1.18

ATP mediates excitatory synaptic transmission in mammalian neurones. Br J Pharmacol (1992) 1.18

Nucleotide signaling in nervous system development. Pflugers Arch (2006) 1.18

Purinergic signaling in embryonic and stem cell development. Cell Mol Life Sci (2011) 1.16

Local control of blood pressure by purines. Blood Vessels (1987) 1.12

An evolutionary history of P2X receptors. Purinergic Signal (2008) 1.11

P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 1.08

Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle. J Cell Physiol (1983) 1.08

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol (2010) 1.07

Therapeutic potential of purinergic signalling for diseases of the urinary tract. BJU Int (2011) 1.07

Molecular mechanisms of purine and pyrimidine nucleotide release. Adv Pharmacol (2011) 1.04

Acupuncture: a novel hypothesis for the involvement of purinergic signalling. Med Hypotheses (2009) 1.01

Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair. Stem Cell Rev (2012) 0.96

Noradrenaline and ATP as cotransmitters in sympathetic nerves. Neurochem Int (1990) 0.96

Purinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases. Int J Urol (2008) 0.95

Receptor-like activity evoked by extracellular ADP in Arabidopsis root epidermal plasma membrane. Plant Physiol (2011) 0.93

Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo. BJU Int (2008) 0.88

Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold. J Med Chem (2010) 0.88

Sperm treatment with extracellular ATP increases fertilization rates in in-vitro fertilization for male factor infertility. Hum Reprod (1999) 0.86

Targeting the visceral purinergic system for pain control. Curr Opin Pharmacol (2011) 0.86

Cooperation in signal transduction of extracellular guanosine 5' triphosphate and nerve growth factor in neuronal differentiation of PC12 cells. Neuroscience (2004) 0.85

Expression of nucleotide P2X receptor subtypes during spermatogenesis in the adult rat testis. Cells Tissues Organs (2001) 0.83

Neurite outgrowth of striatal neurons in vitro: involvement of purines in the growth-promoting effect of myenteric plexus explants. Int J Dev Neurosci (1996) 0.81

Transplantation of the postnatal rat myenteric plexus into the adult rat corpus striatum: an electron microscopic study. Exp Neurol (1994) 0.81

NADPH-diaphorase-containing enteric neurones survive for a year in the adult rat striatum. Neuroreport (1996) 0.79